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van de Watering Leo M G - - 2013
Possible adverse effects of prolonged storage of red blood cell concentrates (RBCs) are being formally assessed both by observational studies and in randomized controlled trials. New mechanisms have been put forth to explain earlier conflicting observations. This review summarizes ongoing investigations into clinical and basic science studies on RBC storage ...
Ghosh An - - 2013
There is growing concern that blood transfusion may be associated with adverse outcomes in critically ill patients. Timing of transfusion in relation to intensive care unit (ICU) stay may be important in designing and understanding transfusion studies. The objective of this study was to determine the timing of red blood ...
Karim Farheen - - 2013
Transfusion of blood and blood products can be associated with hazards which may be at times fatal. Timely reporting of transfusion reactions is imperative for root cause analysis and their prevention in future. We retrospectively reviewed the transfusion reactions at our institution during last seven years. The data was retrieved ...
Krishnan Suresh K - - 2013
Paroxysmal nocturnal hemoglobinuria is a rare acquired stem cell disorder characterized by intravascular hemolysis, aplasia and an increased risk of thrombosis. We describe a patient under treatment with the anti-complement antibody eculizumab who developed pancytopenia, requiring blood transfusions, due to massive splenomegaly. The patient underwent two separate splenic embolizations, which ...
Alinon K - - 2013
Although the number of blood donors has been rapidly increasing in Togo since 2003, it is nevertheless insufficient to cover the demand. To increase needed blood donation in Togo, it is necessary to understand why most people are reluctant to do it. A sample of 400 adult volunteers in Lomé, ...
Boone Jonathan D JD Department of Obstetrics and Gynecology, University of Alabama at Birmingham. Electronic address: - - 2013
Blood products are scarce but essential medical resources. Initially transfusions showed increased perioperative complications, prolonged hospitalizations, and higher mortality. Recently developed restrictive transfusion policies have not shown those adverse affects in critically ill patients. Hospitals adopted these policies to guide blood product administration. The objective of this study is to ...
Wang Jeffrey K - - 2013
To evaluate the association of blood type (non-O vs O) with venous thromboembolism (VTE) risk after radical cystectomy (RC) for bladder cancer. From 1980 to 2005, we identified 2076 consecutive patients with RC for whom blood type was available in 2008 (96.7%). We evaluated the association of blood type with ...
Bendix Brenda J BJ Division of Transfusion Medicine, Mayo Clinic, Rochester, - - 2014
The cold agglutinin (CAGG) titer is offered at our institution to aid in diagnosing cold agglutinin disease (CAD). Our goal was to create a seasonally adjusted reference range using prospective samples and compare it to a reference range generated retrospectively. Prospective CAGG titer testing was performed on healthy blood donors. ...
Banerjee Samik - - 2013
Blood loss is a serious concern during lower extremity total joint arthroplasty with the estimated reduction in hemoglobin concentration known to vary between 2 and 4 g/dL after total knee arthroplasty (TKA). Allogeneic transfusions are commonly used to treat the acute blood loss and postoperative anemia to diminish the potential ...
Matteocci A - - 2013
Red blood cell (RBC) transfusions are a milestone in the treatment for sickle cell anaemia (SSA) and for thalassaemia. RBC alloimmunization remains a major challenge of chronic transfusion therapy, and it can lead to adverse life-threatening events. The alloimmunization risk could depend on multiple factors such as the number of ...
Salpeter Shelley R SR Stanford University School of Medicine, Stanford, Calif. Electronic address: - - 2013
There is accumulating evidence that restricting blood transfusions improves outcomes, with newer trials showing greater benefit from more restrictive strategies. We systematically evaluated the impact of various transfusion triggers on clinical outcomes. The Medline database was searched from 1966 to April 2013 to find randomized trials evaluating a restrictive hemoglobin ...
Kekre Natasha - - 2013
Hematopoietic stem cell transplant (HSCT) recipients are a high risk, immunocompromised group of patients who receive frequent transfusions after transplantation. Transfusion of cytomegalovirus (CMV) negative blood products has long been the standard of care to prevent transfusion-transmitted CMV in this patient population. Leukoreduction of blood products prior to transfusion has ...
Christensen Robert D - - 2013
Abstract Red blood cell transfusions can be life-saving for neonates with severe anemia or active hemorrhage. However, risks of transfusions exist and should always be weighed against potential benefits. At least two transfusion risks are unique to very low birth weight neonates. The first is an association between transfusions given ...
Park Won-Ju - - 2013
This study inquired into any significant difference in blood lead levels (BLLs) among aircraft maintenance crews at the air-bases, each with a different aviation fuel in use, and confirmed an environmental impact of leaded aviation gasoline (AVGAS). This study included a total of 256 male aircraft maintenance personnel, among whom ...
Kalathia Mitul Babubhai MB Department of Paediatrics, Pandit Deendayal Upadhyay Medical College and Hospital, K. T. Sheth Children Hospital, Gujarat, - - 2013
Blood culture is gold standard for diagnosis of neonatal sepsis. Low sensitivity of blood culture is usually due to small volume of blood sample, intrapartum antibiotics, and antibiotics given to newborn before sampling. We evaluated use of Umbilical cord blood culture (UCBC) in diagnosis of neonatal sepsis as compared to ...
Cortés Buelvas Armando A Pathology Department in the School of Health, Universidad del Valle E-mail address: - - 2013
The red cells transfusion is a mainstay in the treatment of anemic patients. These blood transfusions are not without risks. The risk-benefit profile for red cell transfusions to treat anaemia is uncertain, but they may contribute to adverse patient outcomes in some situations. The ability of a patient to tolerate ...
Almeida Fernanda N - - 2013
Few longitudinal studies have examined the long-term effect on deferral for low haematocrit (Hct) or haemoglobin, indicators of presence of anaemia. This study retrospectively analysed 11years of donation history to examine predictors related to such deferrals among repeat blood donors. We included 385,357 donors with at least two visits to ...
Bakker Sietske T - - 2013
Blood homeostasis is maintained by a rare population of quiescent hematopoietic stem cells (HSC), which self-renew and differentiate to give rise to all lineages of mature blood cells. In contrast to most other blood cells, HSCs are preserved throughout life and maintenance of their genomic integrity is therefore paramount to ...
Kelly Lisa M - - 2013
As the use of chickens in biomedical research is increasing, demand is growing for technical skills involving poultry, particularly techniques such as venipuncture. Phlebotomy (blood collection) is an important diagnostic tool for determining causes of morbidity and mortality and for collection of other research-relevant data. This column describes four standard ...
Timberlake Kathryn S - - 2013
To assess whether blood type was associated with diminished ovarian reserve (DOR) (day-3 follicle-stimulating hormone level >10 IU/L), controlling for history of tobacco smoking, body mass index (BMI), history of endometriosis, ovarian surgery, previous pregnancy, and maternal age. Cross-sectional study. Academic medical center, Division of Reproductive Endocrinology and Infertility. Women ...
Sabayan Behnam - - 2013
We investigated the association of 2 markers of endothelial dysfunction, tissue plasminogen activator (t-PA) and Von Willebrand factor (VWF), with cerebral blood flow (CBF) in 541 older participants at high risk for cardiovascular disease. Serum levels of t-PA and VWF were measured at baseline. Participants underwent 2 successive brain magnetic ...
Trifonova Oxana - - 2013
Abstract We live in exciting times with the prospects of postgenomics diagnostics. Metabolomics is a novel "omics" data-intensive science that is accelerating the development of postgenomics diagnostics, particularly with use of accessible peripheral tissue compartments. Metabolomics involves the study of a comprehensive set of low molecular weight substances (metabolites) present ...
Huang Fei - - 2013
Conflicting reports have been published regarding the effect of tranexamic acid (TXA) on reducing blood loss and transfusion in patients undergoing orthopedic surgery. We performed a meta-analysis to evaluate the effectiveness and safety of TXA treatment in reducing blood loss and transfusion in major orthopedic surgery. MEDLINE, PubMed, EMBASE, and ...
Khlifi Rim - - 2013
Chronic exposure to heavy metals has long been recognized as being capable of increasing head and neck cancer (HNC) incidence, such as laryngeal (LC) and nasopharyngeal (NPC), among exposed human populations. The aim of the present study was to evaluate the concentrations of arsenic (As) and cadmium (Cd) in the ...
Muturi Ephantus J - - 2013
Ecological changes associated with anthropogenic ecosystem disturbances can influence human risk of exposure to malaria and other vector-borne infectious diseases. This study in Mwea, Kenya, investigated the pattern of insecticide use in irrigated and nonirrigated agroecosystems and association with the density, survival, and blood-feeding behavior of the malaria vector Anopheles ...
Zhou Feihu F Department of Critical Care Medicine, The Clinical Research, Investigation, and Systems Modeling of Acute illness (CRISMA) Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, - - 2013
Although blood purification improves outcomes in animal studies of sepsis, results of clinical trials have been mixed. We conducted a systematic review and meta-analysis of randomized trials to determine the association between various blood purification techniques and all-cause mortality in humans with sepsis. We searched for relevant studies in MEDLINE, ...
Loor Gabriel - - 2013
Anemia and red blood cell (RBC) transfusions are both associated with morbidity and mortality after cardiac surgery. Patients with the lowest hematocrit (HCT) values during cardiopulmonary bypass (CPB) are the most likely to receive a transfusion, which results in a double-negative exposure. We aimed to clarify the effects of anemia, ...
Müller Sascha A - - 2013
To assess the impact of perioperative blood transfusion on overall and disease-free survival in patients undergoing curative resection for cholangiocarcinoma. In a single-center study, 128 patients undergoing curative resection for cholangiocarcinoma between 2001 and 2010 were assessed. The median follow-up period was 19 months. Transfused and nontransfused patients were compared by ...
Vande Vusse Lisa K LK Division of Pulmonary and Critical Care Medicine, University of Washington, - - 2014
Blood transfusions are common during hematopoietic stem cell transplantation (HSCT) and may contribute to lung injury. This study examined the associations between red blood cell (RBC) and platelet (PLT) transfusions and idiopathic pneumonia syndrome (IPS) among 914 individuals who underwent myeloablative allogeneic HSCT between 1997 and 2001. Patients received allogeneic ...
Weidmann Christian C Mannheim Institute of Public Health, DRK-Blood Service Baden-Württemberg - Hessen, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany ; Institute of Transfusion Medicine and Immunology, DRK-Blood Service Baden-Württemberg - Hessen, Medical Faculty Mannheim, Heidelberg University, Mannheim, - - 2013
The aim of this study was to describe donor satisfaction regarding different aspects of the new German blood donor questionnaire (BDQ) and to assess whether donor satisfaction is associated with the intention to return for further donations. A random number of 6,600 blood donors, donating at the German Red Cross ...
Verlinden Anke - - 2013
Introduction: Collection efficiency (CE) is a reflection of the proportion of cells passing through a cell separator that is harvested. The aim of our study was to evaluate which factors influence CE independently in order to find ways to improve CE and therefore minimize the costs and risks of leukapheresis ...
Vollmar Andrea C - - 2013
Taurine plays an important role in maintaining myocardial function. Irish wolfhound dogs (IW) are at risk for dilated cardiomyopathy (DCM), but a relationship between whole blood taurine (WBT) deficiency and DCM has not been established. Our aim was to determine prevalence of WBT deficiency in IW with and without DCM ...
Banerjee Samik - - 2013
Substantial amounts of perioperative blood loss occur during total knee arthroplasty (TKA) that may require allogeneic transfusion in more than 30% of patients. Increased blood loss leads to poor physical functioning, increases infection risks, and prolongs hospitalization, which may eventually affect the overall clinical outcomes of TKA. In addition, allogeneic ...
Dentali Francesco - - 2013
We would like to thank Aksoy and colleagues for their observations [1], which confirm, also in a younger subset of patients, the results of our previous research documenting the lack of association between ABO blood group and the risk of intracranial haemorrhage (ICH) [2]. ABO blood group has a profound ...
Gutierrez Antonio - - 2013
BACKGROUND: STUDIES EXAMINING THE ASSOCIATION BETWEEN RADIAL APPROACH AND POSTPERCUTANEOUS CORONARY INTERVENTION (PCI) BLEEDING AND MORTALITY HAVE REACHED CONFLICTING CONCLUSIONS. THERE ARE NO CURRENT DATA ABOUT THE USE AND OUTCOMES OF TRANSRADIAL PCI (R-PCI) IN THE VETERANS AFFAIRS SYSTEM.METHODS AND RESULTS: CONSECUTIVE VETERANS (N=24 143 PATIENTS) UNDERGOING PCI IN THE ...
Erickson Michelle A MA 1] GRECC, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA [2] Division of Gerontology and Geriatric Medicine, Department of Internal Medicine, University of Washington School of Medicine, Seattle, Washington, USA [3] Department of Pathology, School of Dental Medicine, University of Pennsylvania, Seattle, Washington, - - 2013
The blood-brain barrier (BBB) plays critical roles in the maintenance of central nervous system (CNS) homeostasis. Dysfunction of the BBB occurs in a number of CNS diseases, including Alzheimer's disease (AD). A prevailing hypothesis in the AD field is the amyloid cascade hypothesis that states that amyloid-β (Aβ) deposition in ...
Thomas S - - 2013
Three cases of vCJD transmission by blood transfusion have been reported in the UK, and a fourth case discovered at post-mortem. Modelling has been conducted to predict the number of cases that may occur in the future through transfusion, based on estimates of prevalence, infectivity and susceptibility, and a number ...
Shaw Richard E - - 2013
Studies have found that cardiac surgery patients receiving blood transfusions are at risk for increased mortality during the first year after surgery, but risk appears to decrease after the first year. This study compared 5-year mortality in a propensity-matched cohort of cardiac surgery patients. Between July 1, 2004, and June ...
Vivek S - - 2013
Background: The purpose of the present study was to determine whether there was an association between periodontal diseases and ABO blood groups. Materials & Methods: An epidemiological study was was carried out on 220 subjects who were randomly selected from individuals referred for periodontal treatment or for other reasons regarding ...
Martin M - - 2013
Risk of transmission of Creutzfeldt-Jakob disease (infectious agent, responsible of spongiform encephalopathy) via blood and blood components (including the plasma-derived medicinal products such as coagulation factors and immunoglobulins) have been a subject of concern for Health authorities since the early 1980s, with a regain of interest in the 1990s, with ...
Browne James A - - 2013
Despite attempts to minimize exposure to allogeneic blood, there are little data on recent nationwide trends in transfusion following total hip arthroplasty (THA) and no consensus on indications. The purpose of this study was to examine the rate, predictors, and inpatient outcomes associated with transfusion after primary THA. This retrospective ...
Vichinsky Elliott - - 2013
Transfusions are the primary therapy for thalassemia but have significant cumulative risks. In 2004, the Centers for Disease Control and Prevention (CDC) established a national blood safety monitoring program for thalassemia. This report summarizes the population and their previous nonimmune and immune transfusion complications. The CDC Thalassemia Blood Safety Network ...
Nielsen Marie K K - - 2013
Methadone blood concentrations in fatal cases are highly variable and there is an appreciable overlap between therapeutic methadone concentrations and the concentrations detected in fatalities. As with other opioids, the background of these methadone-related deaths is unclear. The aim of this study was to investigate if short-time abstinence was contributing ...
Marani Carlo - - 2013
Fifty uniformly treated adult AML patients were analyzed with respect to pre-treatment and post-induction risk factors. Forty-two patients achieving complete hematological remission were assessed for minimal residual disease (MRD) by WT1 gene expression; 34 by flow-cytometry (flow-MRD). Patients who were flow-MRD negative had a better 3-year disease-free (DFS; 79.5% vs. ...
Jennings J Richard JR Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA. - - 2013
This study examined whether overall cerebral blood flow was associated with known vascular risk factors, including cardiometabolic risk factors that comprise the metabolic syndrome, carotid artery intima-media thickness, and the Framingham risk score. Three separate samples were available for analysis. Two comparable samples were combined to form a primary sample ...
Mehta Vishal - - 2013
Following impressions that the use of blood transfusion in sickle cell disease may be inappropriately high, transfusion practice at a major blood bank in an area of high prevalence of sickle cell disease was assessed. Retrospective review of blood usage in sickle cell disease at a major blood bank in ...
Solves Pilar - - 2013
Spinal surgery has been shown to have a high blood transfusion requirement. Preoperative autologous blood donation (PABD) is a strategy to reduce the allogeneic transfusions in this subset of patients. We retrospectively reviewed transfusion outcome of patients undergoing elective major spinal surgery from 2005 to 2011, and included in the ...
Garancini Mattia - - 2013
Abstract Background: Leukocyte-depleted blood transfusions were introduced to reduce transfusion-associated immunomodulation, but the clinical effects of different types of leukocyte depletion have been analyzed rarely. The aim of this survey was to analyze the clinical impact of pre-storage leukocyte-depleted blood transfusions (considered as pre-storage or bedside-filtered) on post-operative complications in ...
Iyengar Amit - - 2013
Blood product transfusion during cardiopulmonary bypass has been demonstrated to be associated with increased morbidity and mortality in adult cardiac surgery populations. The aim of this study was to characterize the risk-adjusted occurrence of postoperative complications and mortality in relation to intraoperative blood product transfusion in our pediatric cardiac surgery ...
Tarantino Ignazio - - 2013
The aim of this study was to assess the putative impact of perioperative blood transfusions on overall survival in patients undergoing curative resection for stage III colon cancer by applying propensity scoring methods. In a single-center study, a total of 309 patients who underwent open curative resection for stages I-III ...
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