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Ziemann Malte M Institute of Transfusion Medicine, University Hospital of Schleswig-Holstein, Lübeck, - - 2014
Traditionally, leukoreduction and selection of blood products from seronegative donors have been used as alternative strategies to reduce the risk of transfusion-transmitted cytomegalovirus infections (TT-CMV) in atrisk patients. After the introduction of universal leukoreduction for red blood cell and platelet concentrates in Germany, a controversy evolved as to whether the ...
Kilic Arman A Division of Cardiac Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, - - 2013
Although red blood cell (RBC) transfusions are frequently used in cardiac operations, an increasing amount of data has demonstrated deleterious consequences. Consequently, the appropriate use of this limited resource is unclear. In this review, we discuss the relationship between anemia and the outcomes of cardiac surgical procedures, the risks associated ...
Zhu Si-Hai SH Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University , Nanjing , - - 2013
Abstract Introduction. Accumulating evidence suggests that enhanced inflammatory responses contribute to the pathogenesis of postoperative cognitive dysfunction (POCD). Blood transfusion can trigger an enhancement of acute inflammatory responses. Therefore, we hypothesized that perioperative blood transfusion is associated with a higher risk of POCD in aged patients following total hip replacement ...
Klatte Tobias T Department of Urology, Medical University of Vienna, Vienna General Hospital, Vienna, - - 2013
ABO blood type is an established prognostic factor in several malignancies, but its role in urothelial carcinoma of the bladder (UCB) is largely unknown. The objective of this study was to determine whether ABO blood type is associated with outcomes after transurethral resection (TURB) of non-muscle-invasive UCB (NMIBC). We retrospectively ...
Chuang Wei-Lien WL Genzyme Corporation, a Sanofi Company, One Mountain Road, Framingham, MA 01701-9322, - - 2013
Niemann-Pick disease type B (NPD-B) is caused by a partial deficiency of acid sphingomyelinase activity and results in the accumulation of lysosomal sphingomyelin (SPM) predominantly in macrophages. Notably, SPM is not significantly elevated in the plasma, whole blood, or urine of NPD-B patients. Here, we show that the de-acylated form ...
Woo Janghee - - 2013
Flow cytometry offers great diagnostic opportunities in the vast majority of hematologic and oncologic diseases with multiple cellular and molecular information within an individual cell. We will discuss various applications of flow cytometry, particularly in hematology and oncology, in addition to general principles and limitations of flow cytometry. They include ...
Liu Jun - - 2013
A systematic review of randomized controlled trials was conducted to examine the efficacy of fibrin sealants for the reduction of postoperative blood loss and allogeneic red blood cell transfusion in total knee arthroplasty (TKA). Studies published through May 2013 were identified from PubMed, Embase, the Cochrane library, ScienceDirect, and other ...
McCully Sean P - - 2013
The international normalized ratio (INR) was developed to assess adequacy of Coumadin dosing. Its use has been generalized to guide fresh frozen plasma (FFP) therapy in stable patients. Thrombelastography (TEG) is a whole-blood assay measuring the viscoelastic properties of the clot in near real time. This study hypothesized that INR ...
Cohen B B Division of Anesthesiology, Pain and Critical Care, Tel Aviv Medical Centre, Affiliated with Sackler Medical School, Tel Aviv University, Tel Aviv, - - 2013
Blood transfusion saves many lives but carries significant risk of injury. Currently, red blood cell (RBC) concentrates can be stored up to 42 days. Concerns have recently been raised about the safety and efficacy of transfusing stored RBCs. Refrigerated storage results in a 'storage lesion' that is reflected by metabolic ...
Santos Antônio Alceu Dos - - 2013
Transfusions of one or more packed red blood cells is a widely strategy used in cardiac surgery, even after several evidences of increased morbidity and mortality. The world's blood shortage is also already evident. To assess whether the risk of mortality is dose-dependent on the number of packed red blood ...
Limberg Jacqueline K - - 2013
Altered vascular shear profiles may contribute to the development of atherosclerosis. Physical activity promotes anti-atherogenic shear patterns, resulting in reduced cardiovascular disease risk. Adults with metabolic syndrome (MetSyn) are at increased risk of developing atherosclerosis and cardiovascular disease. Thus, we hypothesized that conduit artery antegrade shear rate (ASR) would increase ...
Guo Fangming - - 2013
We aimed to investigate the association between local interleukin-6 (IL-6) levels at the infarct-related artery and the risk of slow flow/microvascular dysfunction after PCI in ST-elevation acute myocardial infarction (AMI) patients treated by successful primary PCI. 56 eligible ST-elevation AMI patients (34 male/22 female, mean age: 63.5 ± 10.3 years), undergoing successful primary ...
Meza Benjamin P L BP HIV Prevention Branch, Division of Global HIV/AIDS, Center for Global Health, U.S. Centers for Disease Control and Prevention, Atlanta, GA, United States of America The CDC Experience Applied Epidemiology Fellowship, Scientific Education and Professional Development Program Office, U.S. Centers for Disease Control and Prevention, Atlanta, GA, United States of - - 2013
Acute transfusion reactions are probably common in sub-Saharan Africa, but transfusion reaction surveillance systems have not been widely established. In 2008, the Blood Transfusion Service of Namibia implemented a national acute transfusion reaction surveillance system, but substantial under-reporting was suspected. We estimated the actual prevalence and rate of acute transfusion ...
Amelotti I - - 2013
Among peridomestic structures, chicken coops are sites of major importance for the domestic ecology of Triatoma infestans (Hemiptera: Reduviidae). The aim of this study was to evaluate in an experimental context the effects of a cypermethrin pour-on formulation applied to chickens on blood intake, moulting and mortality in T. infestans, under ...
Mhyre Jill M - - 2013
To define the frequency, risk factors, and outcomes of massive transfusion in obstetrics. The State Inpatient Dataset for New York (1998-2007) was used to identify all delivery hospitalizations for hospitals that reported at least one delivery-related transfusion per year. Multivariable logistic regression analysis was performed to examine the relationship between ...
van de Watering Leo M G - - 2013
Possible adverse effects of prolonged storage of red blood cell concentrates (RBCs) are being formally assessed both by observational studies and in randomized controlled trials. New mechanisms have been put forth to explain earlier conflicting observations. This review summarizes ongoing investigations into clinical and basic science studies on RBC storage ...
Ghosh An - - 2013
There is growing concern that blood transfusion may be associated with adverse outcomes in critically ill patients. Timing of transfusion in relation to intensive care unit (ICU) stay may be important in designing and understanding transfusion studies. The objective of this study was to determine the timing of red blood ...
Karim Farheen - - 2013
Transfusion of blood and blood products can be associated with hazards which may be at times fatal. Timely reporting of transfusion reactions is imperative for root cause analysis and their prevention in future. We retrospectively reviewed the transfusion reactions at our institution during last seven years. The data was retrieved ...
Krishnan Suresh K - - 2013
Paroxysmal nocturnal hemoglobinuria is a rare acquired stem cell disorder characterized by intravascular hemolysis, aplasia and an increased risk of thrombosis. We describe a patient under treatment with the anti-complement antibody eculizumab who developed pancytopenia, requiring blood transfusions, due to massive splenomegaly. The patient underwent two separate splenic embolizations, which ...
Alinon K - - 2013
Although the number of blood donors has been rapidly increasing in Togo since 2003, it is nevertheless insufficient to cover the demand. To increase needed blood donation in Togo, it is necessary to understand why most people are reluctant to do it. A sample of 400 adult volunteers in Lomé, ...
Boone Jonathan D JD Department of Obstetrics and Gynecology, University of Alabama at Birmingham. Electronic address: - - 2013
Blood products are scarce but essential medical resources. Initially transfusions showed increased perioperative complications, prolonged hospitalizations, and higher mortality. Recently developed restrictive transfusion policies have not shown those adverse affects in critically ill patients. Hospitals adopted these policies to guide blood product administration. The objective of this study is to ...
Wang Jeffrey K - - 2013
To evaluate the association of blood type (non-O vs O) with venous thromboembolism (VTE) risk after radical cystectomy (RC) for bladder cancer. From 1980 to 2005, we identified 2076 consecutive patients with RC for whom blood type was available in 2008 (96.7%). We evaluated the association of blood type with ...
Bendix Brenda J BJ Division of Transfusion Medicine, Mayo Clinic, Rochester, - - 2014
The cold agglutinin (CAGG) titer is offered at our institution to aid in diagnosing cold agglutinin disease (CAD). Our goal was to create a seasonally adjusted reference range using prospective samples and compare it to a reference range generated retrospectively. Prospective CAGG titer testing was performed on healthy blood donors. ...
Banerjee Samik - - 2013
Blood loss is a serious concern during lower extremity total joint arthroplasty with the estimated reduction in hemoglobin concentration known to vary between 2 and 4 g/dL after total knee arthroplasty (TKA). Allogeneic transfusions are commonly used to treat the acute blood loss and postoperative anemia to diminish the potential ...
Matteocci A - - 2013
Red blood cell (RBC) transfusions are a milestone in the treatment for sickle cell anaemia (SSA) and for thalassaemia. RBC alloimmunization remains a major challenge of chronic transfusion therapy, and it can lead to adverse life-threatening events. The alloimmunization risk could depend on multiple factors such as the number of ...
Salpeter Shelley R SR Stanford University School of Medicine, Stanford, Calif. Electronic address: - - 2013
There is accumulating evidence that restricting blood transfusions improves outcomes, with newer trials showing greater benefit from more restrictive strategies. We systematically evaluated the impact of various transfusion triggers on clinical outcomes. The Medline database was searched from 1966 to April 2013 to find randomized trials evaluating a restrictive hemoglobin ...
Kekre Natasha - - 2013
Hematopoietic stem cell transplant (HSCT) recipients are a high risk, immunocompromised group of patients who receive frequent transfusions after transplantation. Transfusion of cytomegalovirus (CMV) negative blood products has long been the standard of care to prevent transfusion-transmitted CMV in this patient population. Leukoreduction of blood products prior to transfusion has ...
Christensen Robert D - - 2013
Abstract Red blood cell transfusions can be life-saving for neonates with severe anemia or active hemorrhage. However, risks of transfusions exist and should always be weighed against potential benefits. At least two transfusion risks are unique to very low birth weight neonates. The first is an association between transfusions given ...
Park Won-Ju - - 2013
This study inquired into any significant difference in blood lead levels (BLLs) among aircraft maintenance crews at the air-bases, each with a different aviation fuel in use, and confirmed an environmental impact of leaded aviation gasoline (AVGAS). This study included a total of 256 male aircraft maintenance personnel, among whom ...
Kalathia Mitul Babubhai MB Department of Paediatrics, Pandit Deendayal Upadhyay Medical College and Hospital, K. T. Sheth Children Hospital, Gujarat, - - 2013
Blood culture is gold standard for diagnosis of neonatal sepsis. Low sensitivity of blood culture is usually due to small volume of blood sample, intrapartum antibiotics, and antibiotics given to newborn before sampling. We evaluated use of Umbilical cord blood culture (UCBC) in diagnosis of neonatal sepsis as compared to ...
Cortés Buelvas Armando A Pathology Department in the School of Health, Universidad del Valle E-mail address: - - 2013
The red cells transfusion is a mainstay in the treatment of anemic patients. These blood transfusions are not without risks. The risk-benefit profile for red cell transfusions to treat anaemia is uncertain, but they may contribute to adverse patient outcomes in some situations. The ability of a patient to tolerate ...
Almeida Fernanda N - - 2013
Few longitudinal studies have examined the long-term effect on deferral for low haematocrit (Hct) or haemoglobin, indicators of presence of anaemia. This study retrospectively analysed 11years of donation history to examine predictors related to such deferrals among repeat blood donors. We included 385,357 donors with at least two visits to ...
Bakker Sietske T ST Division of Hematology/Oncology, Department of Medicine, The Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of California-San Francisco, San Francisco, CA, - - 2013
Blood homeostasis is maintained by a rare population of quiescent hematopoietic stem cells (HSCs) that self-renew and differentiate to give rise to all lineages of mature blood cells. In contrast to most other blood cells, HSCs are preserved throughout life, and the maintenance of their genomic integrity is therefore paramount ...
Kelly Lisa M - - 2013
As the use of chickens in biomedical research is increasing, demand is growing for technical skills involving poultry, particularly techniques such as venipuncture. Phlebotomy (blood collection) is an important diagnostic tool for determining causes of morbidity and mortality and for collection of other research-relevant data. This column describes four standard ...
Timberlake Kathryn S - - 2013
To assess whether blood type was associated with diminished ovarian reserve (DOR) (day-3 follicle-stimulating hormone level >10 IU/L), controlling for history of tobacco smoking, body mass index (BMI), history of endometriosis, ovarian surgery, previous pregnancy, and maternal age. Cross-sectional study. Academic medical center, Division of Reproductive Endocrinology and Infertility. Women ...
Sabayan Behnam - - 2013
We investigated the association of 2 markers of endothelial dysfunction, tissue plasminogen activator (t-PA) and Von Willebrand factor (VWF), with cerebral blood flow (CBF) in 541 older participants at high risk for cardiovascular disease. Serum levels of t-PA and VWF were measured at baseline. Participants underwent 2 successive brain magnetic ...
Trifonova Oxana O Institute of Biomedical Chemistry RAMS , Moscow, Russia - - 2013
We live in exciting times with the prospects of postgenomics diagnostics. Metabolomics is a novel "omics" data-intensive science that is accelerating the development of postgenomics diagnostics, particularly with use of accessible peripheral tissue compartments. Metabolomics involves the study of a comprehensive set of low molecular weight substances (metabolites) present in ...
Huang Fei - - 2013
Conflicting reports have been published regarding the effect of tranexamic acid (TXA) on reducing blood loss and transfusion in patients undergoing orthopedic surgery. We performed a meta-analysis to evaluate the effectiveness and safety of TXA treatment in reducing blood loss and transfusion in major orthopedic surgery. MEDLINE, PubMed, EMBASE, and ...
Khlifi Rim - - 2013
Chronic exposure to heavy metals has long been recognized as being capable of increasing head and neck cancer (HNC) incidence, such as laryngeal (LC) and nasopharyngeal (NPC), among exposed human populations. The aim of the present study was to evaluate the concentrations of arsenic (As) and cadmium (Cd) in the ...
Muturi Ephantus J - - 2013
Ecological changes associated with anthropogenic ecosystem disturbances can influence human risk of exposure to malaria and other vector-borne infectious diseases. This study in Mwea, Kenya, investigated the pattern of insecticide use in irrigated and nonirrigated agroecosystems and association with the density, survival, and blood-feeding behavior of the malaria vector Anopheles ...
Zhou Feihu F Department of Critical Care Medicine, The Clinical Research, Investigation, and Systems Modeling of Acute illness (CRISMA) Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, - - 2013
Although blood purification improves outcomes in animal studies of sepsis, results of clinical trials have been mixed. We conducted a systematic review and meta-analysis of randomized trials to determine the association between various blood purification techniques and all-cause mortality in humans with sepsis. We searched for relevant studies in MEDLINE, ...
Loor Gabriel - - 2013
Anemia and red blood cell (RBC) transfusions are both associated with morbidity and mortality after cardiac surgery. Patients with the lowest hematocrit (HCT) values during cardiopulmonary bypass (CPB) are the most likely to receive a transfusion, which results in a double-negative exposure. We aimed to clarify the effects of anemia, ...
Müller Sascha A - - 2013
To assess the impact of perioperative blood transfusion on overall and disease-free survival in patients undergoing curative resection for cholangiocarcinoma. In a single-center study, 128 patients undergoing curative resection for cholangiocarcinoma between 2001 and 2010 were assessed. The median follow-up period was 19 months. Transfused and nontransfused patients were compared by ...
Vande Vusse Lisa K LK Division of Pulmonary and Critical Care Medicine, University of Washington, - - 2014
Blood transfusions are common during hematopoietic stem cell transplantation (HSCT) and may contribute to lung injury. This study examined the associations between red blood cell (RBC) and platelet (PLT) transfusions and idiopathic pneumonia syndrome (IPS) among 914 individuals who underwent myeloablative allogeneic HSCT between 1997 and 2001. Patients received allogeneic ...
Weidmann Christian C Mannheim Institute of Public Health, DRK-Blood Service Baden-Württemberg - Hessen, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany ; Institute of Transfusion Medicine and Immunology, DRK-Blood Service Baden-Württemberg - Hessen, Medical Faculty Mannheim, Heidelberg University, Mannheim, - - 2013
The aim of this study was to describe donor satisfaction regarding different aspects of the new German blood donor questionnaire (BDQ) and to assess whether donor satisfaction is associated with the intention to return for further donations. A random number of 6,600 blood donors, donating at the German Red Cross ...
Verlinden Anke - - 2013
Introduction: Collection efficiency (CE) is a reflection of the proportion of cells passing through a cell separator that is harvested. The aim of our study was to evaluate which factors influence CE independently in order to find ways to improve CE and therefore minimize the costs and risks of leukapheresis ...
Vollmar Andrea C - - 2013
Taurine plays an important role in maintaining myocardial function. Irish wolfhound dogs (IW) are at risk for dilated cardiomyopathy (DCM), but a relationship between whole blood taurine (WBT) deficiency and DCM has not been established. Our aim was to determine prevalence of WBT deficiency in IW with and without DCM ...
Banerjee Samik - - 2013
Substantial amounts of perioperative blood loss occur during total knee arthroplasty (TKA) that may require allogeneic transfusion in more than 30% of patients. Increased blood loss leads to poor physical functioning, increases infection risks, and prolongs hospitalization, which may eventually affect the overall clinical outcomes of TKA. In addition, allogeneic ...
Dentali Francesco - - 2013
We would like to thank Aksoy and colleagues for their observations [1], which confirm, also in a younger subset of patients, the results of our previous research documenting the lack of association between ABO blood group and the risk of intracranial haemorrhage (ICH) [2]. ABO blood group has a profound ...
Gutierrez Antonio - - 2013
BACKGROUND: STUDIES EXAMINING THE ASSOCIATION BETWEEN RADIAL APPROACH AND POSTPERCUTANEOUS CORONARY INTERVENTION (PCI) BLEEDING AND MORTALITY HAVE REACHED CONFLICTING CONCLUSIONS. THERE ARE NO CURRENT DATA ABOUT THE USE AND OUTCOMES OF TRANSRADIAL PCI (R-PCI) IN THE VETERANS AFFAIRS SYSTEM.METHODS AND RESULTS: CONSECUTIVE VETERANS (N=24 143 PATIENTS) UNDERGOING PCI IN THE ...
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