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Barker Alex J AJ Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, - - 2014
To compare pulmonary artery flow using Cartesian and radially sampled four-dimensional flow-sensitive (4D flow) MRI at two institutions. Nineteen healthy subjects and 17 pulmonary arterial hypertension (PAH) subjects underwent a Cartesian 4D flow acquisition (institution 1) or a three-dimensional radial acquisition (institution 2). The diameter, peak systolic velocity (Vmax), peak ...
Tokarski SÅ‚awomir - - 2014
In industrialized countries lung cancer is associated with highest mortality among carcinoma. Progression of the disease is associated with diminished tolerance for physical activities, aggravated dyspnea and lowering of life quality. The aim of study was the evaluation of blood gas, blood saturation and chosen parameters of spirometric examination in ...
Gaspari Romolo J RJ a Department of Emergency Medicine, University of Massachusetts School of Medicine, 55 Lake Avenue North, Worcester, MA 01655, - - 2014
Atropine is used for a number of medical conditions, predominantly for its cardiovascular effects. Cholinergic nerves that innervate pulmonary smooth muscle, glands, and vasculature may be affected by anticholinergic medications. We hypothesized that atropine causes alterations in pulmonary gas exchange. We conducted a prospective interventional study with detailed physiologic recordings ...
Sugimoto Masaya - - 2013
Background: Velocity-encoded cine magnetic resonance imaging (VEC-MRI) has recently been reported as effective for assessing not only pulmonary blood flow (Qp) but also pulmonary arterial pressure (PAP) in adults. However, there have been few reports on the usefulness of VEC-MRI for assessing PAP in children with congenital heart disease (CHD). Methods ...
Liu Jinlong - - 2013
The modified Blalock-Taussig (mB-T) shunt is an effective palliative surgical method in the treatment of cyanotic congenital heart diseases. It increases the pulmonary blood flow through an implanted shunt between systemic and pulmonary arteries. The surgical technique improved over the years. However, it is still a challenge to control appropriate ...
Chang Daniel V - - 2013
Angiogenesis is a critical determinant of alveolarization, which increases alveolar surface area and pulmonary capillary blood volume in infants; however, our understanding of this process is very limited.The purpose of our study was to measure the membrane (DM) and pulmonary capillary (VC) components of pulmonary diffusion to carbon monoxide (DL,CO) ...
Sharma Shruti - - 2013
Background:In our model of congenital heart disease (CHD) with increased pulmonary blood flow (Shunt), we have recently shown a disruption in carnitine homeostasis, associated with mitochondrial dysfunction and decreased eNOS/Hsp90 interactions that contribute to eNOS uncoupling, increased superoxide levels, and decreased bioavailable NO. Thus, we undertook this study to test ...
Dickinson Michael G - - 2013
Pulmonary Arterial Hypertension (PAH) is a progressive pulmonary vasoproliferative disorder characterized by the development of unique neointimal lesions including concentric laminar intima fibrosis and plexiform lesions. Although the histomorphology of neointimal lesions is well described, the pathogenesis of PAH and neointimal development is largely unknown. After three decades of PAH ...
McLean Anthony S - - 2013
PURPOSE OF REVIEW: To review the role of blood analysis in cardiac and pulmonary evaluation. RECENT FINDINGS: A comprehensive understanding of arterial blood gas analysis - often aided by venous blood gas analysis, to help determine the ideal levels of blood oxygenation and hemoglobin (Hb), is reviewed in light of ...
Saugel Bernd - - 2013
BACKGROUND: The aim of the study was to investigate the effect of red blood cell (RBC) transfusion on hemodynamic parameters including transpulmonary thermodilution (TPTD)-derived variables. METHODS: We compared hemodynamic parameters obtained before and after RBC transfusion (2 RBC units) in 34 intensive care unit (ICU) patients. RESULTS: Directly after RBC ...
Fung Y L - - 2013
BACKGROUND AND OBJECTIVES: Transfusion of blood products in particular older products is associated with patient morbidity. Previously, we demonstrated a higher incidence of acute lung injury in lipopolysaccharide-treated sheep transfused with stored blood products. As transfusion following haemorrhage is more common, we aimed to determine whether a 'first hit' of ...
Ghazanfari Tooba - - 2013
The most important long-term morbidity problem of sulfur mustard (SM) toxicity is pulmonary complications but the pathogenesis of these complications is not clearly understood. This study evaluates the peripheral blood mononuclear sub-sets and their correlation with pulmonary function in SM exposed civilian cases 20years post-exposure as gathered in the context ...
Grosse-Wortmann Lars - - 2013
OBJECTIVE: The management of patients with tetralogy of Fallot (ToF) and pulmonary atresia (PA) with major aortopulmonary collateral arteries (MAPCAs) is challenging. Frequently it is difficult to predict whether complete repair with closure of the ventricular septal defect (VSD) will be tolerated. The aim of this study was to investigate ...
Dori Yoav - - 2013
BACKGROUND: THE SIGNIFICANCE AND OPTIMAL TREATMENT OF SYSTEMIC-TO-PULMONARY ARTERIAL COLLATERAL (SPC) VESSELS IN SINGLE VENTRICLE PATIENTS ARE POORLY UNDERSTOOD. THE ACUTE EFFICACY OF SPC EMBOLIZATION HAS NOT BEEN DEMONSTRATED IN A QUANTIFIABLE FASHION. WE SOUGHT TO ASSESS THE ACUTE EFFICACY OF SPC EMBOLIZATION ON BLOOD FLOW AS QUANTIFIED BY PHASE ...
Solomon Steven B SB Critical Care Medicine Department, National Institutes of Health (NIH) Clinical Center, Bethesda, MD 20892, - - 2013
Two-year-old purpose-bred beagles (n = 24) infected with Staphylococcus aureus pneumonia were randomized in a blinded fashion for exchange transfusion with either 7- or 42-day-old canine universal donor blood (80 mL/kg in 4 divided doses). Older blood increased mortality (P = .0005), the arterial alveolar oxygen gradient (24-48 hours after ...
Li H - - 2012
To compare the diagnostic validity of blood enzyme-linked immunospot assay (ELISpot), broncho-alveolar lavage (BAL) ELISpot and the tuberculin skin test (TST) in patients with pulmonary smear-negative tuberculosis (TB) in a country with high TB prevalence. In a prospective, hospital-based study, 107 patients with suspected TB were tested simultaneously using blood ...
Huang Wei - - 2012
The objective of our study was to develop a computing program for computing the transit time frequency distributions of red blood cell in human pulmonary circulation, based on our anatomic and elasticity data of blood vessels in human lung. A stochastic simulation model was introduced to simulate blood flow in ...
Zhang Lili - - 2012
Neurogenic pulmonary edema (NPE) is an acute and serious complication after a central nervous system insult with high mortality. The pronounced activation of sympathetic nervous system and the release of vasoactive substances are necessary prerequisites for the development of NPE. We introduce a hypothesis that stellate ganglion block (SGB) may ...
Hanna Gabi - - 2012
Intravital microscopy of the pulmonary microcirculation in research animals is of great scientific interest for its utility in identifying regional changes in pulmonary microcirculatory blood flow. Although feasibility studies have been reported, the pulmonary window can be further refined into a practical tool for pharmaceutical research and drug development. We ...
Setchi Adriana - - 2012
The ductus arteriosus is one of several shunts in the cardiovascular system. It is a small vessel connecting the aortic arch and pulmonary artery that allows blood to bypass the pulmonary circulation. It is open during foetal development because the foetal lungs cannot function and oxygenation of the blood occurs ...
Benson Alexander B - - 2012
Three transfusion complications are responsible for the majority of the morbidity and mortality in hospitalized patients. This article discusses the respiratory complications associated with these pathophysiologic processes, including definitions, diagnosis, mechanism, incidence, risk factors, clinical management, and strategies for prevention. It also explores how different patient populations and different blood ...
Hughes J Michael B JM Imperial College School of Medicine, Hammersmith Hospital, London, UK. - - 2013
The transfer factor of the lung for nitric oxide (T(L,NO)) is a new test for pulmonary gas exchange. The procedure is similar to the already well-established transfer factor of the lung for carbon monoxide (T(L,CO)). Physiologically, T(L,NO) predominantly measures the diffusion pathway from the alveoli to capillary plasma. In the ...
Sakaguchi Shunji - - 2011
The aim of this study was to investigate the association between the morphologic classification of nailfold capillary microscopy and the clinical and demographic findings in workers exposed to hand-arm vibration. The subjects were 44 male forestry workers (average age; 51.9 ± 14.8 yr). The nailfold capillaries (NC) and the mean ...
West John B - - 2011
Two selective pressures have shaped the evolution of the pulmonary circulation. First, as animals evolved from heterothermic ectotherms to homeothermic endoderms with their corresponding increase in the ability to sustain high oxygen consumptions, the blood-gas barrier had to become successively thinner, and also provide an increasingly large area for diffusive ...
Perruchoud Christophe - - 2011
Objective.  We compared the analgesia and the quality of life of a constant daily dose of intrathecal drug administered at different flow rates in patients treated for chronic pain. We postulate that the quality of the analgesia, at the same daily dose, will show an infusion rate dependent pattern with ...
Lin Min - - 2011
OBJECTIVES: The initiation of the pain sensation experienced following the thermal stimulation of dentine has been correlated with fluid flow in the dentinal tubules. There may be other mechanisms. METHODS: This study examines this possibility using a mathematical model to simulate the temperature and thermal stress distribution in a tooth ...
Yoshimura Takeshi - - 2011
In addition to its regulatory effect on bone mass, calcitonin has been shown to relieve pain and alleviate peripheral circulatory disturbance in patients with Raynaud's syndrome and complex regional pain syndrome. In the present study, we investigated whether calcitonin ameliorates diminished blood flow and enhanced arterial contraction in response to ...
Kohl Sandro - - 2011
PURPOSE: Total knee arthroplasty (TKA) disturbs patellar blood flow, an unintended accompaniment to TKA that may be a cause of postoperative anterior knee pain. We examine whether disrupted patellar blood flow correlates with anterior knee pain following TKA. METHODS: In 50 patients (21 men, 29 women) undergoing TKA, we compared ...
Kim So Yeon - - 2011
Bilateral total knee arthroplasty is generally accompanied by a significant amount of blood loss. We investigated the relationship between the intensity of pain and the amount of blood loss in the early postoperative period after bilateral total knee arthroplasty. A prospective study was conducted on 91 patients who underwent elective ...
Glenny Robb W - - 2011
The primary function of the pulmonary circulation is to deliver blood to the alveolar capillaries to exchange gases. Distributing blood over a vast surface area facilitates gas exchange, yet the pulmonary vascular tree must be constrained to fit within the thoracic cavity. In addition, pressures must remain low within the ...
Durila Miroslav - - 2010
In critically ill patients, either arterial or venous blood is usually available for sampling and measurement of basic coagulation parameters. The aim of this study was to examine whether in these patients the values of coagulation parameters differ significantly with respect to the source of the blood samples. In a ...
Key Nigel S - - 2010
Tissue factor (TF) is a transmembrane protein that initiates coagulation following contact with factor VII/VIIa. Recent experimental evidence, in particular from animal models, suggests an important role for circulating TF in thrombosis. This has led to a growing interest in the measurement of TF in whole blood and in cell-free ...
Abd El Rahman M Y - - 2011
We present a case of a full-term female neonate who presented at 6 h of age with severe cyanosis and was partially responsive to oxygen supplementation. An echocardiogram showed an isolated congenital severe tricuspid valve insufficiency due to rupture of the papillary muscle of the anterior tricuspid valve leaflet. Magnesium sulfate ...
Gonzalez Eduardo - - 2010
Current recommendations for resuscitation of the critically injured patient are limited by a lack of point-of-care (POC) assessment of coagulation status. Accordingly, the potential exists for indiscriminant blood component administration. Furthermore, although thromboembolic events have been described shortly after injury, the time sequence of post-injury coagulation changes is unknown. Our ...
Mendez-Angulo Jose L - - 2010
To evaluate the use of citrated recalcified (nonactivated) thromboelastography (TEG) in healthy horses and horses with colitis and suspected coagulopathies. Prospective, observational study conducted between October 2007 and June 2009. Veterinary Teaching Hospital. Forty-five healthy adult horses and 12 sick adult horses with colitis and prolonged prothrombin time (PT) or ...
Morley Sarah L - - 2011
Acquired coagulopathy is a relatively uncommon occurrence in acute paediatrics but when it occurs is usually associated with significant underlying pathology and often with critical illness. It can be caused by a number of disease processes but infection, blood loss, iatrogenic causes and liver dysfunction are among the commonest. The ...
Desrumaux Catherine - - 2010
Earlier in vitro studies suggested a putative role for the plasma phospholipid transfer protein (PLTP) in the modulation of blood coagulation. The effect of PLTP expression on blood coagulation under both basal and oxidative stress conditions was compared here in wild-type and PLTP-deficient (PLTP-/-) mice. Under basal conditions, PLTP deficiency ...
Yang Bor-Wen - - 2010
To maintain the life of patients with hemophilia, apoplexy or hemorrhage, appropriate blood coagulation is crucial. To study the microscopic phenomena of blood coagulation and the therapeutic effects of blood medication, optical tweezers were applied to estimate the interaction between red blood cells in the coagulation process. By measuring minimum ...
Hellingman A A - - 2010
To identify the optimal mouse model for hind limb ischaemia, which offers a therapeutic window that is large enough to detect improvements of blood flow recovery, for example, using cell therapies. Different surgical approaches were performed: single coagulation of femoral and iliac artery, total excision of femoral artery and double ...
Peng Henry T - - 2010
Thromboelastography (TEG) is drawing more attention for clinical and in vitro studies of blood coagulation. It can be applied to evaluate the effects of both blood-soluble and insoluble biomaterials on whole blood coagulation from the beginning of coagulation through clot formation to the ending with fibrinolysis. TEG may also identify ...
Casutt M - - 2010
BACKGROUND: Hydroxyethyl starch (HES) solutions compromise blood coagulation. Low molecular weight, low-substituted HES products, and electrolyte-balanced solutions might reduce this effect. We compared the effects of in vitro haemodilution on blood coagulation with a balanced 6% HES 130/0.42 solution (HES(BAL)), a saline-based 6% HES 130/0.4 solution (HES(SAL)), a balanced lactated ...
Cimmino Giovanni - - 2011
The term "vulnerable plaque" identifies atherosclerotic lesions prone to rupture. Plaque disruption facilitates the interaction of the inner components of the lesion, tissue factor (TF) among them, with the flowing blood. This results in activation of the coagulation cascade, ultimately leading to thrombus formation, and abrupt vascular occlusion. Despite the ...
Al-Rudainy Laith Abdulmajeed - - 2010
This study aims to determine the level of lead in blood of fuel station workers and in a group of people not occupationally exposed to lead 53 control subjects with low risk lead exposure and 45 fuel station workers comprising the study group were included in this study in a ...
Liu Yunbo - - 2010
Egg white, a protein-containing solution, is characterized as a blood coagulation surrogate for the acoustical and thermal evaluation of therapeutic ultrasound, especially high intensity focused ultrasound (HIFU) devices. Physical properties, including coagulation temperature, frequency dependent attenuation, sound speed, viscosity, and thermal properties, were measured as a function of temperature (20-95 ...
Kupesiz Alphan - - 2010
Fibrinolysis is a complex physiological process that involves the interaction of several anticoagulant proteins. Defects of the fibrinolytic system are extremely difficult to diagnose and study because there are no standardized tests available. Thromboelastography is a novel method that allows the study of both coagulation and fibrinolysis using one sample ...
Xu Zhiliang - - 2010
A combination of the extended multiscale model, new image processing algorithms, and biological experiments is used for studying the role of Factor VII (FVII) in venous thrombus formation. A detailed submodel of the tissue factor pathway of blood coagulation is introduced within the framework of the multiscale model to provide ...
Panteleev Mikhail A - - 2010
Analysis of complex time-dependent biological networks is an important challenge in the current postgenomic era. We propose a middle-out approach for decomposition and analysis of complex time-dependent biological networks based on: 1), creation of a detailed mechanism-driven mathematical model of the network; 2), network response decomposition into several physiologically relevant ...
Konishi Noriko - - 2010
Activated platelets facilitate blood coagulation by providing factor V and a procoagulant surface for prothrombinase. Here, we investigated the potential synergy of a potent factor Xa/prothrombinase inhibitor, TAK-442, plus aspirin or clopidogrel in preventing arterial thrombosis and whole blood coagulation. Thrombus formation was initiated by FeCl(3)-induced rat carotid injury. Bleeding ...
Choi Soo Joo - - 2010
Individuals with type O blood are more likely to have reduced factor VIII and von Willebrand factor levels compared to their non-O counterparts. Hydroxyethyl starch (HES), which is widely used for blood volume replacement, can induce coagulopathy. Therefore, we tested whether blood type O patients show more coagulopathy and blood ...
Knoebl Paul - - 2010
Host defense and blood coagulation are tightly connected and interacting systems, necessary for the integrity of an organism. Complex mechanisms regulate the intensity of a host response to invading pathogens or other potentially dangerous situations. Under regular conditions, this response is limited in time and located to the site of ...
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