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Weiss Frank Ulrich FU Department of Medicine A, University Medicine Greifswald, Greifswald, - - 2014
Serum lipase activities above the threefold upper reference limit indicate acute pancreatitis. We investigated whether high lipase activity-within the reference range and in the absence of pancreatitis-are associated with genetic single nucleotide polymorphisms (SNP), and whether these identified SNPs are also associated with clinical pancreatitis. Genome-wide association studies (GWAS) on ...
Juranovic Tajana T a KBC Rijeka, Internal - - 2014
Abstract We have identified a novel point mutation in the ELANE gene of a 51/2-month-old boy with a severe form of cyclic neutropenia, and we are reporting for the first time the presence of hematogones in the peripheral blood of infants. The novel point mutation occurred at base number 290 ...
Ziegler-Heitbrock Loems L EvA Study Center, Helmholtz-Zentrum Muenchen and Asklepios Fachkliniken, 82131 Gauting, Germany. Electronic address: - - 2014
Monocytes are white blood cells that belong to the mononuclear phagocyte system. They derive from precursors in bone marrow, from there they go into blood, where they have a half-life of 1-2 days, and then they migrate into the various tissues. Monocyte subsets were discovered by means of flow cytometry ...
Diaw Mor M Laboratoire de physiologie et explorations fonctionnelles, FMPOS, UCAD, Dakar, - - 2014
The aim of this study was to compare blood and plasma viscosities, as well as the hematocrit/blood viscosity ratio (HVR), between trained and sedentary SCT carriers. Thirty African male SCT carriers from the city of Dakar (Senegal) participated in the study: one group composed of 15 trained SCT carriers (TSCTc) ...
Bawazir Waleed M WM Bristol Institute for Transfusion Sciences, NHS Blood & Transplant, Bristol, UK; School of Biochemistry, University of Bristol, Bristol, - - 2014
Familial pseudohyperkalemia (FP) is a dominantly inherited condition in which red blood cells (RBCs) have an increased cold-induced permeability to monovalent cations. Potassium leaks into the supernatant of all stored blood with time, but FP RBCs leak potassium more rapidly. We investigated two unrelated blood donors whose RBC donations demonstrated ...
Lopez Genghis H GH Research and Development Division, Australian Red Cross Blood Service, Queensland, - - 2014
The Indian blood group antigens, In(a) and In(b), are clinically significant in transfusion medicine. However, antisera to type these antigens are difficult to obtain. The In(b) antigen is a high frequency antigen present in all populations, while the frequency of the antithetical In(a) ranges from 0.1% in Caucasians up to ...
McKenzie Marna - - 2014
Expression quantitative trait loci (eQTL) are genomic regions regulating RNA transcript expression levels. Genome-wide Association Studies (GWAS) have identified many variants, often in non-coding regions, with unknown functions and eQTL provide a possible mechanism by which these variants may influence observable phenotypes. Limited access and availability of tissues such as ...
Rückerl Regina R ESC-Environmental Science Center, University of Augsburg, Universitätsstr. 2, 86135 Augsburg, Germany; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany. Electronic address: - - 2014
The pathophysiological pathways linking particulate air pollution to cardiovascular disease are still not fully understood. We examined the association between ambient air pollutants and blood markers of inflammation and coagulation/fibrinolysis in three potentially susceptible populations. Three panels of non-smoking individuals were examined between 3/2007 and 12/2008: 1) with type 2 ...
Tashfeen Sunila S Armed Forces Institute of Pathology, Rawalpindi, Pakistan. Electronic address: - - 2014
Find the allele frequencies of Duffy blood group antigens in donor population from northern Pakistan. Cross sectional study. Armed Forces Institute of Transfusion (AFIT), Rawalpindi in year 2012. A total of 1000 healthy, adult blood donors were included in the study. Blood samples were collected in ethylenediamine tetra aceticacid (EDTA) ...
Told Reinhard R Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria; Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, - - 2014
The complement factor H (CFH) tyrosine 402 histidine (Y402H, rs1061170) variant is known to be significantly associated with age-related macular degeneration (AMD). Whether this genetic variant may impact retinal blood flow regulation is largely unknown. This study investigated whether flicker-induced vasodilation, an indicator for the coupling between neural activity and ...
Amengual Jaume J Case Western Reserve University, School of Medicine, Department of Pharmacology, Cleveland, OH 44106, - - 2014
Vitamin A must be adequately distributed within the body to maintain the functions of retinoids in the periphery and chromophore production in the eyes. Blood transport of the lipophilic vitamin is mediated by the retinol-binding protein, RBP4. Biochemical evidence suggests that cellular uptake of vitamin A from RBP4 is facilitated ...
Lee Shern-Long SL KU Leuven-University of Leuven , Department of Chemistry, Division of Molecular Imaging and Photonics, Celestijnenlaan 200F, B-3001 Leuven, - - 2014
Controlling crystal polymorphism constitutes a formidable challenge in contemporary chemistry. Two-dimensional (2D) crystals often provide model systems to decipher the complications in 3D crystals. In this contribution, we explore a unique way of governing 2D polymorphism at the organic liquid-solid interface. We demonstrate that a directional solvent flow could be ...
Zhou Shihang S Department of Occupational and Environmental Health, Dalian Medical University, Dalian, China; Dalian Blood Center, Dalian, - - 2014
Duffy blood group genotyping is useful to ensure transfusion safety and determine the association of Duffy blood group polymorphism with diseases, and therefore has its clinical significance. In order to improve the existing methods for genotyping of Duffy blood group, which normally require post-PCR manipulation, a new method was developed ...
Zaspel Jennifer J a Purdue University, Assistant Professor, Entomology, Purdue - - 2014
Abstract Facultative blood feeding on live animals or carrion is widespread within Lepidoptera. Male moths within the genus Calyptra are known to use their fruit-piercing mouthparts to occasionally feed on mammalian blood. The Palearctic species, Calyptra thalcitri, is known to exhibit differential feeding behaviors apparently based on geographic location. This ...
Lu I-Na IN 1 Department of Clinical Immunology and Rheumatology, Medical University Hanover , Hanover, Germany - - 2014
Abstract Alterations of the frequencies of recent thymic emigrants (RTEs) in blood have been demonstrated to be associated with human immunodeficiency virus-1 (HIV-1) disease progression and immune reconstitution following antiretroviral therapy. Flow cytometry is a technology that offers many advantages over T-cell receptor excision circles (TRECs) quantification to determine the ...
Bai Zhouxian Z *CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences †CAS Key Laboratory of Genome Sciences and Information, University of Chinese Academy of Sciences, Beijing, China ‡Department of Neurology and MIND Institute, School of Medicine ∥Alzheimer's Disease Center, School of Medicine, University of California at Davis, Sacramento, CA §Department of Medicine, University of Maryland School of Medicine, Baltimore, - - 2014
Defining the RNA transcriptome in Alzheimer Disease (AD) will help understand the disease mechanisms and provide biomarkers. Though the AD blood transcriptome has been studied, effects of white matter hyperintensities (WMH) were not considered. This study investigated the AD blood transcriptome and accounted for WMH. RNA from whole blood was ...
Ziegler-Heitbrock Loems L EvA Study Center, Helmholtz-Zentrum Muenchen and Asklepios Fachkliniken, 82131 Gauting, Germany. Electronic address: - - 2014
Monocytes are white blood cells that belong to the mononuclear phagocyte system. They derive from precursors in bone marrow, from there they go into blood, where they have a half-life of 1-2 days, and then they migrate into the various tissues. Monocyte subsets were discovered by means of flow cytometry ...
Najafabadi Zahra Ghayour ZG Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, - - 2014
This study investigated loop-mediated isothermal amplification (LAMP) detection of Plasmodium falciparum and Plasmodium vivax in urine and saliva of malaria patients. From May to November 2011, 108 febrile patients referred to health centers in Sistan and Baluchestan Province of south-eastern Iran participated in the study. Saliva, urine, and blood samples ...
Paris Sandra S French Blood Establishment Rhône Alpes, Lyon, - - 2014
The poor suitability of standard hemagglutination-based assay techniques for large-scale automated screening of red blood cell antigens severely limits the ability of blood banks to supply extensively phenotype-matched blood. With better understanding of the molecular basis of blood antigens, it is now possible to predict blood group phenotype by identifying ...
Mares-Guia Maria Angélica Monteiro de Mello MA Laboratório de Hantaviroses e Rickettsioses, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, - - 2014
Introduction Over the last recent years, the number of Q fever cases have has increased throughout the world. An epidemiological investigation was performed in the area in which the first molecular documentation of Q fever in Brazil was previously reported. Methods Indirect immunofluorescence assay (IFA) and PCR of Coxiella burnetii ...
Alsalhi M S - - 2014
Thalassemias (Thal) are forms of inherited autosomal recessive blood disorders arising out of mutations in the chromosomes 11 or 16. These disorders lead to poor oxygen delivery to blood vessels and consequent splenomegaly, bone deformities, and shorter life spans. The most common detection methods for Thal are complete blood count ...
Umbria Miriam M Unitat d'Antropologia Biològica, Departament de Biologia Animal, Biologia Vegetal i Ecologia, Facultat de Biocièncias, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Barcelona, - - 2014
The main goal of this study is to increase knowledge on the molecular level of the ABO blood group system in Europe by providing data for Poland, Spain, and Andorra populations. A total of 172 oral scrapings samples from individuals of Polish origin, 108 peripheral blood samples of autochthonous individuals ...
Torrance Hew Dt HD *Adult Critical Care Unit, Royal London Hospital, Barts Health NHS Trust, London †Centre for Trauma Sciences, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London ‡Centre for Translational Medicine and Therapeutics, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London §Genome Centre, John Vane Science Centre, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, - - 2014
To explore the hypothesis that blood transfusion contributes to an immunosuppressed phenotype in severely injured patients. Despite trauma patients using disproportionately large quantities of blood and blood products, the immunomodulatory effects of blood transfusion in this group are inadequately described. A total of 112 ventilated polytrauma patients were recruited. Messenger ...
Ewald Erin R ER Johns Hopkins Mood Disorders Center, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, - - 2014
Epigenetic studies that utilize peripheral tissues to identify molecular substrates of neuropsychiatric disorders rely on the assumption that disease-relevant, cellular alterations that occur in the brain are mirrored and detectable in peripheral tissues such as blood. We sought to test this assumption by using a mouse model of Cushing's disease ...
Alvarez-Dominguez Juan R JR Whitehead Institute for Biomedical Research, Cambridge, MA, 02142, - - 2014
Long noncoding RNAs (lncRNAs) are increasingly recognized to contribute to cellular development via diverse mechanisms during both health and disease. Here, we highlight recent progress on the study of lncRNAs that function in the development of blood cells. We emphasize lncRNAs that regulate blood cell fates through epigenetic control of ...
Evans Cory J CJ Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, - - 2014
Analyses of the Drosophila hematopoietic system are becoming more and more prevalent as developmental and functional parallels with vertebrate blood cells become more evident. Investigative work on the fly blood system has, out of necessity, led to the identification of new molecular markers for blood cell types and lineages and ...
Tilley Louise L International Blood Group Reference Laboratory, NHS Blood and Transplant, Bristol, UK. Electronic address: - - 2014
Blood group genotyping has many advantages over conventional phenotyping for both blood donors and patients, and a number of high-throughput methods have now been developed. However, these are limited by a requirement for existing knowledge of the relevant blood group gene polymorphisms, and rare or novel mutations will not be ...
St-Louis Maryse M Recherche et développement, Héma-Québec, Québec, Québec, Canada. Electronic address: - - 2014
For many decades, hemagglutination has been the sole means to type blood donors. Since the first blood group gene cloning in the early 1990s, knowledge on the molecular basis of most red blood cell, platelet and neutrophil antigens brought the possibility of using nucleotide-based techniques to predict phenotype. This review ...
Miri-Moghaddam Ebrahim E Genetics of Non-Communicable Disease Research Centre, Zahedan University of Medical Sciences, Zahedan, Iran; Department of Genetics, Zahedan University of Medical Sciences, Zahedan, Iran. Electronic address: - - 2014
To determine the distribution of Duffy blood group genotypes in Balouch population as a major ethnic group that living in a sub-tropical area in south East of Iran. In this study, the Duffy blood group FY phenotypes were determined using indirect anti-globulin technique and also genotype by PCR-RFLP in 160 ...
Haklová B B Institute of Parasitology, Slovak Academy of Sciences, Hlinkova 3, 040 01 Košice, Slovak - - 2014
SUMMARY The blood parasites from the genus Hepatozoon Miller, 1908 (Apicomplexa: Adeleida: Hepatozoidae) represent the most common intracellular protozoan parasites found in snakes. In the present study, we examined 209 individuals of snakes, from different zoogeographical regions (Africa, America, Asia and Europe), for the occurrence of blood parasites using both ...
Rehkopf David H DH Department of Medicine, Stanford University, Stanford, California, - - 2014
Peripheral blood leukocyte telomere length (LTL) is increasingly being used as a biomarker of aging, but its natural variation in human populations is not well understood. Several other biomarkers show seasonal variation, as do several determinants of LTL. We examined whether there was monthly variation in LTL in Costa Rica, ...
Tasker S S School of Veterinary Sciences & Langford Veterinary Services, University of Bristol, Langford House, Langford, Bristol, BS40 - - 2014
The aim of this study was to determine the agreement between AB blood phenotyping and genotyping and determine whether non-AB blood type incompatibilities exist in UK cats. Blood samples underwent phenotyping (A, B or AB) using microplate agglutination, and genotyping (AA, Ab or bb) using pyrosequencing of a fragment of ...
Dunham Richard M RM *HIV Discovery Performance Unit, GlaxoSmithKline, Research Triangle Park, NC; †Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA (P'ng Loke is now with the Department of Microbiology, Division of Parasitology, New York University Medical Center, New York, NY); ‡Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA; §Division of Infectious Diseases, Department of Medicine, University of California, San Francisco and San Francisco VA Medical Center, San Francisco, CA; ‖Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University, Cleveland, OH; ¶Division of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA; and #Positive Health Program, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, - - 2014
Persistent systemic inflammation is associated with the inability of some HIV-infected patients to normalize circulating CD4 T-cell levels after years of suppressive antiretroviral therapy. In this study, we sought to understand whether such systemic inflammation is also associated with detectable signs of inflammation in biopsies from the rectosigmoid colon. Immunologic ...
Düvel Anna A Immunology Unit, University of Veterinary Medicine, Foundation, Hannover, Hannover, - - 2014
Subclinical endometritis (SCE) is an important postpartum disease in dairy cows, but conventional cytobrush diagnosis often gives imprecise results. The aim of this study was to analyze disease-associated changes in peripheral blood as potential diagnostic parameters. Cellular subpopulations of blood leukocytes from cows with or without SCE (45-55 days postpartum) were ...
de Paula Sabino Adriano A Faculty of Pharmacy, Federal University of Minas Gerais, Av. Antônio Carlos 6627, Pampulha, Belo Horizonte, MG, Brazil, - - 2014
Recent studies have demonstrated association between ABO blood system and thrombosis, indicating that individuals belonging to non-O blood groups (A, B or AB) present an increased risk of venous thrombosis, heart disease, and ischemic stroke (IS) as compared to O blood group carriers. In this study, we investigated the frequency ...
França Angela A CEB-IBB, Centro de Engenharia Biológica - Instituto de Biotecnologia e Bioengenharia, Universidade do Minho, Braga, Portugal; Division of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, - - 2014
Staphylococcus epidermidis biofilm formation on the surface of intravenous catheters is responsible for 22% of the cases of bloodstream infections, in patients in intensive care units in the USA. The ability of S. epidermidis to withstand the high bactericidal activity of human blood is therefore crucial for systemic dissemination. In ...
Macedo-Silva Virgínia P VP Department of Biochemistry, Biosciences Center, Universidade Federal do Rio Grande do Norte, Av. Sen. Salgado Filho, 3000, Natal, RN, Brazil, - - 2014
Leishmania infantum, the causative agent of visceral leishmaniasis (VL) in Brazil, is spread mostly by the bite of the sand fly Lutzomyia longipalpis (Lutz & Neiva). We trapped sand flies in endemic neighborhoods near Natal, Brazil, where cases of human and dog VL were documented. Amplification of species-specific cytochrome b ...
Končarević Saša S Proteome Sciences R&D GmbH & Co. KG, Altenhöferallee 3, 60438 Frankfurt am Main, - - 2014
Peripheral blood mononuclear cells (PBMCs) are an easy accessible cellular part of the blood organ and, along with platelets, represent the only site of active gene expression in blood. These cells undergo immunophenotypic changes in various diseases and represent a peripheral source of monitoring gene expression and posttranslational modifications relevant ...
Bastien Matthieu M Centre de Recherche et de Veille sur les maladies émergentes dans l'Océan Indien, Sainte Clotilde, Reunion Island; Laboratoire d'Ecologie Marine, Université de La Réunion, Saint Denis, Reunion - - 2014
Blood parasites of the sub-genus Haemoproteus have been reported in seabirds, in particular in species in the Suliformes order. These parasites are transmitted by hippoboscid flies of the genus Olfersia; strong specificity has been suggested between the vector and its vertebrate host. We investigated the prevalence of Haemoproteus infection in ...
Acosta Oscar O 0000-0002-1912-0251 Institute of Tropical Medicine Daniel A. Carrion, Faculty of Medicine, Major National University of San Marcos, Lima, Peru ; Genetics and Molecular Biology Center, Faculty of Medicine, University of San Martin of Porres, Lima, Peru ; Institute of Biological Chemistry, Microbiology and Biotechnology, Faculty of Pharmacy and Biochemistry, Major National University of San Marcos, Lima, - - 2014
Carrion's disease (CD), is a human bartonellosis, that is, endemic in the Andes of Peru, Ecuador, and Colombia. Bartonella bacilliformis, a native hemotrophic bacteria, is the causative agent of CD, and the interaction with the host could have produced changes in the gene frequencies of erythrocyte antigens. The goal here ...
Isoda Kentaro K Department of Internal Medicine (I), Osaka Medical College, - - 2014
Objective Proton pump inhibitors (PPIs) are frequently coadministered with calcineurin inhibitors (CNIs) such as tacrolimus (TAC) and cyclosporin A (CSA), to treat or prevent upper gastrointestinal complications in Japanese patients with connective tissue diseases (CTDs). The coadministration of PPIs increases the blood concentration of TAC due to drug interaction. We ...
Binder Alexandra M - - 2013
Investigation of the biological mechanism by which folate acts to affect fetal development can inform appraisal of expected benefits and risk management. This research is ethically imperative given the ubiquity of folic acid fortified products in the US. Considering that folate is an essential component in the one-carbon metabolism pathway ...
Wehmeier Udo F - - 2013
An increasing number of studies examining gene expression associated with diseases in children is likely, in the near future, to provide simple and easy to use methods for the isolation of RNA for gene expression profiling. Prerequisites for such studies are likely to encompass the use of small amounts of ...
Rajatileka Shavanthi - - 2013
Genotyping requires biological sample collection that must be reliable, convenient and acceptable for patients and clinicians. Finding the most optimal procedure of sample collection for premature neonates who have a very limited blood volume is a particular challenge. The aim of the current study was to evaluate the use of ...
Franssen Nathan R NR Department of Biology and Museum of Southwestern Biology, University of New Mexico 167 Castetter Hall, Albuquerque, New Mexico - - 2013
Understanding population-level responses to human-induced changes to habitats can elucidate the evolutionary consequences of rapid habitat alteration. Reservoirs constructed on streams expose stream fishes to novel selective pressures in these habitats. Assessing the drivers of trait divergence facilitated by these habitats will help identify evolutionary and ecological consequences of reservoir ...
Flôres Marli Aparecida Luvisuto Rossett - - 2013
Polymorphisms of Rh, Kell, Duffy, Kidd and Diego blood group systems were studied in 209 unrelated Brazilian Japanese descendants from South of Brazil. The methods used were multiplex-PCR, AS-PCR and RFLP-PCR. The differences in frequencies among the populations were evaluated using chi-square test. The frequencies for Rh, Kell, Kidd and ...
Dubey A - - 2013
Polymerase chain reaction (PCR) offers great promise for the rapid, sensitive and specific diagnosis of tuberculosis (TB). However, blood TB PCR is still not standardised. Evaluation of the Blacklight® Card to standardise TB PCR in blood samples using a multiplex nested PCR method targeting insertion sequence 6110 and MPB64 sequence ...
Tylee Daniel S - - 2013
In this article, we review studies detailing the correspondence between peripheral blood and brain tissue across various domains of high-throughput -omic analysis in order to provide a context for evaluating blood-based biomarker studies. Specifically, we reviewed seven studies comparing patterns of DNA methylation (i.e., an aspect of the epigenome), eight ...
Mohamed S S IGM Hospital, Laboratory Services, Kan'baa aisaarani hingun, Male', 20402, Maldives. - - 2013
We here report the first study on the distribution of red cell antigens and phenotype frequencies of various blood group systems in Maldives. Randomly selected 123 regular blood donors of O group were phenotyped for seven blood group systems by direct tube agglutination and or indirect antiglobulin tests. Blood group ...
Yoshiba Satoko - - 2013
The emergence of left-right (L-R) asymmetry during embryogenesis is a classic problem in developmental biology. It is only since the 1990s, however, that substantial insight into this problem has been achieved by molecular and genetic approaches. Various genes required for L-R asymmetric morphogenesis in vertebrates have now been identified, and ...
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