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van der Baan A A Department of Cardiothoracic Surgery, Leiden University Medical Center, Leiden, The Netherlands - - 2014
Myocardial ischemia/reperfusion injury is a major problem in cardiac surgery, characterized by an enhanced inflammatory response postoperatively. Sevoflurane has anti-inflammatory effects and may attenuate this injury. This study describes a novel approach to using sevoflurane as a local anti-inflammatory drug and not as an anesthetic. Therefore, a pediatric oxygenator with ...
Saito Junichi J Department of Anesthesiology, Hirosaki University Graduate School of Medicine, Hirosaki, 036-8562, Japan, - - 2014
Non-invasively continuous total hemoglobin (SpHb) measurement has not been assessed adequately in acute bleeding and rapid blood transfusion during surgery. Thus, we have assessed the efficacy of SpHb during both acute normovolemic hemodilution (ANH) and autologous blood transfusion (ABT). Twenty-four patients undergoing urological and gynecological surgery were enrolled. ANH was ...
Hopster Klaus K Equine Clinic, University of Veterinary Medicine Hanover, Hanover, - - 2014
Previous studies showed an influence of xylazine on the LiDCO sensor in vitro and in standing horses, but did not prove that this interaction caused error in LiDCO measurements. Therefore, agreement of cardiac output (CO) measurements by LiDCO and bolus-thermodilution (BTD) was determined in horses receiving xylazine infusions. Prospective, experimental ...
Lu Chih-Cherng CC Department of Anesthesiology, Taipei Veterans General Hospital/National Defense Medical Center, 4 F, Chung-Cheng Building, No. 201, Sec. 2, Shipai Rd, Beitou District, Taipei, - - 2014
Sevoflurane, with a relative low blood-gas partition coefficient, is an ideal anesthetic to achieve rapid offset and recovery from general anesthesia. This study will determine the profiles of four concentration-time curves to characterize the pharmacokinetics of sevoflurane elimination. Eight patients (aged 54-76 years) undergoing coronary arterial bypass grafting surgery were enrolled ...
Li Chun-Xia CX Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA - - 2014
The effect of high dose isoflurane on cerebral blood flow (CBF) was investigated in adult macaque monkeys receiving 1% to 2% isoflurane with the pseudo continuous arterial-spin-labeling (pCASL) MRI technique. High concentration (2%) of isoflurane resulted in significant increase in the mean CBF of the global, cortical, subcortical regions and ...
Kodali Bhavani Shankar BS Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston, MA, 02115, - - 2014
Amide local anesthetics are known to inhibit coagulation. 2-chloroprocaine is the only ester agent used in obstetric anesthesia. It is used during obstetric emergencies, and also to supplement inadequate epidural block produced by amide local anesthetics. There is no study to date that has evaluated the effect of ester local ...
Shemesh David D 1 Department of Surgery and Hemodialysis Access Center, Shaare Zedek Medical Center, Jerusalem - - - 2014
The type of anesthesia chosen is an integral part of the decision-making process for arteriovenous access construction. We discuss the different types of anesthesia used, with emphasis on brachial plexus block, which is potentially safer than general anesthesia in this fragile patient population with end-stage renal disease. Brachial plexus block ...
Ha Thanh Ngoc TN Department of Surgery - Otolaryngology Head & Neck Surgery, The University of Adelaide, - - 2014
Objective: Hypotensive anesthesia is often used in endoscopic sinus surgery (ESS) to improve surgical visibility; however its safety and efficacy in this role is yet to be justified. This study aims to evaluate the effect of hypotensive anesthesia on both real-time middle cerebral artery blood flow velocity (Vmca) and the ...
Bezerra Francisco J - - 2014
Cerebral blood flow (CBF) and blood-brain barrier (BBB) permeability by arterial spin labeling (ASL)- and dynamic contrast enhanced (DCE)-magnetic resonance imaging (MRI), respectively were repeatedly measured under either halothane (N  =  5) or isoflurane (N  =  5) anesthesia in a rat stroke model of embolic occlusion of middle cerebral artery ...
Wang Geng G Department of Anesthesiology, Beijing Jishuitan Hospital, Beijing 100035, China. Email: - - 2014
Recurarization has previously been described in the context of acute normovolemic hemodilution. The aim of this study was to investigate the impairment of recovery of neuromuscular function after re-transfusion of intraoperative salvaged blood in patients treated with rocuronium. We enrolled 50 patients undergoing general anesthesia for lumbar surgery. Intraoperative blood ...
Fearon Jeffrey A JA 1.The Craniofacial Center, Dallas, Texas & Director, the Craniofacial Center, Dallas, Texas 2.The Craniofacial Center, Dallas, Texas & The Craniofacial and Plastic Surgery Center, Houston, Texas 3.The Craniofacial Center, Dallas, Texas & Department of Research, Medical City Dallas Hospital, Dallas, - - 2014
Hypotensive anesthesia is routinely utilized during craniosynostosis corrections to reduce blood loss. Utilizing Near-Infrared Spectroscopy, we noted cerebral oxygenation levels often fell below recommended levels. Intrigued by these observations we sought to measure the effects of hypotensive versus standard anesthesia on blood transfusion rates. 100 children undergoing craniosynostosis corrections were ...
Leelanukrom Ruenreong - - 2014
Desflurane is the least soluble and most expensive inhalation agent. Hence, low flow technique is suitable for anesthesia with desflurane. However, one of the disadvantages of low flow technique is the discrepancy among the end-tidal concentration, inspired concentration, and vaporizer setting. To measure the concentrations of desflurane at different sites ...
Sathitkarnmanee Thepakorn T 0000-0002-8401-1510 Department of Anesthesiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, - - 2014
Background. We propose a 1-1-12 wash-in scheme for desflurane-nitrous oxide (N2O) low-flow anesthesia. The objective of our study was to determine the time to achieve alveolar concentration of desflurane (FAD) at 1, 2, 3, 4, 5, and 6%. Methods. We enrolled 106 patients scheduled for elective surgery under general anesthesia. ...
Icaza Eduardo E EE * Resident, † Associate Chair for Faculty Affairs, Associate Professor of Anesthesiology and Neurosurgery, Department of Anesthesiology; Faculty, Neuroscience Graduate Program, University of Michigan, Ann Arbor, - - 2013
The psychedelic experience has been reported since antiquity, but there is relatively little known about the underlying neural mechanisms. A recent neuroimaging study on psilocybin revealed a pattern of decreased cerebral blood flow and functional disconnections that is surprisingly similar to that caused by various anesthetics. In this article, the ...
Takagaki Masatoshi - - 2013
Sedatives in the neurointensive care unit can strongly influence patients' risks of developing secondary brain damage. In particular, isoflurane, a volatile anesthetic, has been recently re-introduced to the neurointensive care unit, and first clinical studies suggest beneficial effects due to elevation of cerebral blood flow and reduction of metabolism. In ...
Sturesson Louise Walther - - 2013
In order to reduce comsumption of inhalational anaesthetsics during high-flow anaesthesia, a system open in regard to oxygen, nitrogen and nitrous oxide, but closed to inhalational anaesthetics, was developed. This was achieved by a reflecting filter for inhalational anaesthetics made of active carbon. The principle has been developed into the ...
Lin Tso-Chou - - 2013
To determine the awakening arterial blood concentration of desflurane and its relationship with the end-tidal concentration during emergence from various durations of general anesthesia. In total, 42 American Society of Anesthesiologists physical status class I-II female patients undergoing elective gynecologic surgery were enrolled. General anesthesia was maintained with fixed 6% ...
Todd Thomas E - - 2013
Establishing a program to monitor waste anesthetic gas (WAG) in order to limit personnel exposure requires measuring the levels of WAG emitted and determining the effectiveness of scavenging methods to reduce such levels. In this study, the authors used infrared spectroscopy to measure levels of WAG emitted while anesthetizing mice ...
Lee Yong-Cheol - - 2013
To determine whether the use of tranexamic acid in the setting of hypotension induced by hypotensive epidural anesthesia (HEA) has any additional beneficial effects in reducing perioperative blood loss and transfusion requirements in total hip replacement. Prospective, randomized, double-blinded trial. University-affiliated hospital. 68 adult, ASA physical status 1 and 2 ...
Salciccia A - - 2013
The objectives of this study were to describe and relate perioperative changes in blood leukocyte counts to the outcome of surgical colic horses, determine a cut-off value in the early postoperative period to obtain an indicator of the outcome, and compare the obtained value to a validation population of horses. ...
Ribeiro Isabel B - - 2013
This study aimed to determine whether asymptomatic horses naturally infected with Theileria equi retain infected erythrocytes in the spleen and whether the presence of the hemoparasite in this organ is associated with parasitemia. We collected samples from 25 adult horses without clinical signs of any disease. From each animal, we ...
Nair Bala G BG Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, Washington 98195, USA. - - 2013
Reduced consumption of inhalation anesthetics can be safely achieved by reducing excess fresh gas flow (FGF). In this study the authors describe the use of a real-time decision support tool to reduce excess FGF to lower, less wasteful levels. The authors applied a decision support tool called the Smart Anesthesia ...
Romito L - - 2013
This study sought to determine the levels of blood contamination found in and/or on used dental anesthetic cartridges and to measure antibacterial effects after exposure to a local anesthetic solution. The study analyzed a total of 1000 used cartridges from an oral surgery clinic, containing 1 of 3 anesthetic types. ...
Barçın Semiha - - 2013
We investigated the effect of Nitrous Oxide (N2O) on controlled hypotension in low-flow isoflurane-dexmedetomidine anesthesia in terms of hemodynamics, anesthetic consumption, and costs. We allocated forty patients randomly into two equal groups. We then maintained dexmedetomidine infusion (0.1μg.kg(-1).min(-1)) for 10 minutes. Next, we continued it until the last 30 minutes ...
McDowell K J - - 2013
The hypotheses that endophyte (Neotyphodium coenophialum) infected fescue seed causes vasoconstriction in horses in vivo, and that ground seed would be cause more pronounced vasoconstriction than whole seed, were tested. Ten horses each received 1 of 3 treatments: endophyte-free ground seed (E-G; n=4 horses), endophyte-positive whole seed (E+W, n=3) or ...
Li Chun-Xia CX Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, United - - 2013
The dose-dependent effect of isoflurane on regional CBF of cortical and subcortical structures in anesthetized macaque monkeys was investigated with the Continuous ASL MRI technique. High concentration of isoflurane resulted in global CBF increase and blood pressure decrease. Evident CBF change was observed in the subcortical structures. Specifically, CBF in ...
Dunkel B - - 2013
REASONS FOR PERFORMING STUDY: Clinical impression suggested that pony and miniature breeds (collectively referred to as ponies) presenting to a referral hospital for investigation of gastrointestinal disease had higher blood lactate concentrations on admission than large breed horses. OBJECTIVES: The study tested the hypothesis that ponies with gastrointestinal disease had ...
Singaravelu S - - 2013
BACKGROUND: /st>Automated control of end-tidal inhalation anaesthetic concentration is now possible. The EtControl™ module of an Aisys Carestation Anaesthetic machine digitally adjusts fresh gas flow and plenum vaporizer output to achieve a target end-tidal concentration. METHODS: /st>We evaluated EtControl in clinical practice by measuring volatile agent consumption and the need ...
Schwarzkopf Tina M - - 2013
The levels of blood gases and energy metabolites strongly influence the outcome of animal experiments, for example in experimental stroke research. While mice have become prominent animal models for cerebral ischemia, little information is available on the effects of anesthetic drugs on blood parameters such as blood gases, glucose and ...
Alstrup Aage K O - - 2013
Progress in neuroscience research often involves animals, as no adequate alternatives exist to animal models of living systems. However, both the physiological characteristics of the species used and the effects of anesthesia raise questions of common concern. Here, we demonstrate the confounding influences of these effects on tracer binding in ...
Takasu Masaki M Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, Gifu 501-1193, - - 2013
To establish blood and biochemical references for the endangered Kiso horse, blood samples were collected from 111 adult Kiso horses, 74.5% of the existing breed. The samples were analyzed for 23 hematological and biochemical parameters to determine their means and standard deviations (SD). We compared the mean ± 2SD with ...
Park Sang Yoong - - 2012
Minimal-flow anesthesia can meet the demands of a modern society that is more sensitive to environmental protection and economic burdens. This study compared the safety and efficacy of minimal-flow desflurane anesthesia with conventional high-flow desflurane anesthesia for prolonged laparoscopic surgery. Forty-six male patients (ASA physical status II or III) undergoing ...
Gomez-Rivera Fernando - - 2012
We compared anesthesia with sevoflurane-remifentanil hydrochloride (SR) to total intravenous anesthesia with propofol-remifentanil hydrochloride (PR) in patients undergoing endoscopic sinus surgery for chronic rhinosinusitis in terms of sinonasal mucosal blood flow, the surgical field visualization score, and blood loss. We performed a double-blinded prospective study at a tertiary care center ...
Reese Shona L - - 2012
The aims of this prospective study were to describe the normal sonographic size and appearance of the feline spleen, and to test effects of sevoflurane anesthesia and blood collection on sonographic characteristics. Sonographic evaluations were performed in 60 healthy blood donor cats prior to anesthesia and blood collection (baseline), after ...
Mallik Tanuja - - 2012
In the administration of minimal flow anesthesia, traditionally a fixed time period of high flow has been used before changing over to minimal flow. However, newer studies have used "equilibration time" of a volatile anesthetic agent as the change-over point. A randomized prospective study was conducted on 60 patients, who ...
Tsai Hsin-I - - 2012
Transfusion-related acute lung injury (TRALI) is the leading morbidity and mortality in hemotherapy in the United States. Although it is a serious complication of blood transfusion, it is still underestimated and under-reported because of under-recognition and misdiagnosis. In this report, we present 15 surgical patients who developed pulmonary complications secondary ...
Lu Chih-Cherng - - 2012
Under a constant inspired concentration, the uptake of a volatile anesthetic into the arterial blood should mainly be governed by alveolar ventilation, according to the assumption that the patient's cardiac output remains stable during anesthesia. We investigated whether ventilation volume affects the rate of desflurane uptake by examining arterial blood ...
Robinson Neil - - 2012
The 2011 International Association of Athletics Federation (IAAF) World Championships took place in Daegu, Korea. For the first time, all athletes were blood tested prior to the competition in order to give a clear signal to the world athletic community of the wish to enter into the era of the ...
Niven Karen - - 2012
Previous studies have found that acts of self-control like emotion regulation deplete blood glucose levels. The present experiment investigated the hypothesis that the extent to which people's blood glucose levels decline during emotion regulation attempts is influenced by whether they believe themselves to be good or poor at emotion control. ...
Lu Chih-Cherng - - 2013
Desflurane, with a low blood-gas partition coefficient, is an ideal anesthetic to achieve rapid offset and recovery from general anesthesia. Investigation of desflurane elimination from blood and respiratory gas should provide useful information with respect to a patient's recovery from anesthesia. Therefore, this study is designed to characterize the pharmacokinetics ...
Kaida Kosuke - - 2012
"Flow" is a positive emotional state which typically occurs when a person perceives a balance between the challenges associated with a situation and his or her capabilities to accomplish these demands. While flow often occurs along with positive feelings and high introspective performance, only a few studies have investigated how ...
Gilchrist Philippe T - - 2012
Vasovagal reactions (VVR) are common, complicating and deterring people from various medical procedures. A recent perspective (R. R. Diehl, ) suggests that VVR developed from the adaptive process of hemorrhagic fainting, perhaps as a means of preparing for anticipated blood loss. The primary goal of this study was to compare ...
Bray Chris - - 2012
The Flow Cytometry Standard (FCS) format was developed back in 1984. Since then, FCS became the standard file format supported by all flow cytometry software and hardware vendors. Over the years, updates were incorporated to adapt to technological advancements in both flow cytometry and computing technologies. However, flexibility in how ...
Grzegorzewski W J - - 2012
The nasal venous blood may be directed through the facial vein into the systemic circulation or through the frontal vein into the venous cavernous sinus of the perihypophyseal vascular complex, where hormones and pheromones permeate from the venous blood into the arterial blood supplying the brain and hypophysis. The present ...
Textor Stephen C - - 2012
African Americans develop hypertension earlier with more target manifestations than whites despite having a higher glomerular filtration rate (GFR) for any level of serum creatinine. STUDY DESIGN & PARTICIPANTS: This study tested the hypothesis that increased GFR and sodium reabsorption in African Americans is associated with increased metabolic work and ...
McGee Edwin C EC - - 2011
HeartWare continuous flow ventricular assist devices (HVAD) configured as biventricular assist devices maintain diurnal flow variation, lead to end-organ recovery, and provide for a successful bridge-to-heart transplantation in the first successful North American use of continuous flow biventricular assist devices.
Olatunji Bunmi O - - 2012
Despite growing evidence implicating disgust in the etiology of blood-injection-injury (BII) phobia, the relevance of disgust for exposure-based treatment of BII phobia remains largely unknown. Individuals with BII phobia were randomly assigned to a disgust (view vomit videos) or neutral activation (view waterfall videos) condition. They were then exposed to ...
Seno Takeharu - - 2011
We examined whether a somatosensory cue suggesting forward self-motion facilitated vection. We provided a consistent air flow to subjects' faces by using an electric fan.Vection strength was increased when the air flow was provided.
Sharma Rajeev - - 2010
A multicentric quasi-experimental study was conducted in Delhi, from March 2007 to September 2007, on i) the factors which stimulate the donors to donate blood, ii) major barriers and myths associated with blood donation and iii) clinicians perception of the rational use of blood. The study design included a face-to-face ...
Sedelmeier Jörg - - 2010
An efficient and easily scalable transformation of alcohols and aldehydes to carboxylic acids and nitroalkane derivatives to the corresponding carbonyls and carboxylic acids using permanganate as the oxidant within a continuous flow reactor is reported. Notably, the generation and downstream processing of MnO(2) slurries was not found to cause any ...
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