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Lelkens C C M CC Royal Netherlands Navy, Medical Corps, Retired, Kortgene, the - - 2014
The use of a functionally closed system (ACP215, Haemonetics) for (de)glycerolization of RBCs allows for prolonged post-thaw storage. Currently, glycerolization is followed by supernatant glycerol reduction before freezing. The aim of this study was to investigate the influence of supernatant glycerol reduction before freezing on the stability of thawed, deglycerolized ...
Cortés Diego Orbegozo DO Department of Intensive Care, Erasme University Hospital, Université Libre de Bruxelles, Brussels - - 2014
Use of high concentrations of inhaled oxygen has been associated with adverse effects but recent data suggest a potential therapeutic role of normobaric hyperoxia (NH) in sepsis and cerebral ischemia. Hyperoxia may induce vasoconstriction and alter endothelial function, so we evaluated its effects on the microcirculation in 40 healthy adult ...
Bianchi Maria M UNICATT Cord Blood Bank, 'A. Gemelli' Hospital, Università Cattolica del Sacro Cuore, Rome, - - 2014
Background: Preterm infants often receive blood transfusions early in life. In this setting, umbilical cord blood (UCB) might be safer than adult blood (A) with respect to infectious and immunologic threats. Objectives: To evaluate, as a first objective, the feasibility of fulfilling transfusion needs of preterm infants with allogeneic UCB ...
Neuman Robert R Division of Cardiology, Emory University School of Medicine, Atlanta, - - 2014
Clinical and animal studies indicate that transfusions of older stored red blood cells (RBCs) impair clinical outcomes as compared to fresh RBC transfusions. It has been suggested that this effect is due to inhibition of nitric oxide (NO)-mediated vasodilation after transfusion of older RBC units. However, to date this effect ...
Lerner Edan E Center for Soft Matter Research, Department of Physics, New York University, New York, New York - - 2014
Athermal steady-state plastic flows were simulated for the Kob-Andersen binary Lennard-Jones system and its repulsive version in which the sign of the attractive terms is changed to a plus. Properties evaluated include the distributions of energy drops, stress drops, and strain intervals between the flow events. We show that simulations ...
Pope Belinda B Pathology Department, Sydney Adventist Hospital, Wahroonga, NSW, Australia; Australasian Research Institute, Sydney Adventist Hospital, Wahroonga, NSW, Australia; Faculty of Medicine, University of New South Wales, Sydney, NSW, - - 2014
Assessment of the overall postthaw (PT) viability of an umbilical cord blood (UCB) unit is an important criterion for determining the quality of the unit for transplantation. Overall PT viability is a measure of cellular damage that can occur to the UCB during collection, storage, processing, freezing, and thawing. This ...
Chaudhuri Pinaki P Institut für Theoretische Physik II, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, - - 2014
Using numerical simulations, the onset of Poiseuille flow in a confined soft glass is investigated. Starting from the quiescent state, steady flow sets in at a time scale which increases with a decrease in applied forcing. At this onset time scale, a rapid transition occurs via the simultaneous fluidization of ...
Lee Hongyeul H Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, - - 2014
Acute airway obstruction after hemoptysis occurs due to the presence of blood clots. These conditions may result in life-threatening ventilation impairment. We report a case of obstruction of the large airway by endobronchial blood clots which were removed using bronchoscopic cryotherapy at the bedside of intensive care unit. A 66-year-old ...
Reinhart Sophie A SA Department of Internal Medicine, Kantonsspital Graubünden, Chur, - - 2014
The storage of red blood cells (RBCs) leads to storage lesions, which have a negative impact on the clinical outcome after transfusion. A hallmark of storage lesions is echinocytosis. Albumin may reverse this shape transformation, which was the topic of this study. Echinocytosis was generated by incubation of blood for ...
Yu Pey-Jen PJ North Shore University Hospital. Electronic address: - - 2014
To determine the incremental risk associated with each intraoperative red blood cell transfusion in cardiac surgery patients. Retrospective analysis on prospectively collected data. Single tertiary care hospital. Seven hundred forty-five patients undergoing on-pump cardiac surgery between January 2010 and June 2012 who received between 1 and 3 units of red ...
Smits Wim W Vrije Universiteit Brussel, Department of Chemical Engineering, Pleinlaan 2, 1050 Brussels, - - 2014
We used numerical simulations to investigate the recent observation that slip flow chromatography can obtain reduced plate heights as low as 0.032. The simulations were carried out for a 2D pillar array and a 3D face centred cubic particle stacking. We found that slip flow can only affect the mobile ...
D'Alessandro A A Department of Biochemistry and Molecular Genetics, School of Medicine University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, - - 2014
The safety and efficacy of stored red blood cells (RBCs) transfusion has been long debated due to retrospective clinical evidence and laboratory results, indicating a potential correlation between increased morbidity and mortality following transfusion of RBC units stored longer than 14 days. We hypothesize that storage in Optisol additive solution-5 leads ...
Likosky Donald S DS Department of Cardiac Surgery, University of Michigan, Ann Arbor, Mich. Electronic address: - - 2014
A number of established regional quality improvement collaboratives have partnered to assess and improve care across their regions under the umbrella of the Cardiac Surgery Quality Improvement (IMPROVE) Network. The first effort of the IMPROVE Network has been to assess regional differences in potentially discretionary transfusions (<3 units red blood ...
van der Baan A A Department of Cardiothoracic Surgery, Leiden University Medical Center, Leiden, The Netherlands - - 2014
Myocardial ischemia/reperfusion injury is a major problem in cardiac surgery, characterized by an enhanced inflammatory response postoperatively. Sevoflurane has anti-inflammatory effects and may attenuate this injury. This study describes a novel approach to using sevoflurane as a local anti-inflammatory drug and not as an anesthetic. Therefore, a pediatric oxygenator with ...
Saito Junichi J Department of Anesthesiology, Hirosaki University Graduate School of Medicine, Hirosaki, 036-8562, Japan, - - 2014
Non-invasively continuous total hemoglobin (SpHb) measurement has not been assessed adequately in acute bleeding and rapid blood transfusion during surgery. Thus, we have assessed the efficacy of SpHb during both acute normovolemic hemodilution (ANH) and autologous blood transfusion (ABT). Twenty-four patients undergoing urological and gynecological surgery were enrolled. ANH was ...
Hopster Klaus K Equine Clinic, University of Veterinary Medicine Hanover, Hanover, - - 2014
Previous studies showed an influence of xylazine on the LiDCO sensor in vitro and in standing horses, but did not prove that this interaction caused error in LiDCO measurements. Therefore, agreement of cardiac output (CO) measurements by LiDCO and bolus-thermodilution (BTD) was determined in horses receiving xylazine infusions. Prospective, experimental ...
Lu Chih-Cherng CC Department of Anesthesiology, Taipei Veterans General Hospital/National Defense Medical Center, 4 F, Chung-Cheng Building, No. 201, Sec. 2, Shipai Rd, Beitou District, Taipei, - - 2014
Sevoflurane, with a relative low blood-gas partition coefficient, is an ideal anesthetic to achieve rapid offset and recovery from general anesthesia. This study will determine the profiles of four concentration-time curves to characterize the pharmacokinetics of sevoflurane elimination. Eight patients (aged 54-76 years) undergoing coronary arterial bypass grafting surgery were enrolled ...
Fearon Jeffrey A JA Dallas and Houston, Texas From the Craniofacial Center; the Craniofacial and Plastic Surgery Center; and the Department of Research, Medical City Dallas - - 2014
Hypotensive anesthesia is routinely used during craniosynostosis corrections to reduce blood loss. Noting that cerebral oxygenation levels often fell below recommended levels, the authors sought to measure the effects of hypotensive versus standard anesthesia on blood transfusion rates. One hundred children undergoing craniosynostosis corrections were randomized prospectively into two groups: ...
Li Chun-Xia CX Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA - - 2014
The effect of high dose isoflurane on cerebral blood flow (CBF) was investigated in adult macaque monkeys receiving 1% to 2% isoflurane with the pseudo continuous arterial-spin-labeling (pCASL) MRI technique. High concentration (2%) of isoflurane resulted in significant increase in the mean CBF of the global, cortical, subcortical regions and ...
Kodali Bhavani Shankar BS Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston, MA, 02115, - - 2014
Amide local anesthetics are known to inhibit coagulation. 2-chloroprocaine is the only ester agent used in obstetric anesthesia. It is used during obstetric emergencies, and also to supplement inadequate epidural block produced by amide local anesthetics. There is no study to date that has evaluated the effect of ester local ...
Shemesh David D 1 Department of Surgery and Hemodialysis Access Center, Shaare Zedek Medical Center, Jerusalem - - - 2014
The type of anesthesia chosen is an integral part of the decision-making process for arteriovenous access construction. We discuss the different types of anesthesia used, with emphasis on brachial plexus block, which is potentially safer than general anesthesia in this fragile patient population with end-stage renal disease. Brachial plexus block ...
Ha Thanh Ngoc TN Department of Surgery - Otolaryngology Head & Neck Surgery, The University of Adelaide, - - 2014
Objective: Hypotensive anesthesia is often used in endoscopic sinus surgery (ESS) to improve surgical visibility; however its safety and efficacy in this role is yet to be justified. This study aims to evaluate the effect of hypotensive anesthesia on both real-time middle cerebral artery blood flow velocity (Vmca) and the ...
Bezerra Francisco J - - 2014
Cerebral blood flow (CBF) and blood-brain barrier (BBB) permeability by arterial spin labeling (ASL)- and dynamic contrast enhanced (DCE)-magnetic resonance imaging (MRI), respectively were repeatedly measured under either halothane (N  =  5) or isoflurane (N  =  5) anesthesia in a rat stroke model of embolic occlusion of middle cerebral artery ...
Wang Geng G Department of Anesthesiology, Beijing Jishuitan Hospital, Beijing 100035, China. Email: - - 2014
Recurarization has previously been described in the context of acute normovolemic hemodilution. The aim of this study was to investigate the impairment of recovery of neuromuscular function after re-transfusion of intraoperative salvaged blood in patients treated with rocuronium. We enrolled 50 patients undergoing general anesthesia for lumbar surgery. Intraoperative blood ...
Leelanukrom Ruenreong - - 2014
Desflurane is the least soluble and most expensive inhalation agent. Hence, low flow technique is suitable for anesthesia with desflurane. However, one of the disadvantages of low flow technique is the discrepancy among the end-tidal concentration, inspired concentration, and vaporizer setting. To measure the concentrations of desflurane at different sites ...
Sathitkarnmanee Thepakorn T 0000-0002-8401-1510 Department of Anesthesiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, - - 2014
Background. We propose a 1-1-12 wash-in scheme for desflurane-nitrous oxide (N2O) low-flow anesthesia. The objective of our study was to determine the time to achieve alveolar concentration of desflurane (FAD) at 1, 2, 3, 4, 5, and 6%. Methods. We enrolled 106 patients scheduled for elective surgery under general anesthesia. ...
Sharpe Christopher C Department of Pathology and Laboratory Medicine, Division of Hematological Pathology, Dalhousie University, Halifax, - - 2014
Effective blood inventory management reduces outdates of blood products. Multiple strategies have been employed to reduce the rate of red blood cell (RBC) unit outdate. We designed an automated real-time web-based dashboard interfaced with our laboratory information system to effectively recycle red cell units. The objective of our approach is ...
Kasar Nilesh V NV Department of Sharira Rachana, G. J. Patel Institute of Ayurveda Studies and Research, New Vallabh Vidya Nagar, Anand, Gujarat, - - 2014
Ayurveda has its own view to understand the development of human body and its various organs. As the quotations are in a concise manner, it is essential to amalgamate the basics stated by various Acharyas with comprehensive explanation of modern science. The liver is a vital organ for metabolism. Acharyas ...
Icaza Eduardo E EE * Resident, † Associate Chair for Faculty Affairs, Associate Professor of Anesthesiology and Neurosurgery, Department of Anesthesiology; Faculty, Neuroscience Graduate Program, University of Michigan, Ann Arbor, - - 2013
The psychedelic experience has been reported since antiquity, but there is relatively little known about the underlying neural mechanisms. A recent neuroimaging study on psilocybin revealed a pattern of decreased cerebral blood flow and functional disconnections that is surprisingly similar to that caused by various anesthetics. In this article, the ...
Takagaki Masatoshi - - 2013
Sedatives in the neurointensive care unit can strongly influence patients' risks of developing secondary brain damage. In particular, isoflurane, a volatile anesthetic, has been recently re-introduced to the neurointensive care unit, and first clinical studies suggest beneficial effects due to elevation of cerebral blood flow and reduction of metabolism. In ...
Sturesson Louise Walther - - 2013
In order to reduce comsumption of inhalational anaesthetsics during high-flow anaesthesia, a system open in regard to oxygen, nitrogen and nitrous oxide, but closed to inhalational anaesthetics, was developed. This was achieved by a reflecting filter for inhalational anaesthetics made of active carbon. The principle has been developed into the ...
Lin Tso-Chou - - 2013
To determine the awakening arterial blood concentration of desflurane and its relationship with the end-tidal concentration during emergence from various durations of general anesthesia. In total, 42 American Society of Anesthesiologists physical status class I-II female patients undergoing elective gynecologic surgery were enrolled. General anesthesia was maintained with fixed 6% ...
Todd Thomas E - - 2013
Establishing a program to monitor waste anesthetic gas (WAG) in order to limit personnel exposure requires measuring the levels of WAG emitted and determining the effectiveness of scavenging methods to reduce such levels. In this study, the authors used infrared spectroscopy to measure levels of WAG emitted while anesthetizing mice ...
Lee Yong-Cheol - - 2013
To determine whether the use of tranexamic acid in the setting of hypotension induced by hypotensive epidural anesthesia (HEA) has any additional beneficial effects in reducing perioperative blood loss and transfusion requirements in total hip replacement. Prospective, randomized, double-blinded trial. University-affiliated hospital. 68 adult, ASA physical status 1 and 2 ...
Salciccia A - - 2013
The objectives of this study were to describe and relate perioperative changes in blood leukocyte counts to the outcome of surgical colic horses, determine a cut-off value in the early postoperative period to obtain an indicator of the outcome, and compare the obtained value to a validation population of horses. ...
Ribeiro Isabel B - - 2013
This study aimed to determine whether asymptomatic horses naturally infected with Theileria equi retain infected erythrocytes in the spleen and whether the presence of the hemoparasite in this organ is associated with parasitemia. We collected samples from 25 adult horses without clinical signs of any disease. From each animal, we ...
Nair Bala G BG Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, Washington 98195, USA. - - 2013
Reduced consumption of inhalation anesthetics can be safely achieved by reducing excess fresh gas flow (FGF). In this study the authors describe the use of a real-time decision support tool to reduce excess FGF to lower, less wasteful levels. The authors applied a decision support tool called the Smart Anesthesia ...
Romito L - - 2013
This study sought to determine the levels of blood contamination found in and/or on used dental anesthetic cartridges and to measure antibacterial effects after exposure to a local anesthetic solution. The study analyzed a total of 1000 used cartridges from an oral surgery clinic, containing 1 of 3 anesthetic types. ...
Barçın Semiha - - 2013
We investigated the effect of Nitrous Oxide (N2O) on controlled hypotension in low-flow isoflurane-dexmedetomidine anesthesia in terms of hemodynamics, anesthetic consumption, and costs. We allocated forty patients randomly into two equal groups. We then maintained dexmedetomidine infusion (0.1μg.kg(-1).min(-1)) for 10 minutes. Next, we continued it until the last 30 minutes ...
McDowell K J - - 2013
The hypotheses that endophyte (Neotyphodium coenophialum) infected fescue seed causes vasoconstriction in horses in vivo, and that ground seed would be cause more pronounced vasoconstriction than whole seed, were tested. Ten horses each received 1 of 3 treatments: endophyte-free ground seed (E-G; n=4 horses), endophyte-positive whole seed (E+W, n=3) or ...
Li Chun-Xia CX Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, United - - 2013
The dose-dependent effect of isoflurane on regional CBF of cortical and subcortical structures in anesthetized macaque monkeys was investigated with the Continuous ASL MRI technique. High concentration of isoflurane resulted in global CBF increase and blood pressure decrease. Evident CBF change was observed in the subcortical structures. Specifically, CBF in ...
Dunkel B - - 2013
REASONS FOR PERFORMING STUDY: Clinical impression suggested that pony and miniature breeds (collectively referred to as ponies) presenting to a referral hospital for investigation of gastrointestinal disease had higher blood lactate concentrations on admission than large breed horses. OBJECTIVES: The study tested the hypothesis that ponies with gastrointestinal disease had ...
Singaravelu S - - 2013
BACKGROUND: /st>Automated control of end-tidal inhalation anaesthetic concentration is now possible. The EtControl™ module of an Aisys Carestation Anaesthetic machine digitally adjusts fresh gas flow and plenum vaporizer output to achieve a target end-tidal concentration. METHODS: /st>We evaluated EtControl in clinical practice by measuring volatile agent consumption and the need ...
Schwarzkopf Tina M - - 2013
The levels of blood gases and energy metabolites strongly influence the outcome of animal experiments, for example in experimental stroke research. While mice have become prominent animal models for cerebral ischemia, little information is available on the effects of anesthetic drugs on blood parameters such as blood gases, glucose and ...
Alstrup Aage K O - - 2013
Progress in neuroscience research often involves animals, as no adequate alternatives exist to animal models of living systems. However, both the physiological characteristics of the species used and the effects of anesthesia raise questions of common concern. Here, we demonstrate the confounding influences of these effects on tracer binding in ...
Takasu Masaki M Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, Gifu 501-1193, - - 2013
To establish blood and biochemical references for the endangered Kiso horse, blood samples were collected from 111 adult Kiso horses, 74.5% of the existing breed. The samples were analyzed for 23 hematological and biochemical parameters to determine their means and standard deviations (SD). We compared the mean ± 2SD with ...
Park Sang Yoong - - 2012
Minimal-flow anesthesia can meet the demands of a modern society that is more sensitive to environmental protection and economic burdens. This study compared the safety and efficacy of minimal-flow desflurane anesthesia with conventional high-flow desflurane anesthesia for prolonged laparoscopic surgery. Forty-six male patients (ASA physical status II or III) undergoing ...
Gomez-Rivera Fernando - - 2012
We compared anesthesia with sevoflurane-remifentanil hydrochloride (SR) to total intravenous anesthesia with propofol-remifentanil hydrochloride (PR) in patients undergoing endoscopic sinus surgery for chronic rhinosinusitis in terms of sinonasal mucosal blood flow, the surgical field visualization score, and blood loss. We performed a double-blinded prospective study at a tertiary care center ...
Reese Shona L - - 2012
The aims of this prospective study were to describe the normal sonographic size and appearance of the feline spleen, and to test effects of sevoflurane anesthesia and blood collection on sonographic characteristics. Sonographic evaluations were performed in 60 healthy blood donor cats prior to anesthesia and blood collection (baseline), after ...
Mallik Tanuja - - 2012
In the administration of minimal flow anesthesia, traditionally a fixed time period of high flow has been used before changing over to minimal flow. However, newer studies have used "equilibration time" of a volatile anesthetic agent as the change-over point. A randomized prospective study was conducted on 60 patients, who ...
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