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Parsons Teresa L TL Johns Hopkins University School of Medicine, Baltimore, - - 2014
Quantifying anti-tuberculosis drug concentrations in multinational trials currently requires collection of modest blood volumes, centrifugation, aliquoting of plasma, freezing, and keeping samples frozen during shipping. We prospectively enrolled healthy individuals into Tuberculosis Trials Consortium Study 29B, a Phase I dose escalation study of rifapentine, a rifamycin under evaluation in tuberculosis ...
van Besien Koen - - 2014
Abstract From June 5(th) to 7(th) the 12(th) Annual International Cord Blood Symposium was held in San Francisco. The meeting was devoted to advances in umbilical cord blood research with a major focus on translational and clinical results in cord blood transplantation and in regenerative medicine. Over three days, a ...
Haugen G G Department of - - 2014
The objective was to evaluate the relation of uterine artery Doppler flow pulsatility index (PI) with total uterine volume reduction following bilateral embolisation of uterine fibroids by injection of polyvinyl alcohol particles. Doppler flow velocity was examined before and within 8 days after embolisation (n = 13). Uterine size was ...
Parthenis Christos C Fetal Medicine Unit, 3rd Department of Obstetrics and Gynaecology, University of Athens, 'Attikon' University Hospital , Athens , Greece - - 2014
Abstract Monochorionicity is responsible for an increased rate of severe complications because of unequal splitting of the placental mass and/or an imbalance in the blood flow across placental vascular anastomoses. Vascular limb occlusion is one of the rare complications of monochorionic twins, usually occurring in the lower extremities after intra-uterine ...
Winters Stephen J SJ Department of Medicine, University of Louisville, United States. Electronic address: - - 2014
Pituitary adenylate cyclase-activating peptide (PACAP) is a centrally-acting peptide with highest concentration within the limbic area of the brain. PACAP is also expressed in and affects the functions of vascular and nervous tissues, endocrine glands, and the placenta. PACAP appears to be associated with the 'fight-or-flight' response to emergency partly ...
Wierzejska Regina - - 2014
The aim of the study was to compare caffeine and paraxanthine concentrations in venous blood of pregnant women and in the umbilical cord blood of their newborns. Pregnant women who gave birth at the Clinic of Obstetrics, Gynecology and Oncology 2nd Faculty of Medicine, Medical University of Warsaw were included ...
Ropacka-Lesiak Mariola - - 2014
To evaluate the relation between retrograde diastolic blood flow in the aortic isthmus and adverse perinatal outcome in fetuses with IUGR. The study included 33 fetuses with IUGR defined as the estimated fetal weight and abdominal circumference under the 10th percentile for a given gestational age. The Doppler examination of ...
Doyle B B Red Cell Immunohaematology Laboratory, Irish Blood Transfusion Service, Dublin, - - 2014
To analyse anti-D quantification levels and frequency of intrauterine transfusion (IUT), per maternal ABO blood group. Maternally derived red cell allo-antibodies can target fetal red cell antigens in utero leading to haemolytic disease and fetal anaemia. When a clinically significant allo-antibody is formed the priority is ascertaining the risk to ...
Tachibana D D Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, Osaka, Japan; Department of Obstetrics and Fetal Medicine, University Medical Center, Hamburg-Eppendorf, Hamburg, - - 2014
To investigate time-related variables of ductus venosus (DV) flow velocity waveforms (FVW) in twin to twin transfusion syndrome (TTTS), comparing the results with reference ranges from normal singleton fetuses, and to evaluate the impact of laser surgery and prognostic factors. In 107 TTTS cases DV-FVWs of both, recipients and donors, ...
Zhou Yu-Qing YQ The Hospital for Sick Children, Toronto - - 2014
This study was to evaluate the flow distribution in the mouse fetal circulation at late gestation using high frequency ultrasound. Twelve fetuses (E17.5) from twelve pregnant CD1 mice were studied using 40MHz ultrasound to assess the flow in eleven vessels based on Doppler measurements of blood velocity and M-mode measurements ...
Hussein Shahad M - - 2014
Glucose is the main source of energy for organ function in neonates. There are few published recent data on neonatal glucose levels during cesarean delivery. A case (cesarean delivery) -control (vaginal delivery) study was conducted at Khartoum Hospital Sudan to compare blood glucose levels of term newborns born after elective ...
Achary K G KG Division of Immunology, Regional Medical Research Center (Indian council of medical Research), Chandrasekharpur, Bhubaneswar, 751023, Orissa, - - 2014
In-utero exposure has been considered as a risk factor for filarial infection. To evaluate the influence of maternal infection on filarial specific IgG subclass response in neonates and their correlation with plasma levels IL-10 and Interferon-γ, 145 pairs of mothers and their respective cord bloods were examined. Transpalcental transfer of ...
Backes Carl H CH Departments of Pediatrics and Obstetrics and Gynecology, Center for Perinatal Research, the Heart Center at Nationwide Children's Hospital and the Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio; the Center for Developmental Therapeutics, Seattle Children's Research Institute, University of Washington School of Medicine, Seattle, Washington; Darlington Memorial Hospital, Darlington, United Kingdom; the College of Nursing, University of Rhode Island, Kingston, and the Warren Alpert Medical School of Brown University, Providence, Rhode - - 2014
To investigate the effects of interventions promoting placental transfusion at delivery (delayed cord clamping or umbilical cord milking) compared with early cord clamping on outcomes among premature neonates of less than 32 weeks of gestation. A systematic search was conducted of PubMed, Embase, and ClinicalTrials.gov databases (January 1965 to December ...
Nakamura Hitomi H Departments of 1Obstetrics and - - 2014
The aim of this study was to determine whether uterine blood flow is an effective parameter to anticipate uterine receptivity. The local uterine blood flow was measured in the endometrium and on the outside of the uterus in mice during the early stage of pregnancy and an implantation failure mouse ...
Mishina Miyuki M Department of Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, - - 2014
Uterine arteriovenous malformation (AVM) is a rare cause of abnormal uterine bleeding; nevertheless, it is a potentially life-threatening condition when the diagnosis is not made. We report a case of uterine AVM with a secondary uterine hematoma diagnosed 2 weeks after curettage due to spontaneous abortion. Ultrasound examination revealed a ...
Rijsselaere T T Department of Reproduction, Obstetrics and Herd Health, Faculty of Veterinary Medicine, Ghent University, Merelbeke, - - 2014
Canine sperm transport, distribution, storage and detachment is a complex, dynamic and highly regulated process. Transport of sperm within the bitch's reproductive tract is rapid and is influenced by the method of semen deposition (natural mating or artificial insemination) and by the timing of breeding in relation to the day ...
Garcia-Canadilla Patricia P BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu), IDIBAPS, University of Barcelona, and Centre for Biomedical Research on Rare Diseases (CIBER-ER), Barcelona, Spain; Physense, DTIC, Universitat Pompeu Fabra, Barcelona, - - 2014
Intrauterine growth restriction (IUGR) due to placental insufficiency is associated with blood flow redistribution in order to maintain delivery of oxygenated blood to the brain. Given that, in the fetus the aortic isthmus (AoI) is a key arterial connection between the cerebral and placental circulations, quantifying AoI blood flow has ...
Prsa Milan M Division of Pediatric Cardiology, Department of Pediatrics, University of Toronto and Hospital for Sick Children, Toronto, - - 2014
-Phase contrast MRI with metric optimized gating is a promising new technique for studying the distribution of the fetal circulation. However, mean and reference ranges for blood flow measurements made in the major fetal vessels using this technique have yet to be established. -We measured flow in the major vessels ...
Doğan S S Department of Obstetrics and Gynecology, Akdeniz University, Faculty of Medicine , Antalya , - - 2014
We aimed to evaluate perinatal outcomes and blood gas indices of isolated single umbilical artery (SUA). In this retrospective study, 134 fetuses with SUA were evaluated. A total of 77 (57.4%) fetuses with isolated SUA (iSUA) were compared with maternal age-matched 95 fetuses with double umbilical arteries (DUA), with respect ...
Kim Byung-Mi BM Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA; Department of Preventive Medicine, School of Medicine, Ewha Medical Research Center, Ewha Womans University, Seoul, South - - 2014
The cord-blood mercury concentration is usually considered the best biomarker in regard to developmental methylmercury neurotoxicity. However, the mercury concentration may be affected by the binding of methylmercury to hemoglobin and perhaps also selenium. As cord-blood mercury analyses appear to be less precise than suggested by laboratory quality data, we ...
Jiang Wenxiao W Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China. Electronic address: - - 2014
A systematic review is done to determine the efficacy and safety of levonorgestrel-releasing intrauterine systems as a treatment using in premenopausal women with symptomatic uterine leiomyoma. We searched the Medline, Central and ICTRP database for all articles published from inception through July 2013 that examined the following outcomes: uterine volume, ...
Sawant Onkar B OB Department of Veterinary Physiology and Pharmacology and Michael E. DeBakey Institute, College of Veterinary Medicine and Biomedical Sciences, 4466 Texas A&M University, College Station, TX, 77843-4466, - - 2014
Not much is known about effects of gestational alcohol exposure on maternal and fetal cardiovascular adaptations. This study determined whether maternal binge alcohol exposure and L-glutamine supplementation could affect maternal-fetal hemodynamics and fetal regional brain blood flow during the brain growth spurt period. Pregnant sheep were randomly assigned to one ...
Haugen Guttorm G Departments of Obstetrics, Oslo University Hospital, Rikshospitalet; University of Oslo, Oslo, - - 2014
To study umbilical vein and fetal liver blood flow related to fetal anthropometric measures following maternal oral glucose loading. Experimental design in a cross-sectional observational study. University hospital. 113 low-risk pregnancies (30 - 32 gestational weeks). Ultrasound Doppler measurements of umbilical vein and ductus venosus blood flow (ml/min) before and ...
Kooijman Marjolein N MN The Generation R Study Group, Departments of Epidemiology, Pediatrics, - - 2014
Impaired fetal abdominal blood flow may lead to smaller kidneys and subsequent impaired kidney function in later life. In a prospective cohort study among 923 pregnant women and their children, we measured fetal growth, kidney volumes, and umbilical and cerebral artery blood flow (median gestational age of 30.3 weeks; 95% ...
Katzman Miriam M a Department of Pediatrics, University of Saskatchewan, c/o 103 Hospital Drive, Saskatoon, SK S7N 0W8, - - 2014
This prospective study investigated associations between cord blood vitamin D, risk factors for low vitamin D, and pregnancy and neonatal outcomes. The study included 65 maternal-fetal dyads delivering between December and February in Saskatoon, Saskatchewan. Eighty-five percent of mothers reported taking daily prenatal vitamin D but 70% of their newborns ...
Towers Craig V CV University of Tennessee Medical Center-Knoxville, Knoxville, - - 2014
Parabens are esters of p-hydroxybenzoic acid and are commonly used as preservatives in foods, cosmetics, pharmaceuticals, and personal care products. They are suspected endocrine disruptors and some have been found to bind estrogen receptors. Gestational exposure in animal studies has suggested a possible effect on later adult social behavior. The ...
Uehara Ichiro I Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Mitaka, Tokyo, - - 2014
Urate, the final oxidation product of purine metabolism, is excreted into urine in humans. Clinically, increased serum urate levels are indicative of pregnancy-induced hypertension (PIH). However, how urate is handled in the placenta is still largely unknown. In this study, we compared maternal serum urate levels with those of umbilical ...
Ou Langbo L Ministry of Education Laboratory of Earth Surface Process, College of Urban and Environmental Sciences, Peking University, Beijing 100871, - - 2014
Considering the different ability of placental transfer, an assessment of the cord:maternal blood ratio for both methylmercury (MeHg) and inorganic mercury (IHg) is needed especially for interpreting the low-level prenatal exposure. In this study, we conducted a Monte Carlo-based meta-analysis to comprehensively estimate that ratio for MeHg (RMeHg) and IHg ...
Brodzki P P Department and Clinic of Reproduction, University of Life Sciences in Lublin, Głęboka, Lublin, Poland. Electronic address: - - 2014
This study was a comparative evaluation of selected immunological parameters in peripheral blood and uterine wash samples from cows with a normal postpartum period compared with cows with endometritis. We aimed to determine the usefulness of these parameters in monitoring the puerperium. In total, 40 cows were included in the ...
Kato Sosuke S Department of Obstetrics and Gynecology, Osaka Medical College, Osaka, - - 2014
The aim of this study was to evaluate the effect of local injection of vasopressin on blood loss and secondary impact on complications during cesarean section in patients with placenta previa. We retrospectively reviewed the medical records of all patients diagnosed with placenta previa admitted to our hospital. Two consecutive ...
Cahill Lindsay S LS Mouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario, - - 2014
Mice reproduce many features of human pregnancy and have been widely used to model disorders of pregnancy. However, it has not been known whether fetal mice reproduce the physiologic response to hypoxia known as brain sparing, where blood flow is redistributed to preserve oxygenation of the brain at the expense ...
Sun Hong H Jiangsu Provincial Center for Disease Control and Prevention, Jiangsu Road 172, 210009 Nanjing, PR - - 2014
To evaluate the current maternal and fetal exposure to cadmium (Cd), lead (Pb) and selenium (Se), and their potential effect on newborn birth outcomes, a cross-sectional study involving an assessment of the levels of these three metals in maternal blood, urine and umbilical cord blood was conducted in 209 pregnant ...
Masoller N N BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu), IDIBAPS, University of Barcelona, and Centre for Biomedical Research on Rare Diseases (CIBER-ER), Barcelona, - - 2014
The aim of our study was to evaluate the association of CHD on head biometry and cerebrovascular blood flow dynamics at the time of diagnosis in the second trimester of pregnancy. 95 consecutive fetuses diagnosed with CHD. At the time of diagnosis of CHD, we assessed fetal biometry and brain ...
García-Esquinas Esther E Environmental and Cancer Epidemiology Unit, National Centre for Epidemiology, Carlos III Institute of Health (Instituto de Salud Carlos III-ISCIII), C/ Sinesio Delgado 6, 28029, Madrid, Spain, - - 2014
This study is part of the BioMadrid Project, a bio-monitoring study designed to assess pollutants in the environment surrounding children born in the Madrid region. Our aim in this report is to evaluate the association between prenatal lead exposure and fetal development using three biological samples (maternal and paternal blood ...
Choi Gyuyeon G College of Medicine, Soonchunhyang University, Seoul, Republic of - - 2014
Polybrominated diphenyl ethers (PBDEs) are of growing public health concern because of their potential toxicities which range from endocrine disruption to neurodevelopment. However, information on their exposure among sensitive human populations is limited. The objectives of this study were to determine the levels of major PBDEs in blood sera of ...
Sharma Megha M Department of Obstetrics and Gynaecology, GMC and Rajindra Hospital, 151 Punjabi Bagh, Patiala, 147001 Pb - - 2014
To study oxytocin, misoprostol, and methylergometrine in active management of the third stage of labor and determine duration of the third stage of labor, blood loss, adverse effects, and need for additional uterotonics in each group. Clinical trial of 300 women with healthy singleton pregnancy allocated into three groups to ...
Noh Eun Ji EJ Department of Obstetrics and Gynecology, Chonnam National University Medical School, Gwangju, - - 2014
The purpose of our study was to investigate the effect of the mode of delivery on the oxidant and antioxidant system in umbilical cord blood. We performed gas analysis of umbilical venous blood and umbilical arterial blood immediately after delivery in 38 women; eighteen women had a vaginal delivery while ...
Kanat M M Departments of Internal Medicine, Istanbul Medipol University, - - 2014
To assess the relation between fetal and maternal blood type (ABO, Rh) incompatibility and development of gestational diabetes mellitus (GDM). A total of 500 pregnant women underwent diagnostic test for GDM by a 100-g oral glucose tolerance test (OGTT) after an 8 to 12-h overnight fast participated in this study. ...
Sparić Radmila - - 2014
Cesarean section is more frequent in pregnant women with uterine myomas, and is usually complicated with perioperative hemorrhage. In some cases, cesarean myomectomy represents an inevitable surgery, adding risk of hemorrhage occurrence. Massive obstetric hemorrhage is the most common cause of maternal mortality and morbidity. The aim of this study ...
Katheria Anup C AC Department of Neonatology, Sharp Mary Birch Hospital for Women and Newborns, San Diego, CA. Electronic address: - - 2014
To determine whether umbilical cord milking (UCM) improves systemic blood flow and reduces neonatal morbidities compared with immediate cord clamping (ICC). Women admitted to a tertiary care center and delivering before 32 weeks' gestation were randomized to receive UCM or ICC. Three blinded serial echocardiograms were performed in the first ...
Camacho L E LE Department of Animal Sciences, North Dakota State University, Fargo, North Dakota, - - 2014
The objective was to examine the effect of maternal nutrient restriction followed by realimentation during midgestation on uterine blood flow (BF). On Day 30 of pregnancy, lactating, multiparous Simmental beef cows were assigned randomly to treatments: control (CON; 100% National Research Council; n = 6) and nutrient restriction (RES; 60% of CON; ...
Hasegawa Junichi J Department of Obstetrics and Gynecology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan, - - 2014
To clarify whether maternal anemia could reduce placental volume in the early gestation. A prospective cross-sectional study was conducted. Consecutive women who visited at 11-13 + 6 weeks' gestation were enrolled. Subjects were divided into two groups by maternal hemoglobin concentration. Cases with maternal anemia were defined as a hemoglobin level less than ...
Su H H Department of Obstetrics and Gynecology Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, - - 2014
Objective:To perform a quantitative review of the evidence on the diagnostic value of inflammatory markers in maternal serum or umbilical cord blood for the diagnosis of early-onset neonatal sepsis (EONS).Study Design:We searched multiple databases for studies published through March 2013 that evaluated the diagnostic performance of procalcitonin (PCT), C-reactive protein ...
Khatib Nizar N The Ultrasound Division, Department of Obstetrics and Gynecology, Rambam Medical Center, Haifa, Israel. Electronic address: - - 2014
The brain sparing phenomenon in the fetus is a protective mechanism aimed at maintaining sufficient blood flow towards the brain during chronic or acute fetal stress, such as that caused by hypoxemia or utero-placental insufficiency. In this study we investigated whether the brain sparing effect can also be elicited by ...
Helbig Anne A Norwegian Resource Centre for Women's Health, Oslo University Hospital, Oslo, Norway ; Department of Obstetrics, Oslo University Hospital, Oslo, - - 2014
Antenatal maternal psychological distress may be associated with reduced placental circulation, which could lead to lower birthweight. Studies investigating this in humans show mixed results, which may be partially due to type, strength and timing of distress. In addition, the arterial vascular resistance measures often used as outcome measures do ...
Ssemaganda Aloysius A Uganda Virus Research Institute - International AIDS Vaccine Initiative, Entebbe, - - 2014
We have previously shown that in successful pregnancies increased arginase activity is a mechanism that contributes to the suppression of the maternal immune system. We identified the main type of arginase-expressing cells as a population of activated low-density granulocytes (LDGs) in peripheral blood mononuclear cells and in term placentae. In ...
Shaw C J CJ Imperial College London, , Hammersmith Campus, Du Cane Road, London W12 0HS, - - 2014
High-intensity focused ultrasound (HIFU) is a non-invasive technology, which can be used occlude blood vessels in the body. Both the theory underlying and practical process of blood vessel occlusion are still under development and relatively sparse in vivo experimental and therapeutic data exist. HIFU would however provide an alternative to ...
Hussein Ayad Ahmed AA Bone Marrow and Stem Cell Transplantation Program, King Hussein Cancer Center, Amman, - - 2014
Cord blood transplant is an accepted treatment for many malignant and non-malignant diseases. We sought to determine the feasibility of collecting cord blood in Jordan and the effect of maternal and fetal factors on the quality of the cord blood units. A total of 124 cord blood units were collected, ...
Olsen Richelle N RN Department of Reproductive Medicine, University of California, San Diego, CA, - - 2014
Objective. Abnormal umbilical artery Doppler (UAD) studies are associated with poor neonatal outcomes. We sought to determine if postnatal measures of systemic blood flow (SBF), as measured by functional echocardiography (fECHO), could identify which fetuses with abnormal UAD were at the highest risk of adverse outcomes. Study Design. This is ...
Aylward L L LL a Summit Toxicology, LLP , Falls Church , Virginia , - - 2014
The developing fetus is likely to be exposed to the same environmental chemicals as the mother during critical periods of growth and development. The degree of maternal-fetal transfer of chemical compounds will be affected by chemical and physical properties such as lipophilicity, protein binding, and active transport mechanisms that influence ...
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