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Hsu Ju-Chun - - 2013
Assessment of the fetal brain volume and blood flow is important in the evaluation of fetal growth. We used three-dimensional (3D) ultrasound and power Doppler to assess the fetal brain volume and the blood flow index during normal gestation. The relationships of these parameters were further analyzed. We assessed the ...
Dąbrowski Roman - - 2013
Pyometra is a life-threatening reproductive disorder that affects the uterus of female dogs. This study was designed to identify the possible indicators of uterine inflammation by comparing C-reactive protein (CRP), serum amyloid A (SAA), and haptoglobin (Hp) concentrations in uterine arterial and peripheral venous blood in bitches with open- and closed-cervix ...
Lemley Caleb O - - 2013
Dietary melatonin supplementation from mid to late gestation increases umbilical artery blood flow and causes disproportionate fetal growth. Melatonin receptors have been described throughout the cardiovascular system; however, limited data exists on the function of placental melatonin receptors. The objectives of the current experiment were to determine fetal descending aorta ...
Gokhale Sg - - 2013
Abstract Objective: To determine transfusion compatibility of maternal RBCs for her neonate upto 4 weeks of age, irrespective of maternal- neonatal ABO mismatch Methods: This was a prospective observational study involving eligible mothers with their neonates delivered in participating site from July 1, 2012 till December31, 2012. Mother's blood was ...
Channa Kalavati - - 2013
Mercury is a persistent environmental pollutant that has the potential to adversely affect human health, particularly, foetal neurodevelopment. The purpose of the study was to investigate prenatal mercury (Hg) exposure in the population in three sites along the South Africa coast. Study subjects included women (n=350) who were admitted for ...
Lemley C O - - 2013
Dietary melatonin supplementation during mid- to late-gestation increased umbilical artery blood flow and caused disproportionate fetal growth. This melatonin-induced increase in umbilical artery blood flow may alter nutrient availability to the fetus, which may lead to alterations in fetal size. The objectives of the current experiment were to determine amino ...
Freeman S L - - 2013
The aim of this study was to measure uterine artery blood velocity daily using Doppler ultrasonography in 10 young and 10 older clinically normal bitches throughout oestrus. Typical arterial waveforms identified in young bitches were characterised by a systolic peak and subsequent flow throughout diastole, whereas in older bitches, flow ...
Varughese E E - - 2013
Reference data to assess function and perfusion of uteroplacental tissues by assessment of uterine blood flow parameters is not available in buffaloes. The objective of the present study was to assess and quantify blood flow parameters at various stages of gestation. A total of 54 Murrah buffaloes, six animals at ...
Tongsong Theera - - 2013
Hemodynamic study was performed on a 32-year-old woman presenting at 27 weeks' gestation. Ultrasound revealed a single normal fetus with mild cardiomegaly, polyhydramnios, and placental chorioangioma. Doppler study showed increased middle cerebral artery peak systolic velocity, normal Tei index, and forward flow of "a" wave with normal preload in the ...
Zhang Tao - - 2013
Limited information exists on the exposure of benzophenone (BP)-type UV filters (i.e., sunscreen compounds) in children, adults, and pregnant women in China. In this study, we determined the concentrations of five BP derivatives, BP-1, BP-2, BP-3, BP-8, and 4OH-BP in urine (n=101) as well as paired specimens of blood and ...
Ballen Karen K KK Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA. - - 2013
Umbilical cord blood is an alternative hematopoietic stem cell source for patients with hematologic diseases who can be cured by allogeneic hematopoietic cell transplantation. Initially, umbilical cord blood transplantation was limited to children, given the low cell dose infused. Both related and unrelated cord blood transplants have been performed with ...
Yu Yanxin - - 2013
Placenta and umbilical cord blood are important media for investigating maternal-fetal exposure to environmental pollutants. Historically hexachlorocyclohexanes (HCHs) were once widely-used in China. In this study, residues of HCHs were measured in placenta and umbilical cord blood samples for 40 women from Beijing. The measured median values of HCHs were ...
Bienertova-Vasku J - - 2013
The aim of the study was to investigate the circulating levels of ciliary neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF) in maternal serum and umbilical cord blood from respective pregnancies in pre-eclampsia (PE) cases and a control cohort. A total of 12 pre-eclampsia cases and 34 healthy controls were ...
Galinsky Robert - - 2013
Background:Intrauterine inflammation adversely affects cardiopulmonary, systemic and cerebral hemodynamics in preterm neonates but the impact on responses to endotracheal tube(ETT) suction, known to affect hemodynamics, is unknown. We hypothesized that intrauterine inflammation would alter the cardiopulmonary and cerebral hemodynamic response to open ETT suction in preterm lambs.Methods:Chronically instrumented fetuses received ...
Cohain Judy Slome - - 2013
Abstract Amniotomy has become a routine part of obstetrical care. It was added along with other procedures adopted 50+ years ago without strong evidence. The scientific data supporting this procedure is poor while there is data suggesting it may increase the frequency of cord prolapse, neonatal GBS infection, pain and ...
Zanardo Vincenzo - - 2013
AIM: The 'two-step' head-to-body delivery method, which involves waiting for the next contraction to deliver the shoulders, causes a decrease in umbilical artery pH. The aim of this study was to assess if foetal acidemia activates gluconeogenesis. METHODS: We tested umbilical artery cord blood glucose concentration and pH after 341 ...
Mokarami P - - 2013
OBJECTIVE: To explore the 'hidden acidosis' phenomenon, in which there is a washout of acid metabolites from peripheral tissues in both vaginal and abdominal deliveries, by investigating temporal umbilical cord blood acid-base and lactate changes after delayed blood sampling. DESIGN: Prospective comparative study. SETTING: University hospital. SAMPLE: Umbilical cord blood ...
Kulkarni A A - - 2013
The coagulation system of the foetus is markedly different from that of adults. To assess the influence of maternal age, mode of delivery and intrapartum events, and foetal gender and weight on the foetal coagulation system. Cord blood was collected from 154 healthy pregnant women, with gestational age 37 - ...
Nakamura Masamitsu - - 2013
The volume of the chorion villosum is associated with the location of the umbilical cord in the first trimester AIMS: To clarify whether villous placental volumes in cases with low cord insertion are smaller than those with normal cord insertion. METHODS: A prospective cohort study was conducted to evaluate the ...
Hasegawa Junichi - - 2013
OBJECTIVES: To clarify the effects of umbilical cord coiling on the umbilical blood flow at 11-13 weeks of gestation. METHODS: A cross-sectional study was conducted among consecutive pregnant females at 11-13 weeks of gestation. Transabdominal ultrasound examinations were performed to obtain the umbilical coiling index (CI), the maximum umbilical arterial peak velocity ...
Su Tina Y - - 2013
BACKGROUND: Lactate measurements have become increasingly preferred over pH analysis in the evaluation of fetal acidaemia in labour. In a busy labour ward, often the umbilical cord may be sampled late and as a result yield unreliable lactate values. AIM: To investigate the agreement of hand-held device Lactate Pro with ...
Singh B - - 2013
Background Cesarean section has been identified as one of the commonest indication for blood transfusion in obstetric practice because it involves risk of major intra-operative blood loss. Different figures varying from less than 500 ml to more than 1000 ml have been quoted as estimated blood loss associated with caesarean ...
Rurak Dan - - 2013
In order to determine if there are changes in blood gas and acid-base status with advancing gestation in the fetal lamb, similar to that reported in the human fetus, blood gas, acid-base and blood metabolite values were measured in 447 control, arterial blood samples from 108 chronically instrumented fetal lambs ...
Okai Takashi - - 2013
High-intensity focused ultrasound (HIFU) has excellent potential as a non-invasive therapeutic tool in various fields of medicine. We present a case of twin reversed arterial perfusion (TRAP) sequence, in which non-invasive blood flow occlusion in the acardiac fetus was successfully achieved by means of HIFU exposure from outside the maternal ...
Zheng Songmao - - 2013
AIM(S): The current investigation aims to provide new insights into fetal exposure to tacrolimus in utero by evaluating maternal and umbilical cord blood (venous and arterial), plasma and unbound concentrations at delivery. This study also presents a case report of tacrolimus excretion via breast milk. METHODS: Maternal and umbilical cord ...
Arthuis C J - - 2013
OBJECTIVE: To monitor and quantify uteroplacental perfusion in rat pregnancies by Doppler ultrasound (DUS) and contrast-enhanced ultrasound (CEUS). METHODS: Fourteen rats were randomized in two groups (the CEUS group and the control group). On days 8, 11, 14, 17, 19 and 20 of gestation, we used DUS to measure the ...
Booth Lindsea C - - 2013
There is increasing evidence that exposure to infection can sensitize the fetus to subsequent hypoxic injury. However, it is unclear whether this involves compromise of the fetal cardiovascular adaptation to acute asphyxia. Chronically instrumented 103 day old (0.7 gestational age, term is 147 days) fetal sheep in utero were randomized ...
Sakuma Yoshiko - - 2013
We investigated the mechanism of transplacental macromolecular transport in rats on the nineteenth day of pregnancy using tracers, transmission electron microscopy and immunohistochemistry. The blood-placental barrier of full-term rat placentas was composed of a trilaminar layer of trophoblast cells that separates the fetal capillaries from the maternal blood spaces: a ...
Hartmann D - - 2013
The objectives of the present study were to compare the effects of a protracted and a conventional induction of parturition on the incidence of retained placenta, and to evaluate the suitability of transrectal Doppler sonography of the uterine arteries as a noninvasive method for the assessment of placental maturation. Protracted ...
Yamamoto Yuka - - 2013
BACKGROUND: Decreased middle cerebral artery (MCA) pulsatility index (PI) is a marker of fetal brain-sparing in placental insufficiency, and it is also found in fetuses with severe congenital heart disease. This study sought to explore the impact of anatomic subtypes in fetal heart disease on MCA-PI and head growth. METHODS: ...
Whitehead C L - - 2013
Objective:To determine whether the intrinsic apoptosis pathway is differentially expressed in placenta and maternal blood in severe preterm fetal growth restriction (FGR) and pre-eclampsia (PE), and to examine whether circulating RNA in maternal blood may be potential biomarkers.Study design:Maternal blood samples and placental biopsies were collected from women with preterm: ...
Gizurarson Sveinbjorn - - 2013
Objectives: Here, we performed a pathophysiological examination of the vascular function of rodent in the presence of placental protein 13 (PP13) and its implication to regulate the development of preeclampsia. Methods: Single i.v. injection and prolonged in vivo exposure to PP13 via osmotic pumps were performed in gravid and non-gravid ...
Stanley Christopher P CP School of Graduate Entry Medicine & Health, Royal Derby Hospital, University of Nottingham, DE22 3DT, - - 2013
Cannabidiol (CBD) has beneficial effects in disorders as wide ranging as diabetes, Huntington's disease, cancer and colitis. Accumulating evidence now also suggests that CBD is beneficial in the cardiovascular system. CBD has direct actions on isolated arteries, causing both acute and time-dependent vasorelaxation. In vitro incubation with CBD enhances the ...
Qaiser Danish Hasan - - 2013
Objective: To determine any significant correlation between the routine haematological parameters of maternal blood and umbilical cord blood of their respective newborns. Study Design: Cross sectional study. Place and Duration of Study: The study was conducted at four public and private hospitals of Karachi including Sindh Government Qatar Hospital, Sindh ...
Georgieva Antoniya - - 2013
OBJECTIVE: To validate umbilical arterial and venous pH and base deficit (pH(UA), pH(UV), BD(UA), and BD(UV), respectively), as well as venous-arterial pH differences, as measures of perinatal condition at birth (in relation to emergency intervention, resuscitation, facial mask, low Apgar, seizures, other cerebral problems or death); to investigate whether BD(UA) ...
Ke Alice Ban - - 2013
Through PET, our laboratory has studied the dynamic biodistribution of (11)C-verapamil, a P-gp substrate, in the nonhuman primate Macaca nemestrina. To gain detailed insight into the kinetics of verapamil transport across the blood-brain barrier (BBB) and the blood-placental barrier (BPB), we analyzed these dynamic biodistribution data by compartmental modeling. METHODS: ...
Hernandez-Andrade Edgar - - 2013
PURPOSE OF REVIEW: To provide evidence that fetal brain vasodilatation can be related with postnatal cerebral structural and functional complications. RECENT FINDINGS: Most early-onset intrauterine growth restricted (IUGR) fetuses show signs of brain vasodilatation. As most of them are born prematurely, a high prevalence of short-term and long-term neurological complications ...
Abdelrazzaq Khalil - - 2013
OBJECTIVE: To identify the role of longitudinal measurements of fetal aortic isthmus blood flow using Doppler ultrasonography in the prediction of perinatal morbidity and mortality. SETTING: Obstetrics department of a university POPULATION AND DESIGN: This prospective study includes women with fetal growth restriction and abnormal umbilical artery Doppler results, seen ...
Piccoli Giorgina B - - 2013
BackgroundChronic kidney disease (CKD) and pre-eclampsia (PE) occur in 3-5% of pregnancies. They often share hypertension and proteinuria and a differential diagnosis may be impossible. However, in PE, the pathogenesis is related to abnormal placentation, which can be detected by abnormal uterine and umbilical Doppler flow velocities, while in CKD, ...
Vonnahme K A - - 2013
Proper establishment of the placenta is important for fetal survival; however, placental adaptations to inadequate maternal nutrition, or other stressors, are imperative for fetal growth to be optimal. The effects of maternal nutritional status and activity level on placental vascular function and uteroplacental blood flows are important to understand as ...
Chang Yao-Lung - - 2013
SUBJECT: This study investigates the placental autophagic activity in growth-restricted fetuses in the monochorionic (MC) twin model. PATIENTS AND METHODS: Forty MC twins were prospectively enrolled in this study, including 21 with and 19 without selective intrauterine growth restriction (sIUGR), defined as birth weight below the tenth percentile. The sIUGR ...
Parra-Saavedra M - - 2013
Objectives: To compare umbilical vein (UV) flow versus standard Doppler parameters in prediction adverse perinatal outcomes in late-onset small-for gestational age (SGA) fetuses. Methods: Umbilical, uterine, and middle cerebral arteries, and UV blood flow (UVBF) were evaluated by Doppler before delivery in a cohort of 193 term SGA fetuses. The ...
Dilworth Mark Robert MR Maternal and Fetal Health Research Centre, Institute of Human Development, University of Manchester, Manchester, United Kingdom ; Manchester Academic Health Science Centre, St. Mary's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United - - 2013
Fetal growth restriction (FGR) is defined as the inability of a fetus to achieve its genetic growth potential and is associated with a significantly increased risk of morbidity and mortality. Clinically, FGR is diagnosed as a fetus falling below the 5(th) centile of customised growth charts. Sildenafil citrate (SC, Viagra™), ...
Chakrabarty P - - 2013
Once Umbilical Cord with Placenta considered a biological waste product and generally discarded after delivery but now cord blood has emerged as a viable source of hematopoietic stem cell transplantation. High-risk premature infants require red cell transfusions for anemia. A unique property of cord blood (CB) for its high content ...
Li Lu-Xi - - 2013
There is a growing concern about the potential health effects of exposure to various environmental chemicals during pregnancy and infancy. The placenta is expected to be an effective barrier protecting the developing embryo against some endocrine disruptors (EDs) circulating in maternal blood. The current study was designed to assess in ...
Sexton Ken - - 2013
Biomarkers of organochlorine pesticides were measured in both venous and umbilical cord blood from 35 pregnant Hispanic women living in Brownsville, Texas, USA. Gas chromatography with an electron capture detector was used to analyze specimens for 30 individual pesticides or their metabolites. Results indicate that blood concentrations were relatively low ...
Poudel Rajan R University of Alberta, Edmonton, Alberta, - - 2013
Preeclampsia (PE) and fetal growth restriction (FGR) contribute significantly to fetal and maternal morbidity and mortality. Although the causes of PE and FGR are not fully understood, both conditions are known to be associated with impaired uterine artery blood flow. Resveratrol, a polyphenol found in a number of plants, has ...
Allan David - - 2013
Umbilical cord blood banking efforts have increased dramatically in the past two decades in response to increasing demand for alternative sources of blood stem cells to support patients requiring hematopoietic stem cell transplantation. Transplant centres have accumulated increasing expertise in their understanding of umbilical cord blood characteristics that are associated ...
Bartkeviciene Daiva - - 2013
Objective: To identify and evaluate the correlation between leukocyte count in maternal blood and the risk of developing fetal inflammatory response syndrome (FIRS). Patients and methods: The study involved 158 infants born at 22 - 34 weeks of gestation and their mothers. Umbilical cord blood cytokines were evaluated in immunoassay tests and ...
Seule Martin - - 2013
One of the major goals in the treatment of patients with aneurysmal subarachnoid hemorrhage (aSAH) is early detection and treatment of delayed ischemic neurologic deficits (DINDs) to prevent cerebral infarction and thus poor outcome or even death. The complex changes of cerebral metabolism, hemodynamics, and oxygenation after SAH are underestimated ...
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