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Donaldson L A - - 1978
In spite of extensive investigations, many aspects of the hemodynamic changes occurring in acute pancreatitis are understood poorly. A dog model was established in which continuous measurements of pancreatic arterial blood flow, cardiac output, and mean arterial blood pressure were made using electromagnetic flow probes and a pressure transducer, respectively. ...
Kajiwara T - - 1978
An experimental study was conducted on the effect of bile diversion on exocrine pancreatic function. Twelve dogs were divided into three groups, one group consisting of a choledochojejunostomy; one, a choledochoduodenostomy, and one, a choledochocholedochostomy. In each group, exocrine pancreatic function was observed before and two months after the operation. ...
Peterson T V - - 1978
Samplings of canine capsular and hilar lymph, and intrarenal venous blood were investigated as in vivo techniques for detecting renal cortical function in control and NH4Cl pretreated anesthetized animals. The glucose concentration of capsular, but not hilar, lymph was indicative of cortical drainage in both groups. When lymph flow was ...
Schapiro H - - 1978
Glucagon can depress normal animal and human pancreatic exocrine secretions and modify experimentally-induced pancreatitis in animals. It has yet to be demonstrated that glucagon has any efficacy in the treatment of the diseased pancreas in man. Glucagon might act on the exocrine pancreas by 1. reducing pancreatic blood flow, 2. ...
Miller L J - - 1978
Duodenal function was studied in 11 healthy volunteers after intragastric instillation of a mixed semi-elemental meal. The duodenum accepted chyme of varying pH, osmolality, and nutrient concentration; and, as a result of biliary, pancreatic, and enteric secretion as well as absorption, it delivered chyme with nearly constant pH, osmolality, and ...
Gingell R - - 1978
The levels of N-nitroso-bis(2-oxopropyl)amine (BOP) and its metabolites in the urine, blood, bile, and pancreatic juice were compared after ip and oral administration of BOP to Syrian golden hamsters to explain the differing organotropic tumor spectra resulting from treatment by these two routes. The levels of BOP and its metabolites ...
Basu P K - - 1978
We used radio-labelled microspheres to study the distribution of blood flow in different regions of rabbit eyes with inflamed corneas resulting from trauma or allograft reaction. The blood flow in the cornea, the anterior uvea and the regional lymph nodes draining it was increased, but total flow in the eye ...
van Heerden J - - 1978
An outbreak of mortality in cattle grazing kikuyu (Pennisetum clandestinum) pastures on a farm in the western Transvaal is described. These pastures had been heavily infested with army worm (Spodoptera exempta) two weeks preceding the onset of deaths. The main symptoms were excessive salivation, paresis of the tongue and pharynx, ...
Kaartinen M - - 1978
Lymph fluid and serum samples from four mammalian species were studied forthe concentration and degree of polymerization of IgA. The results suggest that in the mouse, in the rat and in the dog circulating IgA represents only a small fraction of all IgA entering the blood stream from the lymph ...
Osnes M - - 1978
Six subjects with a normal endoscopic pancreatogram were investigated after an overnight fast by means of a side-viewing duodenoscope. After cannulation of the main pancreatic duct, juice was collected in five-minute samples for 20 minutes. An iso-osmolar solution of 6 g cattle bile was then infused into the duodenum through ...
Jacques S - - 1978
The authors describe a new technique for the microsurgical cannulation of the thoracic duct. A small silastic tube is utilized which can be joined to a subcutaneously implanted one-way flow, CSF, Ommaya-type reservoir. Extended drainage is avoided. No deletion or alteration of major venous channels occurs. Lymph collection is accomplished ...
Makhlouf G M - - 1978
The effects of synetic porcine vasoactive intestinal peptide (VIP) on pancreatic and biliary secretion and on glucose, insulin and calcium blood levels were examined in the dog and compared with the effects of natural porcine VIP. Synthetic VIP was a secretin-like partial agonist of pancreatic and biliary secretion with efficacies ...
Nyman U - - 1978
At femoral angiography in dogs the effects of a new non-ionic contrast medium (C29) were compared with those of one non-ionic medium (metrizamide) and one ionic medium (meglumine/sodium diatrizoate) in current use. In the leg subjected to angiography the pressure gradient over the peripheral vessels decreased and the femoral blood ...
Vreim C E - - 1977
We studied the external lymphatic drainage of the lung in anesthetized dogs, by simultaneously measuring lymph flows from the thoracic duct (TD) and right lymph duct (RLD) during base line and during pulmonary edema. We measured lymph flow for a 2-h base-line period, for 2 h after tying off the ...
Chen R Y - - 1977
The effects of hypothermia on plasma volume (125I-albumin), red blood cell volume (51 Cr-RBC), and capillary permeability (thoracic duct lymph flow and protein concentration) were determined on dogs anesthetized with pentobarbital, paralyzed with succinylcholine, and mechanically ventilated. Red blood cell volume and plasma protein concentration did not change significantly after ...
Meyer E C - - 1977
In anesthetized, ventilated dogs, clearance of 2 +/- 0.2 ml alveolar-instilled 1% isosmolar [125I]albumin ([125I]RISA) was separated into bulk airway displacement and transalveolar tissue permeation by the use of collimated external detectors and by sampling of blood and lymph. The detectors were positioned perpendicular to the plane of bronchial drainage, ...
Järhult J - - 1977
In the cat pancreas, close intra-arterial infusions of hypertonic xylose, glucose and sucrose solutions caused a marked vasodilatation but no secretion. The magnitude of the vasodilator response correlated with the degree of induced glandular hyperosmolality but not with the substance per se. Stimulation of the vagus nerve as well as ...
Coddling J A - - 1977
Effects on pancreatic blood flow and insulin output of infusions of aminophylline, galactose and galactose plus aminophylline were studied on an isolated portion of dog pancreas with only one afferent and one efferent blood vessel remaining. Infusion of aminophylline at 8 mg per minute gave significant increases in pancreatic blood ...
White C W - - 1977
We assessed segmental distribution of blood flow to the right atrium and the region of the sinoatrial node using micropheres (7-10 mum) in 20 anesthetized dogs. Mean right atrial flow averaged 83+/-7 (SE) ml/min X 100 g, which was 56% of the left ventricular blood flow. The distribution of right ...
Balu J N - - 1977
The circulatory patterns in three lymphoid tissues were compared macro- and microscopically. Indian ink or a viscous silicone rubber compound were used as contrast materials and serial 75 micronm sections examined. The findings were checked with the benzidine stain for red blood corpuscles in uninjected tissues. Thymic lobules showed a ...
Olszewski W - - 1977
Changes in normal human leg lymph protein concentration, output, and lymph flow/lymph protein concentration relationship, as well as lactate dehydrogenase and alkaline phosphatase activity were followed during procedures known to increase capillary filtration as venous stasis, muscular exercise and warming of tissues. Lymph flow increased by 83% during two hour ...
Hay J B - - 1977
The blood flow to individual lymph nodes of sheep and rabbits has been determined with 85Sr-labeled microspheres. A popliteal node of the sheep received 0.014% of the cardiac output and a comparable node in the rabbit 0.011%. A sheep lymph node weighing 1 g received an average of 24 ml/h ...
Papp M - - 1977
Graded doses of glucagon (2--8 microgram/kg b. w.), prostaglandin E1 (PGE1) (125--1000 ng/kg b. w.), caerulein (1--32 ng/kg b. w.) and a synthetic C-terminal octapeptide of cholecystokinin-pancreozymin (CCK--PZ) 50--400 ng/kg b. w.) were infused into the superior pancreatioduodenal artery in chloralose-anaesthetized dogs to study the effect on blood flow and ...
Szwed J J - - 1977
Simultaneous measurements of thoracic duct lymph flow and small intestinal lymph flow were carried out in mongrel dogs after the administration of mannitol, ethacrynic acid, furosemide and chlorothiazide. Thoracic duct lymph flow increased only after injection of mannitol. Intestinal lymph flow increased after injection of all diuretics except chlorothiazide. Furthermore, ...
Granger D N - - 1977
The relationship between lymph flow and intestinal secretion was studied in an isolated, vascularly perfused cat ileal preparation in which secretion was caused by three different means: 1) plasma dilution from a constant infusion of Tyrode solution (2.5 ml/min per kg), 2) elevation of intestinal venous pressure to 30 mmHg, ...
Ihse I - - 1977
In a patient a papilla Vateri tumor completely prevented the bile-pancreatic flow into the intestine although the pancreatic juice was secreted into the bile duct via a common channel. Consequently, the bile-pancreatic juice was possible to sample via a percutaneous transhepatic cholangiography (PTC) catheter. This made it possible to study ...
Schuurkes J A - - 1976
Vasopressin (ADH) is known to reduce secretin-stimulated pancreatic exocrine secretion. The present study attempts to relate this inhibitory effect to the vasoconstrictive potency of ADH. Regional blood flow in most of the vascular areas. The greatest reduction in blood flow was seen in the gastrointestinal area especially in the left ...
Glover D J - - 1976
A method for cannulating the efferent duct of the prescapular lymph node of sheep was developed and carried out on over 100 occasions so that lymph could be collected from unanaesthetized sheep under physiological conditions. On average the lymph flowed at 9 ml/h and contained 15 X 10(6) lymphocytes/ml. The ...
Immink W F - - 1976
Responses to norepinephrine (NE) and isoprenaline (ISO) (1-1024 ng/kg i.v.) were assessed by electromagnetic flowmetry on 18 arteries of the splanchnic region in anesthetized dogs. Measurements were judged according to the 2 criteria: 1. direction of effect; 2.sensitivity of vascular areas to catecholamines, expressed as D50 (i.e. the calculated dose ...
GingellR - - 1976
N-Nitroso-2,6-demethylmorpholine (NDMM) administered intraperitoneally to Syrian hamsters was metabolized to N-nitroso-bis(2-hydroxypropy)(2-oxopropyl)amine(HPOP) and N-nitroso-bis(2-hydroxpropyl)amine (BHP) which were identified in blood and urine. The potent pancreatic carcinogen N-nitroso-bis(2-oxoproply)amine was previously shown to form the same metabolites. Preliminary results indicate that NDMM also induces pancreatic and other tumors in Syrian hamsters, similar to ...
Herman P G - - 1976
In 62 New Zealand white rabbits the regional blood flow to the popliteal lymph node was determined using the microsphere distribution and the Rb86C1 indicator methods. In 20 animals local immune response was induced with typhoid O antigen and in 7 with bovine serum albumin. The regional blood flow of ...
Freiman I - - 1976
1. Duodeno-jejunal intestinal loops in rats were perfused with cholera toxin and the pancreatic and biliary secretory responses studied. 2. Intraluminal cholera toxin induced a significant flow of pancreatic and biliary fluid and sustained protein (enzyme) secretion in pancreatic juice, in addition to the expected stimulation of mucosal secretion. 3. ...
Shannon A D - - 1976
An acute pain stimulus resulted in elevated lymph flow and output of cells from the popliteal lymph node of the sheep in the first 15 min after the stress. Efferent lymph flow increased by an average of 93% above the mean resting flow and cell output rose by an average ...
Fjeld N B - - 1976
Generalized hypoxia lasting 60 seconds more than doubled the cardiac lymph flow in dogs. The number of erythrocytes per mm3 of cardiac lymph increased by about 300%. However, there was no change in total protein or in the concentrations of different lipids following hypoxia. Thus, the transfer of erythrocytes across ...
Urlaub B J - - 1976
A previously unreported etiology for post-traumatic abdominal distention was observed in a 5-year-old girl who suffered only head trauma and a prolonged period of hypoxemia. When there is a rapid accumulation of peritoneal fluid containing a high concentration of protein but negative for amylase, no evidence of blood loss, plus ...
Uhley H N - - 1976
Canine cardiac lymph was studied after acute experimental myocardial infarction. The lymph potassium concentration remained the same, the lymph potassium content increased, the lymph pH decreased, and the lymph flow increased while the serum potassium and pH remained the same. It is suggested that localized hypoxia may result in cellular ...
Glazer G - - 1976
Acute haemorrhagic pancreatitis was induced in greyhound dogs by a bile salt/trypsin injection into the main pancreatic duct. Prostaglandin-like activity in the pancreatic venous blood, right atrial blood, and arterial blood was measured by bioassay. Activity rose significantly in the pancreatic venous blood of test dogs but not in controls. ...
Kanno T - - 1976
A technique is described for perfusing isolated rat pancreas with a modified Krebs-Henseleit solution. This preparation made feasible the simultaneous measurement of transmembrane potential, effective membrane resistance, rate of flow of pancreatic juice and amylase output. The hyperpolarizing effect of cholecystokinin-pancreozymin (CCK-PZ) was confirmed by perfusion with a solution containing ...
Suga T - - 1976
Effect of Coenzyme Q10 (CoQ10), an essential coenzyme in oxidative phosphorylation in the mitochondria, was studied in the rat's pancreas. A dose of pancreozymin (0.2 u/100 g body wt) was injected into the femoral vein at 20 min intervals. The initial injection produced a definite increase in amylase output and ...
Carfagna M - - 1976
The authors investigate the distribution of electrophoretic patterns of pancreatic amylase in 319 Sardinians and in 476 blood donors living in Naples. The results obtained show a difference in the phenotype frequency of the Amy2 duplication variant between Sardinians (1.25%) and Neapolitans (5.25%) which is statistically significant (p less than ...
Quin J W - - 1975
Anaesthesia and the trauma of surgery, associated with the cannulation of lymphatic ducts in various regions of the body of the sheep, had a profound effect on lymph flow, protein concentration and leucocyte concentration of lymph. In general lymph flow was depressed and the protein concentration elevated in lymph collected ...
Girardet R E - - 1975
Two techniques for cannulation of the thoracic duct in the rat, thoracic duct shunt and thoracic duct side fistula, are described. They give access, for repetitive sampling, to a normal thoracic duct circulation and are suited for study of the circulation under physiologic conditions. The thoracic duct shunt creates, with ...
Bauguess C T - - 1975
Fatty acid esters of acetaminophen were administered orally to dogs, and blood concentrations of acetaminophen were determined at various time intervals. Blood concentrations of acetaminophen following oral administration of a short chain ester, p-acetamidophenyl acetate, were not significantly different from those found using acetaminophen. Blood concentrations of acetaminophen following oral ...
Feola M - - 1975
Cardiac lymph was obtained from 12 normal dogs (group 1) for two consecutive 2-h control periods and from 7 dogs (group 2) for 2 h before and 2 h after occlusion of the circumflex branch of the left coronary artery. Lymph composition was studied with reference to pH, red blood ...
Ackerman N B - - 1975
The effect of cooling, freezing and warming temperatures on the flow of lymph from the intestines was studied in dogs. When intestinal temperatures were dropped to an average of approximately 40 degrees F., an immediate decrease in lymph flow occurred to a mean value 33 per cent of control levels. ...
Tuzhilin D A - - 1975
Data have been presented correlating changes of blood coagulability, capillary permeability, blood electrolyte content with electrocardiographic abnormalities and symptoms of coronary insufficiency. In acute pancreatitis and in acute exacerbation of chronic pancreatitis, accentuation of these vascular factors may induce symptoms of coronary disease. Data are also presented indicating abnormal blood ...
Schiller W R - - 1975
Pancreas of normal dogs and the inflamed gland of experimental pancreatitis were studied by intra-arterial injection of Microfil, a silicone-rubber compound especially suited for study of the microcirculation. Duodenal vasculature and lobular vessels of the pancreas were studied as were those supplying the duct. Inter-lobular vessels were well visualized in ...
Schick P - - 1975
Autotransfusions of the DNA synthesizing blood cells from 2-2.5 liters of blood, labelled in vitro with 3H-thymidine, were performed in 2 patients with Hodgkin's disease. The fate of the labelled lymphoid cells was followed up for 5 min to 60 h in the circulating blood and occasionally in the lymph ...
Seifert J - - 1975
The uptake and distribution of glucose, galactose, fructose and inulin in dogs was investigated in the lymph of the thoracic duct and in different blood vessels after enteral and parenteral administration. Whereas inulin could be detected neither in the lymph nor in portal venous blood after enteral administration, all other ...
Lefer A M - - 1974
Hemorrhagic shock was produced in dogs by bleeding to a systemic blood pressure of 45 mm Hg for 3 hours, followed by reinfusion of the shed blood. A rapid decrease in pancreatic blood flow occurred and pancreatic perfusion remained at 15-25% of control over the entire 3-hour oligemic period. As ...
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