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Hansen-Flaschen J H - - 1986
Since charge as well as size may influence the passage of plasma proteins from blood to lung lymph, we used uncharged dextrans as tracers to study the effects of hyperoxic lung injury on the molecular sieving properties of the pulmonary microcirculation in unanesthetized sheep. Polydisperse [3H]dextran was infused intravenously into ...
Nuutinen P - - 1986
The effect of profound hemorrhagic hypovolemia on cardiac output and pancreatic blood flow was studied in pigs with the thermodilution method and microsphere technique. Approximately 30-40% of the circulating blood volume was withdrawn slowly during 5 h. Cardiac output and pancreatic blood flow decreased by 35% and 32%, respectively. The ...
Harake B - - 1986
To understand better developmental changes in body fluid dynamics, we studied thoracic duct lymph flow in 9 newborn and 5 adult sheep. The experiments were carried out under general anaesthesia following bilateral ligation of the renal vessels and ureters. After a 30 min control period, we administered three successive 5-min ...
O'Malley V P - - 1986
Blood components have been implicated as factors which modulate organ injury in acute pancreatitis. To isolate these effects we compared a standardized isolated, blood-perfused, canine pancreas model as described by Herman-Taylor and modified by Cameron with a model using fluosol, a fluorocarbon, as the perfusate. Pancreatitis was induced using partial ...
Harper S L - - 1986
Pancreatic acinar tissue O2 tension (PO2) was measured in anesthetized rats using recessed-tip microelectrodes (tip diam 1-2 micron). Pancreatic blood flow was measured using radioactive microspheres. Volume rate of pancreatic secretion, as well as protein concentration, was also measured. Average resting PO2 was 24.8 +/- 1.6 mmHg, with relatively little ...
Frostell C - - 1986
We present results from an improved dog model, in which lymph flows from the thorax and abdomen are separated. The effect of increased alveolar pressure on lymph flows was studied by the application of positive end expiratory pressure (PEEP). Mean (+/- SD) thoracic lymph flow in 10 dogs was 4.1 ...
Donahue P E - - 1986
In response to previous demonstrations that either surgical or chemical sympathectomy can ameliorate the severity of acute experimental pancreatitis, and suggestions that the benefits of sympathectomy are related to alterations in the absolute blood flow or the pattern of blood flow within the pancreas or splanchnic organs, we studied blood ...
Koike K - - 1986
We investigated the intrathoracic contributions to the caudal mediastinal lymph node (CMN) efferent lymph in 12 anesthetized sheep after removing possible systemic contributions from below the diaphragm. We interrupted various pathways that may send lymph to the CMN (chest wall, esophagus, lung). Because the experiment is destructive, we did the ...
Pieper R - - 1986
A new animal model for the selective sampling of both the thoracic and the abdominal lymph is presented. Separation of the abdominal from the thoracic lymph flow provides new information on pulmonary physiology during mechanical ventilation and is a prerequisite for studies on pulmonary lymph flow. This is underscored by ...
Hjelmqvist B - - 1986
Pathologic proteolysis in pancreatitis is an important clue to understand the pathophysiology in pancreatitis. Impairment of pancreatic circulation is also important in the development of severe pancreatitis. In an attempt to study some of the biochemical and circulatory events in experimental pancreatitis in the pig the following experiments were undertaken. ...
Lange J F - - 1986
The pathways of enzyme transfer from the pancreas into the systemic circulation were analyzed in sodium taurocholate-induced acute hemorrhagic pancreatitis in the rat by estimating lipase concentrations in blood, lymph and ascites. During the first few hours of pancreatitis high enzyme levels were observed in thoracic duct lymph. However, cannulation ...
Jønsson V - - 1985
The hitherto largely unsolved problem with a biological definition of spleen versus lymph node seems possible to solve from a phylogenetic point of view. Thus, it is suggested that the spleen be defined as a hemopoietic organ which is able to filter blood with sinusoids. In contradistinction, a lymph node ...
Jansson L - - 1985
The aim of the present study was to evaluate the physiological role of intrapancreatic serotonergic nerves for endocrine pancreatic function. The specific uptake of [3H]5-hydroxytryptamine (5-HT) into pancreatic slices from the rat was completely abolished after an intrapancreatic injection of 5,7-dihydroxytryptamine (5,7-DHT). Since also high-affinity uptake of [3H]5-HT was absent ...
Madrid J A - - 1985
In dogs fitted with a pancreatic cannula and a duodenal cannula the intake of a standard meal induced a significant increase in the flow of pancreatic secretion and in the output of amylase, total protein, bicarbonate and chloride. The oral administration (200 mg/day) of cimetidine to dogs was seen to ...
Garvin P J - - 1985
To determine the effects of a distal splenic arteriovenous fistula on endocrine function and pancreatic blood flow, 25 dogs underwent proximal pancreatectomy with the pancreatic tail left in situ and free intraperitoneal drainage of the pancreatic duct. Group A served as controls. In groups B through E, ligation of all ...
Syed Ali S - - 1985
Since precise information with respect to the microvasculature of the teleost pancreas is lacking, analysis of the so-called principal islets (Brockmann bodies) was performed in Myoxocephalus scorpius with the use of methacrylate resin for the production of cast preparations. Stereoanalytical observations indicate that the circulatory pattern in the juxtasplenic pancreatic ...
Yamagishi F - - 1985
The effects of synthesized phosphodiesterase inhibitors, DM 9278 and HWA 285, on pancreatic exocrine secretion were investigated in isolated and blood-perfused canine pancreas. Close-arterial injections of DM 9278 (10-300 micrograms) and HWA 285 (300-3000 micrograms) caused dose-dependent increases in the flow rate of pancreatic juice and perfusion blood flow. Bicarbonate ...
Rooth P - - 1985
The microcirculation in the islets of Langerhans was examined by fluorescence microscopy in living mice injected with fluorescent dextran. The islet capillary network was denser and more tortuously arranged in obese-hyperglycemic (ob/ob) mice than in lean controls. Injection of norepinephrine (0.5-4.0 micrograms/kg body wt) immediately led to a pronounced inhibition ...
Blitz W - - 1985
In this study the vascular effects of VIP were studied in connection with its secretory performances in the pancreas and the liver. In anesthetized dogs pancreatic blood flow was measured parallel with measurement of bile and pancreatic secretion. VIP was injected intravenously at intervals of 1 minute in amounts of ...
Vetterlein F - - 1985
The influence of tolbutamide (20 mg/kg and 100 mg/kg i.v.) on blood flow to the entire pancreatic gland and to its endocrine tissue was studied in anaesthetized rats. Non-radioactive microspheres 8.8 micron diameter were used for determination of local blood flow rates. The islet tissue was subsequently stained intravitally with ...
Lifson N - - 1985
By intra-arterial postmortem staining of the pancreas with hematoxylin after the administration of nonradioactive microspheres to anesthetized unfasted rats, the following values (+/-SE) were obtained: mean single islet volume, 1.00 +/- 0.12 nl (median 0.32 +/- 0.04 nl, n = 14); pancreatic intensity of perfusion, 1.18 +/- 0.14 ml X ...
Sakai T - - 1985
In congestive heart failure, lymph flow from the cannulated thoracic duct is greatly increased. However, there has been scant data on lymph flow in the intact lymphatic system with systemic circulatory congestion. In the present study, thoracic duct and peripheral lymph flow were qualitatively determined using heated cross-thermocouples in seven ...
Eckhauser F E - - 1985
Microcirculatory derangements in the pancreas associated with acute pancreatitis may contribute to a low-flow state and lead to pancreatic necrosis. This study investigated the effects of glucagon, a selective mesenteric arterial dilator, on pancreatic ischemia in canine bile-trypsin-induced pancreatitis (BTP). Measurements of cardiac Index (CI), total pancreatic blood flow (QP), ...
Yamagishi F - - 1985
Effects of thyrotropin-releasing hormone (TRH) on pancreatic exocrine secretion were investigated in isolated and blood-perfused canine pancreas preparations. During constant intra-arterial infusion of secretin (0.03-0.05 units/min), concentrations of protein and bicarbonate in the pancreatic juice were measured before and after intra-arterial injection of TRH (0.1-10 ng). TRH did not produce ...
Yamagishi F - - 1985
The effects of isosorbide dinitrate (ISDN) on pancreatic exocrine secretion were investigated after intravenous administration in the whole animal and after close-arterial administration on the isolated and blood-perfused dog pancreas preparations. ISDN (10-100 micrograms/kg), injected into the femoral vein, caused a dose-dependent increase in flow rate of pancreatic juice and ...
Price B A - - 1985
The purpose of this study was to investigate the effects of intravenous somatostatin infusion on gastrointestinal blood flow and hormone release in conscious dogs. Gastric, duodenal, jejunal, and pancreatic blood flows, quantitated using radioactive microspheres, were significantly decreased during somatostatin infusion (200 and 500 ng/kg min), resulting in an overall ...
Schröder T - - 1985
The pancreatic blood flow and contrast enhancement in computed tomography (CT) were studied in 10 piglets weighing 17-25 kg with experimental pancreatitis. Each animal served as its own control. CT and blood flow measurements were made both before induction of pancreatitis and 5-6 h after the onset of the disease. ...
Studley J G - - 1985
This study evaluates pancreatic blood flow in the anaesthetised dog. Total flow was measured with an electromagnetic flowmeter and tissue perfusion using a Krypton-85 (85Kr) clearance technique. Cardiac output was also monitored with an electromagnetic flow probe placed on the ascending aorta. The flow and tissue perfusion in the pancreas ...
Binns R M - - 1985
Two types of experiment using local labeling of lymph nodes with FITC showed that lymphocytes emigrate from lymph nodes, predominantly in blood in the pig and in efferent lymph in the sheep. In the first type of experiment with the pig, few cells emigrated via the lymph, while the number ...
Iwatsuki K - - 1985
We investigated the effect of dopamine and arachidonic acid on pancreatic blood flow and exocrine secretion in the isolated blood-perfused pancreas of pentobarbital sodium-anesthetized dogs without or with pretreatment with indomethacin or sodium meclofenamate in the absence and during infusion of prostaglandins I2 or E2 (PGI2 or PGE2). Intra-arterial administration ...
Katz M A - - 1984
Although isolated popliteal node perfusion studies have shown intranodal exchange of water between blood and lymph, questions remain about the significance of such studies. Do some nodes exchange protein with blood, and are there shunt pathways around nodes which tend to buffer intranodal exchange of water? Finally, what is the ...
Studley J G - - 1984
In anesthetised animals basal pancreatic blood flow, both in the normal gland and in acute pancreatitis, and basal renal blood flow have been shown to be dependent on prostaglandins (PGs). However, in conscious dogs it has been demonstrated that the reliance of basal renal blood flow on PGs is only ...
Adair T H - - 1984
Postnodal lymph from the sheep caudal mediastinal node (CMN) is used by many investigators to assess lung vascular protein permeability. We explored the possibility that damage to the CMN blood-lymph barrier could produce increases in postnodal lymph flow and lymph-to-plasma protein concentration ratio (L/P) characteristic of lung vascular damage. Escherichia ...
Axon A T - - 1984
Terminology in classification of pancreatograms was discussed at a recent international workshop on chronic pancreatitis. A new terminology based on morphological radiographic appearances and a new classification to describe the severity and localisation of pancreatogram changes were agreed. Pancreatograms in chronic pancreatitis are graded as normal or equivocal, or as ...
Kim S - - 1984
Effects of 2% lidocaine with epinephrine (1:100,000) administered by the various local anesthetic techniques--i.e., infiltration, mandibular block, and intraseptal injection--on pulpal blood flow in dogs were determined using the 15 microns radioisotope-labeled microsphere injection method. The pulpal blood flow decreased significantly with all three techniques; however, the most drastic reduction ...
Holland S D - - 1984
The possibility that a decrease in extracellular volume, induced by diuretics, would cause a decrease in pancreatic blood flow which, in turn, might compromise pancreatic function was examined. Employing fasted anesthetized mongrel dogs, the acute effects of furosemide, a typical high ceiling diuretic, on pancreatic blood flow and plasma levels ...
Aboul-Enein A - - 1984
Forty women were investigated 6 to 24 months after radical mastectomy for the presence of functioning lymphovenous communications in the arm; 20 cases were edematous and the rest were not. Ten normal volunteer women were also investigated and served as controls. Iodinated (I125) human serum albumin was injected intralymphatically in ...
Iwatsuki K - - 1984
Effects of bromocriptine on the secretion of pancreatic juice were investigated with dog isolated, blood-perfused pancreas. Bromocriptine (1-10 mg) caused dose-dependent increases in the secretion of pancreatic juice. However, bromocriptine did not affect the perfusion blood flow rate. The secretory response to bromocriptine was inhibited by pretreatment with a dopamine ...
Donahue P E - - 1984
Experimental evidence has shown that pancreatic blood flow is severely diminished during acute pancreatitis, but it is unclear whether a decrease in blood flow is a critical event in the evolution of complications of this disease. When an episode of edematous pancreatitis is complicated by necrosis of part of the ...
Whitwam J G - - 1984
The thoracic lymph duct was cannulated at the root of the neck in seven anaesthetized, artificially ventilated dogs. The mean control lymph flow was 1.51 ml kg-1 h-1 (SD +/- 0.35). The administration of 1% halothane caused a 59% decrease in mean lymph flow (to 0.62 ml kg-1 h-1) within ...
Beijer H J - - 1984
Secretin stimulates pancreatic water and CO2 excretion as well as pancreatic blood flow. It has been questioned whether the production (i.e. water and CO2 excretion) is reflected in the input-output difference of nutrients. In pentobarbital anesthetised dogs, pancreatic exocrine secretion was stimulated by secretin (Karolinska), 1 U/kg injected as an ...
Sarli L - - 1984
The influence of bile flow interruption on the pathogenesis of acute pancreatitis has been evaluated in the rat. The pancreatitis was induced by Pfeffer's technique and the severity of the disease was assessed by a macroscopic examination of the pancreatic damage and the calculation of amylase-to-creatinine clearance ratio (ACCR) as ...
Taborsky G J GJ - - 1984
These studies were performed to assess the contribution of the pancreas to the somatostatin-like immunoreactivity (SLI) circulating in arterial and portal venous plasma. Basal SLI concentrations in arterial, pancreatic venous, and portal venous plasma were 95 +/- 9, 277 +/- 32, and 130 +/- 12 pg/ml, (means +/- SEM), respectively. ...
Calvo E L - - 1984
An experimental model to perform dynamic studies of exocrine pancreatic secretion from mice has been developed. It consists of a microsurgical procedure in anesthetized mice using a stereoscopic microscope. The bile-pancreatic common duct was individualized, isolated and cannulated. A specially calibrated capillary tube was placed in the free end of ...
Saito T - - 1984
The present paper describes a technique for the vascular perfusion of the isolated rabbit pancreas, evidence of the viability of the perfused gland and the responses to stimulation by secretin (Sc) and acetylcholine (ACh). The isolated rabbit pancreas was perfused at a constant pressure through the superior mesenteric artery with ...
Yoshikawa H - - 1984
The permselectivity to the small intestinal blood-lymph barrier for the exogenous macromolecules absorbed from the lumen was investigated using in situ rat closed loop experiment. We chose the fluorescein isothiocyanate-labelled dextran (FD) as macromolecule and lipid-surfactant mixed micelles as an absorption promoter. The mean molecular weights of FDs used were ...
Goodwin B S - - 1984
Glucagon effects on the kidney include increased water, creatinine, and amylase clearance. We have compared these effects in several laboratory animal species. Although every species responded to glucagon, 1 mg iv, by some alteration in renal function there were differences in the degree and direction of the changes. Glucagon caused ...
Ohtani O - - 1984
The methods reviewed here include: scanning electron microscopy (SEM) of vascular corrosion casts, SEM of intact tissue, SEM of HCl-collagenase treated tissues, light microscopy (LM) of India ink or silicon rubber injected tissues, with stereomicrography, LM of tissue stained by perfusion with hematoxylin, and a correlative study of intravital microscopy ...
Salido G M - - 1984
The interdigestive pancreatic exocrine secretion of the domestic fowl has been studied following the cosine-vector analysis. For the flow of pancreatic juice the crest phase was at 1040 and the sample amplitude was 2.26 microliter/min. For the amylase output the crest phase was at 1128 and the sample amplitude was ...
Quiros G - - 1984
Cardiovascular and thoracic duct lymph (TDL) flow alterations were investigated in non-starved rats, lightly sedated with neuroleptanalgesia, before and after osmolar loading. 0.29-, 1.0- and 2.0-M xylose solutions were infused at the rate of 4 ml X h-1 for 20 min. Neither control animals receiving 0.29-M infusions (iso-osmolar) nor those ...
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