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Robert J H - - 1988
A recent report from our laboratory showed that pancreatic inflammation induced by hypovolemic shock can be explained to some extent by spoliation in pancreatic perfusion as revealed by electromagnetic flow determinations on the gastroduodenal artery (GDA). On the other hand, when given early in the course of hypovolemic shock, methylprednisolone ...
Conway D R - - 1988
The effect of somatostatin analogue SMS 201-995 on pancreatic blood flow was studied. In 24 dogs all vessels to the pancreas, except for the pancreaticoduodenal artery and vein, were divided. A flow probe was placed around the pancreaticoduodenal artery. The animals were divided into four groups. Control animals received a ...
Larsen H C - - 1988
There is no animal model for Meniere's disease but by obliteration of the endolymphatic duct, endolymphatic hydrops may be achieved in several animal species. In order to measure the cochlear blood flow in ears with endolymphatic hydrops the endolymphatic duct was obliterated in 9 guinea pigs. The blood flow was ...
Muller M - - 1988
1. A new concept of endolymph flow in the vertebrate vestibular system is presented. This approach describes quantitatively the flow in the entire system of three semicircular ducts interconnected by the utriculus and the crus commune. This approach is quite distinct from the classical theory in which the labyrinth is ...
Doi R - - 1988
Effects of intravenously administered synthetic kassinin on splanchnic circulation and exocrine pancreatic secretion were examined in six anesthetized dogs. Kassinin caused dose-related increases in the blood flow in superior mesenteric artery and portal vein, and produced an initial increase followed by a decrease in pancreatic blood flow, but did not ...
Inoue K - - 1988
Little is known regarding the mechanism by which peptide YY exerts an inhibitory effect on exocrine pancreatic secretion. The purpose of this study is to determine if peptide YY affects pancreatic blood flow with simultaneous measurement of exocrine pancreatic secretion in dogs. Pancreatic blood flow was measured by a laser ...
Olofsson P - - 1988
Previous studies suggest that systemic endotoxemia in peritonitis is mainly related to lymphatic transport via the thoracic duct. Rats with fecal peritonitis but with or without a lymph draining thoracic duct fistula were studied with reference to the concentrations of endogenously produced endotoxin in arterial plasma, hemodynamic parameters, organ blood ...
Brace R A - - 1988
The left thoracic lymph duct was catheterized at the base of the neck in the sheep fetus at 123-136 days of gestation, and the lymphatic catheter was connected to a jugular vein catheter so that the lymph could return to the fetus. Lymph flow was studied 5 days after catheter ...
Uchida Y - - 1988
The effects of thyrotropin-releasing hormone (TRH) administered via the lateral ventricle on the blood flow to the interscapular brown adipose tissue (IBAT) was studied in urethane anaesthetized rats. TRH in i.c.v. doses of 50 or 5 micrograms/kg produced a significant and transient decrease in IBAT blood flow. The effect of ...
Robert J H - - 1988
Electromagnetic blood flow determinations were carried out on the superior pancreatic duodena (SPDA), the splenic (SA) and the superior mesenteric (SMA) arteries and compared to cardiac output (CO, thermodilution technique) in 12 anesthetized dogs submitted to hypovolemic shock of various duration: 5 dogs underwent a one-hour and 7 a three-hour ...
Klein E - - 1988
The effect of autonomic denervation on the exocrine pancreatic secretion and blood flow was studied in a group of dogs. Pancreatic secretion was collected and analyzed for volume and bicarbonate by direct cannulation of the main papilla through a duodenotomy prior to and following truncal vagotomy and celiac plexus denervation. ...
Mori M - - 1988
Adult male rats were deprived of food for 1-6 days and the hypothalamo-pituitary axis in these rats was evaluated. Food deprivation caused a progressive decrease in TRH concentration in the peripheral blood with a concomitant reduction in the blood TSH level. No significant change was observed in the hypothalamic, extrahypothalamic ...
Ohara I - - 1988
The effects of three taste solutions on the cephalic phase of pancreatic secretion were studied in conscious dogs. Male beagle dogs weighing 9-11 kg were prepared with gastric and duodenal fistulas. Gustatory receptors were stimulated for 5 min with 100 ml of 0.5% agar solutions containing 0.05, 0.12, and 0.3 ...
Saari A - - 1988
The absorption of contrast medium (CM) from the pancreatic duct into blood and lymph was studied in piglets with oedematous (n = 5), haemorrhagic (n = 6) and chronic (n = 7) pancreatitis. Six healthy animals served as controls. In piglets with oedematous pancreatitis, lymphatic absorption was found to be ...
Schröder T - - 1988
Somatostatin, a 28-amino-acid inhibitory polypeptide has been advocated for the treatment of upper gastrointestinal bleeding and acute pancreatitis. This study examines the effect of somatostatin in acute hemorrhagic pancreatitis in piglets (n = 12), weighing 8-12 kg. Six animals served as controls, and received only fluid resuscitation (0.9%, NaCl, 20 ...
Ohyanagi H - - 1988
Therapeutic use of the perfluorochemical emulsion, Fluosol DA, in acute pancreatitis was experimentally discussed in view of maintaining the local blood flow and oxygen supply in the pancreas to avoid further aggravation of pancreatitis. Acute pancreatitis was induced by deoxycholate injection into the pancreatic duct in adult mongrel dogs. Fluosol ...
Tanaka T - - 1988
A new experimental model of chronic pancreatitis was produced by a combination of chronic ischemia and incomplete obstruction of the pancreatic duct. Ischemia was induced by ligation and separation of branches flowing into the left pancreatic lobe from the splenic artery. Incomplete ductal obstruction was achieved by ligation and separation ...
Weaver F C - - 1988
Although it is known that ducts remain intact in the atrophied pancreata of rats rendered dietarily copper-deficient, no information is available that characterizes the ductal angioarchitecture of the experimentally altered gland. Furthermore, since the vascular relationship between pancreatic ducts and the parenchyma of the normal gland has not been well ...
Kitazawa K - - 1988
Infused into sheep, paraquat causes increased flow of protein-rich lung lymph, increased prostanoid production, and neutrophil accumulation in the lung. The effects of high-dose methylprednisolone on the response to paraquat infusion were studied in awake sheep with chronic lung lymph fistulas. Seven sheep were infused with paraquat (30 mg/kg) alone. ...
Hanaue H - - 1987
One KE of streptococcal preparation OK-432 (PIC) was given orally to 6-week old male Wistar-Imamichi rats twice weekly, and control animals received comparable volumes of saline alone. Samples of thoracic duct lymph and posterior vena caval blood were collected prior to and 4 and 8 weeks following PIC. The T ...
Jansson L - - 1987
Pancreatic blood flow (PBF) and islet blood flow (IBF) have been determined separately in two different regions of the rat pancreas, namely, that perfused by the superior mesenteric artery (SMA) and that perfused by the coeliac artery (CA). Although there were no differences in either the PBF or the IBF ...
Vetterlein F - - 1987
Morphometric data were obtained from the microvasculature in exocrine and endocrine tissue of the rat pancreas. Two groups of anesthetized rats (100 and 300 g body wt, respectively), received intravenous injections of fluorochrome-coupled globulins in order to label the entire vascular system. After circulation of fluorescein-isothiocyanate (FITC)-globulin through the vascular ...
Ahrén B - - 1987
We compared the effects of sympathetic nerve stimulation to that of pancreatic norepinephrine (NE) infusion on pancreatic somatostatin-like immunoreactivity (SLI) and pancreatic polypeptide (PP) secretion in the halothane-anesthetized dog. During electrical stimulation (8 Hz, 1 msc, 10 mA, n = 6) of the sympathetic nerves surrounding the pancreatic artery, the ...
Smith L - - 1987
The effect of lung lymph fistula preparation on pulmonary microvascular permeability was investigated in sheep. Acutely prepared animals (n = 9) were compared with animals with a chronic lung lymph fistula (n = 5). The osmotic reflection coefficients (sigma) for total protein, albumin, immunoglobins (Ig) G and M, and the ...
Lehtola A - - 1987
Acute hemorrhagic pancreatitis was induced in 15 piglets, after which 8 of the piglets were treated with saline infusion only and 7 were treated with saline infusion and peritoneal lavage. Hemodynamic variables were measured hourly. Organ and peritoneal blood flow was determined at 0, 1, and 5 h with radioactive ...
Valenzuela G J - - 1987
Estrogen administration produces blood volume expansion and interstitial fluid retention. We decided to study the effect of estrogen withdrawal on blood volume and determine whether oophorectomy has an effect on lymph flow or protein concentration. The rate of left thoracic duct lymph flow averaged 0.041 +/- 0.005 (SE) and 0.071 ...
Miki K - - 1987
Water immersion (WI) increases plasma volume in awake dogs. The contribution of lymph flow to this fluid shift was studied in six splenectomized conscious dogs with a side fistula of the thoracic duct. Lymph flow, hematocrit (Hct), and plasma (CP) and lymph (CL) protein concentration were measured during 60 min ...
Sumi S - - 1987
Neuromedin-N, a novel neurotensin-like peptide, has recently been identified from porcine spinal cord by using a bioassay for a stimulatory effect on guinea pig ileum. The amino acid sequence of the peptide has been determined to be Lys-Ile-Pro-Tyr-Ile-Leu, which is quite homologous to the COOH-terminal sequence of neurotensin. In this ...
Kawai K - - 1987
Directional blood flow in pancreatic islets may be important for regulation of islet hormone release. We therefore perfused an isolated canine pancreas via the celiac artery (arterial perfusion) and then via the portal vein (venous perfusion) in the same pancreas. Basal insulin and glucagon levels and their rate of release ...
Sarr M G - - 1987
Oxygen-derived free radicals play an important role in the pathogenesis of experimental acute pancreatitis in the isolated perfused canine pancreas. We have previously found that pretreatment with allopurinol inhibits xanthine oxidase--apparently the primary source of free radical generation in this model--and prevents the initial development of pancreatitis. In these experiments, ...
Hall J G - - 1987
Operations were performed to cannulate the efferent duct of the popliteal node of sheep and, at the same time, the blood vascular system was removed surgically from the popliteal fossa so that the node was deprived of it blood supply. Twelve preparations were technically successful in that lymph flowed spontaneously ...
Drake R E - - 1987
The preparation for collecting lung lymph from sheep caudal mediastinal lymph node (CMN) efferent vessels is widely used to study the effects of endotoxin on lung microvascular permeability. However, there are nonpulmonary lymph vessels that drain into the CMN along with the afferent lymph vessels from the lung. Thus CMN ...
Jakab F - - 1987
The effect of PCA on bile and lymph composition in rats was studied. It was established that secretion of bile acid decreased significantly and this resulted in reduced bile flow. In studying lymph flow and protein content, the most important observation was a decrease in the protein concentration of hepatic ...
Studley J G - - 1987
Blood flow in the anesthetized animal has been measured indirectly by plethysmography and directly with the stromuhr, venous outflow, and electromagnetic flow techniques. Tissue perfusion in the gland has been assessed qualitatively with thermocouples and quantitatively by isotope fractionation, the distribution of microspheres, hydrogen desaturation, and clearance of either 133Xe ...
Rooth P - - 1987
The pancreatic microcirculation in noninbred ob/ob mice and normal controls was visualized in a fluorescence microscope and examined for responses to intravenous infusions of epinephrine or norepinephrine. Evaluations of coded video recordings revealed a smooth dose-response relationship and validated a semiquantitative method of analysis. In ob/ob mice the islet microcirculation ...
Bruhn T O - - 1987
Immunoreactive and bioactive corticotropin-releasing factor has been identified in the adrenal gland of dogs, rats and humans. Radioimmunoassay and immunohistochemical experiments have clearly demonstrated that localization of the peptide is confined to the adrenal medulla. CRF-containing cells have a characteristic appearance and are often found in close association with blood ...
Jakab F - - 1987
The lymph flow of the thoracic duct, the protein content of the lymph, bile flow and bile composition are studied during the first three hours of the recirculation phase in experimental liver transplantation. It is established that the lymph flow and the protein content of the thoracic duct decrease as ...
Drake R E - - 1986
The caudal mediastinal lymph node (CMN) has several efferent lymph vessels in most sheep. When investigators cannulate one of the CMN efferent vessels in order to collect lung lymph, it is possible that lymph may be shunted between the cannulated vessel and other vessels which drain from the CMN into ...
Barzilai A - - 1986
A vascular pathogenesis of pancreatitis has been postulated in diabetics, the aged, Ortner's Syndrome, and various low-flow states. This report studies canine pancreatic secretion in a preparation of hypovolemic shock produced by controlled hemorrhage maintained for varying durations. Pancreatic secretion was collected by cannulation of the main pancreatic duct in ...
Barzilai A - - 1986
In a previous report from this laboratory, 1 h of hypovolemia induced a significant decrease in pancreatic flow, bicarbonate and enzyme secretion. These parameters recover after restoration of blood volume, but never return to pre-shock levels. Furthermore, increasing the period of hypovolemia produced further decreases in pancreatic flow and bicarbonate ...
Cassey J G - - 1986
In an attempt to reduce the current morbidity and mortality from acute pancreatitis, a prospective randomized multicentre trial was begun in August 1982. Part of this study involved an attempt to develop a set of prognostic indices which would identify patients with severe pancreatitis on the day of admission to ...
Ji-Chang S - - 1986
A jaundiced dog model was made by common bile duct-inferior vena cava shunt with a silicon rubber tube. Blood bilirubin levels increased from 0.25 +/- 0.16 (SD) mg% to 15 +/- 1.4 (SD) mg%. These dog models were treated with a column containing 200 gm of macroreticular resin NK-110 which ...
Spalding H J - - 1986
Pig lymph nodes have an unusual arrangement of cortical and medullary tissue, and lack a hilus. The aim of the present study was to describe the pathways by which blood reaches these lymph nodes. Natural or synthetic latex casts were made of blood vessels of superficial inguinal, popliteal and jejunal ...
Studley J G - - 1986
Experimental evidence suggests that in acute haemorrhagic pancreatitis in the dog the percentage of the cardiac output distributed to the pancreas falls. Histological evidence indicates arteriovenous shunt flow, but this has not been confirmed by flow measurements. It has recently been reported that in experimental preparations in which pancreatic blood ...
Lehtola A - - 1986
Peritoneal blood flow is closely related to the pathophysiology of peritoneal exudate during acute pancreatitis. Peritoneal blood flow was determined by the radioactive microsphere method before and 5 h after the beginning of the experiment in 39 piglets with acute hemorrhagic pancreatis, acute edemic pancreatitis, or slowly progressing hypovolemia. The ...
Bockman D E - - 1986
Few studies have been published on the ultrastructural changes which accompany human acute pancreatitis, and these have concentrated primarily on parenchyma. The present study concentrates on extraparenchymal changes, compares acute pancreatitis occurring alone with that on a background of chronic pancreatitis, and tests for similarity with observations made previously in ...
Martin D J - - 1986
Lung lymph flow and protein transport were measured in eight anaesthetized dogs while acute hypoxic exposure (FIO2 = 0.10) was performed on prerecruited lung (achieved by an increased left atrial pressure). It was found that the lung lymph flow increase observed during hypoxia (from 71.8 +/- 47.5 to 100.8 +/- ...
Valenzuela G - - 1986
Left thoracic duct lymph flow rate averaged 0.077 +/- 0.003 (SD) and 0.078 +/- 0.003 ml X min-1 X kg-1 in near-term pregnant and nonpregnant sheep (P greater than 0.5). Lymph and plasma protein concentrations were unaltered in the pregnant compared with the nonpregnant animals. The thoracic duct lymph flow ...
Lehtola A - - 1986
The cause of hemodynamic changes occurring during acute pancreatitis remains obscure. Using a pig model of acute hemorrhagic pancreatitis and the reference sample method with 113Tin and 46 Scandium labelled microspheres, blood flow to organs was determined before and five hours after the induction of pancreatitis. Blood pressure, pulse rate ...
Mullins R J - - 1986
Bradykinin is an endogenous inflammatory mediator, and its mechanism of action is incompletely understood. It is controversial whether bradykinin causes a sustained increase in microvascular permeability, or has only a transient effect. In anesthetized dogs intraarterial infusion of bradykinin (0.14 to 0.54 micrograms/kg/min) produced an immediate increase in flow of ...
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