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Yoshihara Hiroyuki H 1Department of Orthopaedic Surgery, SUNY Downstate Medical Center 2Department of Orthopaedic Surgery, Nagoya City University Graduate School of Medical Sciences 3Department of Statistical Sciences, School of Advanced Sciences, The Graduate University for Advanced - - 2014
Study Design. Analysis of population-based national hospital discharge data collected for the Nationwide Inpatient Sample (NIS)Objective. To analyze trends in spinal fusion for pediatric patients with idiopathic scoliosis on a national level with regard to demographics, blood transfusions, and in-hospital outcomesSummary of Background Data. Spinal fusion for pediatric patients with ...
Kutlar Abdullah A Sickle Cell Center, Department of Medicine, Georgia Regents University, 1120 15th Street, Augusta, GA 30912, - - 2014
P-selectin on endothelial cell surfaces is central to impaired microvascular blood flow in sickle cell disease (SCD). Restoration of blood flow is expected to provide therapeutic benefit for SCD patients, whatever the mechanism of action of the treatment. Long-term oral administration of a P-selectin-blocking agent potentially improves blood flow and ...
Sharma Abhisheak A Pharmacokinetics & Metabolism Division, CSIR-Central Drug Research Institute, Lucknow, 226031, India; Academy of Scientific and Innovative Research, New Delhi, - - 2014
Over the past several years, dried blood spot (DBS) sampling technique has emerged as a pertinent method in both qualitative and quantitative bioanalysis context. In the DBS method, the blood sample is directly soaked on to a paper (with or without treatment). After drying it can be analyzed by modern ...
Goozée Rhianna R King's College London, Institute of Psychiatry, Department of Psychosis Studies, London, UK. Electronic address: - - 2014
Evaluating the short- and long-term effects of antipsychotics on brain physiology is a key factor in advancing our understanding of neurophysiological changes in psychosis and improving prediction of treatment response. Understanding the nature of such changes is crucial to the interpretation of neuroimaging findings in patients with schizophrenia and psychoses ...
Yerrabothala Swaroopa S Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire; Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New - - 2014
Our hospital transfusion policy was recently revised to recommend single-unit red blood cell transfusion (RBC TXN) for nonbleeding inpatients when the hemoglobin (Hb) level is not more than 7 g/dL. Our computerized provider order entry system was reconfigured to provide real-time decision support using prospective computerized order auditing based on the ...
Chassé Michaël - - 2014
Optimal selection of blood donors is of paramount importance in ensuring the safety of blood products. The current selection process is concerned principally with the safety of the blood donor and the safety of the patient that receives the blood. Recent evidence suggests that the characteristics of the donor may ...
Kocsis Pál P Pharmacology and Drug Safety Research, Gedeon Richter Ltd. H-1475, Budapest, - - 2014
Concordant results of functional magnetic resonance imaging (fMRI) and behavioral tests prove that some non-blood-brain barrier-penetrating drugs produce robust central nervous system (CNS) effects. The anticholinergic scopolamine interferes with learning when tested in rats, which coincides with a negative blood-oxygen-level-dependent (BOLD) change in the prefrontal cortex (PFC) as demonstrated by ...
Al-Kadri Hanan M - - 2014
This research aimed to assess the effect of health care provider education on the accuracy of post partum blood loss estimation. A non-randomized observational study that was conducted at King Abdulaziz Medical City, Riyadh, Saudi Arabia between January 1, 2011 and June 30, 2011. Hundred and twenty three health care ...
Zorzoli M M UCI, Aigle, - - 2014
The introduction of the athlete's biological passport (ABP) has been a milestone in the fight against doping. The ABP is a collection of measurements of different biological parameters influenced by the administration of doping agents through the time and for each athlete. Two different modules have been developed and validated ...
Davidson D Fraser DF Consultant Clinical Scientist (Biochemistry), Biochemistry Department, University Hospital Crosshouse, - - 2014
It is estimated that 70% of all health care decisions affecting diagnosis or treatment involve laboratory testing. The pre-analytical phase of the testing process shows the highest prevalence of errors accounting for 70% of all mistakes in laboratory diagnostics. It is recommended that laboratories collect statistics on pre-analytical error rates. ...
Waite Jessica L - - 2014
Blood-feeding arthropods can harm their hosts in many ways, such as through direct tissue damage and anemia, but also by distracting hosts from foraging or watching for predators. Blood-borne pathogens transmitted by arthropods can further harm the host. Thus, effective behavioral and immunological defenses against blood-feeding arthropods may provide important ...
Wright Craig C 1Cell and Molecular Therapies (CMT) and Institute of Haematology, Royal Prince Alfred Hospital (RPAH) 2Gene and Stem Cell Therapy Program, Centenary Institute 3Sydney Medical School, University of Sydney, Camperdown, NSW, - - 2014
In Australia, manufacture of blood, tissues and biologicals must comply with the federal laws and meet the requirements of the Therapeutic Goods Administration (TGA) Manufacturing Principles as outlined in the current Code of Good Manufacturing Practice (cGMP). The Therapeutic Goods Order (TGO) No. 88 was announced concurrently with the new ...
Tanaka Asashi A Transfusion Medicine, Clinical Laboratory Medicine, Hachioji Medical Center of Tokyo Medical University, 1163 Tate-machi, Hachioji, Tokyo, 193-0998, Japan, - - 2014
A questionnaire-based survey on chemotherapy-induced anemia (CIA) in cancer patients was conducted between September and November 2010. The number of patients treated with chemotherapy, rate of blood transfusion, volume of blood transfused, severity of anemia, and factors affecting blood transfusion were analyzed according to the type of cancer, in an ...
Parker Robert I RI 1Department of Pediatrics, Stony Brook University School of Medicine, Stony Brook, NY. 2Pediatric Hematology/Oncology, Stony Brook Long Island Children's Hospital, Stony Brook, - - 2014
To provide a concise review of transfusion-related issues and practices in the pediatric patient population, with a focus on those issues of particular importance to the care of critically ill children. Electronic search of the PubMed database using the search terms "pediatric transfusion," "transfusion practices," "transfusion risks," "packed red blood ...
Muñoz Manuel M Manuel Muñoz, Transfusion Medicine, School of Medicine, University of Málaga, 29071-Málaga, - - 2014
Anemia, usually due to iron deficiency, is highly prevalent among patients with colorectal cancer. Inflammatory cytokines lead to iron restricted erythropoiesis further decreasing iron availability and impairing iron utilization. Preoperative anemia predicts for decreased survival. Allogeneic blood transfusion is widely used to correct anemia and is associated with poorer surgical ...
Dalrymple Kirsty K Fife Area Laboratory, Victoria Hospital, - - 2014
After the Department of Health's Better Blood Transfusion recommendations ( DH 2002 ) ten years ago, a network of 18 transfusion practitioners supported by a central team in the Scottish National Blood Transfusion Service was established. This article discusses the impact that transfusion practitioners in Scotland have had in driving ...
Kisielewicz Caroline C Queen Mother Hospital for Animals, Royal Veterinary College, Hatfield, Hertfordshire, - - 2014
To discuss and review blood transfusion practices in dogs and cats including collection and storage of blood and administration of products. To report new developments, controversial practices, less conventional blood product administration techniques and where applicable, describe the relevance to anaesthetists and anaesthesia. PubMed and Google Scholar using dog, cat, ...
Paul Ma Gorzata - - 2014
African trypanosomiasis is a parasitic infection sporadically imported to Europe by tourists or immigrants returning from endemic areas. We present the first and an unusual case of East African trypanosomiasis imported to Poland by a patient returning from a tourist trip to Uganda and Rwanda, which was successfully treated with ...
Goss Cheryl C Departments of Transfusion Medicine and Pediatrics, New York Presbyterian Hospital-Weill Cornell Medical College, New York, New - - 2014
In the absence of curative treatment, such as stem cell transplant, regular transfusions remain the mainstay of therapy for individuals with thalassemia major, a syndrome that results from marked ineffective erythropoiesis and the resultant anemia. The primary objectives of transfusion therapy are twofold: to suppress ineffective erythropoiesis and to ensure ...
Gabriele Stefano S Unit of Child and Adolescent NeuroPsychiatry, Laboratory of Molecular Psychiatry and Neurogenetics, University "Campus Bio-Medico", Via Alvaro del Portillo 21, I-00128 Rome, Italy; Department of Experimental Neurosciences, I.R.C.C.S. "Fondazione Santa Lucia", Rome, - - 2014
Elevated blood serotonin (5-HT) levels were the first biomarker identified in autism research. Many studies have contrasted blood 5-HT levels in autistic patients and controls, but different measurement protocols, technologies, and biomaterials have been used through the years. We performed a systematic review and meta-analysis to provide an overall estimate ...
Tavares Maria M MM Blood Bank, Roger Williams Hospital, Providence, Rhode - - 2014
Data on red blood cell (RBC) transfusion in the United States show variation in practice and overprescribing or overdosing is considered to be prevalent. Education or restrictive interventions could modify practice. RBC transfusion and mortality rates were recorded in a single institution over a 15-year period. The first 3 years ...
Franchini Massimo M Department of Transfusion Medicine and Hematology, Hospital of Mantova, Mantova, - - 2014
The primary goal in transfusion medicine and cellular therapies is to promote high standards of quality and produce ever safer and more efficacious products. The establishment of a transfusion service quality management system, which includes several organizational structures, responsibilities, policies, processes, procedures, and resources, is now mandatory and widely regulated ...
Flegel Willy A WA Department of Transfusion Medicine and Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, - - 2014
Red blood cells (RBCs) degrade progressively during the weeks of refrigerated storage. No universally accepted definition of 'fresh' or 'old' RBCs exists. While practices vary from country to country, preservative solutions permitting shelf life as long as 7 weeks have been licenced. Transfusion of stored RBCs, particularly those at the end ...
Fanning Kent J KJ Agri-Science Queensland, Department of Agriculture, Fisheries and Forestry, Coopers Plains, QLD 4108, - - 2014
Previous reviews of plum phytochemical content and health benefits have concentrated on the European plum, Prunus domestica L.. However, the potential bioactivity of red and dark red fleshed Japanese plum, Prunus salicina Lindl., so called blood plums, appears to warrant a significant increase in exposure as indicated in a recent ...
Oliver James C JC Department of Medicine, University of Alabama at Birmingham, Birmingham, - - 2014
Patient blood management (PBM) programs seek to optimize the utilization of blood components. Since our institution's program started, the annual number of red blood cell (RBC) units transfused has decreased by 27% overall. We collected data for 6 months in 2007 (pre-PBM) compared with the same months in 2011 (post-PBM) ...
Nightingale M J MJ Quality Assurance Department, NHS Blood and Transplant, Southampton, - - 2014
UK blood component labels have evolved to accommodate a plethora of information. Concern has, however, been expressed that current UK labelling is too 'cluttered', detracting from the clarity of critical information. This prompted a holistic review of labelling and available information technology (IT) with the aim of improving the situation. ...
Damoiseaux Jan J Central Diagnostic Laboratory, Maastricht University Medical Center, P. Debyelaan 25, 6229 HX Maastricht, The Netherlands. Electronic address: - - 2014
Cryoglobulinemia refers to the presence of reversible precipitation of immunoglobulins in the blood upon exposure to reduced (body)temperature. In clinical practice, the detection and typing of cryoglobulins appear to be poorly standardized. A consensus protocol for detection and typing of cryoglobulins, as extracted from the literature, is presented. Items that ...
Kelnar Kevin - - 2014
MRX34, a microRNA (miRNA)-based therapy for cancer, has recently entered clinical trials as the first clinical candidate in its class. It is a liposomal nanoparticle loaded with a synthetic mimic of the tumor suppressor miRNA miR-34a as the active pharmaceutical ingredient. To understand the pharmacokinetic properties of the drug and ...
McQuilten Zoe K ZK Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia; Australian Red Cross Blood Service, Melbourne, Victoria, - - 2014
Estimating change in clinical demand for red blood cells (RBCs) from a disaster, as well as triaging introduced in response, is essential to plan effectively for a major blood shortage. We aimed to develop a RBC demand model to assess the impact of restriction policies on RBC use and patient ...
Kiyohara Eiji - - 2014
Detection of circulating tumor cells (CTC) in peripheral blood has been investigated for its prognostic ability, and its potential to measure the effectiveness of treatment(s) in patients with melanoma. However, a highly sensitive and specific assay is required to detect CTC in patients' blood. We have developed a multimarker quantitative ...
Hamel Perrine P Department of Civil Engineering and Monash Water for Liveability (CRC for Water Sensitive Cities), Monash University, Victoria 3800, Australia E-mail: - - 2014
Stormwater management strategies increasingly recognise the need to emulate the pre-development flow regime, in addition to reducing pollutant concentrations and loads. However, it is unclear whether current design approaches for stormwater source-control techniques are effective in restoring the whole flow regime, and in particular low flows, towards their pre-development levels. ...
Marinov I - - 2014
Comparison between consensual approaches for the detection of paroxysmal nocturnal hemoglobinuria (PNH) clones by flow cytometry (FCM) following the international clinical cytometry society (ICCS) guidelines has not been widely reported. We determined the performance characteristics of 4, 5, and 6-color protocols for white blood cell (WBC) and one and two-color ...
- - 2014
Umbilical cord blood (UCB) is a potential source of primitive hematopoietic stem and progenitor cells (HSPC) available for clinical application to reconstitute the hematopoietic system in patients lacking conventional stem cell donors. In the last decade because the frequency of UCB stem cell transplantation has increased, the quality of UCB ...
Chaudhary R K RK Department of Transfusion Medicine, SGPGIMS, Lucknow, Uttar Pradesh, - - 2014
Autoimmune hemolytic anemia (AIHA) is not an uncommon clinical disorder and requires advanced, efficient immunohematological and transfusion support. Many AIHA patients have underlying disorder and therefore, it is incumbent upon the clinician to investigate these patients in detail, as the underlying condition can be of a serious nature such as ...
Jensen A A Campus Clinic Gynecology, Ruhr-University Bochum, Universitätsstraße 140, 44799 Bochum, - - 2014
About 17 million people worldwide live with cerebral palsy, the most common disability in childhood, with hypoxic-ischemic encephalopathy, preterm birth, and low birth weight being the most important risk factors. This review will focus on recent developments in cell therapy for infantile cerebral palsy by transplantation of autologous umbilical cord ...
Freedman John J St Michael's Hospital, Medicine & Laboratory Medicine & Pathobiology, University of Toronto, St Michael's Hospital, 30 Bond Street, Room 2-006, Shuter Wing, Toronto, ON M5B 1W8, Canada. Electronic address: - - 2013
The past is prologue. Reviewing the history of transfusion tells us how far we have come, but also where we need to go. The past has been filled with innovation and important discoveries, but is also fraught with stumbling blocks and unintended side effects. Although much has been achieved and ...
Jauregui Julio J JJ Rubin Institute for Advanced Orthopedics Center for Joint Preservation and Replacement Sinai Hospital of Baltimore Baltimore, - - 2013
Total hip arthroplasty is associated with extensive blood loss, which is often corrected using allogeneic blood transfusions. However, Jehovah's Witnesses often refuse allogeneic blood transfusions or certain types of autologous blood transfusions due to their religious beliefs. This may represent a tremendous challenge for the orthopaedic surgeon and their team. ...
Cherian Jeffrey J JJ Rubin Institute for Advanced Orthopedics Center for Joint Preservation and Replacement Sinai Hospital of Baltimore Baltimore, - - 2013
The substantial blood loss that can occur during total hip arthroplasty frequently requires allogeneic transfusions. Both allogeneic transfusions and post-operative anemia are causes of increased morbidity, cardiovascular risks, and length of stay. This anemia can also lead to decreased vigor, suboptimal rehabilitation, and lowered quality of life in patients undergoing ...
Nightingale Mark J MJ National Health Service Blood and Transplant (NHSBT), Southampton, United - - 2014
The assessment of suppliers of critical goods and services to European blood establishments is a regulatory requirement proving difficult to resource. This study was to establish whether European Blood Alliance member blood services could collaborate to reduce the cost of auditing suppliers without diminishing standards. Five blood services took part, ...
Ohara Masaru - - 2013
At present, dietary polyphenols are popular with consumers because regular consumption of polyphenol-rich foods is likely to be beneficial for human health. However, administrated polyphenols are extensively metabolized in the digestive tract or some other parts before reaching the target organs. Additionally, some of the polyphenols are photosensitive, easily oxidized ...
Zhou Louise - - 2013
Jehovah's witnesses represent a unique group of patients whose religious beliefs prohibit receiving transfusion of all blood products. Since most chemotherapeutic regimens used to treat acute leukemia are myelosuppressive and often resulting in potentially life threatening pancytopenia, their refusal of blood products poses a challenge to clinicians. We report a ...
Bolton-Maggs Paula H B - - 2013
Hemovigilance is an essential part of the transfusion process and is defined as surveillance procedures covering the whole transfusion chain, from collection of blood and its components, intended to collect and assess information on unexpected or undesirable effects resulting from the therapeutic use of labile blood products and to prevent ...
Sheldon Ryan D - - 2013
The capability for externally applied rhythmic limb compressions to improve the outcomes of patients with peripheral artery disease has been recognized for nearly a century. Modern technology has permitted the development of portable and cost-effective intermittent pneumatic compression (IPC) systems to be made readily available for affordable at-home use. Mounting ...
Shenkman Boris B National Haemophilia Centre, Chaim Sheba Medical Centre, Tel-Hashomer, - - 2013
The treatment options in severe thrombocytopenia (platelet count 20×10(9)/L) are limited. The aim of this study was to investigate ways of improving blood clotting and stability in reconstituted thrombocytopenia. Thrombocytopenia (platelets [16±4]×10(9)/L) was created by differential centrifugation of normal blood followed by reconstitution of whole blood which was subjected to ...
Lal Devika S - - 2013
This review will address recent developments in the transfusion management of massively transfused trauma patients, focusing on the use of fixed blood component ratios in massive transfusion protocols. The majority of trauma centers have migrated from laboratory-based transfusion protocols to massive transfusion protocols with fixed blood component ratios. These protocols ...
Ozawa Sherri - - 2013
Patient blood management is the scientific use of safe, effective medical and surgical techniques designed to conserve blood, prevent anemia, decrease bleeding, and optimize coagulation in an effort to improve patient outcomes. Perioperative and primary care nurses play a vital role in promoting and making the best use of patient ...
Refaai Majed A - - 2013
Accumulated evidence demonstrates that allogeneic blood transfusions have clinically significant effects on the recipient's immune system. This transfusion immunomodulation effect is associated with an increased rate of cancer recurrence (uncertain causality) and post-operative infection (established causality). The exact mechanisms of transfusion immunomodulation are still unknown. Data suggests that transfusion immunomodulation ...
Ruban Angela - - 2013
Organophosphate-induced brain damage is an irreversible neuronal injury, likely because there is no pharmacological treatment to prevent or block secondary damage processes. The presence of free glutamate (Glu) in the brain has a substantial role in the propagation and maintenance of organophosphate-induced seizures, thus contributing to the secondary brain damage. ...
Popgeorgiev Nikolay - - 2013
Emerging viral infections in humans are appearing at an increasing rate. Recently, we identified a new Marseillevirus, named Giant Blood Marseillevirus (GBM), by performing viral metagenomics on asymptomatic blood donors. To study and compare the prevalence of Marseillevirus between asymptomatic blood donors and thalassemia patients. Here, we present a combined ...
Kapadia Bhaveen H - - 2013
Elective total knee arthroplasty is frequently associated with considerable blood loss and a concomitant decline in hemoglobin postoperatively. This often leads to high rates of allogeneic transfusions, with reports of up to 69%, to treat postoperative anemia. Allogeneic blood transfusions have been shown to be an independent risk factor for ...
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