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Kumagai Motoi M Department of Anaesthesiology, School of Medicine, Iwate Medical University, Morioka, - - 2014
The effects of total intravenous anaesthesia (TIVA) on cerebral oxygenation in patients undergoing robot-assisted laparoscopic radical prostatectomy (RALP) have not been investigated. We examined the changes in jugular venous oxygen saturation (SjvO2 ) and regional cerebral tissue oxygen saturation (rSO2 ) during RALP under TIVA. Whether rSO2 could reflect SjvO2 ...
Hsu Po-Lin PL Department of Cardiovascular Engineering, Institute for Applied Medical Engineering, RWTH Aachen University, Aachen - - - 2014
Right ventricular assistance is still in the early phase of development compared to left ventricular assist device (LVAD) technology. In order to provide flexible pulmonary support and potentially reduce the known complications, we propose a minimally invasive right ventricular assist device (MIRVAD), located in the pulmonary artery (PA) and operating ...
Manvar Atul A Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, Dublin, Ireland. - - 2014
Non-conventional heating techniques, high-throughput microwave-assisted synthesis and continuous flow penetrate almost every scientific field. Mitsunobu coupling is a ubiquitous choice for the dehydrative redox condensation of primary or secondary alcohols with (pro)nucleophiles. The aim of this review is to showcase the ease of subtle Mitsunobu coupling under super-heating. Surprisingly, this ...
Jahren Silje Ekroll SE Institute for Dynamic Systems and Control, ETH Zurich, Zurich, Switzerland; - - 2014
Arterial waves are seen as possible independent mediators of cardiovascular risks, and the wave intensity analysis (WIA) has therefore been proposed as a method for patient selection for ventricular assist device (VAD) implantation. Interpreting measured wave intensity (WI) is challenging, and complexity is increased by the implantation of a VAD. ...
Hoogduijn Martin J MJ Erasmus Medical Center, Internal Medicine , PO box 2040 , room Ee559a , Rotterdam, Zuid Holland, Netherlands , 3000 CA , +31(0)104635419 , +31(0)104089443 ; - - 2014
Mesenchymal stem cells (MSC) are present in the bone marrow, from where they are thought to migrate via the blood stream to sites of injury. However, virtually all tissues contain resident MSC that may contribute to local regenerative and immunomodulatory processes, thereby hypothetically pre-empting the need for recruiting MSC via ...
Ifland Luke L Global Healing, Berkeley, California, - - 2014
Over the last decade, there has been increased global attention dedicated to improving the availability, safety and use of blood in low-income and middle-income countries. These efforts have focused on a number of common objectives, such as establishing a 100% voluntary nonremunerated blood donor base and implementing component therapy. Recently, ...
Yarci Erbu E Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, - - 2014
Twin anemia/polycythemia sequence (TAPS) is characterized by large intertwin hemoglobin (Hb) differences without signs of twin oligopolyhydramnios. The spontaneous form complicates approximately 3-5% of monochorionic twin pregnancies. TAPS placentas are characterized by the presence of only very few and small unidirectional arteriovenous anastomoses, which allow a slow transfusion of blood ...
Lieshout-Krikke Ryanne W RW Department of Blood-Borne Infections, Sanquin Blood Supply Foundation, Amsterdam, the - - 2014
Donors returning from areas with outbreaks of infectious diseases may donate infectious blood back home. Geographic donor deferral is an effective measure to ensure the blood safety, but donor deferral may pose a threat for the blood supply especially after holiday seasons. Insight into the travel behavior of blood donors ...
Smith Stephanie A SA Biochemistry Department, University of Illinois at Urbana-Champaign, Urbana, Illinois, - - 2014
Polyphosphate (polyP) is an inorganic polymer that has recently been shown to be secreted by activated platelets. It is a potent modulator of the blood clotting and complement systems in hemostasis, thrombosis, and inflammation. This review focuses on what is currently known about which blood cells secrete polyP, and the ...
Gunasekaran K - - 2014
Five types of long-lasting insecticidal nets (LNs), namely, Olyset, Netprotect, PermaNet, DuraNet, and Interceptor, were tested after 20 washes for efficacy in terms of mortality, deterrence effect, blood-feeding inhibition, and induced exophily of the malaria vector Anopheles fluviatilis in experimental huts in Malkangiri district of Odisha State, India. Efficacy of ...
Marcelo Aileen A Sanders-Brown Center on Aging, Department of Anatomy and Neurobiology and Department of Neurology, University of Kentucky, 430 Sanders Brown Building, 800 S. Limestone Street, Lexington, KY, 40536-0230, - - 2014
Vascular dementia (VaD) is the second most common cause of dementia and leads to a decline in cognitive thinking via conditions that lead to blockage or reduced blood flow to the brain. It is a poorly understood disease, and the changes that occur are often linked to other types of ...
Murphy Seamus O SO Kansas City, KS. Electronic address: - - 2014
At our urban academic medical center, efforts to alleviate ED overcrowding have included the implementation of a "fast track" area, increasing the ED size, using hallway beds, and ambulance diversion. In October 2012, we began the first steps of a process that created a system in which the admission process ...
Roh Eun Youn EY Department of Laboratory Medicine, Seoul National University Boramae Medical Center, Seoul, Korea; Seoul Metropolitan Public Cord Blood Bank-ALLCORD, Seoul, - - 2014
The obstetrician's role in vitalizing cord blood (CB) banking is important in both informing donors and beginning CB processing. The aim of the study was to investigate obstetricians' understanding of CB and their roles in informing donors and collection management. Questionnaires examining the management and awareness of CB were distributed ...
Fragoulakis Vassilis V National School of Public Health, Athens, Greece. Electronic address: - - 2014
The goal of this study was to estimate the cost of production of 1 unit of blood from a National Health Service perspective in Greece. In agreement with guidelines, the cost of blood production in this study accounted only for the resources expended for collection, processing, laboratory testing, and storage. ...
Porwit A A Department of Pathobiology and Laboratory Medicine, University of Toronto, University Health Network, Toronto General Hospital, Toronto, - - 2014
Definite progress has been made in the exploration of myelodysplastic syndromes by flow cytometry since the publication of the World Health Organization 2008 classification of myeloid neoplasms. An international working party initiated within the European LeukemiaNet and extended to include members from Australia, Canada, Japan, Taiwan and the United States ...
Jawdat Dunia D Cord Blood Bank, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi - - 2014
Public cord blood banks (CBBs) store cord blood unit (CBU) donations for anyone in need. However, strict regulations need to be followed to build up high-quality bank products that can be used worldwide. We established a public CBB at a tertiary hospital in Saudi Arabia. Here, we investigated the reasons ...
Norgaard Astrid A Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet Copenhagen University Hospital, Copenhagen, - - 2014
The practice of transfusing red blood cells is still liberal in some centres suggesting a lack of compliance with guidelines recommending transfusion of red blood cells at haemoglobin levels of 6-8 g/dL in the non-bleeding patient. Few databases provide ongoing feedback of data on pre-transfusion haemoglobin levels at the departmental ...
Suarez Juan C JC Cleveland Clinic Florida, Department of Orthopedic Surgery, 2950 Cleveland, Clinic Blvd, Weston, FL - - 2014
Total knee arthroplasty (TKA) can be associated with substantial blood loss, leading to increased morbidity and transfusion rates. The study objective was to evaluate routine use of a thrombin-based topical hemostatic matrix in reducing blood loss and transfusion requirements in primary TKA. 108 patients were enrolled in a prospective, randomized, ...
Cross Fiona R FR School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch 8140, New Zealand, Telephone: +64 3 364 2987, ext. 7068, Fax number: +64 3 364 2590. International Centre of Insect Physiology and Ecology (ICIPE), Thomas Odhiambo Campus, P.O. Box 30, Mbita Point, - - 2014
One of the predictions from evolutionary game theory is that individuals will increase their willingness (i.e., become primed) to escalate aggression when they detect the presence of a limiting resource. Here we test this prediction in the context of prey odour priming escalation decisions during vision-based encounters by Evarcha culicivora. ...
Lacroux Caroline C UMR INRA ENVT 1225, Interactions Hôtes Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse, Toulouse, - - 2014
The emergence of variant Creutzfeldt Jakob Disease (vCJD) is considered a likely consequence of human dietary exposure to Bovine Spongiform Encephalopathy (BSE) agent. More recently, secondary vCJD cases were identified in patients transfused with blood products prepared from apparently healthy donors who later went on to develop the disease. As ...
Burch Druin D Public Library of Science, Cambridge, United - - 2014
Druin Burch reflects on new research by Pablo Perel and colleagues and notes that an important fraction of trauma-related deaths could be avoided by improving our knowledge of when to give blood to patients. Please see later in the article for the Editors' Summary.
Mercolini Laura L Laboratory of Pharmaco-Toxicological Analysis; Department of Pharmacy & Biotechnology (FaBiT), Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, 40126 Bologna, - - 2014
Background: A novel analytical approach, based on dried blood spot (DBS) testing, has been developed, validated and applied for the first time to the analysis of ziprasidone (ZPR) for the therapeutic drug monitoring (TDM) of schizophrenic patients. DBS represent a more feasible but reliable matrix, alternative to blood and plasma. ...
Samujh Christopher C University of Louisville, KentuckyOne Health, Louisville, - - 2014
Tranexamic acid (TXA) has been used successfully in primary total knee arthroplasty (TKA) to minimize blood loss and transfusions. The purpose of this study is to determine its efficacy in patients undergoing revision TKA. In a retrospective review of 111 patients (68 control and 43 TXA), treatment patients receiving a ...
Opare-Sem Ohene O Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana, - - 2014
Hospital transfusion committees (HTCs) have been established in the United States to link producers and users as well as to ensure appropriate use of blood. The HTC has been little reported in sub-Saharan Africa (SSA), although it has been established in some hospitals. The minutes of three to four HTC ...
Hawkins Stacey A SA Department of Health, Aging and Society, McMaster University, 1280 Main St. West, KTH 226, Hamilton, ON, L8S 4M4, Canada, - - 2014
Ethno-cultural disparities in blood and tissue donation patterns have been described as an emergent challenge in the context of the transfusion medicine literature (Boulware et al. in Med Care 40(2):85-95, 2002; Molzahn et al. in Nephrol Nurs J 30(1):17-26, 2003, Can J Nurs Res 36(4):110-128, 2004). In the North American ...
Goobie Susan M SM Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Boston, MA, - - 2014
Pediatric patients when undergoing craniotomies and craniofacial surgery may potentially have significant blood loss. The amount and extent will be dictated by the nature of the surgical procedure, the proximity to major blood vessels, and the age, and weight of the patient. The goals should be to maintain hemodynamic stability ...
Hardeman Max M Academic Medical Center, University of Amsterdam, The - - 2014
Recombinant human erythropoietin (rHuEPO) is an agent commonly used by athletes with the aim to improve performance in endurance sports. However, the scientific community continues to debate the risks, benefits and its mechanism of action when used as a doping agent. This paper provides a brief overview on the pros ...
Voorn Veronique M A VM Department of Medical Decision Making, Leiden University Medical Center, Leiden, the - - 2014
Despite evidence that the blood-saving measures (BSMs) erythropoietin (EPO) and intra- and postoperative blood salvage are not (cost-)effective in primary elective total hip and knee arthroplasties, they are used frequently in Dutch hospitals. This study aims to assess the impact of barriers associated with the intention of physicians to stop ...
Bahadur Shalini S Department of Pathology and Blood Bank, Lady Hardinge Medical College, New Delhi, - - 2014
To perform a retrospective audit of transfusion practices, in order to study the appropriate and inappropriate usage of different blood components in pediatric population. The present study, conducted over a period of 3 mo analyzed all the episodes of transfusions and divided them into appropriate and inappropriate according to the type ...
Ejaz Aslam A Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, - - 2014
Transfusion practice among surgeons varies despite several trials supporting the restrictive use of blood products. We sought to define the variation in surgeon transfusion hemoglobin (Hb) triggers and targets among patients undergoing hepatopancreaticobiliary (HPB) procedures, as well as assess perioperative outcomes among patients receiving transfusions under a restrictive vs liberal ...
de Oliveira Carolina Dizioli Rodrigues CD 1Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, - - 2014
Blood doping has been defined as the misuse of substances or certain techniques to optimize oxygen delivery to muscles with the aim to increase performance in sports activities. It includes blood transfusion, administration of erythropoiesis-stimulating agents or blood substitutes, and gene manipulations. The main reasons for the widespread use of ...
Yoshihara Hiroyuki H 1Department of Orthopaedic Surgery, SUNY Downstate Medical Center 2Department of Orthopaedic Surgery, Nagoya City University Graduate School of Medical Sciences 3Department of Statistical Sciences, School of Advanced Sciences, The Graduate University for Advanced - - 2014
Study Design. Analysis of population-based national hospital discharge data collected for the Nationwide Inpatient Sample (NIS)Objective. To analyze trends in spinal fusion for pediatric patients with idiopathic scoliosis on a national level with regard to demographics, blood transfusions, and in-hospital outcomesSummary of Background Data. Spinal fusion for pediatric patients with ...
Kutlar Abdullah A Sickle Cell Center, Department of Medicine, Georgia Regents University, 1120 15th Street, Augusta, GA 30912, - - 2014
P-selectin on endothelial cell surfaces is central to impaired microvascular blood flow in sickle cell disease (SCD). Restoration of blood flow is expected to provide therapeutic benefit for SCD patients, whatever the mechanism of action of the treatment. Long-term oral administration of a P-selectin-blocking agent potentially improves blood flow and ...
Sharma Abhisheak A Pharmacokinetics & Metabolism Division, CSIR-Central Drug Research Institute, Lucknow, 226031, India; Academy of Scientific and Innovative Research, New Delhi, - - 2014
Over the past several years, dried blood spot (DBS) sampling technique has emerged as a pertinent method in both qualitative and quantitative bioanalysis context. In the DBS method, the blood sample is directly soaked on to a paper (with or without treatment). After drying it can be analyzed by modern ...
Patnaik Sibabratta S Department of Pediatrics, Pediatric Intensive Care Unit, Christian Medical College, Vellore, Tamil Nadu, - - 2014
Acquired methemoglobinemia is an uncommon blood disorder induced by exposure to certain oxidizing agents and drugs. Although parents may not give any history of toxin ingestion; with the aid of pulse-oximetry and blood gas analysis, we can diagnose methemoglobinemia. Prompt recognition of this condition is required in emergency situations to ...
Tsantes Argirios E AE Laboratory of Haematology and Blood Bank Unit, Attikon Hospital, School of Medicine, University of Athens, Athens, - - 2014
The cost-effectiveness of universal leucoreduction of blood components remains unclear. When using leucoreduced red blood cells, the decrease in the rate of febrile non-haemolytic transfusion reactions (FNHTR) is the only proven, meaningful clinical benefit, whose relationship to costs can be calculated relatively easily. The aim of this study was to ...
Goozée Rhianna R King's College London, Institute of Psychiatry, Department of Psychosis Studies, London, UK. Electronic address: - - 2014
Evaluating the short- and long-term effects of antipsychotics on brain physiology is a key factor in advancing our understanding of neurophysiological changes in psychosis and improving prediction of treatment response. Understanding the nature of such changes is crucial to the interpretation of neuroimaging findings in patients with schizophrenia and psychoses ...
Yerrabothala Swaroopa S Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire; Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New - - 2014
Our hospital transfusion policy was recently revised to recommend single-unit red blood cell transfusion (RBC TXN) for nonbleeding inpatients when the hemoglobin (Hb) level is not more than 7 g/dL. Our computerized provider order entry system was reconfigured to provide real-time decision support using prospective computerized order auditing based on the ...
Chassé Michaël - - 2014
Optimal selection of blood donors is of paramount importance in ensuring the safety of blood products. The current selection process is concerned principally with the safety of the blood donor and the safety of the patient that receives the blood. Recent evidence suggests that the characteristics of the donor may ...
Kocsis Pál P Pharmacology and Drug Safety Research, Gedeon Richter Ltd. H-1475, Budapest, - - 2014
Concordant results of functional magnetic resonance imaging (fMRI) and behavioral tests prove that some non-blood-brain barrier-penetrating drugs produce robust central nervous system (CNS) effects. The anticholinergic scopolamine interferes with learning when tested in rats, which coincides with a negative blood-oxygen-level-dependent (BOLD) change in the prefrontal cortex (PFC) as demonstrated by ...
Zorzoli M M UCI, Aigle, - - 2014
The introduction of the athlete's biological passport (ABP) has been a milestone in the fight against doping. The ABP is a collection of measurements of different biological parameters influenced by the administration of doping agents through the time and for each athlete. Two different modules have been developed and validated ...
Al-Kadri Hanan M - - 2014
This research aimed to assess the effect of health care provider education on the accuracy of post partum blood loss estimation. A non-randomized observational study that was conducted at King Abdulaziz Medical City, Riyadh, Saudi Arabia between January 1, 2011 and June 30, 2011. Hundred and twenty three health care ...
Davidson D Fraser DF Consultant Clinical Scientist (Biochemistry), Biochemistry Department, University Hospital Crosshouse, - - 2014
It is estimated that 70% of all health care decisions affecting diagnosis or treatment involve laboratory testing. The pre-analytical phase of the testing process shows the highest prevalence of errors accounting for 70% of all mistakes in laboratory diagnostics. It is recommended that laboratories collect statistics on pre-analytical error rates. ...
Waite Jessica L - - 2014
Blood-feeding arthropods can harm their hosts in many ways, such as through direct tissue damage and anemia, but also by distracting hosts from foraging or watching for predators. Blood-borne pathogens transmitted by arthropods can further harm the host. Thus, effective behavioral and immunological defenses against blood-feeding arthropods may provide important ...
Wright Craig C 1Cell and Molecular Therapies (CMT) and Institute of Haematology, Royal Prince Alfred Hospital (RPAH) 2Gene and Stem Cell Therapy Program, Centenary Institute 3Sydney Medical School, University of Sydney, Camperdown, NSW, - - 2014
In Australia, manufacture of blood, tissues and biologicals must comply with the federal laws and meet the requirements of the Therapeutic Goods Administration (TGA) Manufacturing Principles as outlined in the current Code of Good Manufacturing Practice (cGMP). The Therapeutic Goods Order (TGO) No. 88 was announced concurrently with the new ...
Tanaka Asashi A Transfusion Medicine, Clinical Laboratory Medicine, Hachioji Medical Center of Tokyo Medical University, 1163 Tate-machi, Hachioji, Tokyo, 193-0998, Japan, - - 2014
A questionnaire-based survey on chemotherapy-induced anemia (CIA) in cancer patients was conducted between September and November 2010. The number of patients treated with chemotherapy, rate of blood transfusion, volume of blood transfused, severity of anemia, and factors affecting blood transfusion were analyzed according to the type of cancer, in an ...
Parker Robert I RI 1Department of Pediatrics, Stony Brook University School of Medicine, Stony Brook, NY. 2Pediatric Hematology/Oncology, Stony Brook Long Island Children's Hospital, Stony Brook, - - 2014
To provide a concise review of transfusion-related issues and practices in the pediatric patient population, with a focus on those issues of particular importance to the care of critically ill children. Electronic search of the PubMed database using the search terms "pediatric transfusion," "transfusion practices," "transfusion risks," "packed red blood ...
Leach M M M Leach Department of Haematology Leukaemia Research Lab Shelley Road Gartnavel Hospital site Glasgow G12 0YN, UK e-mail - - 2014
The full blood count (FBC) is perhaps the single most common investigation performed in medical patients. It has the potential, when interpreted carefully and in relation to the clinical history, to provide very useful information to assist in diagnosis and management. Clinicians are often alerted to the presence of a ...
Muñoz Manuel M Manuel Muñoz, Transfusion Medicine, School of Medicine, University of Málaga, 29071-Málaga, - - 2014
Anemia, usually due to iron deficiency, is highly prevalent among patients with colorectal cancer. Inflammatory cytokines lead to iron restricted erythropoiesis further decreasing iron availability and impairing iron utilization. Preoperative anemia predicts for decreased survival. Allogeneic blood transfusion is widely used to correct anemia and is associated with poorer surgical ...
Dalrymple Kirsty K Fife Area Laboratory, Victoria Hospital, - - 2014
After the Department of Health's Better Blood Transfusion recommendations ( DH 2002 ) ten years ago, a network of 18 transfusion practitioners supported by a central team in the Scottish National Blood Transfusion Service was established. This article discusses the impact that transfusion practitioners in Scotland have had in driving ...
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