Histamine (10 mug/min for 3 min) infused into the brachial artery caused an increase in forearm blood flow which was reduced by mepyramine (25 mg). This effect was most marked in the first minute of the infusion. Metiamide (25 mg) had no effect on the dilatation during the infusion but ...

Effects of iv and ia administration of histamine and its H1 and H2 blockers (diphenhydramine and metiamide) on systemic arterial pressure, heart rate, and uterine and iliac blood flows were investigated in unanesthetized, chronically instrumented nonpregnant ewes. Intravenous histamine produced tachycardia, hypotension, and decreased iliac and uterine blood flows. In ...

The effect of negative and positive air ionisation on siliconized blood serotonin was studied in vitro. The experiments showed that within 10 min positive ionisation increased serotonin levels in total blood (+40%), plasma (+90%), erythrocytes (+50%) and thrombocytes (+240%). On the other hand, negative ionization (10 min) lowered the serotonin ...

The absolute counts on basophil and eosinophil leucocytes, percentage of vacuolated eosinophil cells and whole blood histamine were determined in 30 controls and 34 patients with bronchial asthma. The basophil counts rose from the quiescent to pre-attack stage and then fell in the acute stage of bronchial asthma. The eosinophil ...

1. Blood levels of nimetazepam after oral administration to dogs were relatively low at early periods after dosage and reached peak levels (7-7-7-9 mug equiv./ml) after 8 h. The time course of blood levels was similar after oral administration of its desmethyl derivative (nitrazepam) to dogs. Blood levels of the ...

Allergic bronchopulmonary aspergillosis is being recognized with increasing frequency in the United States. The characteristics of the disease are recurrent pyrexia, cough, wheezing, sputum plugs containing aspergilli, fleeting pulmonary infiltrates, eosinophilia, dual skin reactions (immediate and late), and antibodies to the fungus in the blood. The pathogenetic mechanism is believed ...

In pentobarbital anesthetized dogs, close arterial injections of bradykinin and kallidin elicit a dose related increase in femoral blood flow. Treatment with the kininase inhibitor BPP9alpha augments the femoral blood flow responses to bradykinin and kallidin by five and threefold respectively. The sensitivity of the preparation permits the detection of ...

Gastric mucosal blood flow was simultaneously determined by aminopyrine clearance and gamma-labeled microspheres (15 +/- 5 mu in diameter) in anesthetized dogs prepared with a chambered segment of stomach greater curvature. Paired flow measurements were made in 11 dogs (n = 28) secreting in response to intravenous histamine (1mug per ...

Histamine metabolism was studied in 35 patients with polycythaemia vera (PV) at different stages of their disease and compared with controls and patients with secondary polycythaemia. In addition to blood and urinary histamine the main urinary metabolites of histamine, methylhistamine (MeHi) and 1-methyl-4-imidazoleacetic acid (MeImAA) were measured. In patients with ...

The digital circulation was isolated in 12 ponies under pentobarbital anesthesia. Blood flow was either controlled by a pump or measured under natural perfusion. The responses to rapid changes and stoppages of blood flow indicated no evidence of autoregulation or reactive hyperemia. Local administration of acetylcholine, histamine, and prostaglandins E1 ...

Intra-arterial histamine produced a dose-dependent increase in common carotid blood flow due to an active vasodilation. A supramaximal dose of mepyramine (H1-blocker) only partially suppressed the effects of lower doses of histamine without influencing those of its higher amounts. Both metiamide and burimamide (H2-blockers) effectively antagonized the mepyramine-resistant carotid vasodilator ...

An in vivo canine gastric chamber preparation was used to determine effects of exogenous cyclic AMP and dibutyryl cyclic AMP on histamine-driven acid secretion and the role of blood flow in these responses. Histamine was infused intravenously at a submaximal rate 1.2 mu/kg-min) followed by the intraarterial infusion of either ...

The blood histamine levels, basophil and eosinophil counts and the percentage of vacuolated eosinophils were observed in 30 controls and 15 patients of urticaria. There was a definite rise in eosinophil and basophil count during the acute stage of the disease which decreased in the quiescent or the symptom-free stage. ...

In general, many similarities are seen between cerebral blood flow and cochlear blood flow in response to vasodilating drugs. Cochlear vessels appear to be weakly controlled by the adrenergic nervous system. Cholinergic agents dilate cochlear vessels, although the vasodilation in the cochlea does not necessarily cause an increase in cochlear ...

A specific assay for determination of carbamyl phosphate (carbamyl P) in blood has been developed using the enzymatic conversion of carbamyl P to citrulline by ornithine carbamyl transferase (OCT). This assay, for evaluation of bioavailability of carbamyl P, is necessary for study of the in vivo and in vitro effects ...

The contents of serotonin (hydroxytryptamine) and pyridoxal phosphate (PLP) in the blood of 11 hyperactive children and 11 controls were determined on an outpatient basis. A significant decrease in serotonin content was found in blood samples from hyperactive patients as compared with controls. There were no differences in PLP content ...

It has been shown previously that there is a greater gastric mucosal blood flow response to histamine than to gastrin stimulation for similar acid secretory values. We have confirmed these observations under steady state conditions and also shown that the oxygen consumption depends on acid secretion in a similar way ...

We have developed methods for quantitatively monitoring the in vivo flow of tryptophan between the kynurenine and serotonin pathways. Our data suggest that endotoxin-poisoned mice have more tryptophan flowing into the serotonin pathway than normal mice both with and without tryptophan load. It appears that the distribution of tryptophan between ...

Rhesus monkeys were trained in a discriminated conditioned emotional responses paradigm. The discriminated conditioned response (CR) complex consisted of bar-press suppression, increased terminal aortic blood flow, and increased arterial pressure. Bar-press suppression and blood flow responses were temporarily eliminated by single-stage bilateral prefrontal lobectomy but not by extensive posterior cortical ...

Cardiac glycosides which inhibit Na/K-ATPase (ouabain, scilliroside, scillirosidin) as well as heparin and histamine were infused into a cannulated branch of the middle cerebral artery or by isolated head perfusion in cats and dogs. Ouabain permeating the blood-brain barrier (BBB) caused the same selective swelling of astrocytes and of certain ...

Excretion of the vaso-active amines tyramine, serotonin, noradrenaline, adrenaline and histamine and blood levels of serotonin, noradrenaline, adrenaline and histamine, were estimated in 10 patients before, during and after an attack of migraine. During the headache process there was a statistically significant fall in the excretion of tyramine and a ...

1. A convenient spectrophotometric assay for the determination of l-ergothioneine in solution including deproteinized blood haemolysate was developed. 2. The method consists of deproteinization by heat precipitation and Cu(2+)-catalysed oxidation of thiols such as glutathione and of l-ascorbic acid, both in alkaline media, and titration of l-ergothioneine (which is not ...

Ninety-six percent of mice that were bled of 50 percent of their blood volume when they were 9 weeks old succumbed to myelogenous leukemia by 15 months after phlebotomy, the majority of them dying between 7 and 10 months after this treatment. These results suggest that (i) anemia is an ...

1. Hepatic volume was recorded by a plethysmographic technique in cats anaesthetized with pentobarbitone; the hepatic artery and portal vein remained intact. Dose-response curves were obtained for intravenous infusions of adrenaline, noradrenaline, angiotensin, vasopressin and histamine.2. Adrenaline and noradrenaline decreased hepatic blood volume and did not differ significantly in potency. ...

1. The effects of three beta-adrenoceptor blocking agents on isoprenaline induced changes in systemic and regional blood flow have been investigated in rats anaesthetized with pentobarbitone. The blood flow to the principal vascular beds was measured by the (86)Rb fractionation method.2. Isoprenaline infusion at a rate of 0.3 (mug/kg)/min intravenously ...

In the 4 years since Hammes (87) reviewed, in this journal, the application of flow and relaxation techniques to the study of primary processes in chemical reactions these methods have been applied to a wide range of biochemical problems. These applications have been facilitated by advances in stopped flow and ...

1. The responses of the cutaneous blood vessels of the guinea-pig to histamine and bradykinin have been studied in order to determine whether these factors mediate vascular changes by acting on different blood vessel receptors.2. In animals injected intravenously with bovine serum albumin labelled with phosphorus (32)P the reactions to ...

1 The vascular responses of human skin to two synthetic analogues of histamine, 2-methyl histamine (an H1-receptor agonist) and 4-methyl histamine (an H2-receptor agonist) have been studied in vivo.

14C-Labelled histamine was incubated with canine or human blood at 37° C. After 1 hr 80 to 100% of the added histamine could be recovered in unchanged form. When [14C]-histamine was added to whole blood in vitro it tended to become equally distributed between the cell and plasma fraction of ...

1. Alcoholic extracts of the plasma of rabbits obtained from arterial or venous blood differ from those of human plasma in having a marked depressor action on the blood pressure of anesthetized cats. This action is unantagonized on atropinization. Extracts of the plasma of dogs, on the other hand, are ...

1. In anaesthetized dogs, various amounts of [(14)C]histamine were introduced into the lumen of a ligated intestinal loop or of the ligated stomach and the absorption of this histamine was studied by determining the radioactive histamine in the venous blood coming from the ligated part.2. After the introduction of 5-5000 ...

1. Plasma and blood cell volumes were measured simultaneously with [(131)I]albumin and [(32)P]erythrocytes, together with the arterial haematocrits, in acutely splenectomized dogs anaesthetized with sodium barbital. These measurements were made during control runs and after the administration of vasoactive substances.2. With these data and previously derived equations the mean composite ...

Patients with chronic gingivitis and alveolar pyorrhea suffering simultaneously from gastric-intestinal illnesses, showed an increased content of histamine in the blood serum (from 9 to 18 gamma %). (2) Patients with aphthosis relapsing stomatitis and multiform exudative erythema showed a sharply increased histamine content in the blood (from 10.3 to ...

(14)C-Labelled histamine was incubated with canine or human blood at 37 degrees C. After 1 hr 80 to 100% of the added histamine could be recovered in unchanged form. When [(14)C]-histamine was added to whole blood in vitro it tended to become equally distributed between the cell and plasma fraction ...

The amounts of [(14)C]histamine in arterial blood, in renal venous blood and in urine during a steady intravenous infusion of [(14)C]histamine were measured in five anaesthetized dogs. The extraction ratio for [(14)C]histamine was 0.7 to 0.8, indicating that the histamine was efficiently taken up from the blood by the kidney. ...

1. Alcoholic extracts of the plasma of rabbits obtained from arterial or venous blood differ from those of human plasma in having a marked depressor action on the blood pressure of anesthetized cats. This action is unantagonized on atropinization. Extracts of the plasma of dogs, on the other hand, are ...

1. Histamine exerts a local dilator effect upon capillaries and upon the smallest arterioles and venules which border the capillary system. There occurs also an opening up of large numbers of capillaries of which no trace can be seen before the application of histamine. 2. When injected intravenously in amounts ...