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Boscarino Cathy C From the Defence Research and Development Canada-Toronto (C.B.); and Sunnybrook Health Sciences Centre (H.T., J.C., A.N., A.B.), Toronto; Canadian Field Hospital(H.T., A.B.), Canadian Forces Health Services, Canadian Forces Base, Petawawa; Canadian Blood Services (J.A., A.L.H.); Royal Alexandra Hospital (P.E.), Edmonton, Alberta, Canada; and Medical Corps (E.G.), Surgeon General's Headquarters, Israel Defense Force, Ramat Gan, - - 2014
Transfusing packed red blood cells (PRBCs) into Special Forces may provide a survival advantage from hemorrhage-induced battlefield injuries; however, the effect of the unique operational stressors on RBC integrity is not known. Pooled PRBCs (20 U) (7 days old), stored in Golden Hour containers, were exposed to the following simulated ...
van 't Erve Thomas J TJ Interdisciplinary Program in Human Toxicology, The University of Iowa, Iowa City, - - 2014
The degeneration of red blood cells (RBCs) during storage is a major issue in transfusion medicine. Family studies in the 1960s established the heritability of the RBC storage lesion based on poststorage adenosine triphosphate (ATP) concentrations. However, this critical discovery has not been further explored. In a classic twin study ...
Sun Tingyi T Department of Forensic Medicine, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, - - 2014
We developed a mathematical model using interpolation function, to characterize the correlation between blood ATP levels in the right ventricle of rabbit and post mortem interval (PMI) at different ambient temperatures. Forty-eight healthy rabbits were randomly divided into 6 groups of 8 each. The sacrificed rabbits were maintained in calorstats ...
Lockwood Sarah Y SY Department of Chemistry, Michigan State University, East Lansing, MI - - 2014
Red blood cells (RBCs) release adenosine triphosphate (ATP) in response to a variety of stimuli, including flow-induced deformation. Hydroxyurea (HU), a proven therapy for individuals with sickle cell disease (SCD), is known to improve blood flow. However, the exact mechanism leading to the improved blood flow is incomplete. Here, we ...
Cieslar S R L SR Department of Animal and Poultry Science, University of Guelph, Ontario N1G 2W1, - - 2014
To test which, if any, of the major milk precursors can elicit a rapid change in the rate of mammary blood flow (MBF) and to define the time course and magnitude of such changes, 4 lactating cows were infused with glucose, amino acids, or triacylglycerol into the external iliac artery ...
Autio Joonas A JA 1] Department of Neurobiology, A. I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland [2] Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, - - 2014
We found novel types of parenchymal functional magnetic resonance imaging (fMRI) signals in the rat brain during large increases in metabolism. Cortical spreading depression (CSD), a self-propagating wave of cellular activation, is associated with several pathologic conditions such as migraine and stroke. It was used as a paradigm to evoke ...
Hess J R JR Department of Laboratory Medicine, University of Washington, Seattle, WA, - - 2014
Blood banking underpins modern medical care, but blood storage, necessary for testing and inventory management, reduces the safety and efficacy of individual units of red blood cells (RBCs). Stored RBCs are damaged by the accumulation of their own waste products, by enzymatic and oxidative injury, and by metabolically programmed cell ...
Minogue Timothy D TD U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, - - 2013
Rapid pathogen detection is crucial for the timely introduction of therapeutics. Two groups (UK and US) independently evaluated inhibitor-resistant PCR reagents for direct testing of substrates. In the UK a multiplexed B. anthracis (target) & B. subtilis (internal control) PCR was used to evaluate 4 reagents against 5 PCR inhibitors ...
Spildrejorde Mari - - 2013
Binding of extracellular adenosine 5'-triphosphate (ATP) or lipopolysaccharide (LPS) to the damage-associated molecular pattern receptor P2X7 or the pathogen-associated molecular pattern receptor Toll-like receptor (TLR)4, respectively, can induce the release of the pleiotropic cytokine interleukin (IL)-1β in humans and mice. However, the release of IL-1β in dogs remains poorly defined. ...
Brands Judith J Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Maastricht, the Netherlands ; Department of Medicine, Cardiovascular Institute, School of Medicine, University of Pittsburgh Pittsburgh, - - 2013
Adenosine-mediated recruitment of microvascular volume in heart and muscle has been suggested to include, in addition to vasodilation of resistance vessels, an increased accessibility of the endothelial glycocalyx for flowing plasma as a result of an impairment of its barrier properties. The aim of the current study was to investigate ...
Layec Gwenael - - 2013
Although phosphorus magnetic resonance spectroscopy ((31)P-MRS) based evidence suggests that in vivo peak mitochondrial respiration rate in young untrained adults is limited by the intrinsic mitochondrial capacity of ATP synthesis, it remains unknown whether a large, locally targeted, increase in convective O2 delivery would alter this interpretation. Consequently, we examined ...
Sun Ting-Yi - - 2013
Relationship between ATP changes of rabbit blood and postmortem interval (PMI) was studied. Twenty-four healthy rabbits were sacrificed and randomly divided into 3 groups with 8 rabbits of each group. The bodies of three groups were placed in calorstat at temperature of 15°C, 25°C and 35°C, respectively. The blood from ...
Hansen Adele - - 2013
BACKGROUND: Washing of red blood cell concentrates (RCCs) is required for potassium-sensitive transfusion recipients, including neonates in need of large-volume transfusions. When open, nonsterile washing systems are used, postwash outdate time is limited to 24 hours, often leading to problems providing the component to the patient before expiry. STUDY DESIGN ...
Wittfeldt Ann - - 2013
This study was undertaken to determine if ticagrelor augments adenosine-induced coronary blood flow and the sensation of dyspnea in human subjects. Ticagrelor is a P2Y(12) receptor antagonist that showed superior clinical benefit versus clopidogrel in a phase III trial (PLATO [Platelet Inhibition and Patient Outcomes]). Ticagrelor has been shown to ...
Okajima Yasuhisa - - 2013
Extensive DNA damage leads to the activation of poly(ADP-ribose) polymerase and subsequently to the formation of poly(ADP-ribose). When the damage is severe or leads to cell death, poly(ADP-ribose) may leak into the blood circulation. The metabolism of poly(ADP-ribose) in the bloodstream is not well understood. Thus, in the present study, ...
Nucci Carlo - - 2013
To evaluate the levels of malondialdehyde (MDA) and total antioxidant capacity (TAC) in the blood and aqueous humor of glaucomatous and nonglaucomatous patients. To measure the adenosine triphosphate/adenosine diphosphate/adenosine monophosphate (ATP/ADP/AMP) concentration as a biomarker of the blood energy charge potential. We examined 40 consecutive patients with primary open-angle glaucoma ...
Nishino Taiko - - 2013
Although intraerythrocytic ATP and 2,3-bisphophoglycerate (2,3-BPG) are known as direct indicators of the viability of preserved red blood cells and the efficiency of post-transfusion oxygen delivery, no current blood storage method in practical use has succeeded in maintaining both these metabolites at high levels for long periods. In this study, ...
Suviolahti Elina - - 2012
Global immunosuppression can be measured by assessing adenosine triphospate (ATP) levels in mitogen-stimulated CD4+ T cells. We investigated the effect of storage time on ATP levels in 234 blood samples from 18 healthy individuals and 152 transplant patients. The difference between day 0 (<13 hours post-blood draw) and day 1 ...
Heinonen Ilkka - - 2012
Pulmonary blood flow (PBF) is an important determinant of endurance sports performance, yet studies investigating adaptations of the pulmonary circulation in athletes are scarce. In the present study we investigated PBF, its distribution, and heterogeneity at baseline and during intravenous systemic adenosine infusion in ten highly trained male endurance athletes ...
Muzzi Mirko M Department of Preclinical and Clinical Pharmacology University of Florence, Florence, Italy. - - 2013
In light of the relevance of therapeutic hypothermia to stroke treatment, we investigated whether 5'-adenosine monophosphate (AMP)-dependent cooling affords protection from ischemic brain injury. We show that hypothermia by AMP is because of adenosine A1 receptor (A1R) activation and is not invariantly associated with hypotension. Inhibition of ecto-5'-nucleotidase-dependent constitutive degradation ...
Liu Xiao - - 2012
Extracellular adenine nucleotides ATP and ADP on vascular endothelial cells may play a role in the localization of atherogenesis by regulating the release of nitric oxide from endothelial cells and modulating intracellular calcium levels. To quantitatively investigate the concentration distribution of nucleotides on the luminal surface of the human thoracic ...
Pereira Carla M - - 2013
Natal dispersal of sea turtles is an energetically demanding activity that is fuelled primarily by aerobic metabolism. However, during intense exercise reptiles can use anaerobic metabolism to supplement their energy requirements. We assessed anaerobic metabolism in dispersing hatchling loggerhead and flatback turtles by measuring the concentrations of blood lactate during ...
Rudzinski Wojciech - - 2012
OBJECTIVES: The purpose of this study was to compare the efficacy and safety of intracoronary nitroprusside and intravenous adenosine for assessing fractional flow reserve (FFR). BACKGROUND: Intravenous infusion of adenosine is a standard method to achieve a coronary hyperemia for fractional flow reserve measurement. However, adenosine is expensive, causes multiple ...
Tokan Rola Sahyoun RS Ankara University, Faculty of Medicine, Department of Pediatrics, Ankara, - - 2012
Objective: This study aimed to compare the storage properties of red blood cell (RBC) concentrates of umbilical cordblood (UCB) and adult donor blood (ADB), and to evaluate the feasibility of UCB-RBC concentrate as an autologoussource for blood transfusion in very low birth weight (VLBW) preterm neonates. Material and Methods: In ...
Araia Makda H MH Department of Epidemiology & Community Medicine, University of Ottawa, Ottawa, Ontario, - - 2012
Effective parental education about newborn blood-spot screening may facilitate prompt follow-up, reduce psychosocial harms, and promote trust in screening programs. However, little is known about the aspects of education delivery and content that are of most importance for fostering understanding and meeting parental expectations. We aimed to identify elements of ...
Onwuemene Oluwatoyosi - - 2012
Transfusion therapy in postpartum hemorrhage (PPH) traditionally has been modeled after precedents set in the Vietnam and Korean wars. However, data from recent military combat casualties suggest a different transfusion strategy. Transfusion of packed red blood cells, fresh frozen plasma, and platelets in a ratio of 1:1:1 improves dilutional coagulopathy ...
Franchini Massimo - - 2012
The antigens of the ABO system (A, B, and H determinants, respectively) consist of complex carbohydrate molecules. It has been known for nearly half a century that the ABO blood group exerts a major influence on plasma levels of the von Willebrand factor (VWF)-factor VIII (FVIII) complex and that normal ...
Kirklin James K - - 2012
Average 2-year survival after cardiac transplantation is approximately 80%. The evolution and subsequent approval of larger pulsatile and, more recently, continuous flow mechanical circulatory support (MCS) technology for destination therapy (DT) offers the potential for triage of some patients awaiting cardiac transplantation to DT. The National Heart, Lung, and Blood ...
Manopunya Manatsawee - - 2012
Massive bleeding into a uterine leiomyoma is an extremely rare cause of hypovolemic shock. Only one case of this life-threatening condition has been reported. Our patient was a 39-year-old woman who had a gradual growth of a subserous myoma throughout pregnancy and sudden rapid growth after cesarean section at 35 weeks ...
Altermatt J L - - 2012
Objectives of the experiment were to determine the effects of mare age and gonadotropin treatments on dominant follicle vascularity, ovarian blood flow and dominant follicle growth and to associate follicular vascularity with oocyte developmental capacity. Growing follicles >30mm from young (4-9 years) and old (>20 years) mares were assessed for ...
Dentali Francesco - - 2012
It is well known that the ABO blood group exerts a major influence on hemostasis, as O blood group individuals have lower von Willebrand factor and factor VIII levels than non-O blood group subjects. To evaluate the possible clinical implication of the different ABO blood groups on the risk of ...
Briana Despina D - - 2012
Transforming growth factor-α (TGF-α) and TGF-β1 are major anti-inflammatory cytokines and substantially contribute to normal pregnancy outcome. TGF-α stimulates placental mitosis, whereas TGF-β1 is a critical regulator of trophoblast invasion and fetal growth. We aimed to study cord blood TGF-α and TGF-β1 concentrations in intrauterine-growth-restricted (IUGR, usually associated with abnormal ...
Kawabata Masato - - 2012
Abstract The present study examined the extent to which scores on the Dispositional Flow Scale-2 (DFS-2) could differentiate individuals who frequently experience flow characteristics in physical activity from those who do not. A total of 993 participants completed the Japanese version of the DFS-2. Latent class factor analysis (LCFA), which ...
Neal Matthew D - - 2012
The design and implementation of massive transfusion protocols with ratio-based transfusion of blood and blood products are important and active areas of investigation. A significant yet controversial body of literature exists to support the use of hemostatic resuscitation in massive transfusion and new data to support the use of adjuncts, ...
El-Galaly T C - - 2012
Non-O blood type is a recognized, though often unattended, constitutional risk factor for venous thromboembolism (VTE). A meta-analysis reported that persons with non-O blood type had an odds ratio for VTE of 1.79 (95% CI 1.56-2.05) over persons with blood type O [1]. Evidence also suggests that combined exposure to ...
Willems Elise - - 2012
Bloodstream infections remain a major challenge in medicine. Optimal detection of pathogens is only possible if the quality of preanalytical factors is thoroughly controlled. Since the laboratory is responsible for this preanalytical phase, the quality control of critical factors should be integrated in its quality control program. The numerous recommendations ...
Wang Shu-Hua - - 2012
We compared the performance of the T-SPOT.TB assay with blood used within 0 to 3.5 h after collection (control) to its performance with blood stored for 0 to 3.5, 5 to 8, 18 to 21, or 31 to 33 h with the addition of T-Cell Xtend (experimental), using samples from ...
Chang Chao-Sung - - 2012
"When should we trigger a transfusion?" is always a critical question between the patient's benefits and risks in red blood cell (RBC) transfusion. A computerized transfusion decision support system (CTDSS) has been used since September 2004 in an academic medical center with 1400 beds. In this study, the factors affecting ...
Bryant Gillian L - - 2012
Despite increased worldwide popularity of keeping reptiles as pets, we know little about hematologic and biochemical parameters of most reptile species, or how these measures may be influenced by intrinsic and extrinsic factors. Blood samples from 43 wild-caught pythons (Morelia spilota imbricata) were collected at various stages of a 3-yr ...
Denis Cécile V - - 2012
Hemostasis and thrombosis represent two sides of the same coin. Hemostasis maintains blood fluidity in the vascular system while allowing for rapid thrombus formation to prevent excessive hemorrhage after blood vessel injury. Thrombosis is a pathologic extension of the normal hemostatic mechanism, occurring when unwanted clot formation develops in certain ...
Goncalez Thelma T - - 2012
The characteristics of blood recipients including diagnoses associated with transfusion and posttransfusion survival are unreported in Brazil. The goals of this analysis were: 1) to describe blood utilization according to clinical diagnoses and patient characteristics and 2) to determine the factors associated with survival of blood recipients. A retrospective cross-sectional ...
Madsen Anne Mette - - 2012
The purpose of this study was to investigate the aerosolization of particles (micro- and macroconidia and fragments) from Botrytis cinerea cultures in relation to potential human inhalation in indoor environments. The influence of the following factors on the aerosolization of B. cinerea particles was studied: exposure to airflow, relative humidity ...
Poppe Lindsey B - - 2012
Purpose A multidisciplinary initiative to promote more cost-effective use of blood factor derivatives and increase pharmacist involvement in associated order verification, dispensing, and monitoring activities is described. Summary After an evaluation of a hospital's procedures for the use of blood factor derivatives identified inconsistencies and opportunities for cost savings, a ...
Reitsma Pieter H - - 2012
Venous thromboembolism is an episodic disease with an annual incidence of 2 to 3/1000 per year that is associated with a high morbidity and mortality. Risk factors for venous thromboembolism come in many guises. They fit into an extended version of Virchow's triad and they tilt the hemostatic balance toward ...
Yoon Jong Hyun - - 2012
In a bubble column reactor with an inner diameter of 6cm and a height of 63cm for the culture of cyanobacteria two different shapes of bubbles can be generated, resulting in bubbly flow or slug flow. Growth of Anabaena variabilis under slug flow (1.9g/l/day) was 1.73 times higher than that ...
Schilperoort R P S - - 2012
Long-term and high-frequency in-sewer monitoring opens up a broad range of possibilities to study (influences on) water quantity and quality variations. Using data from the Eindhoven wastewater system in The Netherlands both dry weather flow and wet weather flow situations have been studied. For approximately 160 dry weather days mean ...
Sorensen B - - 2012
Trauma-induced coagulopathy has a multifactorial aetiology. Coagulopathy is related to blood loss including consumption of clotting factors and platelets and haemodilution. Additionally hyperfibrinolysis, hypothermia, acidosis and metabolic changes affect the coagulation system. This is a review of pathophysiology and new treatment strategies for trauma-induced coagulopathy. Paradigms are actively changing and ...
Floyd C Timothy - - 2012
We have previously shown that lyophilized salmon thrombin and fibrinogen (STF) embedded in a dissolvable dextran dressing is as efficacious as Combat Gauze (CG) with regard to controlling hemorrhage and survival in non-coagulopathic swine with femoral artery lacerations. A major limitation of currently available advanced field dressings is the inability ...
Shen Hongchang - - 2012
Ionized calcium was involved in various cellular signal pathways,and regulates many cellular processes, including those relevant to tumorigenesis. We hypothesis that imbalance of calcium homeostasis is correlated with development of lung carcinomas. We collected the clinical data of 1084 patients with non small cell lung cancer (NSCLC) treated in Shandong ...
Hahn Steffen - - 2012
Isotopic discrimination and turn-over are fundamental to the application of stable isotope ecology in animals. However, detailed information for specific tissues and species are widely lacking, notably for herbivorous species. We provide details on tissue-specific carbon and nitrogen discrimination and turn-over times from food to blood, feathers, claws, egg tissues ...
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