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Abe S - - 2014
Aim: Previously, we devised a method for estimating123I labeled N-isopropyl-p-iodoamphetamine (123I IMP) arterial blood activity at 10 minutes after intravenous injection of 123I IMP (Ca10) without any blood sampling using 123I IMP autoradiography (ARG) acquisition data, and verified its usefulness for quantification of regional cerebral blood flow (rCBF). In this ...
Lee Yann-Leei YL Department of Surgery, University of South Alabama College of Medicine, Mobile, Alabama; Department of Pharmacology, University of South Alabama College of Medicine, Mobile, - - 2014
Transfusion-related acute lung injury (TRALI) is the most frequent and severe complication in patients receiving multiple blood transfusions. Current pathogenic concepts hold that proinflammatory mediators present in transfused blood products are responsible for the initiation of TRALI, but the identity of the critical effector molecules is yet to be determined. ...
Igressa A A Department of Neurosurgery, Medical Centre Cologne-Merheim, Cologne, - - 2014
The early detection and treatment of sepsis in patients is essential for a positive outcome. Microbiological analysis of blood cultures, as the gold standard for diagnosis, is rather slow. However, more rapid methods like PCR have become available recently and are being evaluated clinically. We present data from the monitoring ...
Conhaim Robert L RL *Department of Surgery, University of Wisconsin School of Medicine and Public Heath; †William S. Middleton Memorial Veterans Hospital; and ‡Department of Pediatrics, University of Wisconsin School of Medicine and Public Heath, Madison, - - 2014
We showed previously that a 30% blood loss in rats, without resuscitation, caused significant accumulation of microthrombi and leukocytes within the pulmonary circulation by 24 h. We hypothesized that the microthrombi formed spontaneously as a consequence of hemorrhage-induced stasis within the low-pressure pulmonary circuit and that the leukocytes were attracted ...
DeKoninck Philip P Fetal Medicine Unit, Department of Obstetrics and Gynecology, University Hospitals Leuven & Cluster Organ Systems, Department of Development and Regeneration, KU Leuven, Leuven, - - 2014
To evaluate whether assessment pulmonary vascular reactivity in response to maternal hyperoxygenation using fractional moving blood volume (FMBV) is associated with lesser variability between individual measurements than what is observed with direct Doppler measurements. Forty-five measurements were performed in 15 singleton fetuses with normal lung development at three time points ...
Demoly Pascal P Département de Pneumologie et Addictologie, Hôpital Arnaud de Villeneuve and University Hospital of Montpellier, 371 Ave. du Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France. Electronic address: - - 2014
Although understanding of the scientific basis of aerosol therapy with dry powder inhalers (DPIs) has increased, some misconceptions still persist. These include the beliefs that high resistance inhalers are unsuitable for some patients, that extra fine (<1.0 μm) particles improve peripheral lung deposition and that inhalers with flow rate-independent fine ...
Luan Haixing - - 2014
It is speculated that blood transfusion may induce adverse consequences after cancer surgery due to immunosuppression. This study was intended to assess the impact of perioperative blood transfusion on the prognosis of patients who underwent lung cancer resection. Eligible studies were identified through a computerized literature search. The pooled relative ...
Gerace Enrico E Centro Regionale Antidoping "A. Bertinaria" - Laboratorio Regionale di Tossicologia, Regione Gonzole 10/1, Orbassano, Turin 10043, Italy. Electronic address: - - 2014
The distribution of mephedrone in the body fluids and tissues of a subject found dead after the concomitant intake of cocaine and mephedrone is reported. Mephedrone (4-methylmethcathinone) is a designer drug of the phenethylamine family that is able to cause central nervous system stimulation, psychoactivity and hallucinations and that is ...
Bodenstein Marc - - 2014
A recent method determines regional gas flow of the lung by electrical impedance tomography (EIT). The aim of this study is to show the applicability of this method in a porcine model of mechanical ventilation in healthy and diseased lungs. Our primary hypothesis is that global gas flow measured by ...
Dijkstra Dorothea D Department of Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, D-30625, Hannover, Germany; Department of Pediatric Pneumology, Allergology, and Neonatology, Hannover Medical School, D-30625, Hannover, - - 2014
During asthma attacks, allergens activate sensitized basophils in the lung, thereby aggravating symptoms. Due to the paucity of basophils in bronchial lavage fluid and the lack of specific basophil detection and quantification methods, basophil-directed research in these samples was hampered in the past. This study aimed to establish and validate ...
Smolich Joseph J JJ Murdoch Childrens Research - - 2014
Although a reduction in lung liquid volume increases fetal pulmonary blood flow, the changes in central flow patterns which sustain this increased pulmonary perfusion are unknown. To address this issue, eight anesthetized late-gestation fetal sheep were instrumented with pulmonary trunk (PT), ductus arteriosus (DA) and left pulmonary artery (PA) micromanometer ...
Conhaim Robert L - - 2014
This article describes a method for quantifying blood flow distribution among lung alveoli. Our method is based on analysis of trapping patterns of small diameter (4 μm) fluorescent latex particles infused into lung capillaries. Trapping patterns are imaged using confocal microscopy, and the images are analyzed statistically using SAS subroutines. ...
Severinghaus John W JW Emeritus Anesthesiology and Cardiovascular Research Institute, University of California at San Francisco, San Francisco, CA, 94957, USA, - - 2014
Recent events have called long-overdue attention to one of the first investigators to discover the roles of something in air changing the color of the pulmonary blood flowing through the lung.
Knowles Lynn M LM Department of Urology; University of Pittsburgh School of Medicine; Shadyside Medical Center; Pittsburgh, PA - - 2014
Blood clotting specifically supports the metastatic dissemination of malignant cells to the lung. We have recently demonstrated that 2 tumor types that are prone to form lung metastases, renal cell carcinoma and soft tissue sarcoma, share specific adhesive mechanisms that support the invasion and colonization of blood clots in the ...
Osaro Erhabor E Department of Haematology and Transfusion Medicine, Faculty of Medical Laboratory Science Usmanu Danfodiyo University, Sokoto, - - 2014
Blood transfusions remain a substantial source of HIV in SSA particularly among children and pregnant women. This aim of this retrospective study was to investigate the prevalence of p24 antigen among HIV antibody seronegative blood donors in Sokoto, North West Nigeria. A total of 15,061 HIV antibody negative blood donors ...
Schachner Emma R ER Department of Biology, University of Utah, Salt Lake City, Utah 84112, - - 2013
The unidirectional airflow patterns in the lungs of birds have long been considered a unique and specialized trait associated with the oxygen demands of flying, their endothermic metabolism and unusual pulmonary architecture. However, the discovery of similar flow patterns in the lungs of crocodilians indicates that this character is probably ...
Kreyer S S Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Bonn, - - 2014
Lung protective ventilation may lead to hypoventilation with subsequent hypercapnic acidosis (HA). If HA cannot be tolerated or occurs despite increasing respiratory rate or buffering, extracorporeal CO2-removal using a percutaneous extracorporeal lung assist (pECLA) is an option. We hypothesised that compensation of HA using pECLA impairs regional perfusion. To test ...
Anselmo Aaron C - - 2013
Nanoparticulate drug delivery systems are one of the most widely investigated approaches for developing novel therapies for a variety of diseases. However, rapid clearance and poor targeting limit their clinical utility. Here, we describe an approach to harness the flexibility, circulation, and vascular mobility of red blood cells (RBCs) to ...
Chang Yulin V - - 2013
To present in vivo, human validation of a previously proposed method to measure key pulmonary parameters related to lung microstructure and physiology. Some parameters, such as blood-air barrier thickness, cannot be measured readily by any other noninvasive modality. Healthy volunteers (n = 12) were studied in 1.5T and 3T whole ...
Lovering Andrew T - - 2013
Large-diameter, intrapulmonary arteriovenous anastomoses exist in human lungs. In developing fetuses, blood flows physiologically through pulmonary arteriovenous channels that appear to regress during lung maturation. Blood flow through intrapulmonary arteriovenous anastomoses is a normal occurrence during exercise or inhalation of reduced oxygen gas mixtures in most healthy humans. However, the ...
Haldar Rudrashish R Department of Anaesthesiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, - - 2013
Transfusion associated circulatory overload (TACO) and transfusion related acute lung injury (TRALI) are two dissimilar pathological conditions associated with transfusion of blood products where the time course of the events and clinical presentation overlap leading to uncertainty in establishing the diagnosis and initiating the treatment, which otherwise differs. We encountered ...
Shan Fei - - 2013
To evaluate the effect of the temporal interval (TI) between scan acquisitions on the radiation dose and vascular parameters of computed tomography perfusion (CTP) in small peripheral lung cancers. With 7 excluded, 40 patients with peripheral lung cancer (diameter ≤4 cm) prospectively underwent a 30-second CTP study. Vascular parameters were calculated for ...
Naso-Kaspar Claire K - - 2013
'Lingering death' cases occur when the circumstances of death indicate an opiate overdose, but measured opiate blood levels are only in the therapeutic range; death results from cardiac and respiratory depression. This study examined the relative concentration of opiates in femoral blood and in the medulla oblongata (sites for cardiac ...
Richter Torsten - - 2013
After gastric aspiration events, patients are at risk of pulmonary dysfunction and the development of severe acute lung injury and acute respiratory distress syndrome, which may contribute to the development of an inflammatory reaction. The authors' aim in the current study was to investigate the role of the spatial distribution ...
Frings Virginie - - 2013
To investigate the effect of image-derived input functions (IDIF), input function corrections and volume of interest (VOI) size in quantification of [(18)F]FLT uptake in non-small cell lung cancer (NSCLC) patients. Twenty-three NSCLC patients were scanned on a HR+ scanner. IDIFs were defined over the aorta and left ventricle. Activity concentration ...
Amoako Kagya A - - 2013
Hollow fiber artificial lungs are increasingly being used for long-term applications. However, clot formation limits their use to 1-2 weeks. This study investigated the effect of nitric oxide generating (NOgen) hollow fibers on artificial lung thrombogenicity. Silicone hollow fibers were fabricated to incorporate 50 nm copper particles as a catalyst ...
Barbera Nunziata - - 2013
Tramadol is a synthetic opioid, widely used for post-surgical and chronic pain. Lethal overdose due only to tramadol is not common; more often the poisoning is due to tramadol in combination with other substances. Reported is a suicidal case of lethal tramadol poisoning in a 48-year-old woman. Tramadol and its ...
Pereda J - - 2013
Vascularization and blood cell circulation are crucial steps during lung development. However, how blood vessels are generated and when lung circulation is initiated is still a matter of debate. A morpho-functional analysis of pulmonary vasculature was done using human lung samples between 31 and 56 days post-fertilization (pf). The immunolocalization and ...
Végh Tamás - - 2013
Background: Previously a report has suggested that administration of lung protective strategy for one-lung ventilation (OLV) results in oxygen desaturation of the brain parenchyma. The aim of our work was to confirm that the maintenance of normocapnia during protective OLV strategy results in alteration of cerebral blood flow and cerebral ...
Ivanov K P - - 2013
Human lungs weighing ca 600g permit the passage of 5-6 l of blood per minute. The blood capacity of the human lungs is about 0.5 l. Consequently, each 0.5 l of blood is during 5seconds. The questions arise of how such a large mass of blood passes through such a ...
Jimoh S A SA School of Anatomical Sciences, University of the Witwatersrand, Johannesburg, South - - 2013
The terminal respiratory units of the gas exchange tissue of the avian lung, the air capillaries (ACs) and the blood capillaries (BCs), are small and rigid: the basis of this mechanical feature has been highly contentious. Because the strength of the blood-gas barrier (BGB) of the mammalian lung has been ...
Williams Kurt J - - 2013
Exercise-induced pulmonary hemorrhage (EIPH), which has been reported in humans and a variety of domestic animals following strenuous exercise, is most often documented in racehorses. Remodeling of pulmonary veins (VR) in equine EIPH was recently described, suggesting that it contributes to the pathogenesis of the disease. The cause of VR ...
Pahor Kevin - - 2013
The purpose of this study was to determine whether gasoline residues could be detected post-mortem in lung tissue and heart blood of fire victims. The lungs and heart blood were investigated to determine whether they were suitable samples for collection and could be collected without contamination during an autopsy. Three ...
Maina John N - - 2013
Structural failure of blood-gas barrier (BGB) and epithelial-epithelial cell connections (EECCs) in different vascular regions of the exchange tissue of the lung was studied in rested and exercised chickens. The number of red blood cells (nRBCs) was counted and protein concentration (PC) measured after lavaging the respiratory system, and blood ...
Ivanov K P - - 2013
Blood flow through the human lungs weighing 600 g is about 5 to 6 liters per minute. Blood capacity of human lung is about 500 ml. Therefore, 500 ml blood is oxygenated for 5 sec. Questions arise how such a large volume of blood passes through such a small mass ...
Urun Yuksel - - 2013
Background: The ABO blood groups and Rh factor may affect the risk of lung cancer. Materials and Methods: We analyzed 2,044 lung cancer patients with serologically confirmed ABO/Rh blood group. A group of 3,022,883 healthy blood donors of Turkish Red Crescent was identified as a control group. We compared the ...
Kaya Halil - - 2013
To investigate the effects of aprotinin, on blood gasses, oxidant-antioxidant status, and lung histopathology in an experimental bilateral blunt chest trauma model. Conducted at the Experimental Animal Laboratory of Meram Medical School at Selcuk University, Konya, Turkey, the study comprised 21 New Zealand female albino rabbits who were divided into ...
Bosson Jenny A JA Division of Medicine/Respiratory Medicine and Allergy, Department of Public Health and Clinical Medicine, Umeå University, Umeå, - - 2013
Ozone concentrations are predicted to increase over the next 50 years due to global warming and the increased release of precursor chemicals. It is therefore urgent that good, reliable biomarkers are available to quantify the toxicity of this pollutant gas at the population level. Such a biomarker would need to ...
Houston Neralee - - 2012
BACKGROUND: Few data exist on the functional activity of airway neutrophils in the milieu of the cystic fibrosis (CF) lung. We assessed reactive oxygen species (ROS) production by sputum neutrophils and the relationship to neutrophil viability. Identical assessments were made on peripheral blood neutrophils from CF patients. METHODS: ROS production ...
Nilsson M C A - - 2012
BACKGROUND: Inhalation of nitric oxide (INO) exerts both local and distant effects. INO in healthy pigs causes down-regulation of endogenous nitric oxide (NO) production and vasoconstriction in lung regions not reached by INO, especially in hypoxic regions, which augments hypoxic pulmonary vasoconstriction. In contrast, in pigs with endotoxemia-induced lung injury, ...
Sznitman Josué - - 2012
Over the past few decades, our understanding of the fluid mechanics characterizing the pulmonary acinus of the lungs has been fundamentally revisited. In the present paper, we review the current knowledge of acinar convective airflows and their role in determining the fate of inhaled aerosols in the distal regions of ...
Ivanov K P - - 2012
According to some authors, reduction in oxygen level in the lung alveoli results in constriction of afferent vessels, while others observed no vessel constriction. The issue is of principle importance in relation to the lung involvement in body adaptation to hypoxia. Conventional methods are inefficient to solve it, therefore we ...
Cummings Kristin J - - 2012
BACKGROUND: We evaluated the effectiveness of workplace changes to prevent indium lung disease, using 2002-2010 surveillance data collected by an indium-tin oxide production facility. METHODS: We assessed pulmonary function using lower limits of normal. Blood indium concentration and personal air sampling data were used to estimate exposure. RESULTS: Abnormalities were ...
Schmidt Amy E - - 2012
Transfusion-related acute lung injury (TRALI) is a serious condition characterized by respiratory distress, hypoxia, and bilateral pulmonary infiltrates, which occur within 6 hours of transfusion. Several theories have been proposed to explain the underlying pathologic mechanisms of TRALI. Immune-mediated TRALI accounts for over 80% of reported cases and is mediated ...
Teke Hava Üsküdar HÜ Department of Hematology, Anesthesiology, Cardiology, Kayseri Education and Research Hospital, Kocasinan, Kayseri, - - 2014
Transfusion-related acute lung injury (TRALI) is related to the transfusion of blood components. Typically, it is a clinical syndrome, characterized by the sudden onset of dyspnea, hypoxemia and bilateral non-cardiogenic pulmonary edema. A 83-year-old female patient with a history of AML developed TRALI after receiving 6 units of platelets. TRALI symptoms ...
Aksenov Daniil - - 2012
Oxygen tension (PO(2)) was measured in rabbit whisker barrel cortex using oxygen sensitive electrodes to investigate the impact of isoflurane anesthesia on oxygen autoregulation. Responses to 90sec episodes of 100% oxygen inspiration were obtained from rabbits before anesthesia, and then when the animals were anesthetized with 0.5% or 1.5% isoflurane. ...
Arghir Oana C - - 2012
Von Willebrand disease (vWD) is the most common inherited bleeding disorder based on an autosomal abnormality of von Willebrand factor. Transfusion is a lifesaving medical intervention among patients with bleeding disorders. Patients with vWD are exposed to Transfuse Related Acute Lung Injury (TRALI) when they become recipients of multiple blood ...
Bach Katinka P - - 2012
Mechanical ventilation of preterm babies increases survival but can also cause ventilator-induced lung injury (VILI), leading to the development of bronchopulmonary dysplasia (BPD). It is not known whether shear stress injury from gases flowing into the preterm lung during ventilation contributes to VILI. Preterm lambs of 131 days' gestation (term ...
Alijanpour Ebrahim E Department of Anesthesiology and Intensive Care, Babol University of Medical Sciences, Babol, - - 2012
Many of the multiple traumatized patients who refer to the hospital need transfusion. Transfusion-related acute lung injury (TRALI) is a serious clinical syndrome associated with the transfusion of plasma-containing blood components. In the article, we present a case of TRALI following transfusion of packed red blood cells Case Presentation: A ...
Uckert S - - 2011
Although histamine has been suggested to be involved in the control of male sexual function, including the induction of penile erection, its role in the human corpus cavernosum penis is still poorly understood. The aim of our study was to evaluate the course of histamine plasma levels through different stages ...
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