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Abawajy Jemal - - 2014
Blood biochemistry attributes form an important class of tests, routinely collected several times per year for many patients with diabetes. The objective of this study is to investigate the role of blood biochemistry for improving the predictive accuracy of the diagnosis of cardiac autonomic neuropathy (CAN) progression. Blood biochemistry contributes ...
Ortega-Ferrusola C C Laboratory of Equine Reproduction and Spermatology, Veterinary Teaching Hospital, University of Extremadura, Cáceres, - - 2014
Doppler ultrasonography is an important tool in the andrological evaluation in humans; however, this method is not so extensively used by equine andrologists. Spectral or pulse Doppler is a useful non-invasive method for the early diagnosis of subfertility problems in the male, especially those triggered by vascular disturbance. The identification ...
Bourdin C C AP-HP, Groupe hospitalier Pitié-Salpêtrière, Service de Parasitologie Mycologie, F-75013, Paris, - - 2014
PCR detection of Toxoplasma gondii in blood has been suggested as a possibly efficient method for the diagnosis of ocular toxoplasmosis (OT) and furthermore for genotyping the strain involved in the disease. To assess this hypothesis, we performed PCR on 121 peripheral blood samples from 104 patients showing clinical and/or ...
Echavarría-Pinto Mauro M aCardiovascular Institute, Hospital Clínico San Carlos bCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain cAMC Heart Centre, Academic Medical Centre - University of Amsterdam, Amsterdam dThorax Center, Erasmus Medical Center, Rotterdam, the Netherlands eFaculty of Medicine, Complutense University of Madrid, Madrid, - - 2014
The purpose of this study is to summarize cumulative evidence suggesting that the combination of fractional flow reserve (FFR), coronary flow reserve (CFR) and the index of microcirculatory resistance (IMR) might provide a more comprehensive invasive assessment of ischaemic heart disease (IHD). Myocardial flow impairment in IHD results from both ...
Nefzi Faten F Laboratory of Infectious Diseases and Biological Agents, Faculty of Pharmacy, University of Monastir, Monastir, - - 2014
Human herpesvirus-6 (HHV-6) and human cytomegalovirus (HCMV) DNAs were quantified by real-time PCR assays in blood and saliva obtained from 50 patients with acute leukemia at the time of diagnosis (50 of each matrix), aplasia (65 of each matrix), remission (55 of each matrix), and relapse (20 of each matrix) ...
Pfitzer S S Faculty of Veterinary Science, Department of Paraclinical Sciences, University of Pretoria, Onderstepoort 0110, South Africa Faculty of Veterinary Science, Department of Production Animal Studies, University of Pretoria, Onderstepoort 0110, South - - 2014
The electric stunner (e-stunner) is commonly used to handle Nile crocodiles (Crocodylus niloticus) on commercial farms in South Africa, but while it seems to improve handling and safety for the keepers, no information regarding physiological reactions to e-stunning is currently available. The aim of this study was therefore to compare ...
Nayeri Fatemeh F Family Health Institute, Maternal- Fetal & Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran. - - 2014
Hypoglycemia is considered as a serious risk factor in neonates. In the majority of cases, it occurs with no clinical symptoms. Accordingly, early diagnosis is extremely imperative, which can also lead to less morbidity and mortality. The aim of this study was to assess the importance of screening blood glucose ...
Warren Courtney D CD 1Center for Athletic Performance and Physical Therapy, Scottsdale, Arizona 2Louisiana Tech University, Department of Kinesiology 3University of Nevada, Las Vegas, Department of Physical - - 2014
Baseball pitching has been described as an anaerobic activity from a bioenergetics standpoint with short bouts of recovery. Depending on the physical conditioning and muscle fiber composition of the pitcher as well as the number of pitches thrown per inning and per game, there is the possibility of pitchers fatiguing ...
Tang Ya Hui YH Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA, - - 2014
While transient ischemic attack (TIA) is a well-known harbinger of ischemic stroke, the mechanisms that link TIA to subsequent strokes remain poorly understood. The overall aim of this study was to determine whether: 1) brief periods of transient cerebral ischemia render this tissue more vulnerable to thrombus development and 2) ...
Sharir Rinat R Heart Institute, , Kaplan Medical Center, Rehovot , Israel, affiliated to the Hebrew University, Jerusalem, Israel Department of Cardiology, Tel-Aviv Sourasky Medical Center, Tel-Aviv Sackler Faculty of Medicine, Tel Aviv University, Tel - - 2014
Ischemic damage is associated with upregulation of pro-inflammatory cytokines, as well as invasion of leukocytes and lymphocytes to the injured muscle. Regulatory T cells (Tregs) exert suppressive effects on several immune and non-immune cellular elements. We hypothesized that adoptive Treg cell transfer and depletion will influence reestablishment of flow in ...
Silachev Denis N DN A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russian - - 2014
Vascular pathologies pose a significant health problem because of their wide prevalence and high impact on the rate of mortality. Blockade of blood flow in major blood vessels leads to ischaemia associated with oxidative stress, where mitochondria act as a major source of reactive oxygen species (ROS). While low levels ...
Sufianova G Z GZ Department of Pharmacology, Tyumen State Medical Academy, Russian Ministry of Health, Tyumen, - - 2014
The antioxidant effect of an adenosine A1 receptor agonist cyclopentyladenosine was studied on the model of focal cerebral ischemia. Ischemic injury of the brain was accompanied by changes in LPO processes (in the blood and brain tissue) and failure of some factors for antioxidant protection (peroxidase and catalase) that inactivate ...
Plotnikova T M TM Department of Pharmacology, Siberian State Medical University, Tomsk, - - 2014
We studied the effects of novel sterically hindered phenol, 4-methyl-2,6-diisobornyl phenol (dibornol) on the rheological properties of the blood in the model of myocardial ischemia/reperfusion. Dibornol (100 mg/kg intraperitoneally for 3 days before and 5 days after ischemia/reperfusion) decreased blood viscosity by 9-25% in comparison with that in sham-operatedanimals by ...
Cao Jinyi J Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. - - 2014
Combination of Radix Astragali (Huangqi) and Carthamus tinctorius L. (Honghua) has been extensively used as traditional herb medicine in China for the treatment of stroke and myocardial ischemia diseases with Qi deficiency and blood stasis (QDBS) syndrome. To investigate the effect of Huangqi-Honghua combination (HH) and its main components astragaloside ...
Bracko Oliver O Department of Neurology, University Hospital Zurich, Zurich, - - 2014
Tissue tolerance to ischemia can be achieved by noxious stimuli that are below a threshold to cause irreversible damage ('preconditioning'). Understanding the mechanisms underlying preconditioning may lead to the identification of novel therapeutic targets for diseases such as stroke. We here used the oxidative chain inhibitor 3-nitropropionic acid (NPA) to ...
Cetin N N Recep Tayyip Erdogan University, Medical Faculty, Department of Pharmacology, Rize, Turkey. - - 2014
The purpose of this study was to investigate the biochemical, histopathological and immunohistochemical effects of venous blood on ischemia/reperfusion-induced oxidative DNA damage and mutation in rabbit kidneys in comparison to melatonin treatment, which has a known protective effect against ischemia/reperfusion (IR) injury. The rabbits were divided into five groups: renal ...
Li Chong Hui CH Department of Hepatobiliary Surgery, Chinese PLA General Hospital, Chinese PLA Medical College, Beijing, China; Institute of Hepatobiliary Surgery, Chinese PLA General Hospital, Chinese PLA Medical College, Beijing, - - 2014
The recovery of microvascular liver blood flow (LBF) after ischemia is an important determinant of the degree of hepatocellular injury. Laser speckle contrast imaging (LSCI) was recently suggested to be a suitable instrument for monitoring the LBF. This study was designed to evaluate LSCI in monitoring the LBF changes during ...
Jennings Robert B RB Duke University, Durham, NC. Electronic address: - - 2014
The extent and rate at which necrosis develops in experimental acute myocardial infarction in the dog heart is presented together with an analysis of the role played by protective mechanisms in myocyte death. Preconditioning with ischemia delays but does not prevent myocyte death. Arterial collateral flows exceeding 30% of control ...
Zhang Qi Q Department of Rehabilitation, Huashan Hospital, Fudan University, Shanghai, - - 2014
Stroke is an acute cerebrovascular disease with high incidence, morbidity, and mortality. Preischemic treadmill training has been shown to be effective in improving behavioral and neuropathologic indices after cerebral ischemia. However, the exact neuroprotective mechanism of preischemic treadmill training against ischemic injury has not been elucidated clearly. The present study ...
Ma Xu-Dong XD the First Affiliated Hospital?Medical School of Xi'an Jiaotong University, Department of Neurosurgery , Xi'an, 710061 China Email: 747001758@qq.com , 515668506@qq.com , 329328237@qq.com , 397591604@qq.com , - - 2014
Abstract Ischemic postconditioning refers to controlling reperfusion blood flow during reperfusion after ischemia, which can induce an endogenous neuroprotective effect and reduce ischemia-reperfusion injury. Activation of endogenous neuroprotective mechanisms plays a key role in protecting against brain ischemia-reperfusion injury. The mechanisms of cerebral ischemic postconditioning are not completely clear, and ...
Cho Sang-Ho SH Department of Thoracic and Cardiovascular Surgery, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Korea. ; Department of Thoracic and Cardiovascular Surgery, Chungbuk National University College of Medicine, - - 2014
Cold agglutinins are predominately immunoglobulin M autoantibodies that react at cold temperatures with surface antigens on the red blood cell. This can lead to hemagglutination at low temperatures, followed by complement fixation and subsequent hemolysis on rewarming. Development of hemagglutination or hemolysis in patients with cold agglutinins is a risk ...
Ito Umeo U Laboratory for Neurodegenerative Pathology, Department of Sensory and Motor Systems, Tokyo Metropolitan Institute of Medical Science; Division of Neuropathology, Department of Brain Disease Research, Shinshu University School of Medicine, Matsumoto, - - 2014
Previously we found that, after temporary cerebral ischemia, microvasculogenic secondary focal cerebral cortical ischemia occurred, caused by microvascular obstruction due to compression by swollen astrocytic end-feet, resulting in focal infarction. Herein, we examined whether mannitol infusion immediately after restoration of blood flow could protect the cerebral cortex against the development ...
Ma Bo B State Key Laboratory for Bioactive Substances and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P.R. - - 2014
Compound FLZ is a synthetic novel derivate of natural squamosamide, which has potent neuroprotective effects based on our previous study. We are now aiming to investigate the effects of FLZ on cerebral blood flow (CBF), infarct volume, neurological function, heat shock protein 70 (Hsp70), and Hsp27 expression in transient focal ...
Koch Sebastian S Miller School of Medicine, Department of Neurology, University of Miami, Miami, Florida, - - 2014
Ischemic preconditioning is emerging as an innovative and novel cytoprotective strategy to counter ischemic vascular disease. At the root of the preconditioning response is the upregulation of endogenous defense systems to achieve ischemic tolerance. Identifying suitable biomarkers to show that a preconditioning response has been induced remains a translational research ...
Qiao Yujie Y From the Department of Radiology, Division of Neuroradiology (Y.Q., G.Z., M.W.) and Department of Public Health Sciences (J.P., W.X.), University of Virginia, Charlottesville; Department of Radiology (M.W.) and Department of Neurology (P.M., A.E.), Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Military General Hospital of Beijing PLA, Beijing, China (G.Z.); and Department of Neurology, University of Pittsburgh, Pittsburgh, PA - - 2014
This study aims to determine whether perfusion computed tomographic (PCT) thresholds for delineating the ischemic core and penumbra are time dependent or time independent in patients presenting with symptoms of acute stroke. Two hundred seventeen patients were evaluated in a retrospective, multicenter study. Patients were divided into those with either ...
Brenner Michael M Department of Neurobiology and the Civitan International Research Center, Center for Glial Biology in Medicine, Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama. Electronic address: - - 2014
The role of GFAP in CNS injury is reviewed as revealed by studies using GFAP null mice. In order to provide background information for these studies, the effects of absence of GFAP in the uninjured astrocyte is also described. Activities attributable to GFAP include suppressing neuronal proliferation and neurite extension ...
Li Peiying P From the State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Department of Anesthesiology, Huashan Hospital, Fudan University, Shanghai, China (P.L., L.M., X.L., Y. Gao, J.C., X.H.); Center of Cerebrovascular Disease Research (P.L., L.M., Y. Gan, J.Z., J.C., X.H.) and Departments of Surgery and Immunology, Starzl Transplantation Institute (A.W.T.), University of Pittsburgh School of Medicine, PA; Geriatric Research, Educational and Clinical Center, Veterans Affairs Pittsburgh Health Care System, PA (P.L., X.H.); and Cerebrovascular Diseases Research Institute, Xuanwu Hospital of Capital Medical University, Beijing, People's Republic of China - - 2014
Our recent research revealed that adoptively transferred regulatory T cells (Tregs) reduced acute ischemic brain injury by inhibiting neutrophil-derived matrix metalloproteinase-9 (MMP-9) and protecting against blood-brain barrier damage. The mechanisms underlying Treg interactions with neutrophils remain elusive. This study evaluates the contribution of program death 1-ligand 1 (PD-L1) to Treg-mediated ...
Figueira Estela Rr ER Department of Gastroenterology, Laboratory of Medical Investigations LIM37 Discipline of Liver and Gastrointestinal Transplantation, Hospital das Clinicas, University of Sao Paulo, Brazil. - - 2014
Ischemic preconditioning (IPC) has been shown to decrease liver injury and to increase hepatic microvascular perfusion after liver ischemia reperfusion. This study aimed to evaluate the effects of IPC on hemodynamics of the portal venous system. Thirty-two rats were randomized into two groups: IPC group and control group. The rats ...
Tsukada Hideo H Central Research Laboratory, Hamamatsu Photonics K.K., Shizuoka, - - 2014
To assess the capability of (18)F-2-tert-butyl-4-chloro-5-{6-[2-(2-fluoroethoxy)-ethoxy]-pyridin-3-ylmethoxy}-2H-pyridazin-3-one ((18)F-BCPP-EF), a novel positron emission tomography (PET) probe for mitochondrial complex I (MC-I) activity, as a specific marker of ischemia-induced neuronal death without being disturbed by inflammation, translational research was conducted using an animal PET in ischemic brains of Cynomolgus monkeys (Macaca fascicularis). Focal ...
Zhou Yun Y The Center of Neurology and Rehabilitation, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, - - 2014
Ginsenoside Rg1 is regarded as one of main bioactive compounds responsible for pharmaceutical actions of ginseng with little toxicity and has been shown to have possibly neuroprotective effects. However, the mechanism of its neuroprotection for acute ischemic stroke is still elusive. The purpose of present study is thus to assess ...
Abdul-Ghani S S The Bristol Heart Institute, Faculty of Medicine and Dentistry, University of Bristol, - - 2014
Brief ischaemia of one organ protects the heart against a sustained ischaemia-reperfusion insult (Remote ischaemic preconditioning, RIPC). The nature of the signal released from the remote organ and the timing of the triggered changes in the target organs remain controversial. It is not known whether RIPC also alters blood flow ...
Liu Fudong F Department of Neuroscience, University of Connecticut Health Center, Farmington, CT, - - 2014
Transient middle cerebral artery occlusion (tMCAO) in rodents is one of the most widely utilized models in experimental stroke studies on focal cerebral ischemia. tMCAO can be modeled in different ways, all aimed at mimicking the clinical scenario of early reperfusion after an ischemic infarct. Some models utilize mechanical occlusion ...
Jiang Zheng Z Department of Cellular Biology & Anatomy, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana, United States of - - 2014
The role of nitric oxide synthases (NOSs) in early blood-brain barrier (BBB) disruption was determined using a new mouse model of transient focal cerebral ischemia. Ischemia was induced by ligating the middle cerebral artery (MCA) at its M2 segment and reperfusion was induced by releasing the ligation. The diameter alteration ...
Seiyama Akitoshi A Division of Medical Devices for Diagnoses, Human Health Sciences, Graduate School of Medicine, Kyoto University, 53 Shogoin, Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan, - - 2014
Three experiments were conducted for the present study. First, to elucidate the mechanism and functional significance underlying ischemic vasoconstriction, we investigated the relationship between arteriolar constriction and tissue energy metabolism during bilateral common carotid artery occlusion in gerbils. Second, to identify differences in the postischemic recovery of physiologic parameters between ...
Mirzoyan Ruben S RS Zakusov Institute of Pharmacology RAMS, 8 Baltiyskaya Street, Moscow 125315, - - 2014
Objectives. The influence of 5-hydroxyadamantane-2-on was studied on the rats' brain blood flow and on morphological state of brain tissue under the condition of brain ischemia. The interaction of the substance with NMDA receptors was also studied. Methods. Study has been implemented using the methods of local blood flow registration ...
Masoumy Mohamad M Department of Surgery, Georgia Regents University, Augusta, Georgia, United States of - - 2014
Ischemia-Reperfusion (IR) injury of limb remains a significant clinical problem causing secondary complications and restricting clinical recovery, despite rapid restoration of blood flow and successful surgery. In an attempt to further improve post ischemic tissue repair, we investigated the effect of a local administration of bone marrow derived stem cells ...
Kawamura Kunio K Department of Neurology, Brain Research Institute, Niigata University, Niigata, - - 2014
An angiogenesis factor, angiopoietin-1 (Ang1), is associated with the blood-brain barrier (BBB) disruption after focal cerebral ischemia. However, whether hemorrhagic transformation and cerebral edema after tissue plasminogen activator (tPA) treatment are related to the decrease in Ang1 expression in the BBB remains unknown. We hypothesized that administering Ang1 might attenuate ...
Bridts Chris H CH Department of Immunology and Allergology, University of Antwerp, Campus Drie Eiken, D.T.596, Universiteitsplein 1, 2610, Wilrijk, - - 2014
The basis of flow cytometric allergy diagnosis is quantification of changes in expression of basophilic surface membrane markers (Ebo et al., Clin Exp Allergy 34: 332-339, 2004). Upon encountering specific allergens recognized by surface receptor FcεRI-bound IgE, basophils not only secrete and generate quantifiable bioactive mediators but also up-regulate the ...
Panou Vasiliki V Department of Respiratory Diseases, Aalborg University Hospital, Mølleparkvej 4, 9000 Aalborg, - - 2014
Hemoglobin Aalborg is a moderately unstable hemoglobin variant with no affiliation to serious hematological abnormality or major clinical symptoms under normal circumstances. Our index person was a healthy woman of 58, not previously diagnosed with hemoglobinopathy Aalborg, who developed acute respiratory failure after a routine cholecystectomy. Initially she was suspected ...
Bere Zsófia Z Department of Medical Physics and Informatics, Faculty of Medicine, University of Szeged, H-6720 Szeged, Korányi fasor 9, Hungary; Department of Physiology, Faculty of Medicine, University of Szeged, H-6720 Szeged, Dóm tér 10, Hungary. Electronic address: - - 2013
Spontaneous depolarizations around the core are a consistent feature of focal cerebral ischemia, but the associated regional hemodynamic changes are heterogeneous. We determined how the features of depolarizations relate to subsequent cerebral blood flow (CBF) changes in global forebrain ischemia. Forebrain ischemia was produced in halothane-anesthetized rats (n=13) by common ...
Jackman Katherine K Brain and Mind Research Institute, Departments of Radiology and Microbiology and Immunology, Weill Cornell Medical College, New York, New York - - 2013
Loss-of-function mutations of progranulin (PGRN) have been linked to frontotemporal dementia, but little is known about the effects of PGRN deficiency on the brain in health and disease. PGRN has been implicated in neurovascular development, inflammation, and Wnt signaling, a pathway involved in the formation of the blood-brain barrier (BBB). ...
Bouts Mark J R J - - 2013
Vascular occlusion sites largely determine the pattern of cerebral tissue damage and likelihood of subsequent reperfusion after acute ischemic stroke. We aimed to elucidate relationships between flow obstruction in segments of the internal carotid artery (ICA) and middle cerebral artery (MCA), and (1) profiles of acute ischemic lesions and (2) ...
Chen Yuanxin Y Weill Cornell Medical College, Houston Methodist Research Institute, \Systems Medicine and Bioengineering Department, TT and WF Chao Center for BRAIN, Houston, Texas - - 2013
Decreased cerebral blood flow causes brain ischemia and plays an important role in the pathophysiology of many neurodegenerative diseases, including Alzheimer's disease and vascular dementia. In this study, we photomodulated astrocytes in the live animal by a combination of two-photon calcium uncaging in the astrocyte endfoot and in vivo imaging ...
Carnevale Matías E - - 2013
The aim of this work was to compare the efficiency of cold storage (CS) and hypothermic machine perfusion (HMP) methods of preserving grafts excised from non-heart-beating donors that had suffered 45 minutes of warm ischemia. We developed a new solution for HMP to use in liver transplantation, based on BES, ...
Li Peiying - - 2013
Cerebral ischemia has been shown to result in peripheral inflammatory responses followed by long-lasting immunosuppression. Our recent study demonstrated that intravenous delivery of regulatory T cells (Tregs) markedly protected against transient cerebral ischemia by suppressing neutrophil-derived matrix metallopeptidase 9 production in the periphery. However, the effect of Tregs on systemic ...
Kuntz Mélanie - - 2013
The disappointing clinical outcomes of neuroprotectants challenge the relevance of preclinical stroke models and data in defining early cerebrovascular events as potential therapeutic targets. The kinetics of blood-brain barrier (BBB) leakage after reperfusion and the link with parenchymal lesion remain debated. By using in vivo and in vitro approaches, we ...
Grosche Astrid - - 2013
Objective-To determine the effect of large colon ischemia and reperfusion on concentrations of the inflammatory neutrophilic protein calprotectin and other clinicopathologic variables in jugular and colonic venous blood in horses. Animals-6 healthy horses. Procedures-Horses were anesthetized, and ischemia was induced for 1 hour followed by 4 hours of reperfusion in ...
Xue Zhang - - 2013
Ischemic tolerance exists in many organs, among which the cerebral ischemic tolerance and its potential clinical applications are most notable.The discovery of new triggers of cerebral ischemic tolerance has brought more interesting insights into the molecular mechanisms.The remote ischemic preconditioning and pharmacological induction of cerebral ischemic tolerance have shown promising ...
Xin Nian - - 2013
Dragon's blood is a bright red resin obtained from Dracaena cochinchinensis (Lour.) S.C.Chen (Yunnan, China). As a traditional Chinese medicinal herb, it has great traditional medicinal value and is used for wound healing and to stop bleeding. Its main biological activity comes from phenolic compounds. In this study, phenolic compounds ...
Sumi Makoto - - 2013
Dietary flavonoid intake shows a significant inverse association with mortality from coronary heart disease, incidence of myocardial infarction and stroke. Quercetin is one of the most common flavonoids in our diet and has a several favorable biological activities. Quercetin glucosides, which are enzymatically trans-glycosylated isoquercitrin, have high water-solubility and bioavailability ...
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