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Castellaro Marco M Department of Information Engineering, University of Padova, Padova, - - 2014
QUASAR arterial spin labeling (ASL) permits the application of deconvolution approaches for the absolute quantification of cerebral perfusion. Currently, oscillation index regularized singular value decomposition (oSVD) combined with edge-detection (ED) is the most commonly used method. Its major drawbacks are nonphysiological oscillations in the impulse response function and underestimation of ...
Sikka Gautam G Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD - - 2014
Melanopsin (opsin4; Opn4), a non-image-forming opsin, has been linked to a number of behavioral responses to light, including circadian photo-entrainment, light suppression of activity in nocturnal animals, and alertness in diurnal animals. We report a physiological role for Opn4 in regulating blood vessel function, particularly in the context of photorelaxation. ...
Crecelius Anne R AR 1Department Health and Sport Science, University of Dayton, Dayton, OH 2Digital Sport Science Laboratory, Nike Inc., Beaverton, OR 3Departments of Health and Exercise Science and 4Biomedical Sciences, Colorado State University, Fort Collins, - - 2014
Regulation of vascular tone is a complex response that integrates multiple signals which allow for blood flow and oxygen supply to appropriately match oxygen demand. Here, we discuss the potential role of intravascular ATP as a primary factor in these responses and put forth the hypothesis that deficient ATP release ...
Liu Jianxiong J Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee, - - 2014
Cerebral blood flow dysregulation caused by oxidative stress contributes to adverse neurologic outcome of seizures. A carbon monoxide (CO) donor CORM-A1 has antioxidant and cytoprotective properties. We investigated whether enteral supplements of CORM-A1 can improve cerebrovascular outcome of bicuculline-induced seizures in newborn piglets. CORM-A1 (2 mg/kg) was given to piglets via ...
Atry Farid - - 2014
In this article Spectral Domain Optical Coherence Tomography is used to measure the hemodynamic response induced by optogenetic stimulation in the somatosensory cortex of transgenic mice. By analyzing the 3D angiograms and Doppler measurements produced by coherence tomography, we observed significant increase in blood flow as a result of increased ...
Hurr Chansol C Environmental and Autonomic Physiology Laboratory, Department of Kinesiology and Health Education, The University of Texas at - - 2014
African Americans (AA) have increased risk for cardiovascular, cerebral vascular, and metabolic disease including hypertension, stroke, coronary artery disease, metabolic syndrome, and type II diabetes relative to Caucasian Americans (CA). While it is accepted that endothelial function is impaired in AA; less is known regarding their cerebral vasodilatory capacity to ...
Maia Alex Sandro Campos AS Animal Science Department, UNESP-Universidade Estadual Paulista, Prof. Paulo Donato Castellane Route, 14884-900, Jaboticabal, São Paulo State, Brazil, - - 2014
Notwithstanding the solar radiation is recognized as a detrimental factor to the thermal balance and responses of animals on the range in tropical conditions, studies on the amount of thermal radiation absorbed by goats therein associated with data on their production and heat exchange are still lacking. Metabolic heat production ...
Han Sangbin S Department of Anesthesiology and Pain Medicine, Sungkyunkwan University School of Medicine, Seoul, - - 2014
The occurrence of glycemic disturbances have been described in patients undergoing intermittent hepatic inflow occlusion (IHIO) for tumor removal. However, the glycemic responses to IHIO in living liver donors are unknown. In the present study, we investigated the glycemic response to IHIO in these patients and examined the association between ...
Griffeth Valerie E M VE Department of Bioengineering and Medical Scientist Training Program, University of California San Diego, La Jolla, CA, USA; Center for Functional Magnetic Resonance Imaging, Department of Radiology, University of California San Diego, La Jolla, CA, - - 2014
Quantitative functional MRI (fMRI) experiments to measure blood flow and oxygen metabolism coupling in the brain typically rely on simple repetitive stimuli. Here we compared such stimuli with a more naturalistic stimulus. Previous work in primary visual cortex showed that direct attentional modulation evokes a blood flow (CBF) response with ...
Oteri Giacomo G University of Messina, Department of Dentistry, messina, Italy ; - - 2014
Background: Soft tissue regeneration and remodeling is fundamental in periodontal surgery, thus we investigated the angiogenic response elicited in subcutaneous tissue of rats by a proprietary polyethylene glycol hydrogel formulation (PEG) alone, or conjugated with specific amelogenins (EMD) or Nanobioglass particles (NBG). Methods: Discs with three different formulations (PEG, PEG-EMD, ...
Heffernan Matthew J MJ Pennsylvania State University College of Medicine, Penn State Hershey Heart and Vascular Institute, Hershey, - - 2014
Voluntary apnea activates the central and peripheral chemoreceptors, leading to a rise in sympathetic nerve activity and limb vasoconstriction (i.e., brachial blood flow velocity and forearm cutaneous vascular conductance decrease to a similar extent). Whether peripheral and/or central chemoreceptors contribute to the cutaneous vasoconstrictor response remains unknown. We performed three ...
Palkovits Stefan S Department of Clinical Pharmacology, Medical University of Vienna, Vienna, - - 2014
In the retina, blood flow and neural activity are tightly coupled. Stimulation of the retina with flickering light is accompanied by an increase in blood flow. The current study seeks to investigate whether an increase in oxygen tension modulates flicker (FL)-induced vasodilatation in the human retina. A total of 52 ...
Siero Jeroen C W JC Department of Radiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, Netherlands. Electronic address: - - 2014
Blood-oxygenation-level-dependent (BOLD) MRI is widely used for inferring neuronal activation and is becoming increasingly popular for assessing cerebrovascular reactivity (CVR) when combined with a vasoactive stimulus. The BOLD signal contains changes in cerebral blood flow (CBF) and thus information regarding neurovascular coupling and CVR. The BOLD signal, however, is also ...
Badjatia Neeraj N R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD, USA, - - 2014
The metabolic response to injury is well described; however, very little is understood about optimal markers to measure this response. This summary will address the current evidence about monitoring nutritional status including blood glucose after acute brain injury (ABI). An electronic literature search was conducted for English language articles describing ...
Trahair Laurence G LG Discipline of Medicine, The University of Adelaide, Adelaide, S Australia, - - 2014
Context: Studies relating to the cardiovascular effects of glucagon-like peptide-1 (GLP-1) and its agonists, which slow gastric emptying, have not discriminated between fasting and postprandial, blood pressure (BP) and heart rate (HR). Objective: To determine whether exogenous GLP-1 modulates the effects of an intraduodenal (ID) glucose infusion on BP, HR ...
Jackson Nathan - - 2014
Smart hydrogels for biomedical applications are highly researched materials. However, integrating them into a device for implantation is difficult. This paper investigates an integrated delivery device designed to deliver an electro-responsive hydrogel to a target location inside a blood vessel with the purpose of creating an occlusion. The paper describes ...
Pan Yingtian Y Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794, USA. Electronic address: - - 2014
Despite widespread applications of multiphoton microscopy in microcirculation, its small field of view and inability to instantaneously quantify cerebral blood flow velocity (CBFv) in vascular networks limit its utility in investigating the heterogeneous responses to brain stimulations. Optical Doppler tomography (ODT) provides 3D images of CBFv networks, but it suffers ...
Canalis A M - - 2014
Argentinian native plants Aspidosperma quebracho-blanco, Lantana grisebachii and Ilex paraguariensis are known to have antiinflammatory and antioxidant properties. We demonstrated it in vivo by the redox changes in murine hemolymphatic tissues after infusive extract intake of these plants as revealed in organic trophism, tissue phenolics, hydroperoxides, superoxide, nitrites and gamma-glutamyltranspeptidase ...
Pakpour Nazzy N Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, California, - - 2014
During the process of blood feeding insect vectors are exposed to an array of vertebrate-derived blood factors ranging from byproducts of blood meal digestion to naturally occurring products in the blood including growth hormones, cytokines and factors derived from blood-borne pathogens themselves. In this review, we examine the ability of ...
Regan Rosemary E RE Department of Physiology, University of Toronto Toronto, ON, M5S 1A8, - - 2014
Cerebrovascular reactivity (CVR), measures the ability of the cerebrovasculature to respond to vasoactive stimuli such as CO2. CVR is often expressed as the ratio of cerebral blood flow change to CO2 change. We examine several factors affecting this measurement: blood pressure, stimulus pattern, response analysis and subject position. Step and ...
Montoro Casandra I - - 2014
Objective: There is ample evidence for cognitive deficits in fibromyalgia syndrome (FMS). The present study investigated cerebral blood flow responses during arithmetic processing in FMS patients and its relationship with performance. The influence of clinical factors on performance and blood flow responses were also analyzed. Method: Forty-five FMS patients and ...
Hinzman Jason M JM 1 Department of Neurosurgery, University of Cincinnati (UC), Neurotrauma Centre at UC Neuroscience Institute, UC College of Medicine, and Mayfield Clinic, Cincinnati, OH, USA - - 2014
Cortical spreading depolarization causes a breakdown of electrochemical gradients following acute brain injury, and also elicits dynamic changes in regional cerebral blood flow that range from physiological neurovascular coupling (hyperaemia) to pathological inverse coupling (hypoperfusion). In this study, we determined whether pathological inverse neurovascular coupling occurred as a mechanism of ...
Kellner Patrick P Department of Anesthesiology and Critical Care Medicine, Halle-Wittenberg University, - - 2014
In order to examine the immunomodulatory effects of antithrombin III (AT-III) and C1 esterase inhibitor (C1-INH) in human monocytes, we investigated the intracellular expression of interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)-α in an ex-vivo laboratory study in a whole blood setting. Heparinized whole blood samples from 23 healthy ...
Wasik Agata M - - 2014
Abstract The differential diagnosis between mantle cell lymphoma (MCL) and B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (B-CLL/SLL) is essential since MCL usually has a more aggressive clinical course. By flow cytometry both MCL and B-CLL are CD19, CD20 and usually CD5 positive. However ambiguities in other immune phenotypic markers of ...
Bhowmik Arka A School of Mechanical, Materials and Energy Engineering, Indian Institute of Technology Ropar, Rupnagar, Punjab 140001, - - 2014
A theoretical study on vascularized skin model to predict the thermal evaluation criteria of early melanoma using the dynamic thermal imaging technique is presented in this article. Thermographic evaluation of melanoma has been carried out during the thermal recovery of skin from undercooled condition. During thermal recovery, the skin has ...
Bazigou Eleni E Department of Bioengineering, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK. Electronic address: - - 2014
Fluid homeostasis in vertebrates critically relies on the lymphatic system forming a hierarchical network of lymphatic capillaries and collecting lymphatics, for the efficient drainage and transport of extravasated fluid back to the cardiovascular system. Blind-ended lymphatic capillaries employ specialized junctions and anchoring filaments to encourage a unidirectional flow of the ...
Memon Muhammad Qasim - - 2014
To assess how acute consumption of fructose affects flow-mediated dilatation in brachial artery. The randomised cross-over study was conducted at the University of Nottingham's Medical School, Nottingham, United Kingdom in July 2009. Ten healthy, white European males visited the laboratory twice, on separate mornings. On each visit, the volunteers consumed ...
Kalani Anuradha A Department of Physiology and Biophysics, School of Medicine, University of Louisville, Louisville, Kentucky, - - 2014
Although blood-brain barrier (BBB) integrity is maintained by the cross-talk of endothelial cells, junction proteins, and neurogliovascular network, the epigenetic mechanisms behind BBB permeability are largely unknown. We are reporting for the first time miR29b-mediated regulation of BBB, which is a novel mechanism underlying BBB integrity. We hypothesize that miR29b ...
Quick Christopher M CM Texas A&M - - 2014
Lymph flow is the primary mechanism for returning interstitial fluid to the blood circulation. Currently, the adaptive response of lymphatic vessels to mesenteric venous hypertension is not known. This study sought to determine the functional responses of post-nodal mesenteric lymphatic vessels. We surgically occluded bovine mesenteric veins to create mesenteric ...
Fromm Jonathan R JR University of Washington Medical Center, Box 357110, 1959 NE Pacific St, Seattle, WA 98195; e-mail: - - 2014
Objectives: We have recently demonstrated that classical Hodgkin lymphoma (CHL) can be immunophenotyped by flow cytometry (FC), thus obviating the need for immunohistochemistry in many cases. The previously described nine-color assay, however, cannot be used by laboratories that do not have access to a nine- or ten-color flow cytometer. Therefore, ...
Lu Xiaoguang - - 2014
Dai Huang Fu Zi Tang(DHFZT),an oriental herbal formula, has long been used clinically in treatment of intestinal obstruction,acute pancreatitis,cholecystalgia and chronic diarrhea for thousands of years. Recent studies have demonstrated that DHFZT can reduce intestinal pathological injury and the concentration of enterogenous endotoxin in an animal model. But the underlying ...
Datar Sanjeev A SA Department of Pediatrics, University of California, San Francisco, - - 2014
We have previously shown decreased pulmonary lymph flow in our lamb model of chronically increased pulmonary blood flow, created by the in utero placement of an 8-mm aortopulmonary shunt. The purpose of this study was to test the hypothesis that abnormal lymphatic function in shunt lambs is due to impaired ...
Marino Daniela D Tissue Biology Research Unit, Department of Surgery, University Children's Hospital Zurich, August Forel-Strasse 7, 8008 Zurich, - - 2014
The first bioengineered, autologous, dermo-epidermal skin grafts are presently undergoing clinical trials; hence, it is reasonable to envisage the next clinical step at the forefront of plastic and burn surgery, which is the generation of autologous skin grafts that contain vascular plexuses, preformed in vitro. As the importance of the ...
Rahbar Elaheh E Center for Translational Injury Research, Department of Surgery, University of Texas Health Science Center, Houston, TX, 77030, - - 2014
To assess lymphatic flow adaptations to edema, we evaluated lymph transport function in rat mesenteric lymphatics under normal and increased fluid volume (edemagenic) conditions in situ. Twelve rats were infused with saline (intravenous infusion, 0.2 ml/min/100g body weight) to induce edema. We intravitally measured mesenteric lymphatic diameter and contraction frequency, ...
Gauvrit Sébastien - - 2014
Dicer is an RNase III enzyme that cleaves double stranded RNA and generates functional interfering RNAs that act as important regulators of gene and protein expression. Dicer plays an essential role during mouse development because the deletion of the dicer gene leads to embryonic death. In addition, dicer-dependent interfering RNAs ...
Wang Yingdi Y Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, 300 George St, New Haven, CT 06520, - - 2014
The role of blood flow in regulating signaling pathways and gene expression in the blood vasculature is well known. Recent studies have identified equally important roles of flow-mediated signaling in the lymphatic circulation including control of lymphatic vascular growth, remodeling, regeneration and maintenance of the lymphatic fate. In this review, ...
Macey Paul M PM UCLA School of Nursing, University of California Los Angeles, Los Angeles, California, United States of America; Brain Research Institute, University of California Los Angeles, Los Angeles, California, United States of - - 2014
Obstructive sleep apnea (OSA) is accompanied by brain injury, perhaps resulting from apnea-related hypoxia or periods of impaired cerebral perfusion. Perfusion changes can be determined indirectly by evaluation of cerebral blood volume and oxygenation alterations, which can be measured rapidly and non-invasively with the global blood oxygen level dependent (BOLD) ...
Burgess Keith R KR Peninsula Sleep Laboratory, Sydney, New South Wales, - - 2014
To further our understanding of central sleep apnea (CSA) at high altitude during acclimatization, we tested the hypothesis that pharmacologically altering cerebral blood flow (CBF) would alter the severity of CSA at high altitude. The study was a randomized, placebo-controlled single-blind study. A field study at 5,050 m in Nepal. ...
Bougamont M M Scott Polar Research Institute, Department of Geography, University of Cambridge, Cambridge CB2 1ER, - - 2014
The dynamic response of the Greenland Ice Sheet (GrIS) depends on feedbacks between surface meltwater delivery to the subglacial environment and ice flow. Recent work has highlighted an important role of hydrological processes in regulating the ice flow, but models have so far overlooked the mechanical effect of soft basal ...
Kellner Elias E Department of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg, - - 2014
Evaluation of blood supply of different organs relies on labeling blood with a suitable tracer. The tracer kinetics is linear: Tracer concentration at an observation site is a linear response to an input somewhere upstream the arterial flow. The corresponding impulse response functions are currently treated empirically without incorporating the ...
Chacón Max M Departamento de Ingeniería Informática, Universidad de Santiago de Chile, Santiago, - - 2014
The classic dynamic autoregulatory index (ARI), proposed by Aaslid and Tiecks, is one of the most widely used methods to assess the efficiency of dynamic cerebral autoregulation. Although this index is often used in clinical research and is also included in some commercial equipment, it exhibits considerable intra-subject variability, and ...
Zhikun G - - 2013
We investigated the distribution and relationship between draining lymphatic vessels, lymphatic capillaries, and microvascular blood vessels in rabbit ventricular tissue. The left and right ventricular tissue from 15 healthy adult rabbits was obtained, processed, and sectioned for analysis. 5'-nucleotidase-alkaline phosphatase (5'-Nase-Alpase) double staining was first used to identify lymphatic and ...
Haldorsen I S - - 2013
Background:We aimed to study the angiogenic profile based on histomorphological markers in endometrial carcinomas in relation to imaging parameters obtained from preoperative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted imaging (DWI) and to explore the potential value of these markers to identify patients with poor outcome.Methods:In fifty-four surgically staged ...
Minuti A - - 2013
The aim of the study was to assess the small intestine permeability by using lactulose as a sugar probe and blood metabolites in sheep after a challenge with repeated indomethacin injections. According to a change-over design, 7 adult sheep (4 males, 3 females) were subjected to 4 intramuscular injections (every ...
Aki Ryoichi - - 2013
Lymph nodes are often the first target of metastatic cancer which can then remetastasize to distant organs. The progression of lymph node metastasis is dependent on sufficient blood supply provided by angiogenesis. In the present study, we have developed a color-coded imaging model to visualize angiogenesis of lymph nodes metastasis ...
Meier Thomas O - - 2013
Introduction: Morphological abnormalities of microvessels are described in psoriasis. However, there are conflicting data as to whether their function is also altered. Objective: Our aim was to study the morphology and function of the lymphatic capillaries of psoriatic skin. Methods: Morphology and permeability of initial lymphatics were studied by microlymphography ...
On Ngoc H - - 2013
The present study characterizes the effects of lysophosphatidic acid (LPA) on blood-brain barrier (BBB) permeability focusing specifically on the time of onset, duration, and magnitude of LPA-induced changes in cerebrovascular permeability in the mouse using both magnetic resonance imaging (MRI) and near infrared fluorescence imaging (NIFR). Furthermore, potential application of ...
Wang Jing - - 2013
Carbon nanotubes (CNTs) find their extensive application as a promising material in medicine due to unique characteristics. However, such materials have been accompanied with potentially hazardous effects on human health. The toxicity of CNTs may vary depending on their structural characteristics, surface properties and chemical composition. To gain insight into ...
Lebau Olaf - - 2013
The removal of middle molecules during continuous extracorporeal detoxification therapies is a scientific field of increasing attention. However, it is difficult to find suitable and inexpensive markers and methods regarding the in vitro clearance of molecules in a weight range between 10 and 20 kDa. We present an easy and ...
Rane Swati - - 2013
Purpose:To extend a commonly used noninvasive arterial spin labeling magnetic resonance (MR) imaging method for measuring blood flow to evaluate lymphatic flow.Materials and Methods:All volunteers (n = 12) provided informed consent in accordance with institutional review board and HIPAA regulations. Quantitative relaxation time (T1 and T2) measurements were made in ...
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