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Sidtis John J JJ Nathan Kline Institute, Geriatrics , Brain and Behavior Laboratory , 140 Old Orangeburg Road , Building 35 , Orangeburg, New York, United States, 10962 , 845 398 5577 , 845 398 5575 , NYU Langone School of Medicine, Psychiatry, New York, United States ; - - 2014
Vowels provide the acoustic foundation of communication through speech and song, but little is known about how the brain orchestrates their production. Positron emission tomography was used to study regional cerebral blood flow during sustained production of the vowel /a/. Acoustic and blood flow data from 13, normal, right-handed, native ...
Pichler M M University Clinic for Ruminants, Clinical Unit for Herd Health Management in Ruminants, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, 1210 Vienna, - - 2014
The objective of this study was to evaluate the suitability of the electronic handheld devices FreeStyle Precision (FSP; Abbott Germany, Wiesbaden, Germany) and GlucoMen LX Plus (GML; A. Menarini GmbH, Vienna, Austria) for the measurement of β-hydroxybutyrate (BHBA) in whole blood in dairy goats. Additionally, glucose concentration was analyzed with ...
Grover Aditya A Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, 12901 Bruce B. Downs Blvd. MDC 30, Tampa, Florida, 33612-4749, - - 2014
Gliomas are some of the most aggressive types of cancers but the blood-brain barrier acts as an obstacle to therapeutic intervention in brain-related diseases. The blood-brain barrier blocks the permeation of potentially toxic compounds into neural tissue through the interactions of brain endothelial cells with glial cells (astrocytes and pericytes) ...
Yamada Shigeki S From the *Department of Neurosurgery and Stroke Center, Rakuwakai Otowa Hospital, Kyoto; †Interfaculty Initiative in Information Studies/Institute of Industrial Science, The University of Tokyo, Tokyo; and ‡Department of Neurosurgery, Hamamatsu Rosai Hospital, Shizuoka, - - 2014
The aim of this study was to establish the novel automatic method to quantify blood flow volumes of the major intracranial arteries by using SPECT. We created the vascular templates to cover the territory supplied by the major intracranial arteries. Each blood flow volume was calculated as the regional cerebral ...
Li Hongmei - - 2014
Accumulation and deposition of beta-amyloid peptides (Abeta) in the brain is a central event in the pathogenesis of Alzheimer's disease (AD). Besides the parenchymal pathology, Abeta is known to undergo active transport across the blood-brain barrier and cerebral amyloid angiopathy (CAA) is a prominent feature in the majority of AD. ...
Penn David L DL Department of Neurological Surgery, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, AB-136, Boston, MA 02115, USA. Electronic address: - - 2014
Aneurysmal subarachnoid haemorrhage is a cerebrovascular disease associated with an overall mortality as high as 50%. Delayed ischaemic neurologic deficits are a major contributor to this statistic, as well as the significant morbidity associated with the disease. Studies examining the pathophysiologic events causing these devastating changes in cerebral blood flow ...
Watabe Tadashi T Department of Molecular Imaging in Medicine, Osaka University Graduate School of Medicine, Suita, Japan, - - 2014
Paradoxical reduction of cerebral blood flow (CBF) after administration of the vasodilator acetazolamide is the most severe stage of cerebrovascular reactivity failure and is often associated with an increased oxygen extraction fraction (OEF). In this study, we aimed to reveal the mechanism underlying this phenomenon by focusing on the ratio ...
Watabe Tadashi T Department of Molecular Imaging in Medicine, Osaka University Graduate School of Medicine, Suita, Japan, - - 2014
Local cerebral perfusion pressure (CPP) is a primary factor controlling cerebral circulation and previous studies have indicated that the ratio of cerebral blood flow (CBF) to cerebral blood volume (CBV) can be used as an index of the local CPP. In this study, we investigated whether the CBF/CBV ratio differs ...
Brina O O From the Interventional Neuroradiology Unit (O. Brina, R.O., P. Bouillot, K.-O.L., V.M.P.), Service of Neuroradiology, and Service of Neurosurgery (P. Bijlenga, K.S.), University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland; Medisys Research Laboratory (O. Bonnefous) and Interventional X-Ray (F.v.N., T.G., D.R.), Philips Healthcare, Zürich, Switzerland; and Division of Neuroradiology (V.M.P.), Department of Medical Imaging, and Division of Neurosurgery (V.M.P.), Department of Surgery, Toronto Western Hospital, University Health Network, Toronto, Ontario, - - 2014
Digital subtraction angiography is the gold standard vascular imaging and it is used for all endovascular treatment of intracranial anerysms. Optical flow imaging has been described as a potential method to evaluate cerebral hemodynamics through DSA. In this study, we aimed to compare the flow patterns measured during angiography, by ...
Friess Stuart H SH Washington University School of Medicine, Pediatrics , Campus Box 8028, 5th FL MPRB , 660 S. Euclid Avenue , St. Louis, Missouri, United States , 63110 , 314-286-2799 , 314-286-2894 ; - - 2014
Low cerebral blood flow (CBF) states have been demonstrated in children early after TBI and have been correlated with poorer outcomes. Cerebral perfusion pressure support following severe traumatic brain injury (TBI) is commonly implemented to correct cerebral hypoperfusion but the efficacy of various vasopressors has not been determined. Sixteen four ...
Orakcioglu Berk B Department of Neurosurgery, Ruprecht-Karls-University, Heidelberg, Germany, - - 2014
Changes in the perihemorrhagic zone (PHZ) of intracerebral hemorrhage (ICH) are variable. Different mechanisms contribute to secondary neuronal injury after ICH. This multimodal monitoring study investigated early changes in the PHZ of ICH. Twenty-four swine were anesthetized, ventilated, and underwent monitoring of vital parameters. Next to an intracranial pressure-probe (ICP), ...
Ostergaard Leif L 1] Department of Neuroradiology, Aarhus University Hospital, Aarhus, Denmark [2] Center of Functionally Integrative Neuroscience and MINDLab, Aarhus University, Aarhus, - - 2014
Most patients who die after traumatic brain injury (TBI) show evidence of ischemic brain damage. Nevertheless, it has proven difficult to demonstrate cerebral ischemia in TBI patients. After TBI, both global and localized changes in cerebral blood flow (CBF) are observed, depending on the extent of diffuse brain swelling and ...
Fridley Jared J Baylor College of Medicine, Neurosurgery , 1709 Dryden, Suite 750 , Houston, Texas, United States , 77030 , 713-798-4696 , -798-8063 ; - - 2014
The goal of this study was to examine cortical cerebral blood flow (CBF) in patients with traumatic brain injury (TBI), and determine whether lobar cortical CBF is a better predictor of long-term neurological outcome assessed by Glasgow outcome scale (GOS) than global cortical CBF. Ninety-eight patients with TBI had a ...
Stokum Jesse A JA Department of Neurosurgery, University of Maryland School of Medicine, 22 S. Greene St., Suite S12D, Baltimore, MD, 21201-1595, - - 2014
Cerebral edema formation stems from disruption of blood brain barrier (BBB) integrity and occurs after injury to the CNS. Due to the restrictive skull, relatively small increases in brain volume can translate into impaired tissue perfusion and brain herniation. In excess, cerebral edema can be gravely harmful. Astrocytes are key ...
Ivanov A A Neurosurgery, UIC/Chicago, Chicago, IL, - - 2014
The use of digital subtraction angiography (DSA) for semi-quantitative cerebral blood flow (CBF) assessment is a new method. In this report we sought to correlate angiographic transit times (TT) in patients with aneurysmal subarachnoid haemorrhage (aSAH) in relation to Hunt &Hess (H&H) grade. A cohort of 28 patients with aSAH ...
Hodkinson Duncan J DJ Department of Neuroimaging Sciences, Institute of Psychiatry, King's College London, London, - - 2014
Diurnal rhythms have been observed in human behaviors as diverse as sleep, olfaction, and learning. Despite its potential impact, time of day is rarely considered when brain responses are studied by neuroimaging techniques. To address this issue, we explicitly examined the effects of circadian and homeostatic regulation on functional connectivity ...
Donahue Manus J MJ From the Departments of Radiology (M.J.D., L.M.D., C.C.F., A.D., J.C., M.K.S.), Neurology (M.J.D., L.C.J., P.C., A.O., D.R., L.H., H.K.), Psychiatry (M.J.D.), Physics (M.J.D.), and Neurosurgery (J.M., J.C., M.K.S.) and Center for Quantitative Sciences (Y.S.), Vanderbilt University, Nashville, TN; and Department of Neurosurgery, Geisel School of Medicine, Dartmouth College, Lebanon, NH (R.S.); - - 2014
A promising method for identifying hemodynamic impairment that may serve as a biomarker for stroke risk in patients with intracranial stenosis is cerebrovascular reactivity (CVR) mapping using noninvasive MRI. Here, abilities to measure CVR safely in the clinic using hypercarbic hyperoxic (carbogen) gas challenges, which increase oxygen delivery to tissue, ...
Rasmussen Rune - - 2014
One of the main causes of mortality and morbidity following subarachnoid hemorrhage (SAH) is the development of cerebral vasospasm, a frequent complication arising in the weeks after the initial bleeding. Despite extensive research, no effective treatment of vasospasm exists to date. Prostacyclin is a potent vasodilator and inhibitor of platelet ...
Arteaga Daniel F DF Department of Radiology, Vanderbilt University School of Medicine, Nashville, Tennessee, - - 2014
'Vascular steal' has been proposed as a compensatory mechanism in hemodynamically compromised ischemic parenchyma. Here, independent measures of cerebral blood flow (CBF) and blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI) responses to a vascular stimulus in patients with ischemic cerebrovascular disease are recorded. Symptomatic intracranial stenosis patients (n=40) underwent ...
Chang Feiyan F 1Department of Radiology, China-Japan Friendship Hospital, BeiJing, China, 100029 2Department of Orthopedics, China-Japan Friendship Hospital, BeiJing, China, 100029 Feiyan Chang and Zhongshi Li contribute equally to the preparation of the - - 2014
Study Design. A prospective study using magnetic resonance imaging on a consecutive cohort of patients with cervical vertigo.Objective. To quantitatively investigate the cerebral blood flow (CBF) changes associated with cervical vertigo by using 3D Pseudo-Continuous Arterial Spin Labeling (3D PCASL).Summary of Background Data. Previous studies reported blood flow velocity reduction ...
Rathnasamy Gurugirijha G Department of Anatomy, MD10, Yong Loo Lin School of Medicine, National University of Singapore, - - 2014
Cerebral edema/brain edema refers to the accumulation of fluid in the brain and is one of the fatal conditions that require immediate medical attention. Cerebral edema develops as a consequence of cerebral trauma, cerebral infarction, hemorrhages, abscess, tumor, hypoxia, and other toxic or metabolic factors. Based on the causative factors ...
Zhao Zhen Z Zilkha Neurogenetic Institute and Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, - - 2014
Two recent papers in Nature, Ben-Zvi et al. (2014) and Nguyen et al. (2014), report a surprising dual role for the blood-brain barrier transporter MFSD2A in both establishing BBB integrity and in uptake of the fatty acid DHA.
Budohoski Karol P KP Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke's Hospital, University of Cambridge, Cambridge, - - 2014
Cerebral vasospasm has traditionally been regarded as an important cause of delayed cerebral ischaemia (DCI) which occurs after aneurysmal subarachnoid haemorrhage, and often leads to cerebral infarction and poor neurological outcome. However, data from recent studies argue against a pure focus on vasospasm as the cause of delayed ischaemic complications. ...
Deo Anand K AK Department of Pharmaceutics, University of Washington, Seattle, - - 2014
Studies in animals and postmortem human brain tissue support a role for P-glycoprotein in clearance of cerebral β-amyloid across the blood-brain barrier (BBB). We tested the hypothesis that BBB P-glycoprotein activity is diminished in Alzheimer disease (AD) by accounting for an AD-related reduction in regional cerebral blood flow (rCBF). We ...
Zhao Zhen-Yu ZY Department of Neurology, Linyi People's Hospital Affiliated to Shandong University, Linyi, - - 2014
Neurological complications have rarely been described after blood transfusion. Posterior reversible encephalopathy syndrome (PRES) is a recently recognized entity affecting predominantly the posterior cerebral hemispheres. We report two distinctive cases with history of chronic anemia that developed headache, blurred vision and seizure after blood transfusion. Magnetic resonance imaging indicated vasogenic ...
Birngruber Thomas T HEALTH - Institute for Biomedicine and Health Sciences, Joanneum Research, Graz, - - 2014
The neuroprotective blood-brain barrier (BBB) keeps many drug candidates below therapeutic levels in the central nervous system. Glutathione PEGylated liposomal doxorubicin (2B3-101) has been developed to safely enhance the delivery of doxorubicin to brain tumors. However, doxorubicin concentration in extracellular brain fluid cannot yet be reliably measured using conventional techniques. ...
Griauzde J J From the Departments of Radiology (J.G., J.J.G., N.C.), Neurosurgery (J.J.G., N.C., T.J.W., A.S.P.), and Otolaryngology (J.J.G.), University of Michigan Hospitals, Ann Arbor, - - 2014
Spontaneous intracranial hypotension can be a therapeutic challenge to the treating physician. In this study, we present our experience with the administration of a large-volume blood patch to multiple sites in the epidural space through a single-catheter access site. A retrospective review was conducted of patients with spontaneous intracranial hypotension ...
Nomura Sadahiro S Department of Neurosurgery, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi, - - 2014
Recently, focal brain cooling (FBC) was proposed as a method for treating refractory epilepsy. However, the precise influence of cooling on the molecular basis of epilepsy has not been elucidated. Thus the aim of this study was to assess the effect of FBC on glutamate (Glu) concentration, cerebral blood flow ...
Amorim Robson Luis RL From the Division of Neurosurgery (R.L.A., A.F.d.A., W.S.P., M.J.T., E.B.-S.-S.) and Department of Radiology (G.S.G., M.M.), University of São Paulo Medical School, São Paulo, - - 2014
Decompressive craniectomy (DC) reduces mortality and improves functional outcome in patients with malignant middle cerebral artery infarction. However, little is known regarding the impact of DC on cerebral hemodynamics. Therefore, our goal was to study the hemodynamic changes that may occur in patients with malignant middle cerebral artery infarction after ...
Ter Laan Mark M Department of Neurosurgery, University Medical Center Groningen, University of Groningen, Groningen, The - - 2014
Transcutaneous electrical neurostimulation (TENS) and spinal cord stimulation have been shown to increase peripheral and cerebral blood flow. We postulate that certain pathological conditions attenuate cerebral autoregulation, which may result in a relative increase of the importance of neurogenic regulation of cerebral blood flow, which could be decreased by electrical ...
Huang Ji-Yun JY Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, Zhejiang University, Hangzhou, - - 2014
Diabetes mellitus increases the risk of stroke, but the mechanisms are unclear. The present study tested the hypothesis that diabetes mellitus disturbs the brain microcirculation and increases the susceptibility to cerebral damage in a middle cerebral artery occlusion (MCAO) model of ischemia. Diabetes was induced by streptozocin in mice expressing ...
Erickson Michelle A MA University of - - 2014
Increased blood levels of the chemokine CCL11 (eotaxin) in aging were recently shown to negatively regulate adult hippocampal neurogenesis. How circulating CCL11 could affect the CNS is not clear, but one possibility is that it can cross the blood-brain barrier (BBB). Here, we show that CCL11 undergoes bidirectional transport across ...
Varsos Georgios V GV Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke's Hospital, University of Cambridge, Hills Road, Cambridge, CB2 0QQ, UK, - - 2014
The vascular wall tension (WT) of small cerebral vessels can be quantitatively estimated through the concept of critical closing pressure (CrCP), which denotes the lower limit of arterial blood pressure (ABP), below which small cerebral arterial vessels collapse and blood flow ceases. WT can be expressed as the difference between ...
Boyko Matthew M Department of Anesthesiology and Critical Care, Faculty of Health Sciences, Soroka Medical Center Ben Gurion University of the Negev, Beer Sheba, - - 2014
It is well known that abnormally elevated glutamate levels in the brain are associated with secondary brain injury following acute and chronic brain insults. As such, a tight regulation of brain glutamate concentrations is of utmost importance in preventing the neurodegenerative effects of excess glutamate. There has been much effort ...
Mattsson Niklas N 1 Department of Veterans Affairs Medical Centre, Centre for Imaging of Neurodegenerative Diseases, San Francisco, CA, - - 2014
Patients with Alzheimer's disease have reduced cerebral blood flow measured by arterial spin labelling magnetic resonance imaging, but it is unclear how this is related to amyloid-β pathology. Using 182 subjects from the Alzheimer's Disease Neuroimaging Initiative we tested associations of amyloid-β with regional cerebral blood flow in healthy controls ...
Minten Carsten C 1 Theodor Kocher Institute, University of Bern, CH-3012 Bern, - - 2014
The Duffy antigen/receptor for chemokines, DARC, belongs to the family of atypical heptahelical chemokine receptors that do not couple to G proteins and therefore fail to transmit conventional intracellular signals. Here we show that during experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis, the expression of DARC is upregulated ...
Oryan A A Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran, P.O. Box: - - 2014
Cerebral coenurosis is caused by Coenurus cerebralis, the larval stage of Taenia multiceps. The metacestode causes severe lesions in the brain and spinal cord of the intermediate host, so-called "gid" or "stagger" disease. Whereas, the non-cerebral coenurosis caused by Coenurus gaigeri, the larval stage of Taenia gaigeri, particularly affects goats. ...
Lech Teresa T Institute of Forensic Research, Westerplatte 9, 31-033 Krakow, Poland. Electronic address: - - 2014
In this work, a case of deliberate self-poisoning is presented. A 14-year-old girl suddenly died during one of the several hospitalizations. Abdominal computer tomography showed a large number of metallic particles in the large intestine. Analysis of blood and internal organs for mercury and other toxic metals carried out by ...
Caplan Gideon A GA Department of Geriatric Medicine, Prince of Wales Hospital, Sydney, Australia; Prince of Wales Clinical School, University of New South Wales, Sydney, Australia. Electronic address: - - 2014
Delirium superimposed on dementia (DSD) is frequently not diagnosed, at great cost. Both delirium and dementia are associated with cerebral hypoperfusion. A switch to anaerobic glycolysis in the central nervous system during delirium compared to Alzheimer's dementia (AD) suggests greater hypoperfusion in DSD. The main aims of this study were ...
Blanchette Marie M Département de médecine nucléaire et radiobiologie, Centre d'imagerie moléculaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Quebec, - - 2014
Drug delivery to the brain is influenced by the blood-brain barrier (BBB) and blood-tumor barrier (BTB) to an extent that is still debated in neuro-oncology. In this paper, we studied the delivery across the BTB and the BBB of compounds with different molecular sizes in normal and glioma-bearing rats. Studies ...
Tso Michael K MK Division of Neurosurgery, St. Michael's Hospital, Toronto, ON, - - 2014
Increasingly, experimental research in subarachnoid hemorrhage (SAH) has investigated early brain injury and the microcirculation. A number of pathophysiological changes occur in the cerebral microvessels after SAH including altered vasoreactivity, vasoconstriction, inflammation, blood-brain barrier impairment, increased microthrombi, and inversion of neurovascular coupling. This focused review looks at the current state ...
Zhao Yong-Lin - - 2014
Abstract Caveolin-1 is the principal marker of caveolae in endothelial cells. It plays an important role in physiological and pathological conditions of the blood-brain barrier and serves as a mediator in drug delivery through the blood-brain barrier. Caveolin-1 is related to the diminished expression of tight junction-associated proteins and metabolic ...
Nakamura Yukio Y Department of Orthopaedic Surgery, Showa Inan General Hospital, Komagane, 399-4117, Japan, - - 2014
The aim of this study was to examine and compare the areas of brain blood flow in patients with chronic low back pain (CLBP) without structural abnormality and acute low back pain (ALBP) with lumber disc herniation (LDH). Functional neuroimaging studies provide evidence of abnormalities in the regional cerebral blood ...
Kainerstorfer Jana M JM Department of Biomedical Engineering, Tufts University, 4 Colby St, Medford, MA 02155. Electronic address: - - 2014
Perturbations in cerebral blood volume (CBV), blood flow (CBF), and metabolic rate of oxygen (CMRO2) lead to associated changes in tissue concentrations of oxy- and deoxy-hemoglobin (ΔO and ΔD), which can be measured by near-infrared spectroscopy (NIRS). A novel hemodynamic model has been introduced to relate physiological perturbations and measured ...
Abshagen J J Research Department for Underwater Acoustics and Marine Geophysics, Bundeswehr Technical Center WTD71-FWG, Berliner Straße 115, 24340 Eckernförde, - - 2014
Results from an underwater experiment under sea conditions on flow noise beneath a flat-plate turbulent boundary layer are presented. The measurements were performed with a towed body at towing speeds U=2.3,…,6.1 m/s and depths h=-150,…,-100 m. Flow noise is measured with a linear array of equally spaced hydrophones (Δx=70 mm) ...
Shi Di D Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, - - 2014
In the present study, an in vitro blood-brain barrier model was developed using murine brain endothelioma cells (b.End3 cells). Confirmation of the blood-brain barrier model was completed by examining the permeability of FITC-Dextran at increasing exposure times up to 96 h in serum-free medium and comparing such values with values from ...
Joshi Shailendra S Department of Anesthesiology. Electronic address: - - 2014
Disruption of blood brain barrier (BBB) is used to enhance chemotherapeutic drug delivery. The purpose of this study was to understand the time course of hemodynamic and metabolic response to intraarterial (IA) mannitol infusions in order to optimize the delivery of drugs for treating brain tumors. Principal results: We compared ...
Kuo Jinn-Rung - - 2014
Near-infrared spectroscopy (NIRS) is a modern measuring technology in neuroscience. It can be used to noninvasively measure the relative concentrations of oxyhemoglobin (OxyHb) and deoxyhemoglobin (DeoHb), which can reflect information related to cerebral blood volume and cerebral oxygen saturation. Therefore, it has the potential for noninvasive monitoring of cerebral ischemia. ...
Warrillow Sj S Department of Intensive Care, Austin Health, Victoria, - - 2014
Severe cerebral oedema is a life-threatening complication of acute liver failure. Hyperammonaemia and cerebral hyperaemia are major contributing factors. A multimodal approach, which incorporates hyperventilation, haemodiafiltration, hypernatraemia and hypothermia (quadruple-H therapy), may prevent or attenuate severe cerebral oedema. This approach is readily administered by critical care clinicians and is likely ...
McQueen Jamie J Centre for Neuroregeneration, University of Edinburgh, Edinburgh, United Kingdom ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United - - 2014
Chronic cerebral hypoperfusion, a sustained modest reduction in cerebral blood flow, is associated with damage to myelinated axons and cognitive decline with ageing. Oligodendrocytes (the myelin producing cells) and their precursor cells (OPCs) may be vulnerable to the effects of hypoperfusion and in some forms of injury OPCs have the ...
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