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Cancelas Jose A JA Hoxworth Blood Center, University of Cincinnati, Cincinnati, Ohio; Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, - - 2014
Transfusion of long-stored red blood cells (RBCs) is associated with decreased in vivo RBC recovery, delivery of RBC breakdown products, and increased morbidity and mortality. Reducing the burden of this RBC "storage lesion" is a major challenge in transfusion medicine. Additive solution-7 (AS-7) is a new RBC storage solution designed ...
Reynolds Leryn J LJ 1Departments of Nutrition and Exercise Physiology, 2Medical Pharmacology and Physiology, and 3Medicine-Division of Gastroenterology and Hepatology, University of Missouri, Columbia, - - 2014
Insulin-stimulated increases in skeletal muscle blood flow play a role in glucose disposal. Indeed, 7 days of aerobic exercise in type 2 diabetes patients increased blood flow responses to an oral glucose tolerance test (OGTT) and improved glucose tolerance. More recent work suggests that reduced daily physical activity impairs glycemic ...
da Silva Cláudia Maria CM Department of Obstetrics and Gynecology, School of Medicine, Federal University of Minas Gerais, Avenida Professor Alfredo Balena, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, - - 2014
The aim of this study was to evaluate the presence of myeloperoxidase (MPO), N-acetyl-β-D-glucosaminidase (NAG), tumor necrosis factor alpha (TNF-α) and vascular endothelial growth factor (VEGF) in peripheral and menstrual blood in women with (n=10) and without (n=7) endometriosis. NAG and MPO activities were evaluated by enzymatic methods, whereas TNF-α ...
Ainslie Philip N PN 1 School of Health and Exercise Sciences, University of British Columbia , Okanagan Campus, Kelowna, British Columbia, Canada - - 2014
Abstract Ainslie, Philip N., and Andrew W. Subudhi. Invited Review: Cerebral blood flow at high altitude. High Alt Med Biol. 15:133-140, 2014.-This brief review traces the last 50 years of research related to cerebral blood flow (CBF) in humans exposed to high altitude. The increase in CBF within the first ...
Hadjipanayi Ektoras E Experimental Plastic Surgery; Clinic for Plastic and Hand Surgery; Klinikum Rechts der Isar, Technische Universität München; Munich, Germany; Department of Plastic, Reconstructive, Hand and Burn Surgery; Bogenhausen Hospital; Munich, - - 2014
Cellular hypoxic preconditioning is being employed to obtain complex, yet physiological, secretomes rich is angiogenic factors. We previously proposed exposing peripheral blood cells (PBCs) to hypoxic stress stimulation, and demonstrated that controlled release of PBC-derived factor mixtures induces directional microvessel growth in vitro. Hypoxia therefore provides a useful tool for ...
Donahue Manus J MJ 1] Radiology and Radiological Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee, USA [2] Psychiatry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA [3] Neurology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA [4] Physics and Astronomy, Vanderbilt University, Nashville, Tennessee, - - 2014
The purpose of this study was to evaluate how cerebral blood flow and bolus arrival time (BAT) measures derived from arterial spin labeling (ASL) MRI data change for different hypercarbic gas stimuli. Pseudocontinuous ASL (pCASL) was applied (3.0T; spatial resolution=4 × 4 × 7 mm(3); repetition time/echo time (TR/TE)=3,600/11 ms) sequentially in ...
Jackman Katherine A KA From the Feil Family Brain and Mind Research Institute (K.A.J., P.Z., G.F., P.M.P., C.C., V.P., G.M., C.I.) and Department of Radiology (H.U.V.), Weill Cornell Medical College, New York; and Department of Natural Sciences, Baruch College, City University of New York - - 2014
Obstructive sleep apnea, a condition associated with chronic intermittent hypoxia (CIH), carries an increased risk of stroke. However, CIH has been reported to either increase or decrease brain injury in models of focal cerebral ischemia. The factors determining the differential effects of CIH on ischemic injury and their mechanisms remain ...
Lawley Justin S JS 1 Institute for Exercise and Environmental Medicine, United - - 2014
The primary aim of this study was to investigate the effect of systemic poikilocapnic hypoxia on the forearm cutaneous thermal hyperemia. A secondary aim was to examine the relationship between the individual susceptibility to oxygen desaturation and cutaneous vasodilator capacity. Twelve healthy participants (7 male) were exposed to 9 hours ...
Iversen Nina K NK Department of Biological Sciences, Developmental Integrative Biology Cluster, University of North Texas, USA; Zoophysiology, Department of Bioscience, Aarhus University, - - 2014
Prenatal hypoxia due to placental insufficiency results in deleterious phenotypes and compensatory mechanisms including increased sympathetic tone. Utilizing the embryonic chicken model, we investigated (i) changes in nitric oxide (NO) mediated tone in response to chronic hypoxic development, and (ii) the in vivo role of NO-mediated tone during acute hypoxic ...
Venemans-Jellema Annemarie A Department of Clinical Epidemiology, Leiden University Medical Center; De Onderzoekerij, - - 2014
Long distance air travel is associated with an increased risk of venous thrombosis. The most obvious factor that can explain air travel related thrombosis is prolonged seated immobilization. In addition, hypobaric hypoxia has been shown to affect coagulation and the lowered atmospheric pressures present in the cabin during the flight ...
Ogoh Shigehiko S 1 Toyo University, - - 2014
Under normoxic conditions, a reduction in arterial carbon dioxide tension (PaCO2) causes cerebral vasoconstriction, thereby reducing cerebral blood flow (CBF) and modifying dynamic cerebral autoregulation (dCA). To what extent these effects are altered by acute hypoxia and the associated hypoxic ventilatory response (respiratory chemoreflex) is unclear. This study tested the ...
Lewis Nia C S NC 1University of British - - 2014
We examined whether: 1) global-cerebral blood flow (CBF) would increase across a six hours bout of normobaric poikilocapnic hypoxia and be mediated by a larger increase in blood flow in vertebral artery (VA) than in the internal carotid artery (ICA) 2); additional increases in global-CBF will be evident following an ...
Paparde Arturs A University of Latvia Faculty of Biology, Department of Human and Animal Physiology; University of Latvia Institute of Experimental and Clinical Medicine. Electronic address: - - 2014
The present study was undertaken to determine the effect of arterial blood hypoxemia induced by acute systemic hypoxia (pO2=12%) on capillary recruitment and diameter, and red blood cell (RBC) velocity in human nail fold capillaries during rest, arterial post-occlusive reactive hyperemia (PRH), and venous occlusion (VO) using intravital video-capillaroscopy. Capillary ...
Imray Christopher C 1 Warwick Medical School, University Hospitals Coventry and Warwickshire NHS Trust , Warwick, United Kingdom - - 2014
Abstract Imray, Christopher, Colin Chan, Alison Stubbings, Hannah Rhodes, Susannah Patey, Mark H. Wilson, Damian M. Bailey, and Alex D. Wright for the Birmingham Medical Research Expeditionary Society. Time course variations in the mechanisms by which cerebral oxygen delivery is maintained on exposure to hypoxia/altitude. High Alt Med Biol 15:000-000, ...
Fan Jui-Lin JL 1 Faculty of Biology and Medicine, Institute of Sports Sciences, University of Lausanne , Lausanne, Switzerland - - 2014
Abstract Fan, Jui-Lin, and Bengt Kayser. Repeated pre-syncope from increased inspired CO2 in a background of severe hypoxia. High Alt Med Biol 15, 000-000, 2014.-We describe a case of experimentally induced pre-syncope in a healthy young man when exposed to increased inspired CO2 in a background of hypoxia. Acute severe ...
Eliason Erika J EJ Department of Zoology, University of British Columbia, 6270 University Boulevard, Vancouver, Canada, V6T 1Z4. Electronic address: - - 2014
Fish routinely encounter hypoxic environments, which may have detrimental effects on digestion and performance. The present study measured oxygen consumption (MO2), gastrointestinal blood flow (GBF), cardiac output (Vb) and heart rate (fH) in rainbow trout Oncorhynchus mykiss at 10-11.5°C while exposed to a 1.5h step-wise hypoxia treatment (80, 60 and ...
Ouyang Yu Y Department of Biomedical Engineering, University of California, Davis, California, - - 2014
Glia account for 90% of human brain cells and have a significant role in brain homeostasis. Thus, specific in vivo imaging markers of glial metabolism are potentially valuable. In the brain, 2-fluoroacetate is selectively taken up by glial cells and becomes metabolically trapped in the tricarboxylic acid cycle. Recent work ...
Charriaut-Marlangue Christiane C From the Univ Paris Diderot, Sorbonne Paris Cité, INSERM U1141, Paris, France (C.C.-M., T.N., A.P.D., P.-L.L., Z.C., J.P., T.B., O.B.); PremUP Foundation, Paris, France (C.C.-M., P.-L.L., J.P., O.B.); Univ Paris Diderot, Sorbonne Paris Cité, AP-HP, Hôpital Lariboisière, Physiologie clinique - Explorations Fonctionnelles, Paris, France (P.B.); Univ Paris Diderot, Sorbonne Paris Cité, INSERM, U965, Paris, France (P.B.); UPMC, Paris Universitas, AP-HP, Hôpital Armand Trousseau, Service de Réanimation, pédiatrique, Paris, France (S.R.); and Univ Paris Diderot, Sorbonne Paris Cité, AP-HP Service de Réanimation et Pédiatrie Néonatales, Hôpital Robert Debré, Paris, France - - 2014
The best conceivable treatment for hypoxia-ischemia (HI) is the restoration of blood flow to the hypoxic-ischemic region(s). Our objective was to examine whether boosting NO-cGMP signaling using sildenafil citrate, a phosphodiesterase-type 5 inhibitor, could modify cerebral blood flow and reduce lesions in the developing brain. HI was induced in P7 ...
Foster Glen E GE University of British Columbia, - - 2014
Incidence of blood flow through intracardiac shunt and intrapulmonary arteriovenous anastomoses (IPAVA) may differ between Sherpas permanently residing at high altitude (HA) and sea-level (SL) inhabitants as a result of evolutionary pressure to improve gas exchange and/or resting pulmonary hemodynamics. To test this hypothesis we compared sea-level inhabitants at SL ...
Shi Hua H Huazhong University of Science and Technology, Department of Biomedical Engineering, MoE Key Laboratory for Biomedical Photonics, Wuhan 430074, ChinabWuhan National Laboratory for Optoelectronics, Britton Chance Center for Biomedical Photonics, Wuhan - - 2014
ABSTRACT. Early detection of tissue hypoxia in the intensive care unit is essential for effective treatment. Reduced nicotinamide adenine dinucleotide (NADH) has been suggested to be the most sensitive indicator of tissue oxygenation at the mitochondrial level. However, no experimental evidence comparing the kinetics of changes in NADH and other ...
Heinonen Ilkka I Turku PET Centre, University of Turku and Turku University Hospital, PO Box 52, FI-20521 Turku, Finland. - - 2014
As it remains unclear whether hypoxia of cardiomyocytes could trigger the release of brain natriuretic peptide (BNP) in humans, we investigated whether breathing normobaric hypoxic gas mixture increases the circulating NT-proBNP in healthy male subjects. Ten healthy young men (age 29 ± 5 yrs, BMI 24.7 ± 2.8 kg/m2) breathed normobaric hypoxic gas mixture (11% O2/89% N2) ...
Subudhi Andrew W AW 1University of Colorado Colorado - - 2013
Cerebral autoregulation (CA) acts to maintain brain blood flow despite fluctuations in perfusion pressure. Acute hypoxia is thought to impair CA, but it is unclear if CA is affected by acclimatization or related to the development of acute mountain sickness (AMS). We assessed changes in CA using transfer function analysis ...
Masamoto Kazuto - - 2013
The present study aimed to determine the spatiotemporal dynamics of microvascular and astrocytic adaptation during hypoxia-induced cerebral angiogenesis. Adult C57BL/6J and Tie2-green fluorescent protein (GFP) mice with vascular endothelial cells expressing GFP were exposed to normobaric hypoxia for 3 weeks, whereas the three-dimensional microvessels and astrocytes were imaged repeatedly using ...
Subudhi Andrew W - - 2013
Cerebral hypoxemia associated with rapid ascent to high altitude can be life threatening; yet, with proper acclimatization, cerebral function can be maintained well enough for humans to thrive. We investigated adjustments in global and regional cerebral oxygen delivery (DO2) as 21 healthy volunteers rapidly ascended and acclimatized to 5260m. Ultrasound ...
Gabbay Itay E - - 2013
Diabetic foot is traditionally attributed to a triad of neuropathy, ischemia and infection. Cellular hypoxia in diabetic foot can neither be attributed to an occlusive large artery disease (which are mostly patent) nor to the so called diabetic small vessel disease (where such occlusion was never proved). The physiological findings ...
Fu Shi-Jian - - 2013
This study quantified and compared hypoxia tolerance and swim performance among cyprinid fish species from rapid-flow, slow-flow and intermediate-flow habitats (4 species per habitat) in China. In addition, we explored effects of short-term acclimation on swim performance, maximum metabolic rate (Mo2 max) and gill remodelling to detect habitat-associated patterns of ...
Berg Ronan Mg - - 2013
Sepsis may be associated with disturbances in cerebral oxygen transport and cerebral haemodynamic function, thus rendering the brain particularly susceptible to hypoxia. The purpose of this study was to assess the impact of isocapnic hypoxia and hyperoxia on dynamic cerebral autoregulation in a human-experimental model of the systemic inflammatory response ...
Harris Ashley D AD CUBRIC, School of Psychology, Cardiff University, Cardiff, - - 2013
Hypoxic hypoxia (inspiratory hypoxia) stimulates an increase in cerebral blood flow (CBF) maintaining oxygen delivery to the brain. However, this response, particularly at the tissue level, is not well characterised. This study quantifies the CBF response to acute hypoxic hypoxia in healthy subjects. A 20-min hypoxic (mean P(ETO2) = 52 ...
Rupp Thomas - - 2013
This study investigated the changes in cerebral near-infrared spectroscopy (NIRS) signals, cerebrovascular and ventilatory responses to hypoxia and CO2 during altitude exposure. At sea level (SL), after 24 hours and 5 days at 4,350 m, 11 healthy subjects were exposed to normoxia, isocapnic hypoxia, hypercapnia, and hypocapnia. The following parameters were measured: ...
Ostergaard Leif - - 2013
The mortality after aneurysmal subarachnoid hemorrhage (SAH) is 50%, and most survivors suffer severe functional and cognitive deficits. Half of SAH patients deteriorate 5 to 14 days after the initial bleeding, so-called delayed cerebral ischemia (DCI). Although often attributed to vasospasms, DCI may develop in the absence of angiographic vasospasms, ...
Spilk Samson S Penn State Hershey Heart and Vascular Institute, The Pennsylvania State University College of Medicine, The Milton S. Hershey Medical Center, Hershey, - - 2013
Systemic hypoxia causes skeletal muscle vasodilation, thereby preserving O2 delivery to active tissues. Nitric oxide (NO), adenosine, and prostaglandins contribute to this vasodilation, but other factors may also play a role. We tested the hypothesis that regional inhibition of endothelium-derived hyperpolarizing factor with the cytochrome P-450 2C9 antagonist fluconazole, alone ...
Bianchini Kristin - - 2013
In rainbow trout development, a switch occurs from high-affinity embryonic hemoglobin (Hb) and round, embryonic erythrocytes to lower-affinity adult Hb and oval, adult erythrocytes. Our study investigated the early ontogeny of rainbow trout blood properties and the hypoxia response. We hypothesized that hypoxia exposure would delay the ontogenetic turnover of ...
Friederich-Persson Malou M Department of Medical Cell Biology, Uppsala University, Biomedical Center, Husargatan 3, SE-751 23, Uppsala, Sweden. - - 2013
Diabetic nephropathy is strongly associated with both increased oxidative stress and kidney tissue hypoxia. The increased oxidative stress causes increased kidney oxygen consumption resulting in kidney tissue hypoxia. To date, it has been difficult to determine the role of kidney hypoxia, per se, for the development of nephropathy. We tested ...
Sharkey Leslie C - - 2013
Lactate is a product of anaerobic metabolism. Lactate concentration in blood is used clinically as an indicator of tissue hypoperfusion and hypoxia to determine disease severity, assess response to therapy, and predict outcome. This article reviews lactate physiology, sample collection and processing, and interpretation of lactate concentration in clinical practice.
Walsh Brian H - - 2013
To explore the association between multiple umbilical cord blood proteins and severity of hypoxic-ischemic encephalopathy as defined by continuous multichannel electroencephalography. A prospective case-control cohort study, which was divided into separate exploratory and validation cohorts. A single tertiary neonatal intensive care facility. The study recruited full-term infants with perinatal asphyxia ...
Wanek Justin J Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois 60612, - - 2013
Retinal hypoxia is a common pathological condition usually caused by ischemia that may result in alterations in oxidative energy metabolism. We report measurements of oxygen delivery by the retinal circulation (DO2_IR) and inner retinal oxygen metabolism (MO2_IR) under systemic normoxia and hypoxia in rat. Rats were ventilated with fractions of ...
Saad Ahmed A Division of Nephrology and Hypertension, Department of Radiology, Mayo Clinic, 200 First St, Rochester, MN 55905, - - 2013
To test the hypothesis that fractional kidney hypoxia, measured by using blood oxygen level-dependent (BOLD) magnetic resonance (MR) imaging, correlates with renal blood flow (RBF), tissue perfusion, and glomerular filtration rate (GFR) in patients with atherosclerotic renal artery stenosis (RAS) better than regionally selected region of interest-based methods. The study ...
Rowland Kathryn J KJ Division of Pediatric Surgery, St Louis Children's Hospital, Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, - - 2013
Massive small bowel resection (SBR) results in an adaptive response within the remnant bowel. We have previously shown an immediate reduction in intestinal blood flow and oxygen saturation (sO2) after SBR. We therefore sought to determine the duration of resection-induced intestinal hypoxia and expression of hypoxia-inducible factors (HIFs) following SBR. ...
Fitzgerald Robert S - - 2013
This study aimed to dissect the roles played by the autonomic interoreceptors, the carotid bodies (cbs) and the aortic bodies (abs) on the vascular resistances of several organs in anesthetized, paralyzed, artificially ventilated cats challenged by systemic hypoxemia. Two 15min challenges stimulated each of 5 animals in two different groups: ...
Applegate Richard L RL - - 2013
Early and aggressive treatment of circulatory failure is associated with increased survival, highlighting the need for monitoring methods capable of early detection. Vasoconstriction and decreased oxygenation of the splanchnic circulation is a sentinel response of the cardiovasculature during circulatory distress. Thus we measured esophageal oxygenation as an index of decreased ...
Jerome Neil P - - 2013
PURPOSE: To study vascular responsiveness to hypoxia and hypercarbia together with vessel size index (VSI) in a 9L rat glioma (n = 11) using multimodal MRI. MATERIALS AND METHODS: VSI was determined using T2 and T 2* MRI following AMI-227 contrast agent. Blood oxygenation level dependent (BOLD) signal response was determined ...
Hashiguchi Nobuko - - 2013
The purpose of this study was to investigate the effects of 6-hour exposure to low relative humidity (RH) and low air pressure in a simulated air cabin environment on body fluid loss (BFL) and blood viscosity. Fourteen young healthy male subjects were exposed to four conditions, which combined RH (10% ...
Takuwa Hiroyuki H Biophysics Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, - - 2013
Effects of chronic hypoxia on hemodynamic response to sensory stimulation were investigated. Using laser-Doppler flowmetry, change in cerebral blood flow (CBF) was measured in awake mice, which were housed in a hypoxic chamber (8% O₂) for 1 month. The degree of increase in CBF evoked by sensory stimulation was gradually ...
Villien Marjorie - - 2013
Changes in cerebral perfusion and CO(2) cerebrovascular reactivity during and immediately after a sojourn at high altitude remain unclear but may be critical for acclimatization. The aim of the present study was to assess the effects of 6days at 4,350m on cerebral perfusion and cerebrovascular reactivity (CVR) to CO(2) by ...
Huang Shiliang S Research Imaging Institute, Department of Ophthalmology, University of Texas Health Science Center, San Antonio, TX 78229, - - 2013
Methylene blue USP (MB) at low doses has metabolic-enhancing and antioxidant properties and exhibits experimental neurotherapeutic benefits, but little is known about its in vivo effects on cerebral blood flow (CBF), functional evoked responses, and the associated changes in cerebral metabolic rate of oxygen (CMRO2). This study used magnetic resonance ...
Juurlink Bernhard H J - - 2013
The evidence that hypoxia is a precipitating factor in causing early MS lesions includes increased protein levels of hypoxia-inducible factor-1 α ; presence of the D-110 hypoxia-inducible protein; increased expression of hypoxia-inducible genes in lesions as well as in adjacent normal-appearing white matter (NAWM); loss of myelin-associated glycoprotein in myelin ...
Peng Qian-Qian - - 2013
High altitude acclimatization is a series of physiological responses taking places when subjects go to altitude. Many factors could influence these processes, such as altitude, ascending speed and individual characteristics. In this study, based on a repeated measurement design of three sequential measurements at baseline, acute phase and chronic phase, ...
McGinnis Woody R WR Autism Research Institute, 4182 Adams Avenue, San Diego, CA 92116, USA. - - 2013
Electrophysiological findings implicate site-specific impairment of the nucleus tractus solitarius (NTS) in autism. This invites hypothetical consideration of a large role for this small brainstem structure as the basis for seemingly disjointed behavioral and somatic features of autism. The NTS is the brain's point of entry for visceral afference, its ...
Riddle Art A Department of Pediatrics, Oregon Health & Science University, Portland, Oregon, United States of - - 2013
Although the spectrum of perinatal white matter injury (WMI) in preterm infants is shifting from cystic encephalomalacia to milder forms of WMI, the factors that contribute to this changing spectrum are unclear. We hypothesized that the variability in WMI quantified by immunohistochemical markers of inflammation could be correlated with the ...
Harris Ashley D AD Cardiff University Brain Imaging Research Centre, School of Psychology, Cardiff University, Cardiff, UK. - - 2013
To demonstrate the feasibility of measuring the temporal dynamics of cerebral lactate concentration and examine these dynamics in human subjects using magnetic resonance spectroscopy (MRS) during hypoxia. A respiratory protocol consisting of 10-minute baseline normoxia, 20-minute inspiratory hypoxia, and ending with 10-minute normoxic recovery was used, throughout which lactate-edited MRS ...
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