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Vaes Roel H - - 2013
<sec id="st1"><title>ABSTRACT</title> <bold><italic>Purpose:</italic></bold> Absolute treatment criteria for reducing the access volume of a high-flow access (HFA, access flow >2 L/min) are absent. Previous studies suggested that a HFA may influence the systemic circulation including blood pressure (BP) and heart rate (HR). The aim of this study was to determine these ...
Conversy Bérénice - - 2013
Blood donation is an essential step in transfusion medicine that must take into account the donor's welfare, collection effectiveness, and blood product quality. This prospective study enrolled 13 canine blood donors, each subjected to both gravity and suction collection methods, in a randomized order. Clinical parameters, including heart rate (HR), ...
Elterman Joel J Oregon Health & Science University, Portland, Oregon 97239, USA. - - 2013
Red blood cell transfusion practices vary, and the optimal hemoglobin for patients with traumatic brain injury has not been established. A retrospective review of data collected prospectively as part of a randomized, controlled trial involving emergency medical service agencies within the Resuscitation Outcomes Consortium was conducted. In patients with a ...
Holcomb John B - - 2013
PURPOSE OF REVIEW: Early identification of shock and coagulopathy coupled with damage control resuscitation are central tenets of early trauma management. In traumatic injury, haemorrhage is responsible for almost 50% of deaths occurring within the first 24 h of injury and up to 80% of intraoperative trauma mortalities. Immediate haemorrhagic mortality ...
Ruiz Agustín - - 2013
Plasma amyloid beta (Aβ) levels are being investigated as potential biomarkers for Alzheimer's disease. In AB128 cross-sectional study, a number of medical relevant correlates of blood Aβ40 or Aβ42 were analyzed in 140 subjects (51 Alzheimer's disease patients, 53 healthy controls and 36 individuals diagnosed with mild cognitive impairment). We ...
Tatavarty Vedakumar - - 2012
Dendritic spines are small protrusions that receive synaptic signals in neuronal networks. The actin cytoskeleton plays a key role in regulating spine morphogenesis, as well as in the function of synapses. Here we report the first quantitative measurement of F-actin retrograde flow rate in dendritic filopodia, the precursor of dendritic ...
Ball S J - - 2012
A new species of isosporan (Apicomplexa: Eimeriidae) is reported from the greenfinch, Carduelis chloris (Passeriformes: Fringillidae), in England. Oocysts of Isospora daszaki n.sp. are spherical to subspherical, 18.8 × 20.3 (16.8-22.4 × 16.8-25.2) μm, with a shape index (length/width) of 1.08 (1.07-1.1). Micropyle, polar granules and oocyst residuum are absent. Sporocysts are 9.4 × 14.8 (8.4-11.2 × 12.6-18.2) μm, a ...
Abd Elaal Mohammad M - - 2012
Spontaneous bacterial peritonitis (SBP) is a significant cause of mortality in cirrhosis. Reducing toxic burden of infected ascitic fluid through paracentesis needs further studies as adjunctive therapy of SBP. We aimed to evaluate different therapies for SBP. Thirty-six cirrhotic ascitic patients with SBP were examined and classified according to treatment ...
Kumar Naresh - - 2012
Major spine surgery is associated with significant blood loss, which has numerous complications. Blood loss is therefore an important concern when undertaking any major spine surgery. Blood loss can be addressed by reducing intraoperative blood loss and replenishing perioperative blood loss. Reducing intraoperative blood loss helps maintain hemodynamic equilibrium and ...
Hamed C T - - 2011
There is no data available on the ABO/Rh(D) frequencies in the Mauritanian population. We retrospectively analysed records of a 5-year database that contained ABO/Rh phenotype and ethnic origin of 10 116 volunteers giving blood at the national blood transfusion centre to derive the frequencies of ABO/Rh(D) groups in the Mauritanian population. ...
James Adelbert B - - 2011
BACKGROUND: The prevalence of blood donor eligibility factors has a major impact on the availability of blood donors and thus the blood supply in the United States. The prevalence of these factors may differ between demographic groups and thus help explain the differences in blood donation rates. STUDY DESIGN AND ...
Remizova Marina I - - 2011
It has been found that dinitrosyl iron complexes with glutathione (DNIC-GS) injected into the blood flow of rats at a dose of 0.05μmoles/kg prior to hemorrhage significantly improve cardiac function under conditions of hemorrhagic shock manifested in increased stroke volume, left ventricular work and cardiac output to a level exceeding ...
Dimopoulou Ioanna - - 2011
Microdialysis (MD) provides the opportunity to monitor tissue metabolic changes. This study aimed to describe the kinetics of MD-derived metabolites during the course of critical sepsis, to assess whether these metabolites are useful in grading sepsis severity, and to investigate their prognostic use. To this end, 54 mechanically ventilated septic ...
Shaz Beth H - - 2011
Nationally, minorities are underrepresented in community blood donation programs. The reason for this disparity is poorly understood. To better understand why minorities do not donate, first, accurate blood donor and donation data are needed. Donor and donation demographic data were collected for 2004-2007 from a single blood collection agency in ...
Leong Benjamin - - 2011
Logistics complicate fluid resuscitation of traumatic shock on the battlefield. Traumatic shock can result in oxygen debt (O(2)D) accumulation that is fatal. However, the ability of fluid strategies to repay O(2)D are not commonly reported. This pilot study examined various resuscitation fluids, including a combination of PEGylated bovine hemoglobin and ...
Lundy David J - - 2011
This article discusses the role of microcirculatory dysfunction in the pathophysiology of sepsis, reviewing the role of the endothelium in modulating microcirculatory flow, discussing the function of nitric oxide in mediating microcirculatory blood flow, and outlining means of evaluating microcirculatory function in septic patients. Finally, potential novel therapies and challenges ...
Nachuraju Parimala - - 2011
This study investigated the systemic and microvascular hemodynamic changes related to increased nitric oxide (NO) availability following significant hemorrhage, made available by administration of NO releasing nanoparticles (NO-nps). Hemodynamic responses to hemorrhagic shock were studied in the hamster window chamber. Acute hemorrhage was induced by arterial controlled bleeding of 50% ...
Alders David Jc - - 2011
Heterogeneity of regional coronary blood flow is caused in part by heterogeneity in O(2) demand in the normal heart. We investigated whether myocardial O(2) supply-demand mismatching is associated with the myocardial depression of sepsis. Regional blood flow (microspheres) and O(2) uptake ((13)C-acetate infusion and analysis of resultant NMR spectra) were ...
Khatoon Imrana - - 2011
In this study, Escherichia coil DH5alpha (ATCC 35218) were exposed to 0-100 microg/mL chromium oxide nanoparticles (Cr2O3, Nps) for 15-120 min to study the internalization of Nps by flowcytometry. A concentration-duration dependent increased side scatter (SSC) confirmed the internalization of Cr2O3 NPs by the E. coli. This study suggests that ...
Bodetoft Stefan S aDepartments of Emergency Medicine bClinical Physiology, Skåne University Hospital, Lund, - - 2011
Oxygen (O2) is a cornerstone in the treatment of critically ill patients, and the guidelines prescribe 10-15 l of O2/min even to those who are initially normoxic. Studies using indirect or invasive methods suggest, however, that supplemental O2 may have negative cardiovascular effects. The aim of this study was to ...
Campos Dulcimar P - - 2010
To assess clinical and laboratory parameters and serum cytokine levels in 55 neonates who developed early-onset sepsis. Clinical parameters associated with early-onset neonatal sepsis were assessed. White blood cell differential and serum C-reactive protein and glucose levels were measured upon diagnosis of sepsis and 48 hours later. IL-beta, IL-10, IL-6, ...
Cook C L - - 2010
The effect of obstructions in steady flow on swimming by rainbow trout Oncorhynchus mykiss was examined in a respirometry swim tunnel to test the prediction that fish interacting with obstructions require less energy to hold station. When an obstruction was present, O. mykiss altered the kinematics of swimming and the ...
Kim Nam-Soo - - 2010
OBJECTIVES: The objective of this study was to assess the association between the blood total mercury concentration and fish consumption in the Korean general adult population using a representative sample. METHODS: We studied the blood mercury concentration in a representative sample of 1,749 Koreans who were included in the Third ...
Sriram Krishna - - 2011
We report the development of a mathematical model that quantifies the effects of small changes in systemic hematocrit (Hct) on the transport of nitric oxide (NO) in the microcirculation. The model consists of coupled transport equations for NO and oxygen (O2) and accounts for both shear-induced NO production by the ...
Roehl Anna B - - 2010
BACKGROUND AND OBJECTIVE: Stable haemodynamics and its cardioprotective and neuroprotective properties favour xenon as an ideal but expensive anaesthetic agent. The aim of this study was to optimize a semi-closed anaesthesia circuit for xenon anaesthesia with respect to economics and patient safety. METHODS: A semi-closed nonrebreathing circuit was compared with ...
Rodriquez Dario D - - 2010
BACKGROUND: Transportation of the critically ill or injured war fighter requires the coordinated care and judicious use of resources. Availability of oxygen (O2) supplies for the mechanically ventilated patient is crucial. Size and weight of cylinders makes transport difficult and presents an increased risk of fire. A proposed solution is ...
Powell Mark D - - 2011
Anaemia is a common pathology associated with many infectious and non-infectious diseases. The effects of haemolytic anaemia induced by i.p. injection of phenylhydrazine (PHZ) were studied in Atlantic cod. Phenylhydrazine injection (0.3 mg kg(-1)) in a DMSO and saline vehicle induced a reproducible and stable anaemia reducing haematocrit, (Hct) by 62% over ...
Cruz Ruy J RJ - - 2011
Several studies have shown that the distribution of cardiac output to the intra-abdominal organs may vary during low-flow states. In this study, we developed an experimental model to selectively reduce the abdominal aortic blood flow in order to assess the initial impact of selective hepatosplanchnic hypoperfusion on regional blood flow ...
Cabrales Pedro - - 2010
Hemoglobin (Hb)-based O(2) carriers (HBOCs) constitute a class of therapeutic agents designed to correct the O(2) deficit under conditions of anemia and traumatic blood loss. The O(2) transport capacity of ultrahigh-molecular-weight bovine Hb polymers (PolybHb), polymerized in the tense (T) state and relaxed (R) state, were investigated in the hamster ...
Ogoh Shigehiko - - 2010
Hypoxia is known to impair cerebral autoregulation (CA). Previous studies indicate that CA is profoundly affected by cerebrovascular tone, which is largely determined by the partial pressure of arterial O(2) and CO(2). However, hypoxic-induced hyperventilation via respiratory chemoreflex activation causes hypocapnia, which may influence CA independent of partial pressure of ...
Hong Nancy J - - 2010
We showed that luminal flow increases net superoxide (O(2)(-)) production via NADPH oxidase in thick ascending limbs. Protein kinase C (PKC) activates NADPH oxidase activity in phagocytes, cardiomyocytes, aortic endothelial cells, vascular smooth muscle cells, and renal mesangial cells. However, the flow-activated pathway that induces NADPH oxidase activity in thick ...
Hernández Andrés - - 2010
The purpose of this research was to develop new techniques to 1) rapidly sample venous O(2) saturation to determine contraction-by-contraction oxygen uptake (Vo(2)), and 2) precisely control the rate and pattern of blood flow adjustment from one chosen steady state to another. An indwelling inline oximeter probe connected to an ...
Tilak K S - - 2009
The acute toxicity of Nuvan to the grass carp Ctenopharyngodon idella was determined using static and continuous flow through system for 24, 48, 72 and 96 hr. The median lethal concentration (LC50) values were 13.1, 10.9, 9.8 and 6.5 mg l(-1) respectively in static system and 10.7, 9.5, 8.0 and ...
Vazquez Alberto L - - 2010
Little is known regarding the changes in blood oxygen tension (P(O2)) with changes in brain function. This work aimed to measure the blood P(O2) in surface arteries and veins as well as tissue with evoked somato-sensory stimulation in the anesthetized rat. Electrical stimulation of the forepaw induced average increases in ...
Meir Jessica U - - 2009
The emperor penguin (Aptenodytes forsteri) thrives in the Antarctic underwater environment, diving to depths greater than 500 m and for durations longer than 23 min. To examine mechanisms underlying the exceptional diving ability of this species and further describe blood oxygen (O2) transport and depletion while diving, we characterized the ...
Dyson Alex - - 2009
PURPOSE: Standard resuscitation practice for shock states mandates use of high flow, high concentration oxygen. However, this may induce microvascular constriction and potentially impair regional oxygen delivery. We thus investigated the impact of varying inspired oxygen concentrations in a rat model of progressive haemorrhage. METHODS: Tissue oxygen tension (the balance ...
Kamimori Gary H - - 2009
Enhanced sympathoadrenal activity has been implicated in the pathogenesis of acute mountain sickness (AMS). This study was designed to examine the time course of circulating catecholamines in individuals with and without AMS. METHODS: Subjects were low-altitude residents (10 men, 8 women) who had not been exposed to altitude within the ...
Masamoto Kazuto - - 2009
The dynamic changes in cerebral metabolic rate of oxygen (CMRO2) and oxygen supply during brain functions have not been well-characterized. To examine this issue, experiments with electrophysiology, oxygen microelectrode and laser-Doppler flowmetry were performed in the anesthetized rat somatosensory cortex. During neural activation, brain tissue partial pressure of oxygen (P(O2)) ...
Devor Anna - - 2008
The present study addresses the relationship between blood flow and glucose consumption in rat primary somatosensory cortex (SI) in vivo. We examined bilateral neuronal and hemodynamic changes and 2-deoxyglucose (2DG) uptake, as measured by autoradiography, in response to unilateral forepaw stimulation. In contrast to the contralateral forepaw area, where neuronal ...
Belcher C M - - 2008
Several studies have attempted to determine the lower limit of atmospheric oxygen under which combustion can occur; however, none have been conducted within a fully controlled and realistic atmospheric environment. We performed experimental burns (using pine wood, moss, matches, paper, and a candle) at 20 degrees C in O2 concentrations ...
Yang Yuesong - - 2009
The purpose of this study was to investigate the feasibility of a noninvasive approach that combines magnetic resonance imaging (MRI) oximetry and flow measurement to obtain the oxygen consumption in the myocardium and in the whole body. Thirteen healthy male volunteers [mean (+/-S.D.) age: 35+/-7 years] underwent this MR study, ...
Ma Yilong - - 2008
This study reports an online temperature correction method for determining tissue oxygen partial pressure P(tO2) in the striatum and a novel simultaneous measurement of brain P(tO2) and temperature (T(brain)) in conjunction with global oxygen consumption V(O2) in non-sedated and non-anesthetized freely moving Arctic ground squirrels (AGS, Spermophilus parryii). This method ...
McCoy C - - 2008
A series of studies was conducted to determine the effect of systemically and topically active insecticides on blood consumption by fleas (Ctenocephalides felis). Infestations were conducted by placing fleas into plexi-glass chambers attached to the lateral rib cage of domestic short-hair cats. After pre-defined periods, fleas and flea feces were ...
Yazer Mark H - - 2008
BACKGROUND: There are two principal types of group O alleles; deletional alleles feature 261delG leading to nonfunctional truncated protein. Nondeletional alleles have the consensus guanosine at residue 261. The major nondeletional allele, O2, encodes full-length protein with Gly268Arg. While reports vary, O2 has been proposed to encode weakly functional A-glycosyltransferase ...
Valente Alessio - - 2008
Prior studies have suggested urinary oxygen tension (P(u)O2) as a putative index of renal blood flow (RBF) and tissue oxygenation. In the present study, we collected intraoperative data from eight anaemic, bladder-catheterized patients who received erythrocyte transfusions during various surgical procedures under general anaesthesia. Urinary and arterial blood gas analysis ...
Vazquez Alberto L - - 2008
The dynamics of blood oxygen delivery and tissue consumption produced by evoked stimulation of the rat somato-sensory cortex were investigated. Tissue oxygen tension (P(O2)) and laser Doppler flowmetry (LDF) measurements were recorded under two experimental conditions: normal, which represented both oxygen delivery and consumption, and suppressed CBF (achieved using a ...
Khorrami Sheva - - 2008
The extent to which hematocrit (Hct) is regulated and the impact of altered Hct on blood oxygen transport in avian embryos are largely unknown. Consequently, we investigated how acute blood removal or Ringer solution injection modified Hct in day 15 embryos, and how ;blood doping' with erythrocyte-enriched whole blood influenced ...
Eliason Erika J - - 2008
The present study is the first to simultaneously and continuously measure oxygen consumption (MO(2)) and gastrointestinal blood flow (q(gi)) in fish. In addition, while it is the first to compare the effects of three isoenergetic diets on q(gi) in fish, no significant differences among diets were found for postprandial MO(2), ...
Rigamonti A - - 2008
BACKGROUND: The effect of blood storage on tissue oxygen delivery has not been clearly defined. Some studies demonstrate reduced microvascular oxygen delivery, whereas others do not. We hypothesize that storage of rat blood will limit its ability to deliver oxygen to cerebral tissue. METHODS: Anaesthetized rats underwent haemorrhage (18 ml ...
Shibata Masahiro - - 2008
To study the role of nitric oxide (NO) in regulating oxygen consumption by vessel walls, the oxygen consumption rate of arteriolar walls in rat cremaster muscle was measured in vivo during flow-induced vasodilation and after inhibiting NO synthesis. The oxygen consumption rate of arteriolar walls was calculated based on the ...
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