Search Results
Results 351 - 400 of 1083
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Wachter C - - 1995
1. Acid back-diffusion through a disrupted gastric mucosal barrier increases blood flow to the stomach without any change in systemic blood pressure. This study was undertaken to examine the gastric acid-evoked changes in blood flow in a number of visceral and somatic arterial beds and to elucidate the mechanisms which ...
Yoshida M - - 1995
In order to investigate the pathogenesis of acute gastric mucosal lesion after thermal injury, microcirculatory disturbance was assessed and observation of the behaviour of leucocytes was performed. Gastric blood flow decreased at 15 min post-thermal injury, and partially improved at 2 h; however, it decreased again at 5 h post-thermal ...
Niv Y - - 1995
OBJECTIVE: Alkaline tide is the observed alkalinization of blood and urine after stimulation of gastric acid secretion. In previous studies, we found good correlation between gastric acid output and alkaline tide in arterialized venous blood. METHODS: In the present study, the alkaline tide phenomenon was further investigated in 26 duodenal ...
Miura S - - 1995
Spatial alterations in blood flow during the development of mucosal injury induced by ischemia-reperfusion in rats were determined with a two-dimensional laser Doppler tissue perfusion imager. The rats were anesthetized with pentobarbital, and the stomach was exteriorized on a stage; the mucosa was then sequentially scanned. The mucosa was constantly ...
Iwata F - - 1995
The hyperemia at the duodenal ulcer margin is important for ulcer healing. We studied the effect of tobacco cigarette smoke on the hyperemia at the margin of mepirizole-induced duodenal ulcer. Duodenal mucosal blood flow values measured by iodo[14C]antipyrine (IAP) autoradiography and hydrogen gas clearance (HGC) were compared. Twenty-four hours after ...
Suresh P - - 1995
Three-week-old turkeys were injected intravenously with Bordetella avium-specific immunoglobulin G (IgG), and absorbance readings were measured in blood, tracheal washings, and lacrimal secretions using an enzyme-linked immunosorbent assay at various time intervals. IgG was detected in tracheal and lacrimal secretions as early as 5 minutes after injection and peaked at ...
Guslandi M - - 1995
OBJECTIVE: To determine the state of local blood flow in ulcerative colitis. METHODS: Rectal blood flow was measured by means of laser Doppler flowmetry during endoscopy in 20 patients with active or inactive ulcerative colitis and in 20 healthy controls. RESULTS: A significant (p < 0.01) reduction in the values ...
Uusaro A - - 1995
Despite the widespread use of gastric tonometry to assess splanchnic oxygen transport, no human data are available on the relationship between splanchnic blood flow, splanchnic oxygen delivery and gastric mucosal pH. We have studied the effect of splanchnic blood flow and oxygen delivery on gastric mucosal pHi after cardiac surgery. ...
Huang C K - - 1995
Erythromycin has been shown to act on motilin receptors on gastrointestinal smooth muscle in vitro and to accelerate gastric emptying in normal subjects as well as in patients with diabetic mellitus. To evaluate the motor pattern that accounts for this accelerated emptying, the effects of 12.5 mg/min erythromycin vs. placebo ...
Sakano T - - 1995
Gastric mucosal lesions are an important complication in endotoxemia. In order to define the role played by the vagus nerve and endothelial-derived relaxing factor (EDRF) in gastric mucosal blood flow, an investigation was carried out on four groups of rats: a control group; a group given lipopolysaccharide (LPS, 5 mg/kg); ...
Gustafsson U - - 1995
The aim of this study was to elaborate on a computerized microthermistor technique for indirect measurement of esophageal blood flow and to investigate if any changes in circulation could be found in patients who are provoked by esophageal acid perfusion of their acid-sensitive mucosa. A thermistor was mounted in a ...
Sato N - - 1995
Gastric blood circulation maintains the structure and functions of the stomach, and thereby is closely associated with the pathogenesis and the healing of gastrointestinal lesions. Gastric mucosal blood flow, regulated by systemic neural and humoral factors, is also modified by local metabolic factors such as prostaglandins, leukotrienes. PAF and other ...
Hoshiko, Tatsuhide
The effect of intravenous administration of various gastrointestinal hormones or peptides on the colonic mucosal blood flow was investigated by a reflex spectrum apparatus (TS-200, Sumitomo Denko Co). Various gastrointestinal hormones (pentagastrin, secretin, substance P, vasoactive intestinal polypeptide) were administered via the femoral vein at different doses. The hormones were ...
Yoshida, Noboru
We measured colonic mucosal blood flow using a reflectance spectrophotometry in Wistar rats during and after continuous injection of prostaglandins (PGs: PGE1, PGE2 and PGI2), as vasodilators, and thromboxane A2 (TXA2) as a vasoconstrictor. Administration of PGs increased colonic mucosal blood volume and oxyhemoglobin saturation of the colonic mucosal tissue, ...
Bouchard G - - 1994
Glutathione appears to be a major osmotic factor in the generation of bile salt-independent flow (BSIF). This study was designed to investigate its importance in the pathology of 17-alpha-ethinyl estradiol (EE)-induced cholestasis. Five-day EE treatment at the dose level of 5 mg/kg/day significantly decreased bile flow (57% of controls) and ...
Koskinen L O - - 1994
TRH has pronounced vascular effects. The final transmitter mechanisms of these effects are not fully understood. The present study was conducted in order to elucidate whether these effects are mediated by prostaglandic or muscarinic mechanisms. Muscarinic blockade augmented the vasoconstricting- and pressor effect of TRH; vasodilation in the brain was ...
Johansson K - - 1994
Laser Doppler flowmetry (LDF) was used for endoscopic measurement of regional blood flow in 20 patients who had undergone previous gastric resection for peptic ulcer. Twenty-five patients with intact stomach and normal endoscopic findings were used as controls. In resected patients, the degree of enterogastric reflux gastritis was assessed by ...
Casadevall M - - 1994
The aim of the study was to assess whether changes in gastric mucosal blood flow induced by acute normovolaemic anaemia influence the susceptibility of the gastric mucosa to ethanol-induced damage, and the relationship of these changes with nitric oxide biosynthesis. Acute normovolaemic anaemia, promoted by exchanging 3 ml of blood ...
Holzer P - - 1994
1. Acid back-diffusion through a disrupted gastric mucosal barrier is known to increase gastric mucosal blood flow via a neural mechanism. The present study examined how the acid-evoked change in the gastric microcirculation compares with blood flow changes in the left gastric artery, one of the major arteries supplying the ...
Panés J - - 1994
It has been suggested that estrogen-progestagen therapy may be useful in preventing bleeding from gastric angiodysplasia, a vascular lesion similar to that described in portal-hypertensive gastropathy. In this study we assessed the effects of estrogen-progestagen therapy on gastric microcirculation and systemic and splanchnic hemodynamics in portal-hypertensive and sham-operated rats. One ...
Pethö G - - 1994
1. This study examined whether the hyperaemia following acid challenge of the rat gastric mucosa involves bradykinin, a peptide formed in response to tissue injury. 2. Gastric mucosal blood flow in urethane-anaesthetized rats was assessed by the hydrogen gas clearance method. Infusion of a bradykinin solution (10 microM) into the ...
Pierie J P - - 1994
OBJECTIVE: To assess the value of relative blood perfusion of the gastric tube in prediction of impaired healing of cervical oesophagogastrostomies. DESIGN: Prospective study. SETTING: University hospital, The Netherlands. SUBJECTS: Thirty patients undergoing transhiatal oesophagectomy and partial gastrectomy for cancer of the oesophagus or oesophagogastric junction, with gastric tube reconstruction ...
Guttu K - - 1994
To study the influence of acid base balance on gastric mucosal repair, NH4Cl or NaHCO3 was given intravenously to anesthetized cats after mucosal damage induced by intraluminal 2 M NaCl. Saline at pH 5 or 1 was perfused via an oral tube through the stomach lumen and evacuated via a ...
Guslandi M - - 1994
Chronic gastritis is frequently accompanied by Helicobacter pylori infection and associated with a reduced gastric blood flow. To investigate the possible relationship between the two phenomena, 20 outpatients with histological antral gastritis with or without concomitant duodenal ulcer, 10 of them Hp positive and 10 negative, were selected and compared ...
Benazzo M - - 1994
Nasal blood flow is finely regulated by local release of neurotransmitters, neuropeptides and other bioactive molecules acting via paracrine mechanisms. We have investigated the effects of endothelin-1 (ET-1), a potent vasoconstrictor peptide, on the blood perfusion of rabbit nasal mucosa by laser Doppler flowmetry. After injection with ET-1, a potent ...
Leung F W - - 1994
BACKGROUND: Knowledge of the effect of parenteral nicotine on physiologic gastric hyperemia is limited. This study examined the effect of intravenous nicotine on gastric hyperemia and and secretion induced by pentagastrin. METHODS: In starved, urethane-anesthetized rats, gastric corpus blood flow was monitored continuously in a localized area of the mucosa, ...
Konturek S J - - 1994
Gastric mucosa exhibits the ability to adapt to ulcerogenic action of aspirin but the mechanism of this phenomenon is unknown. In this study, acute gastric lesions were produced by single or repeated doses of acidified aspirin in rats with intact or resected salivary glands and with intact or suppressed synthase ...
Groeneveld A B - - 1994
The objective of this article is to review splanchnic tonometry. The English literature, involving both animal and human studies, was used for review, with emphasis on papers on physiological and methodological principles and clinical applications. Tonometry involves the measurement of intraluminal PCO2 as a measure of mucosal PCO2 in the ...
Sørbye H - - 1994
Blood flow plays an important role in protection of normal gastric mucosa and in the protection and healing of damaged mucosa. Blood flow contributes to protection by supplying the mucosa with oxygen and HCO3-, and by removing H+ and toxic agents diffusing from the lumen into the mucosa. Low mucosal ...
Gustaw P - - 1994
Endogenous nitric oxide which is enzymatically formed by endothelial cells from L-arginine has been implicated in the control of gastrointestinal circulation. Its role in the mediation of gastric tissue oxygenation has not been studied. We investigated the role of NO in the control of gastric blood flow and oxygen uptake. ...
Endoh K - - 1994
Epidemiological and experimental evidence have shown that nicotine has harmful effects on the gastric mucosa. The mechanisms by which cigarette smoking or nicotine adversely affect the gastric mucosa have not been fully elucidated. In this report, clinical and experimental data are reviewed. The effects of nicotine from smoking on gastric ...
Kaye S A - - 1994
We investigated duodenal and gastric mucosal blood flow by endoscopic laser Doppler flowmetry (LDF) in ten patients with systemic sclerosis (SSc) and in ten healthy volunteers. In addition, we tested for the presence of small bowel bacterial overgrowth by jejunal aspiration. Jejunal aspiration and LDF were done consecutively, via a ...
Borén T - - 1994
The bacterium Helicobacter pylori is tropic for epithelial cells and the mucus layer in the stomach lining, and is associated with the development of gastritis, ulcers and possibly also gastric malignancies. Adherence to the gastric epithelial cells is mediated by fucosylated blood-group antigens associated with blood-group O phenotype, which could ...
Ho K J - - 1994
Twelve adult patients with indwelling common bile duct T-tube were selected for the study of circadian fluctuation of biliary excretion. From the 10th postoperative day on when the enterohepatic circulation was well reestablished a 5 ml bile sample was collected at the end of each 4-h interval for 3 to ...
Guttu K - - 1994
BACKGROUND/AIMS: The hyperemic response after superficial gastric mucosal damage is essential for repair of the mucosa. Only indirect evidence suggests that this is caused by supply of bicarbonate. Therefore, this study tested the effect of maintaining the availability of bicarbonate after prevention of the hyperemic response after damage by 2 ...
Kawano S - - 1994
To clarify the characteristics of congestive gastropathy, we investigated gastric mucosal hemodynamics and energy metabolism in cirrhotic patients, using a reflectance spectrophotometry system and high performance liquid chromatography. The index of the gastric mucosal blood volume of cirrhotic patients with esophageal varices was significantly higher, and the index of gastric ...
Hachiya A - - 1994
The relationship of gastric mucosal hemodynamics, energy metabolism, and acid to antral histological lesion incidence following hemorrhage and retransfusion was investigated in rats. Decrease of mucosal blood flow and of the index of mucosal oxygen saturation (ISO2) during hemorrhage were slightly greater in the corpus than in the antrum. ATP ...
Hasibeder W - - 1994
The mucosa of the small intestine has some unique microcirculatory features that may result in significant tissue oxygenation changes even under physiological conditions. To prove this hypothesis we investigated mucosal and serosal oxygenation in an autoperfused, innervated jejunal segment in pigs. Eight animals (30-40 kg) were anesthetized, paralyzed, and normoventilated. ...
Nylander O - - 1994
Proximal duodenum was perfused with HCl for 5 min and the effects on blood-to-lumen clearance of 51Cr-EDTA (ED-Cl), morphology, luminal alkalinization, and blood flow determined in anesthetized rats. The rate of alkalinization was determined by back titration and blood flow assessed by laser Doppler flowmetry or by ultrasonic transit time ...
Mailman D - - 1994
1. The role of endogenous mucosal nitric oxide (NO) in the local regulation of H2O absorption and blood flow in rat ileum was studied by perfusing L-arginine (L-Arg) (0.1-1.0 mM) and NG-nitro L-arginine (L-NOARG) (0.01-1.0 mM) through the lumen. D-Arginine (D-Arg) or L-Arg (1 mM), combined with L-NOARG, were used ...
Leung F W - - 1994
The importance of blood flow in duodenal ulcer healing is unclear. Endoscopic reflectance spectrophotometry measures the index of oxygen saturation (ISO2), which is significantly correlated with blood flow. In 97 consecutive patients who presented with duodenal ulcer bleeding, the difference in the index of oxygen saturation (delta ISO2: ulcer margin ...
Cho C H - - 1994
The effects of 5-hydroxytryptamine (5-HT) on gastric mucosal blood flow and lesion formation have been established. However, the mechanisms accounting for the reduction of gastric mucosal blood flow have not been defined. The current study aimed to test the hypothesis that decrease of gastric mucosal blood flow in rats is ...
Duff B E - - 1994
The application of a rapidly vascularized epithelial equivalent that inhibits wound contraction would have great potential in the prevention and repair of tracheal stenosis. An animal model was developed to simulate the effects of circumferential tracheal injury and an autologous epithelial equivalent was created from a fibroblast-collagen matrix and subsequently ...
Loeschke K - - 1994
To explore the quantitative significance of passive water flow through tight junctions of leaky epithelia, transepithelial water flow rates were measured in Necturus gallbladder mounted in chambers. Osmotic flows generated by raffinose gradients were asymmetrical with the greater flow in the mucosal-to-serosal direction. In tissue fixed in situ, intercellular spaces ...
Marroni N - - 1994
The effects of chronic normovolemic anemia on gastric microcirculation and gastric mucosal susceptibility to ethanol-induced gastric damage were investigated in anesthetized rats. Blood exchange by a plasma expander during four consecutive days rendered the animals anemic with a 34% decrease in the baseline hematocrit but without affecting blood volume. Chronic ...
Guslandi M - - 1994
Twelve patients with dyspepsia whose gastric abnormalities ranged from diffuse reddening of the mucosa to multiple erosions were treated for 4 weeks with oral sulglycotide, a sulphated glycopeptide with known gastroprotective and ulcer-healing properties. Before and after treatment, gastric mucosal blood flow was assessed by means of laser Doppler flowmetry. ...
Zhang X Y - - 1994
In anesthetized rats we tested the hypothesis that cigarette smoke potentiates acid-induced duodenal mucosal injury by inducing mesenteric vasoconstriction. Rats inhaled room air or 6 or 12 ml/min cigarette smoke. Study 1: 0.1 N HCl-induced duodenal mucosal injury and H+ loss were assessed by histologic evaluation and titration, respectively. Study ...
Tanaka T - - 1994
The effect of 3-ethyl-1-(6-hydroxy-6-methylheptyl)-7-propylxanthine (A90 6119) on 40% ethanol-induced gastric lesions and gastric mucosal blood flow was investigated in rats. Gastric mucosal blood flow was measured by the hydrogen gas clearance technique and the test compounds and vehicle were administered intraduodenally. A90 6119 dose-dependently increased gastric mucosal blood flow and ...
Zacchi P - - 1994
The impact of stress on gastroesophageal reflux and antireflux mechanisms remains largely unexplored. To a major extent, reflux depends on a balance between gastroesophageal junction resistance to flow and gastric tone. We hypothesized that these two forces could be differently affected by stress, and to test the hypothesis we quantified ...
Konturek S J - - 1994
Gastric mucosa adapts to ulcerogenic action of aspirin but the mechanism of this phenomenon is unknown. In this study, acute gastric lesions were produced by single or repeated oral administration of acidified aspirin in rats with intact or deactivated (by capsaicin) sensory nerves and with intact or suppressed synthase of ...
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