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Dufner Annette A Centre for Advanced Study in Bioethics, University of Münster, Geiststrasse 24-26, Room 1.18, 48151, Muenster, Germany, - - 2014
There is a widespread consensus that a commodification of body parts is to be prevented. Numerous policy papers by international organizations extend this view to the blood supply and recommend a system of uncompensated volunteers in this area-often, however, without making the arguments for this view explicit. This situation seems ...
White Michael J MJ University of Birmingham, School of Sport and Exercise Sciences, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom - - 2014
Compared to Caucasian Americans, African Americans present increased risk of cerebrovascular events such as stroke (Roger et al. 2011), even after controlling for age, insulin dependent diabetes, hypercholesterolemia, and education (Sacco et al. 1995). The mechanisms explaining this increased prevalence of cerebral vascular disease in African Americans therefore remain elusive, though African ...
Douet Jean Yves JY aUMR INRA ENVT 1225, Interactions Hôte Agent Pathogène, Ecole Nationale Vétérinaire de Toulouse, Toulouse, France bDepartment of Veterinary Medicine, University of Cambridge, Cambridge, - - 2014
Risk assessments for transmission of variant Creutzfeldt-Jakob disease predicted that leukocyte reduction would be inefficient at preventing transmission of the disease by blood transfusion. Nevertheless, approximately 14 years ago, a significant proportion of European countries decided to implement leukocyte reduction treatment within their human blood supplies in order to mitigate ...
Petersein Charlotte C Department of Psychiatry and Psychotherapy, University of Leipzig, Semmelweisstr. 10, 04103, Leipzig, - - 2014
Lithium is an important psychopharmacological agent for the treatment of unipolar as well as bipolar affective disorders. Lithium has a number of side effects such as hypothyroidism and aggravation of psoriasis. On the other hand, lithium has pro-inflammatory effects, which appear beneficial in some disorders associated with immunological deficits, such ...
Wheeler R R University Hospital Southampton NHS Foundation Trust, - - 2014
Surgeons dealing with an adult refusing a blood transfusion find themselves in an unenviable position, torn between wishing to preserve the patient's life while also respecting his or her wishes. This article looks at the legal framework for such circumstances as set out in the Mental Capacity Act 2005.
Burnouf Thierry T Graduate Institute of Biomedical Materials and Tissue Engineering, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: - - 2014
The world is regularly exposed to emerging infections with the potential to burst into a pandemic. One possible way to treat patients, when no other treatment is yet developed, is passive immunization performed by transfusing blood, plasma or plasma immunoglobulin fractions obtained from convalescent donors who have recovered from the ...
Moore Carmel - - 2014
Ageing populations may demand more blood transfusions, but the blood supply could be limited by difficulties in attracting and retaining a decreasing pool of younger donors. One approach to increase blood supply is to collect blood more frequently from existing donors. If more donations could be safely collected in this ...
Lattimore Samuel S National Health Service Blood and Transplant/Public Health England Joint Epidemiology Unit, Immunisation, Hepatitis and Blood Safety Department, National Centre for Infectious Disease Surveillance and Control, London, - - 2014
As populations in the developed world shift toward an older and more ethnically diverse population, the challenges of recruiting and retaining sufficient donors to secure an adequate, safe supply of blood in the future will increase. The study population included all first-time (n = 348,740) and repeat (n = 1,805,255) blood donors and their ...
Lam Hilton Y HY Institute of Health Policy and Development Studies, National Institutes of Health University of the Philippines Manila ; Institute of Clinical Epidemiology, National Institutes of Health University of the Philippines - - 2014
Due to a USAID-funded study on blood banks, a national policy was instituted in 1994 that set standards for Philippine blood services, promoted voluntary donation, and led to a ban on commercial blood banks. In this follow-up study, we assess the safety of the supply by determining the residual risk ...
Klausen Sofie Strand SS Department of Immunology and Transfusion Medicine, Haukeland University Hospital, Bergen, Norway; Insitute of Clinical Science, Faculty of Medicine and Dentistry, University of Bergen, Bergen, - - 2014
Bacterial contamination of blood and its cellular components remains the most common microbiological cause of transfusion associated morbidity and mortality, even in developed countries. This yet unresolved complication is seen more often in platelet transfusions, as platelet concentrates are stored at room temperature, in gas permeable containers with constant agitation, ...
Pekel G G Ophthalmology Department, Pamukkale University, Denizli, Turkey - - 2014
The retina and ocular vasculature are vulnerable to alterations in systemic hemodynamics, such as in open heart surgeries. Our aim was to investigate retinal vascular caliber (RVC), ocular pulse amplitude (OPA), peripapillary retinal nerve fiber layer (RNFL) and macular thickness in coronary artery bypass grafting (CABG) surgery patients. Twenty-six patients ...
Swaminathan Swarup S SS From Harvard-MIT Division of Health Sciences and Technology (Swaminathan), Harvard Medical School, Boston, Massachusetts, and the Department of Ophthalmology & Visual Sciences (Oh, Kang, Rhee), Case Western Reserve University, Cleveland, Ohio, - - 2014
The elevated intraocular pressure (IOP) of primary open-angle glaucoma is caused by impaired outflow of aqueous humor through the trabecular meshwork. Within the juxtacanalicular region, alterations of both extracellular matrix homeostasis and the cellular tone of trabecular meshwork endothelial and the inner wall of Schlemm canal cells affect outflow. Newer ...
Shi Ling L Department of Nursing, College of Nursing and Health Sciences, University of Massachusetts, Boston, MA, - - 2014
Despite a steady increase in total blood collections and voluntary non-remunerated blood donors, China continues to have many challenges with its blood donation system. The country's donation rate remains low at 9%o, with over 60% of donors being first-time donors. Generally there is a lack of adequate public awareness about ...
Schlenke Peter P Department for Blood Group Serology and Transfusion Medicine, Medical University Graz, Graz, - - 2014
Nowadays patients receiving blood components are exposed to much less transfusion-transmitted infectious diseases than three decades before when among others HIV was identified as causative agent for the acquired immunodeficiency syndrome and the transmission by blood or coagulation factors became evident. Since that time the implementation of measures for risk ...
Kanakamedala Priyanka P Department of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, Indiana, - - 2014
To examine the relationship between change in optic nerve head (ONH) morphology and retinal blood flow in patients with open-angle glaucoma (OAG) of African (AD) and European descent (ED) over 3 years. 112 patients with OAG (29 AD; 83 ED) underwent assessment of ONH morphology using Heidelberg retinal tomography (HRT-III), and ...
Schmidl Doreen D Department of Clinical Pharmacology, Medical University of Vienna , Vienna , Austria - - 2014
Abstract Gender medicine has been a major focus of research in recent years. The present review focuses on gender differences in the epidemiology of the most frequent ocular diseases that have been found to be associated with impaired ocular blood flow, such as age-related macular degeneration, glaucoma and diabetic retinopathy. ...
Guidoboni Giovanna G Department of Mathematical Sciences, Indiana University Purdue University Indianapolis, 402 N. Blackford St, LD 270 E, Indianapolis, IN, 46202, United States - - 2014
Purpose: This study investigates the relationship between intraocular pressure (IOP) and retinal hemodynamics and predicts how arterial blood pressure (BP) and blood flow autoregulation (AR) influence this relationship. Methods: A mathematical model is developed to simulate blood flow in the central retinal vessels and retinal microvasculature as current flowing through ...
Januleviciene Ingrida I *Eye Clinic, Lithuanian University of Health Sciences, Kaunas, Lithuania †Glaucoma Research and Diagnostic Center, Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, - - 2014
To evaluate the effects of trabeculectomy on ocular hemodynamic parameters in pseudoexfoliative glaucoma (PXG) and primary open-angle glaucoma (POAG) patients and to analyze serum antiphospholipid antibody levels (APLAs) in PXG. Thirty open-angle glaucoma patients were included in the prospective study. Intraocular pressure (IOP), ocular perfusion pressure (OPP), blood pressure, and ...
Feke Gilbert T GT Massachusetts Eye & Ear Infirmary, Department of Ophthalmology, Harvard Medical, School, 243 Charles Street, Boston, Massachusetts, - - 2014
To assess whether brimonidine 0.15% alters retinal vascular autoregulation and short-term visual function in normal tension glaucoma patients who demonstrate retinal vascular dysregulation. Non-randomized clinical trial. In this prospective study, 46 normal tension glaucoma patients not previously treated with brimonidine underwent retinal vascular autoregulation testing and visual function assessment using ...
Coşkun Mesut M Department of Ophthalmology, Medical Faculty, Mustafa Kemal University, Hatay. Electronic address: - - 2014
To research the effects of sub-Tenon's anaesthesia (STA) on ocular hemodynamics in patients with cataract using colour Doppler imaging (CDI). Prospective clinical study. Thirty-four eyes of 34 patients with age-related cataract. Peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistive index (RI) values of the ophthalmic artery (OA), central retinal ...
Harritshøj Lene Holm LH Department of Clinical Immunology, Blood Bank, Rigshospitalet, Copenhagen, - - 2014
To overcome problems and delays of the preparation of autologous serum eye drops, a production line of ABO-specific allogeneic serum eye drops from male blood donors was set up in a blood bank. Feasibility, clinical routine, safety and efficacy were evaluated in a cohort of patients with severe ocular surface ...
Ubuka Makoto M Department of Ophthalmology, Sakura Medical Center of Toho University, 564-1, Shimoshidu, Sakura, Chiba, 285-8741, - - 2014
Purpose: To investigate whether intravitreal infusion solution containing epinephrine affects optic nerve head (ONH) blood flow during vitreous surgeries. Methods: The subjects were 22 patients with epimacular membrane or idiopathic macular hole. During vitreous surgery, ONH blood flow was examined before and 10 min after intravitreal infusion of solution containing ...
Konieczka K K Department of Ophthalmology, University of Basel, - - 2014
The pathogenesis of the glaucomatous optic neuropathy (GON) is an ongoing bone of contention. While the role of intraocular pressure (IOP) is well known, it is also clear that a variety of other factors, particularly those of a vascular nature, are involved as well. In contrast to other eye diseases, ...
Ozsahin Mustafa M Department of Physical Medicine and Rehabilitation - - 2014
Abstract Purpose: To analyze the hemodynamic features of orbital blood flow velocities using Doppler ultrasonography in ankylosing spondiylitis (AS) patients, as well as to compare these results with those of healthy controls. Methods: 33 AS patients and 32 healthy controls were consecutively included in the study groups. The same radiologist ...
Abegão Pinto Luís L Department of Ophthalmology, Lisbon's Center Hospitals - Central, Lisbon, Portugal; Department of Ophthalmology, University Hospitals Leuven (UZ Leuven), Leuven, - - 2014
(1) To characterize the retrobulbar circulation in patients with optic disc drusen (ODD) using colour Doppler imaging; (2) to explore the differences in retrobulbar hemodynamics in patients with primary open-angle glaucoma (POAG). Retrospective analysis using three diagnostic groups: patients with ODD, age-matched healthy controls and age- and visual defect-matched patients ...
Ikemura Tsukasa T Graduate School of Human-Environment Studies, Kyushu University , Kasuga, Fukuoka, Japan ; Graduate School of Decision Science and Technology, Tokyo Institute of Technology , Ookayama, Meguro, - - 2014
The hypothesis that heat stress reduces the ocular blood flow response to exhaustive exercise was tested by measuring ocular blood flow, blood pressure, and end- tidal carbon dioxide partial pressure (PETCO2) in 12 healthy males while they performed cycle ergometer exercise at 75% of the maximal heart rate at ambient ...
Lim Jeremiah K H JK Department of Optometry and Vision Sciences, The University of Melbourne, Victoria, - - 2014
To investigate the effect of ageing on the recovery of ocular blood flow, intravitreal oxygen tension and retinal function during and after intraocular pressure (IOP) elevation. Long Evans rats (3- and 14-month-old) underwent acute stepwise IOP elevation from 10 to 120 mmHg (5 mmHg steps each 3 minutes). IOP was ...
Petrović Tamaš T Scientific Veterinary Institute Novi Sad, Novi Sad, Serbia. - - 2014
Hepatitis E virus (HEV) infection is rarely reported in industrialized countries, but recent studies have revealed quite variable seroprevalence rates among European populations, including blood donors. In Serbia, very limited data about HEV seroprevalence are available. This study aimed to determine the prevalence of anti-HEV IgG antibodies and HEV RNA ...
Nowosiad-Magda M M Department of Microbiology and Immunology, Pomeranian Medical University, Szczecin, Poland. Electronic address: - - 2014
Blood products infusions are often administrated to graft recipients. Post-transfusion reactions of anti-human leukocyte antigen antibodies (anti-HLA) are responsible for transfusion-related acute lung injury, but cases of graft rejection after blood product infusions were recently also proven. The aim of this study was to assess, with the use of the ...
Lee Eric E Department of Ophthalmology, Indiana University School of Medicine, Indianapolis - - - 2013
<p><bold>Purpose:</bold> To evaluate the impact of retinal blood flow on optic nerve head (ONH) morphology in patients with open-angle glaucoma (OAG) with and without diabetes mellitus (DM).</p><p><bold>Methods:</bold> A total of 66 patients with OAG (14 with DM, 52 without DM) were assessed at baseline and 3-year follow-up for retinal capillary ...
Yusuf Imran H - - 2013
Abstract Neisseria meningitidis is a major cause of childhood morbidity and mortality worldwide. We describe an exceptional case of an immunocompetent 15-month-old child presenting with a unilateral anterior uveitis, hypopyon, and sepsis. Anterior chamber aspirate demonstrated gram-negative cocci before Neisseria meningitidis was identified in blood and cerebrospinal fluid. Meningococcal endophthalmitis ...
Chihiro Mayama M D - - 2013
Several factors besides high intraocular pressure assumed to be associated with the development and progression of glaucoma, and calcium channel blockers (CCBs) have been an anticipated option for glaucoma treatment by improving ocular perfusion and/or exerting neuroprotective effects on retinal ganglion cells with safety established in wide and long-term usage. ...
Willekens Koen - - 2013
To investigate the relationship between optic nerve sheath diameter (ONSD) and retrobulbar blood flow velocities, as measured by color Doppler imaging (CDI) in glaucoma patients. We performed a prospective, randomized, observer-masked study involving a total of 197 subjects. Once enrolled, they were divided by three groups: healthy controls (n = 51), normal-tension ...
Feiz Vahid - - 2013
To determine the penetration of orally administered trimethoprim (TMP)-sulfamethoxazole (SMX) into the aqueous and vitreous cavity of noninflamed human eyes. Nine adult patients undergoing cataract surgery and 10 adult patients undergoing pars plana vitrectomy were given 3 doses of oral TMP-SMX every 12 hours before the surgery. Aqueous and blood ...
He Zheng Z Department of Optometry & Vision Sciences, University of Melbourne Parkville, Victoria, - - 2013
Retinal function is known to be more resistant than blood flow to acute reduction of ocular perfusion pressure (OPP). To understand the mechanisms underlying the disconnect between blood flow and neural function, a mathematical model is developed in this study, which proposes that increased oxygen extraction ratio compensates for relative ...
Nirmal Jayabalan - - 2013
The present study was conducted to test the hypothesis; OCT may be active from blood-to-vitreous for the uptake of its substrates. Ocular uptake of Tetraethylammonium (TEA) across blood ocular barriers and the tissue distribution was evaluated invivo in New Zealand albino rabbits after intravenous administration. Quinidine (blocker) pretreatment resulted in ...
Siesky Brent - - 2013
To investigate differences in ocular blood flow in individuals of African descent (AD) and European descent (ED) with open angle glaucoma (OAG). A retrospective data analysis was performed on OAG patients of AD and ED who were previously examined for ocular blood flow within the Department of Ophthalmology at Indiana ...
Ninomiya Hiroyoshi - - 2013
OBJECTIVE: To examine the blood supply to the eyes of bottlenose dolphin (Tursiops truncatus), spotted seal (Phoca largha), and California sea lion (Zalophus californianus). Emphasis is placed on exploring the anatomic function in the context of aquatic life. PROCEDURE: Methyl methacrylate casts were prepared and studied using a scanning electron ...
Samera Waleed Abu - - 2013
To investigate ocular blood flow changes in healthy myopic patients following laser in situ keratomileusis (LASIK) using color Doppler imaging. Sixteen eyes of 16 myopic patients were studied. LASIK was performed and intraocular pressure was raised to levels ≥65 mmHg. Color Doppler images were obtained to study the ophthalmic and central ...
Harris Alon A Department of Ophthalmology, Glick Eye Institute, Indiana University Medical Center, Indianapolis, IN, - - 2013
Glaucomatous damage has been described as a slowly progressive neuronal degenerative process along the visual pathway. Decreased cerebral and ocular blood flow as well as impaired vascular autoregulation has been identified in glaucoma and have been shown to correlate with visual field loss. In low-tension glaucoma patients, diffuse cerebral ischemic ...
Singh Kirti - - 2013
Carotid Doppler measures blood flow velocity and vascular resistance index in the central retinal arteries and short posterior ciliary arteries. The blood flow profile of the optic nerve in chronic angle-closure glaucoma (CACG), however, has not been well documented. We report a 48-year-old female patient who presented with grossly asymmetric ...
Cattini Stefano - - 2013
ABSTRACT. Diffuse correlation spectroscopy (DCS) measurements in vivo recorded from rabbits' ocular fundus are presented. Despite the complexity of these ocular tissues, we provide a clear and simple demonstration of the DCS abilities to analyze variations in physiological quantities of clinical interest. Indeed, the reported experimental activities demonstrate that DCS ...
Almasieh Mohammadali - - 2013
A clear correlation between vascular deficits and retinal ganglion cell (RGC) loss in glaucoma has not yet been established. The question arose as to whether there is loss of inner retinal vessels following intraocular pressure (IOP) increase and, if so, whether it occurs prior to, concomitantly with, or after RGC ...
Tobe Leslie A - - 2013
Purpose: To discuss the techniques and mechanisms of retinal oximetry with a focus on utilization of retinal oximetry in the assessment of retinal oxygen saturation in glaucoma.
Methods: We reviewed recent literature found by searching combinations of the following search terms: glaucoma, retinal oximetry, ocular blood flow, retinal blood flow, oxygen ...
Adeyinka Odunlami Olufemi - - 2013
To assess blood flow velocity in newly diagnosed indigenous black-skinned Africans with primary open angle glaucoma (POAG). Prospective case-control study at Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria on 50 newly diagnosed POAG patients (POAG group) and 50 control patients (control group). Ocular Doppler Color Imaging was performed on subjects ...
Saito Michiyuki - - 2013
To quantitatively evaluate the time course of macular choroidal blood flow velocity in acute central serous chorioretinopathy (CSC). This retrospective observational case series included 21 eyes of 20 patients (17 men, 3 women; mean age, 53.0 years) with treatment-naïve acute CSC. Laser speckle flowgraphy was performed to calculate macular mean ...
Wong Vickie H Y - - 2013
To consider the hypothesis that streptozotocin (STZ)-induced hyperglycemia renders rat retinal function and ocular blood flow more susceptible to acute IOP challenge. Retinal function (electroretinogram [ERG]) was measured during acute IOP challenge (10100 mm Hg, increments of 5 mm Hg, 3 minutes per step, vitreal cannulation) in adult Long-Evans rats ...
Mayama Chihiro - - 2013
An association between glaucoma development or progression and compromised ocular blood flow has been postulated as a result of population-based studies and prospective cohort studies. Blood flow in the optic nerve head (ONH) is of primary importance in the pathogenesis of glaucoma. The potential to modify the blood flow in ...
Piper Chelsea - - 2013
To characterize the hemodynamic features and the association with structural damage in the optic nerve head (ONH) of idiopathic bilateral optic atrophy (BOA) in rhesus macaque monkeys. In five animals with BOA and nine healthy animals under general anesthesia (pentobarbital), intraocular pressure (IOP) was manometrically controlled. ONH blood flow was ...
Janulevičienė Ingrida I Department of Ophthalmology, Medical Academy, Lithuanian University of Health Sciences, Eivenių 2, 50161 Kaunas, Lithuania. - - 2013
OBJECTIVE. The aim of this study was to evaluate intraocular pressure (IOP), retrobulbar blood flow (RBF), and ocular side effects after the application of topical dorzolamide/timolol fixed combination (DTFC) drops vs topical nebulized DTFC mist in patients with primary open-angle glaucoma. MATERIAL AND METHODS. A total of 15 POAG patients ...
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