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Uždavinienė, Diana
For the first time to our knowledge the distribution of magnesium and calcium between blood plasma and blood cells in hepatitis C infected samples has been analyzed. The character of the distribution depends very much on the metal and the duration of the infection, suggesting that there is a variety ...
Gai Yong-Hao YH Department of Ultrasound, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. - - 2014
The aim of this study was to investigate the ultrasonic features of the cavo-hepato-atrial pathway in Budd-Chiari syndrome (BCS), by which blood is drained from the occluded inferior vena cava (IVC) to the right atrium via hepatic veins. Ultrasonograms from 11 patients with BCS with cavo-hepato-atrial pathways were retrospectively studied. ...
Richter Torsten T Department of Anesthesia and Intensive Care, Carl Gustav Carus University Hospital, Technische Universität Dresden, Dresden, - - 2014
Gastric aspiration events are recognized as a major cause of pneumonitis and the development of acute respiratory distress syndrome. The first peak in the inflammatory response has been observed one hour after acid-induced lung injury in rats. The spatial pulmonary blood flow (PBF) distribution after an acid aspiration event within ...
Martin Caroline C M2S Laboratory, UFR APS, University of Rennes 2-ENS Cachan, Campus de Ker Lann, Bruz, France - - 2014
Energy flow has been hypothesized to be one of the most critical biomechanical concepts related to tennis performance and overuse injuries. However, the relationships among energy flow during the tennis serve, ball velocity, and overuse injuries have not been assessed. To investigate the relationships among the quality and magnitude of ...
Bodenstein Marc M 1Department of Anaesthesiology, University Medical Center Mainz, Mainz, - - 2014
ABSTRACT Purpose of the Study: Detection of cyclical recruitment of atelectasis after induction of lavage (LAV) or oleic acid injury (OAI) in mechanically ventilated pigs. Primary hypothesis is that oxygen oscillations within the respiratory cycle can be detected by SpO2 recordings (direct hint). SpO2 oscillations reflect shunt oscillations that can ...
Stankovic Zoran Z Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N Michigan Avenue Suite 1600, Chicago, IL, 60611, USA, - - 2014
We sought to evaluate the feasibility of k-t parallel imaging for accelerated 4D flow MRI in the hepatic vascular system by investigating the impact of different acceleration factors. k-t GRAPPA accelerated 4D flow MRI of the liver vasculature was evaluated in 16 healthy volunteers at 3T with acceleration factors R = 3, ...
Pareja-Carrera Jennifer J Department of Wildlife Toxicology, Instituto de Investigación en Recursos Cinegéticos (IREC-CSIC, UCLM, JCCM), Ronda de Toledo s/n, 13071 Ciudad Real, Spain. Electronic address: - - 2014
Livestock from the ancient mining area of Sierra Madrona and Alcudia Valley (Spain) is exposed to elevated levels of lead (Pb), as previous studies based on blood monitoring have revealed. Here we have studied blood, liver and muscle Pb levels in sheep in order to know if Pb exposure could ...
Cocciolillo Sila S Sila Cocciolillo, Leonardo Marzio, Digestive Physiopathology Unit, Gabriele d'Annunzio University, Pescara Civic Hospital, 65124 Pescara, - - 2014
To determine intra-hepatic blood flow and liver stiffness in patients with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) using contrast-enhanced ultrasound and fibroscan. This prospective study included 15 patients with NAFLD, 17 patients with NASH and 16 healthy controls. In each patient, real-time ultrasound was used to locate ...
Pereira Adriano Jose AJ Bern University Hospital and University of - - 2014
Acute reduction of portal vein blood flow (Qpv) increases hepatic arterial perfusion (Qha) [the hepatic arterial buffer response (HABR)]. Angiotensin II (AT-II) reduces Qpv but its effect on HABR is not known. We explored interactions of AT-II and enalapril with hepatic blood flow regulation. 20 healthy anesthetized pigs were randomized ...
Kim Peter T W PT Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX, - - 2014
Adequate hepatic arterial (HA) flow to the bile duct is essential in liver transplantation. This study was conducted to determine if the ratio of directly measured HA flow to weight is related to the occurrence of biliary complications after deceased donor liver transplantation. A retrospective review of 2684 liver transplants ...
Nakamura Kimitoshi K Department of Pediatrics, Kumamoto University Hospital, Honjo 1-1-1, Chuo-ku, Kumamoto, 860-8556 - - 2014
Urea cycle disorders (UCDs) are inborn errors of the metabolic pathway producing urea from ammonia, which occurs primarily in the liver. Decreased excretion of nitrogen in the urea cycle due to deficiency of carbamoyl phosphate synthase I (CPSI), ornithine transcarbamylase (OTC), argininosuccinate synthase (ASS), argininosuccinate lyase (ASL), arginase (ARG), and ...
Hartman Neil R NR Division of Applied Regulatory Science, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD 20993-0002, USA. Electronic address: - - 2014
The clinical use of local anesthetic products to anesthetize mucous membranes has been associated with methemoglobinemia (MetHba), a serious condition in which the blood has reduced capacity to carry oxygen. An evaluation of spontaneous adverse event reporting of MetHba submitted to FDA through 2013 identified 375 reports associated with benzocaine ...
Karoli Ritu R Department of Medicine, Era's Lucknow Medical College, Lucknow, Uttar Pradesh, - - 2014
Transfusion-related acute lung injury (TRALI) is a serious clinical syndrome associated with the transfusion of plasmacontaining blood components. Recently, TRALI has come to be recognized as the leading cause of transfusion-related mortality. This complication typically presents as shortness of breath, hypoxemia, hypotension, fever, and non cardiogenic pulmonary edema, occurring within ...
Zhuang Wanchuan W Department of Hematology, Lianyungang Second People's Hospital affiliated to Bengbu Medical College, Lianyungang, - - 2014
Hepatitis E virus (HEV) infection is responsible for over 50% of acute viral hepatitis cases, and the blood transfusion route has emerged as a possible means of sporadic HEV infection. The aim of this study was to determine the seroprevalence of HEV among blood donors in East China. Blood samples ...
Kouegnigan Rerambiah L L Centre national de transfusion sanguine (CNTS), Libreville, - - 2014
Blood transfusion is a life-saving therapeutic act without alternative. Each blood transfusion carries the risk of blood-borne pathogens transmission. The present study, is the first establishing the usefulness of blood donors screening questionnaire in the setting of the Gabonese National Blood Transfusion Center. Nine hundred and thirty-four blood donors aged ...
Dragoteanu Mircea M Mircea Dragoteanu, Ioan-Adrian Balea, Cecilia-Diana Piglesan, Department of Nuclear Medicine, Regional Institute for Gastroenterology and Hepatology, Prof. Dr. Octavian Fodor, 400162 Cluj-Napoca, - - 2014
To investigate the hepatic hemodynamics in the Budd-Chiari syndrome (BCS) using per-rectal portal scintigraphy (PRPS) and liver angioscintigraphy (LAS). Fourteen consecutive patients with BCS were evaluated by PRPS between 2003 and 2012. Ten of them underwent LAS and liver scan (LS) with Tc-99m colloid. Eleven patients had clinical manifestations and ...
Wang X X Department of Anesthesiology, Children's Hospital of Fudan University, Shanghai, - - 2014
We measured pre-operative hepatic blood flow and postoperative morphine concentration in infants with or without biliary atresia. Thirty-four infants (0-3 months) with biliary atresia undergoing portoenterostomy (Kasai operation) were included and hepatic blood flow was assessed by magnetic resonance imaging before surgery in 12 of them. Sixteen subjects (0-3 months) without liver ...
Orbegozo Cortés D D Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, - - 2014
/st>Several different crystalloid solutions are available for i.v. fluid administration but there is little information about their specific advantages and disadvantages. /st>We performed a systematic search of MEDLINE, EMBASE, and CENTRAL up until May 17, 2012, selecting all prospective human studies that directly compared any near-isotonic crystalloids and reported any ...
Erlandsen Erland J EJ Department of Clinical Biochemistry, Viborg Regional Hospital , Viborg , - - 2014
Objective. The purpose of this study in humans was to examine the influence of the gastrointestinal tract and liver on the serum concentrations of cystatin C. Methods. Eighteen healthy volunteers and 28 patients suspected of having chronic intestinal ischemia underwent catheterization of the abdominal aorta and the central hepatic vein. ...
Mohajeri G G Department of Animal Science, College of Abouraihan, University of Tehran, P.O. Box 11365-4117, Tehran, - - 2014
The present study examines blood metals levels and health parameters in dairy cows reared in areas around a Pb-Zn industrial complex located near the city of Zanjan-Iran. Blood samples (n = 27) were collected from cows reared around the smelter. Blood samples (n = 25) were also collected from cows reared in areas where ...
Chang Jae H JH - - 2014
Atorvastatin is eliminated by CYP3A4, which follows carrier-mediated uptake into hepatocytes by OATP1B1, OATP1B3 and OATP2B1. Multiple clinical studies demonstrated that OATP inhibition by rifampin had a greater impact on atorvastatin systemic concentration than itraconazole - mediated CYP3A4 inhibition. If it is assumed that the blood and hepatocyte compartments are ...
Ng Chaan S CS From the Departments of *Diagnostic Radiology, †Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX; ‡CT Research, GE Healthcare, Waukesha, WI; Departments of §Gastrointestinal Medical Oncology, and ∥Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, - - 2014
The objective of this study was to assess the effects of pre-enhancement set point (T1) positioning on computed tomographic perfusion (CTp) parameter values. The CTp data from 16 patients with neuroendocrine liver metastases were analyzed with distributed parameter modeling to yield tissue blood flow (BF), blood volume, mean transit time, ...
Vliegenthart Adriaan D B AD 1 British Heart Foundation Centre for Cardiovascular Science, The Queen's Medical Research Institute, The University of Edinburgh , Edinburgh, United Kingdom - - 2014
Abstract Paracetamol is the commonest cause of acute liver failure in the Western world and biomarkers are needed that report early hepatotoxicity. The liver-enriched microRNA (miRNA), miR-122, is a promising biomarker currently being qualified in humans. For biomarker development and drug toxicity screening, the zebrafish has advantages over rodents; however, ...
Shyamala V V Research Diagnostics, Inc., Bengaluru, - - 2014
The aim of the study was to assess the blood safety in India through prevalence in thalassaemic population. Safety of the blood supply is a subject of great concern for all recipients. This review attempts to assess the relevance and format of tests for viruses in the context of transfusion ...
Kilpatrick S S Division of Veterinary Clinical Sciences, The Roslin Institute, Royal (Dick) School of Veterinary Studies, Hospital for Small Animals, The University of Edinburgh, Roslin, Midlothian EH25 - - 2014
Increased whole blood manganese concentrations have been reported in humans with primary liver disease. Due to the neurotoxic effects of manganese, altered manganese homeostasis has been linked to the development of hepatic encephalopathy. Whole blood manganese concentrations are increased in cases of canine congenital portosystemic shunts, but it remains unclear ...
Mikkelsen Kasper S KS Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, - - 2014
The galactose analog 2-(18)F-fluoro-2-deoxy-d-galactose ((18)F-FDGal) is a suitable PET tracer for measuring hepatic galactokinase capacity in vivo, which provides estimates of hepatic metabolic function. As a result of a higher affinity of galactokinase toward galactose, the lumped constant (LC) for (18)F-FDGal was 0.13 in healthy subjects. The aim of the ...
Wang Chih-Hsien CH Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, - - 2014
Coagulopathy is common in patients with end-stage liver disease requiring liver transplantation (LT). Thromboelastography (TEG) test results are used for analyzing coagulation data and making a decision about the transfusion requirements. However, whether it is necessary to correct the abnormal coagulation profile during LT is a matter of considerable debate. ...
Sugimoto Katsutoshi K Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan. Electronic address: - - 2014
The aim of this study was to assess quantitatively the Kupffer-phase enhancement patterns of hepatic hemangiomas in contrast-enhanced ultrasound (CEUS) with Sonazoid. A total of 46 patients with 46 hepatic hemangiomas (17.1 ± 6.2 mm in diameter, 34 typical type and 12 high-flow type) underwent CEUS in the Kupffer phase. The lesion-to-liver contrast ...
Lee Heun H Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 682-060, South - - 2014
We herein used data from the Korean National Health and Nutritional Examination Survey (KNHANES) 2008-2012 to examine the associations between blood mercury levels and subclinical changes of liver function in a representative sample of the adult Korean population. This study was based on data obtained from KNHANES, in which a ...
Cantrell Frank Lee FL California Poison Control System, San Diego Division, 200 West Arbor Drive, San Diego, 92103-8925, CA; Department of Clinical Pharmacy, University of California San Francisco, 521 Parnassus Avenue, San Francisco, 94117, - - 2014
Methylphenidate (MPD) is a widely prescribed stimulant used primarily for the treatment for attention-deficit/hyperactivity disorder (ADHD). Suicide attempts involving MPD ingestion have been well described; however, deaths attributed solely to MPD ingestion have not been reported. A 62-year-old woman was found dead on her floor. The only discrepancy in among ...
Ott Peter P Department of Hepatology and Gastroenterology, Aarhus University Hospital, 8000C, Aarhus, Denmark, - - 2014
Hyperammonemia is necessary for development of the cerebral complications to liver disease including hepatic encephalopathy and cerebral edema but the mechanisms are unclear. Ammonia is taken up by the brain in proportion to its arterial concentration. The flux into the brain is most likely by both diffusion of NH3 and ...
Paroskie Allison A Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United - - 2014
Acute non-hemolytic transfusion reactions, consisting of both allergic and febrile reactions, are common occurring in up to 10.2% of transfused blood products [1], however anaphylaxis, or severe allergic reactions, are rare following transfusion. The incidence of anaphylaxis is more common after the transfusion of plasma containing products with estimations from ...
Rahbari N N NN Department of General, Visceral and Transplant Surgery, Heidelberg, - - 2014
Various devices have been developed to facilitate liver transection and reduce blood loss in liver resections. None of these has proven superiority compared with the classical clamp-crushing technique. This randomized clinical trial compared the effectiveness and safety of stapler transection with that of clamp-crushing during open liver resection. Patients admitted ...
Saitoh Wataru W Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd., - - 2014
To clarify the relationship between arginine metabolism and hepatic injury, metabolomic analysis was performed in rats treated with 3 representative hepatotoxicants, monocrotaline (MCT), concanavalin A (ConA), and α-naphthyl isothiocyanate (ANIT); or a myotoxicant, tetramethyl-p-phenylenediamine (TMPD). A single dose of MCT, ConA, or ANIT dose-dependently induced hepatocellular necrosis accompanied by decreased ...
Ara C C General Surgery Department, Inonu University School of Medicine, Malatya, - - 2014
Intraoperative blood loss and red blood cell transfusion requirements have a negative impact on outcome after orthotopic liver transplantation. In this study we compared blood transfusion requirements, bile duct injury, and dissection of hepatic artery rates in the patients with or without partial cholecystectomy during recipient hepatectomy. From December 2008 ...
Feng Guiying G Department of Medical Ultrasound, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, - - 2014
Microbubble-enhanced therapeutic ultrasound (MEUS) can block the blood flow in the organs. The aim of this study was to evaluate the hemostatic effect of microbubble-enhanced pulsed, low-intensity ultrasound in a New Zealand White rabbit model of avulsion trauma of the liver. The therapeutic ultrasound (TUS) transducer was operated with the ...
Eriksson Sam S Department of Surgery, Clinical Sciences Lund, Lund University, Sweden ; Skåne University Hospital, Lund, - - 2014
Liver microcirculation can be affected by a wide variety of causes relevant to liver transplantation and resectional surgery. Intraoperative assessment of the microcirculation could possibly predict postoperative outcome. The present pilot study introduces laser speckle contrast imaging (LSCI) as a new clinical method for assessing liver microcirculation. LSCI measurements of ...
Derbyshire Emily R ER Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, - - 2013
Drugs that target both malaria's liver and blood stages will be needed to reduce the disease's substantial worldwide morbidity and mortality. Evaluation of a 259-member library of compounds that block proliferation of the blood stage of malaria revealed several scaffolds - dihydroquinazolinones, phenyldiazenylpyridines, piperazinyl methyl quinolones, and bis-benzimidazoles - with ...
Nagengast Andrea K AK Department of Surgery, University of Louisville, Louisville, Kentucky, - - 2013
Total hepatic blood flow (HBF) via the hepatic artery and portal vein is highly dependent on gastrointestinal perfusion. During postprandial hyperemia, intestinal blood flow depends on nutrient composition, gastrointestinal location, and time. Immune-enhancing diets (IEDs) containing n-3 polyunsaturated fatty acids (PUFAs) selectively augment blood flow in the ileum at 60-120 ...
He Yong Y Malcom Randall VAMC, Gainesville, Fla; Division of Vascular Surgery and Endovascular Therapy, Department of Surgery, College of Medicine, University of Florida, Gainesville, - - 2013
After vascular interventions, unidentified mechanisms disrupt the homeostasis of a focal narrowing to initiate an intimal thickening response. We hypothesize that perturbations in the hemodynamic microenvironment are the initiating event for this disruption of homeostasis and intimal thickening in vein bypass grafts. The objective of this study was to investigate ...
Wang Yinghuan Y Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, - - 2014
Benalaxyl as a xylem-systemic fungicide is usually direct sprayed on the soil surface, which is potential harm to the animals lived in the soil. However, the stereoselectivity of benalaxyl in reptiles have rarely been studied. In this study, Chinese lizards (Eremias argus) were firstly used to evaluate the stereoselectivity in ...
Hao Xue-Jia - - 2013
Assessment of tumor response after argon-helium cryoablation is critical in guiding future therapy for unresectable hepatocellular carcinoma. This study aimed to evaluate liver hemodynamics in hepatocellular carcinoma after argon-helium cryoablation with computed tomography perfusion. The control group comprised 40 volunteers without liver disease. The experimental group was composed of 15 ...
Cucchetti A - - 2013
Background: The possibility of outlining a risk profile for perioperative blood transfusion of cirrhotic patients submitted to hepatic resection can help to rationalize transfusion policy. Methods: Data from 323 hepatic resections, performed in cirrhotic patients, were reviewed. Bootstrap and a leave-one-out logistic regressions were applied to test the accuracy of ...
Alvarez J - - 2013
Liver dysfunction due to a low cardiac output state after cardiac surgery is associated with a poor prognosis, but whether one inotrope is superior to another in improving hepatic perfusion remains uncertain. This study compared the systemic and hepatic haemodynamic effects of levosimendan to dobutamine in patients with a low ...
Baig Mukhtiar M Mukhtiar Baig, PhD, Professor in Clinical Biochemistry, Faculty of Medicine Rabigh, King Abdulaziz University, Jeddah, Kingdom of Saudi - - 2013
To determine the knowledge, misconceptions and motivations towards blood donation among university students in KSA. This cross sectional study was carried out at the King Abdulaziz University, Rabigh campus, Jeddah, KSA. A total of 326 adult males were interviewed and each individual completed a questionnaire in Arabic language on various ...
Noiret L - - 2013
Hyperammonaemia is a common complication of chronic liver failure. Two main factors are thought to underlie this complication: a loss of hepatic detoxification function and the development of portosystemic shunting. However few studies have tried to quantify the importance of portosystemic shunting. Here we used a theoretical approach to test ...
Putchakayala Krishna - - 2013
Despite increased use of acute hemodilution (AH) to reduce perioperative blood transfusion in patients undergoing partial hepatectomy, there is a lack of data on safety in those with comorbid medical illness. We performed a retrospective review of 96 patients undergoing partial hepatectomy with AH and low central venous pressure (CVP) ...
Harimoto Norifumi N Department of Surgery, Iizuka Hospital, Fukuoka, Japan. - - 2013
Stroke volume variation (SVV), which is measured by analyzing arterial blood pressure waveform characteristics, is a simple and sensitive indicator of fluid responsiveness. The current retrospective study was to investigate SVV and central venous pressure (CVP) during hepatic resection under clamping of both the infrahepatic inferior vena cava (IVC) and ...
Shiba Hiroaki - - 2013
Background/Aims: Because recent studies have reported that allogenic blood transfusion exerts negative immunomodulatory effects, we tried decreasing the use of blood products in perioperative management of hepatic resection since 2003. We retrospectively assessed the changes in our blood transfusion policy on hepatic resection for hepatocellular carcinoma (HCC). Methodology:Subjects were 78 ...
Taouli Bachir B 1 Department of Radiology, Body MRI, Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave Levy Pl, Box 1234, New York, NY - - 2013
The objective of our study was to report our initial experience with dynamic contrast-enhanced MRI (DCE-MRI) for perfusion quantification of hepatocellular carcinoma (HCC) and surrounding liver. DCE-MRI of the liver was prospectively performed on 31 patients with HCC (male-female ratio, 26:5; mean age, 61 years; age range, 41-83 years). A ...
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