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Kang Joo H JH 1] Wyss Institute for Biologically Inspired Engineering, Boston, Massachusetts, USA. [2] Vascular Biology Program, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [3] Harvard School of Engineering and Applied Sciences, Cambridge, Massachusetts, USA. - - 2014
Here we describe a blood-cleansing device for sepsis therapy inspired by the spleen, which can continuously remove pathogens and toxins from blood without first identifying the infectious agent. Blood flowing from an infected individual is mixed with magnetic nanobeads coated with an engineered human opsonin-mannose-binding lectin (MBL)-that captures a broad ...
Yokomizo Tomo T Sepacell Development Planning Department, Asahi Kasei Medical, Oita, - - 2014
Leukofiltration of blood components is currently implemented worldwide as a precautionary measure against white blood cell-associated adverse effects and the potential transmission of variant Creutzfeldt-Jakob disease (vCJD). A newly developed bifunctional filter (Sepacell Prima, Asahi Kasei Medical) was assessed for prion removal, leukoreduction (LR), and whether the filter significantly affected ...
Bennuru Sasisekhar S National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of - - 2014
Administration of ivermectin (IVM) as part of mass drug administration (MDA) campaigns for onchocerciasis and/or lymphatic filariasis (LF) has been suspended in areas co-endemic for Loa loa due to severe post-treatment adverse events (SAEs) associated with high-burden of infection (>30,000 mf/ml). One simple approach for preventing SAEs is to identify ...
Politou Marianna - - 2014
Herpes viruses infection transmitted through healthy but infected blood donors pose a danger to herpes-naive immunocompromised recipients. The risk of transfusion-related HHV-8 transmission is different in endemic and not endemic areas. HHV-6 and HHV-8 seroprevalence and viral load among blood donors have been reported from different countries. The aim of ...
McDowell Kristy L KL Division of Emerging and Transfusion-Transmitted Diseases, Office of Blood Research and Review, Food and Drug Administration, Silver Spring, - - 2014
Variant Creutzfeldt-Jakob disease (vCJD) is a fatal neurodegenerative infection that can be transmitted by blood and blood products from donors in the latent phase of the disease. Currently, there is no validated antemortem vCJD blood screening test. Several blood tests are under development. Any useful test must be validated with ...
Teetzmann Ralf R Department of Anesthesiology, Stord Hospital, Helse Fonna HF, - - 2014
We have conducted a randomized controlled study where 164 patients were randomized to receive autologous salvaged blood collected by Sangvia™ Blood Salvage System or allogeneic red cell concentrates if transfusion was indicated by clinical judgement. The study was powered to detect if transfusion of autologous blood reduced the occurrence of ...
Gan V C H VC Institute of Infectious Disease and Epidemiology, Tan Tock Seng Hospital Singapore, - - 2014
Arthropod-borne viruses (arboviruses) are a growing threat to global health. Complex vector-virus-host interactions lead to unpredictable epidemiological patterns. Difficulties in accurate surveillance including imperfect diagnostic tools impair effective response to outbreaks. With arboviral infections causing a wide spectrum of disease severity, from asymptomatic infection to fatal neuroinvasive and haemorrhagic fevers, ...
Tabrizi Reza R From the *Department of Maxillofacial Surgery, Shahidbeheshti University of Medical Science, Tehran; †Department of Anesthesiology, Shiraz University of Medical Science, Shiraz; ‡Department of Maxillofacial Surgery, Shahidbeheshti University of Medical Sciences, Tehran; and §Department of Maxillofacial Surgery, Shiraz University of Medical Science, Shiraz, - - 2014
This uni-blind randomized clinical trial study investigated the effect of clonidine premedication on preoperative blood loss during open rhinoplasty. The subjects were randomly divided into 2 groups. The members of the first group received oral clonidine as a single dose (0.2 mg) 2 hours before the induction of general anesthesia, ...
Safabakhsh Hamidreza - - 2014
Human T-cell lymphotropic virus (HTLV-I) is associated with adult T cell leukemia/lymphoma (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The major routes of HTLV-I transmission are mother-to-child, sexual contact, and blood transfusion. Mashhad is one of the main endemic areas in the world for HTLV-I, and minimizing the risk of ...
Anderson Colin - - 2013
Yohimbine is an alkaloid that has been encountered on the streets as an aphrodisiac, hallucinogen, dietary supplement and erectile dysfunction drug. Yohimbine hydrochloride is an alpha 2-adrenoreceptor antagonist, blocking the pre- and postsynaptic alpha-2 adrenoreceptors and causing an increased release of noradrenaline and dopamine. An average oral dose of 5-15 ...
Yano Tetsuya - - 2012
Blood compatibility of a ventricular assist device (VAD) depends on the dynamics of blood flow. The focus in most previous studies was on blood flow in the VAD. However, the tip shape and position of the VAD inflow cannula influence the dynamics of intraventricular blood flow and thus thrombus formation ...
Jeon Kisoo - - 2012
In this study, a direct-flow-type nose-only exposure chamber developed for inhalation toxicity experiments using a numerical analysis and experiments is evaluated. Maintaining a uniform flow rate and test article concentration are the critical factors when designing an inhalation exposure chamber. Therefore, this study evaluated whether the flow rate and particle ...
Chen Li-Chia - - 2012
A novel concept for electroosmotic flow (EOF) control in a microfluidic chip is presented by using a self-assembled monolayer (SAM) as the insulator of a flow field-effect transistor. A bi-directional EOF control with the mobility values of 3.4×10-4 and -3.1×10-4 cm2/V s can be attained corrsponding to the applying gate ...
Magnusson Emma - - 2012
In this study we investigate the effect of programmed cross-flows on the error in the hydrodynamic radii (r(h)) determination with asymmetrical flow field-flow fractionation (AsFlFFF). Three different standard polystyrene particles (nominal radii of 30 and 40 and 50nm) are fractionated with exponentially and linearly decaying cross-flows with different decay rates. ...
Martin Michel - - 2012
ABSTRACT A simple theoretical model for the size selectivity, Sd, in the lift mode of retention in field-flow fractionation (FFF) is developed on the basis of the near-wall lift force expression. Sd is made up of two contributions: the flow contribution, Sd,f, arising from the variation of the flow velocity ...
Berthe A - - 2012
Flow fields are one of the key factors associated with the life threatening formation of thrombi in artificial organs. Therefore, knowledge of flow field is crucial for the design and optimization of a long-term blood pump performance. The blood chamber flow of a novel counterpulsation heart assist device (CPD) has ...
Sebastian Cabeza Victor - - 2012
Segmented flow is often used in synthesis of nanomaterials to achieve narrow particle size distribution, and this effect is commonly attributed to the reduced dispersion associated with segmented flows. On the basis of the analysis of flow fields and the resulting particle size distributions, we demonstrate that it is the ...
Ritter M - - 2012
OBJECTIVES: To evaluate the influence of different biopsy forcipes on the deflection, irrigant flow, and optical characteristics of flexible ureterorenoscopes and to assess tissue quality for histopathologic evaluation in an ex vivo setting. MATERIALS AND METHODS: The following five different biopsy forcipes were compared: Olympus (FB-56D-1; diameter 5Fr.), R. Wolf ...
Peixinho J - - 2012
Results are reported on a combined experimental and numerical investigation of a free surface flow at small Reynolds numbers. The flow is driven by the rotation of the inner of two horizontal concentric cylinders, with an inner to outer radius ratio of 0.43. The outer cylinder is stationary. The annular ...
Malet Sanz Laia - - 2012
Continuous flow chemistry as a technique and the latest developments in the field are being reviewed from a Pharma point of view.
Wendt Daniel - - 2012
Abstract The aim of the present study was to evaluate and compare the in vitro and flow dynamics of the Magna (MB) and the Magna Ease aortic valve bioprosthesis (MEB) within the ascending aorta. A 2D-particle-image-velocimetry (2D-PIV) study was performed to compare the flow dynamics induced by each pericardial Carpentier-Edwards ...
Kirillov Oleg N - - 2011
By methods of modern spectral analysis, we rigorously find distributions of eigenvalues of linearized operators associated with an ideal hydromagnetic Couette-Taylor flow. The transition to instability in the limit of a vanishing magnetic field has a discontinuous change compared to the Rayleigh stability criterion for hydrodynamical flows, which is known ...
Raschi Marcelo - - 2012
Hemodynamics is thought to be a fundamental factor in the formation, progression and rupture of cerebral aneurysms. Understanding these mechanisms is important to improve their rupture risk assessment and treatment. In this study we analyze the blood flow field in a growing cerebral aneurysm using experimental particle image velocimetry (PIV) ...
Jin Guanqiao - - 2011
: To assess the diagnostic accuracy of computed tomographic (CT) perfusion technique in discriminating recurrent nasopharyngeal carcinoma (NPC) after radiation therapy. : Forty-eight patients with a pathologic finding as reference standards were divided into 2 groups, recurrent and nonrecurrent NPCs. Perfusion parameters blood flow (BF), blood volume (BV), permeability surface ...
Sayed Douaa - - 2011
The biological effects of high levels of radiation exposure are fairly well known, but the effects of low levels of radiation are more difficult to determine because the deterministic effects do not occur at these levels. In order to assess the risk of this exposure on BM thrombopoiesis, we measured ...
Mitchell Jeffrey T - - 2011
The field of crisis intervention has grown dramatically during the last hundred years. Many new procedures and techniques have been added to the crisis intervention repertoire. Periodically, providers of crisis intervention, psychological first aid, critical incident stress management, or Peer Support overlook important elements of crisis intervention or make inadvertent ...
Naddaf S R - - 2011
The mainstay of diagnosis of relapsing fever (RF) is demonstration of the spirochetes in Giemsa-stained thick blood smears, but during non fever periods the bacteria are very scanty and rarely detected in blood smears by microscopy. This study is aimed to evaluate the sensitivity of different methods developed for detection ...
Ismail Asaad H - - 2011
Complete blood counts were analyzed for 30 samples of human blood with radiation dose rate ranging between 10 and 41μSv/h using a Radium-226 source with different time of exposure. A new technique involving a nuclear track detector type CR-39(CR-39 NTDs) was used to estimate the alpha particle density incident on ...
Soleymani S - - 2010
Continuous, reliable and real-time assessment of major determinants of cardiovascular function in preterm and term neonates has long been an elusive aim in neonatal medicine. Accordingly, aside from continuous assessment of heart rate, blood pressure and arterial oxygen saturation, bedside monitoring of major determinants of cardiovascular function of significant clinical ...
Highton David D Department of Neurocritical Care, The National Hospital for Neurology and Neurosurgery, University College London Hospitals, Queen Square, London, - - 2010
There is increasing interest in the application of near infrared spectroscopy (NIRS) as a noninvasive monitor of cerebral oxygenation. This review will briefly describe the principles of NIRS and examine current evidence for its clinical application as a monitor of the adequacy of cerebral oxygenation in adults. There has been ...
Feiner John R - - 2010
BACKGROUND: Methemoglobin in the blood cannot be detected by conventional pulse oximetry and may bias the oximeter's estimate (Spo(2)) of the true arterial functional oxygen saturation (Sao(2)). A recently introduced "pulse CO-oximeter" (Masimo Rainbow SET® Radical-7) that measures SpMet, a noninvasive measurement of the percentage of methemoglobin in arterial blood ...
Bliss David - - 2010
Veno-venous extracorporeal life support (vvECLS) is an important treatment methodology for adult respiratory failure and complex airway reconstruction. However, the supplemental oxygen provided to the venous circulation artificially raises the observed mixed venous saturation (SvO(2)), thereby eliminating its utility in evaluating the match between oxygen delivery and consumption in the ...
Sharma Deepak - - 2010
We describe a 13-year-old child who developed inadvertent intraoperative cerebral oxygen desaturation attributed to empiric hyperventilation during posterior fossa craniotomy, diagnosed by jugular venous oximetry. Although restoration of normocapnia at age-appropriate mean arterial blood pressure improved jugular venous saturation (SjvO), it remained below acceptable values. Transcranial-Doppler (TCD) ultrasonography-guided stepwise increase ...
Toiyama Kentaro - - 2010
Hypoxic gas ventilation therapy has recently been performed to prevent post-birth increased pulmonary blood flow in cases of congenital heart diseases with increased pulmonary blood flow. However, how the oxygen supply to the tissues changes during breathing a hypoxic gas mixture, remains unknown. The changes in cerebral oxygen saturation and ...
Fujima Noriyuki - - 2011
Susceptibility-weighted imaging (SWI) has been used for quantitative and non-invasive measurement of blood oxygen saturation in the brain. In this study, we used SWI for quantitative measurement of oxygen saturation in the spinal vein to look for physiological- or caffeine-induced changes in venous oxygenation. SWI measurements were obtained for 5 ...
Baulig Werner - - 2010
The present study compares the accuracy of a new continuous venous oxygenation monitoring system (PediaSat Oximetry Catheter) with laboratory blood oximetry in paediatric surgical patients. Children and adolescents undergoing cardiac, orthopaedic or craniofacial surgery with major blood loss were included. A 4.5 Fr two-lumen or 5.5 Fr three-lumen central venous ...
Kirichuk V F - - 2010
We studied the effect of terahertz radiation at NO frequencies 150.176-150.664 GHz on gaseous and electrolyte composition of the blood in albino rats during stress. Partial or complete recovery of the studied parameters of blood gases and electrolytes in stressed animals was observed after 15- and 30-min terahertz irradiation at ...
Walton Zachary D - - 2010
We investigate the hypothesis that the photoplethysmograph (PPG) waveform can be analyzed to infer regional venous oxygen saturation. Fundamental to the successful isolation of the venous saturation is the identification of PPG characteristics that are unique to the peripheral venous system. Two such characteristics have been identified. First, the peripheral ...
Liu Xuan X Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21218, USA. - - 2010
Although spectroscopic optical coherence tomography (OCT) has been shown to be a promising method for measuring blood oxygen saturation with high-spatial resolution and accuracy, there are several technical issues that need to be addressed before it could become a practical method. In this letter, we have attempted to address two ...
Mittnacht Alexander J C - - 2010
PURPOSE OF REVIEW: Tissue oximetry has been suggested as a noninvasive tool to continuously monitor and detect states of low body perfusion. This review summarizes recent developments and available data on the use of near infrared spectroscopy (NIRS) in children at risk for low perfusion. RECENT FINDINGS: During states of ...
Sutter Mark - - 2010
Hydroxocobalamin is a new antidote approved by the FDA for the treatment of cyanide poisoning. Our report describes a patient with cyanide poisoning who survived after treatment with hydroxocobalamin and complications we encountered with hemodialysis. A 34-year-old female presented to the emergency department after a syncopal event and seizures. Her ...
Park Hyeon Min - - 2010
Stellate ganglion block (SGB) is known to increase blood flow to the innervations area of the stellate ganglion. Near infrared spectroscopy reflects an increased blood volume and allows continuous, non-invasive, and bedside monitoring of regional cerebral oxygen saturation (rSO(2)). We investigated the influence of SGB on bilateral cerebral oxygenation using ...
Jesić Milos M - - 2010
INTRODUCTION: Haemoglobin saturation is an obligatory oxygen parameter in the assessment of neonatal oxygenation. Although, pulse oximetry is currently one of the major methods in the determination of haemoglobin saturation, capillary blood saturation is still present in the diagnostic process. As well known, haemoglobin saturation value of capillary blood is ...
Jain Varsha V Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, - - 2010
Measuring the global cerebral metabolic rate of oxygen (CMRO(2)) is a valuable tool for assessing brain vitality and function. Measurement of blood oxygen saturation (HbO(2)) and flow in the major cerebral outflow and inflow vessels can provide a global estimate of CMRO(2). We demonstrate a rapid noninvasive method for quantifying ...
Döbele T - - 2010
In our clinical daily routine, it is noticeable that lower cardiac indices are reached more often without negative consequences when using mini extracorporeal circulation (ECC) systems than when using open ECC systems. We evaluated haemoglobin concentration, haematocrit, blood flow, cardiac index (CI) and mixed-venous oxygen saturation (vSO2) in patients undergoing ...
Rukin E M - - 2010
Local exposure to light with hollow cathode lamp radiating band spectrum typical of manganese, copper, potassium, sodium, calcium, and magnesium enhances migration of these elements from the solution applied to the skin to the blood in rats. This effect is most pronounced at low initial blood level of manganese. Its ...
Baulig Werner - - 2010
BACKGROUND AND OBJECTIVE: In-vitro performance of the PediaSat system for continuous monitoring of central venous oxygen saturation by spectrophotometry has been evaluated. METHODS: PediaSat continuous fibre-optic oximetry catheters were inserted in a black testing chamber, connected with an extracorporeal circuit and filled with human whole blood. Oxygen inflow into the ...
Kubo Keitaro - - 2010
The purpose of this study was to investigate the effects of acupuncture (dry needling) and heating (application of hot pack) treatments on the blood volume and oxygen saturation of the human Achilles tendon in vivo. Nine healthy males participated in this study. During the treatments (acupuncture and heating; both 10 ...
Keating Paul - - 2010
A significant patent ductus arteriosus (PDA) is a common finding in the first days of life and, if persistent, is associated with an increased morbidity and mortality in the preterm newborn. Our aim was to investigate, using near-infrared spectroscopy, the effect of indomethacin on the fractional tissue (cerebral) oxygen extraction ...
De Smet D - - 2010
The most important forms of brain injury in premature infants are partly caused by disturbances in cerebral autoregulation. As changes in cerebral intravascular oxygenation (HbD), regional cerebral oxygen saturation (rSO(2)), and cerebral tissue oxygenation (TOI) reflect changes in cerebral blood flow (CBF), impaired autoregulation can be measured by studying the ...
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