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Gambaro Veniero V 1Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Via Mangiagalli n.25, Milano 20133, - - 2014
Postmortem samples from 14 cases of suspected heroin overdose were subjected to a preliminary systematic toxicological analysis in order to highlight the presence of unknown exogenous compounds (e.g., drugs of abuse, alcohol) that may have played a role in the mechanism of death. This analysis unveiled histories of poly-drug use ...
Henriksson Peter P Department of Clinical Sciences, Karolinska University Hospital, all Karolinska Institutet, SE-171 77, Stockholm, - - 2014
Exposure to second-hand smoke, as by passive smoking, seems to increase the incidence of cardiovascular events. It has been shown that active smoking of a single cigarette causes an immediate and significant decrease in microcirculatory blood flow velocity, whereas the acute effects of exposure to second-hand smoke on microcirculatory flow ...
Kronschläger Martin M Gullstrand Lab, Ophthalmology, Dept. of Neuroscience, Uppsala University, Sweden. Electronic address: - - 2014
Topically applied caffeine was recently identified as a promising candidate molecule for cataract prevention. Little is known about the pharmacokinetics for topically applied caffeine. Potential toxicity of 72 mM caffeine on the ocular surface and the lens was qualitatively monitored and no toxic effects were observed. The concentration of caffeine was ...
Desrosiers Nathalie A NA Chemistry and Drug Metabolism Section, Clinical Pharmacology and Therapeutic Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, - - 2014
Δ(9)-Tetrahydrocannabinol (THC), 11-hydroxy-THC (11-OH-THC), and 11-nor-9-carboxy-THC (THCCOOH) have been reported in blood from frequent cannabis smokers for an extended time during abstinence. We compared THC, 11-OH-THC, THCCOOH, cannabidiol, cannabinol, THC-glucuronide, and THCCOO-glucuronide blood and plasma disposition in frequent and occasional cannabis smokers.METHODS: Frequent and occasional smokers resided on a closed ...
Nielsen Samara Joy SJ Division of Health and Nutrition Examination Surveys, National Center for Health Statistics, CDC, Hyattsville, MD (SJN, BKK, YA, and CLO), and the US Public Health Service, Rockville, MD - - 2014
Seafood is part of a healthy diet, but seafood can also contain methyl mercury-a neurotoxin. The objective was to describe seafood consumption in US adults and to explore the relation between seafood consumption and blood mercury. Seafood consumption, obtained from a food-frequency questionnaire, and blood mercury data were available for ...
Grasser Erik K EK Laboratory of Integrative Cardiovascular and Metabolic Physiology, Division of Physiology, Department of Medicine, University of Fribourg, Chemin du Musée 5, 1700, Fribourg, Switzerland, - - 2014
Energy drinks are beverages containing vasoactive metabolites, usually a combination of caffeine, taurine, glucuronolactone and sugars. There are concerns about the safety of energy drinks with some countries banning their sales. We determined the acute effects of a popular energy drink, Red Bull, on cardiovascular and hemodynamic variables, cerebrovascular parameters ...
Sutlovic Davorka D From the *Department of Pathology and Forensic Medicine, University Hospital Centre Split; and †Department Forensic Medicine, University of Split School of Medicine, Split, - - 2014
The effect of long-term storage on alcohol stability in postmortem blood samples was investigated. Seventy-nine blood samples were used in this study. For the first time, blood alcohol concentrations were measured within 1 to 4 days after being taken at the Laboratory of Forensic Toxicology. After storage (ranging from 191 ...
Kwak Ho-Seok HS Department of Laboratory Medicine, Cheil General Hospital and Women's Healthcare Centre, Kwandong University School of Medicine , Seoul , Republic of - - 2014
Objective. Phosphatidylethanol (PEth) is formed endogenously by the direct action of ethanol, and has a half-life long enough to make it a reliable biomarker of alcohol exposure in early pregnancy. In this study, we aimed to characterize PEth blood concentrations to differentiate different levels of alcohol exposure in pregnant women. ...
Edirisinghe Anuruddhi Samanthika AS a Department of Forensic Medicine, Faculty of Medicine , University of Kelaniya , Thallagolla Road, Ragama 11010 , Sri - - 2013
Reckless driving behaviour associated with alcohol has been well known. In Sri Lanka, research on blood alcohol concentration (BAC) in road fatalities is scares. Thus, we studied the BAC in vulnerable road users (VRUs) encountered in medico-legal autopsies. A retrospective descriptive study based on case records of VRU fatalities from ...
Kochanowicz Jan - - 2013
Introduction: While chronic cigarette smoking can lead to increased risk of stroke, the acute effects of smoking have not been established. We studied the changes in blood flow parameters in the major cerebral arteries caused by smoking one cigarette.Method: Using transcranial color-coded sonography (TCCS), we studied the anterior cerebral artery ...
Telenga Eef D - - 2013
It has been suggested that smoking asthmatics benefit less from corticosteroid treatment than never-smoking asthmatics. We investigated differences in blood and sputum inflammatory profiles between ex-, current-, and never-smokers and assessed their ICS treatment response after 2-week and 1-year treatment. We analyzed FEV1, PC20 methacholine and PC20 AMP, (differential) cell ...
Nakayama T - - 2013
Streptococcus suis is an emerging zoonotic agent. This study aimed to investigate whether S. suis is likely to translocate across the intestines of human hosts who have liver disease and/or consume alcohol. Both the alcoholism and cirrhosis models exhibited high mRNA expression of TGF and collagen1, but only the cirrhosis ...
Kalahasthi Ravi Babu - - 2013
The present study was carried out to find the relationship between blood lead levels (BLLs) and morbidities among 391 male workers employed in a factory manufacturing lead-acid storage batteries. A predesigned questionnaire was used to collect information on subjective health complaints and clinical observation made during a clinical examination. In ...
Battilocchio Claudio - - 2013
A flow chemistry Meerwein-Ponndorf-Verley (MPV) reduction procedure using partially hydrated zirconium oxide via a machine-assisted approach is reported. The heterogeneous reductive system could be applied to a wide range of functionalized substrates, allowing clean and fast delivery of the alcohol products within a few minutes (6-75 min). In three examples ...
Bjermo Helena - - 2013
The aim of the present study was to examine the body burden of lead (Pb), mercury (Hg), and cadmium (Cd) in blood among Swedish adults and the association between blood levels, diet and other lifestyle factors. The study was based on a subgroup (n=273) of the national survey Riksmaten 2010-11 ...
Vidyasagar Rishma - - 2013
Black tea consumption has been shown to improve peripheral vascular function. Its effect on brain vasculature is unknown, though tea contains small amounts of caffeine, a psychoactive substance known to influence cerebral blood flow (CBF). We investigated the effects on CBF due to the intake of tea components in 20 ...
Yang Albert Y - - 2013
ABSTRACT: We report an incidental finding of absent liver uptake of Tc leukocyte scan in an alcoholic patient with acute Zosyn (piperacillin and tazobactom)-related drug reaction with eosinophilia and systemic symptoms, persistent elevated white blood cell counts, and negative blood culture. Alcoholic steatohepatitis was confirmed in this patient through further ...
Mendy Angelico - - 2013
Lead is often present in our environment, but its effect on thyroid function is still unclear. In this study, multiple linear regressions were performed between log-transformed blood lead levels and thyroid function parameters of 4652 adults from the 2007-2008 National Health and Nutrition Examination Survey. The models were adjusted for ...
Hernández Redondo Ana - - 2013
BACKGROUND: Ethyl glucuronide (EtG) and ethyl sulfate (EtS) are non-oxidative minor metabolites of ethanol. They are detectable in various body fluids shortly after initial consumption of ethanol and have a longer detection time frame than the parent compound. They are regarded highly sensitive and specific markers of recent alcohol uptake. ...
Korotkova Elena I - - 2013
The total antioxidant activity (TAA) of human serum blood of patients suffering from alcoholism was tested by cathode voltammetry with a model process of oxygen electroreduction. A known spectrophotometrical method was used for comparison. As results the total antioxidant activity of serum blood of patients with alcoholism was estimated by ...
Webster Joan - - 2013
Blood for transfusion may become contaminated at any point between collection and transfusion and may result in bacteraemia (the presence of bacteria in the blood), severe illness or even death for the blood recipient. Donor arm skin is one potential source of blood contamination, so it is usual to cleanse ...
Hossen Molla Sabir - - 2013
Objective: The aim of this study was to investigate Haemogregarine parasites (Apicomplexa: Haemogregarinidae) of freshwater turtles (Lissemys punctata andersoni, Geoclemys hamiltonii) of India. Methods: Turtles were collected by net from two ponds of South 24 Parganas, West Bengal, India. A small amount of blood was taken from the subcarapacial vein ...
Peebles Karen C - - 2013
Cigarette smoking is associated with an increased risk of stroke but the mechanism is unclear. The study examined whether acute and chronic cigarette smoking alters the dynamic relationship between blood pressure and cerebral blood flow. We hypothesised that acute and chronic smoking would result in a cerebral circulation that was ...
Weber Anke - - 2013
The purpose of this study was to test the effect of ethyl alcohol on the koniocellular and magnocellular pathway of visual function and to investigate the relationship between such visual field changes and retrobulbar blood flow in healthy subjects. In 12 healthy subjects (mean age 32 ± 4 years), color ...
Salvagno Gian Luca GL Department of Life and Reproduction Sciences, University of Verona, Verona, - - 2013
It is still uncertain whether or not avoidance to let disinfectant alcohol dry at the site of venipuncture is a source of spurious hemolysis when drawing venous blood. In a consecutive series of 52 outpatients referred for routine laboratory testing, venous blood was drawn by direct venipuncture with (odd group) ...
Gundersen Hilde - - 2012
Aims: Although it is known that alcohol has vasoactive properties, previous studies have not investigated the relationship between cerebral blood flow (CBF) and cerebral blood volume (CBV) after alcohol consumption. The aim of this study was to investigate effects of alcohol on CBF and CBV, both globally and regionally, in ...
Madeddu Roberto - - 2012
A human blood biomonitoring campaign to detect the environmental exposure to metals (Cd, Cu, Cr, Mn, Pb and Zn) in 265 subjects was performed in the South-Western part of Sardinia (an Italian island) that is a particular area with a great history of coal and metal mining (Pb/Zn mainly) activities ...
Nilsson Helena - - 2012
Levels of perfluorocarboxylates (PFCAs) in biological compartments have been known for some time but their transport routes and distribution patterns are not properly elucidated. The opinions diverge whether the exposure of the general population occurs indirect through precursors or direct via PFCAs. Previous results showed that ski wax technicians are ...
Thierauf Annette - - 2012
In the last century, several mathematical models have been developed to calculate blood ethanol concentrations (BAC) from the amount of ingested ethanol and vice versa. The most common one in the field of forensic sciences is Widmark's equation. A drinking experiment with 10 voluntary test persons was performed with a ...
Iwasaki Wataru - - 2012
Alcohol has a variety of effects on the human body, affecting both the sympathetic and parasympathetic nervous system. We examined the peripheral blood flow of alcohol drinkers using a micro-integrated laser Doppler blood flow meter (micro-electromechanical system blood flow sensor). An increased heart rate and blood flow was recorded at ...
Kvigne Valborg L - - 2012
Very little is known about the alcohol elimination rates of newborns who have had chronic alcohol exposure in utero. In these case reports, blood alcohol levels were taken immediately before delivery, at delivery, and postdelivery for 2 mothers who drank alcohol during their pregnancies and 3 single-birth newborns. Newborn A1 ...
Reischl Roland J - - 2012
Acetaldehyde is a strongly electrophilic compound that is endogenously produced as a first intermediate in oxidative ethanol metabolism. Its high reactivity towards biogenic nucleophiles has toxicity as a consequence. Acetaldehyde readily undergoes a non-enzymatic condensation reaction and consecutive ring formation with cysteine to form 2-methylthiazolidine-4-carboxylic acid (MTCA). For analytical purposes, ...
Goldim Mariana Pereira de Souza - - 2012
This study investigates the miniaturization of the screening technique using dried blood spots on filter paper (DBS) to measure GBA and CT activities, and GBA and β-galactosidase activities in leukocytes. 274 DBS from individuals with suspected GD were screened for 1.5 years. Of these, we confirmed the diagnosis in 13.5%. ...
Viel Guido - - 2012
The present paper aims at a systematic review of the current knowledge on phosphatidylethanol (PEth) in blood as a direct marker of chronic alcohol use and abuse. In March 2012, the search through "MeSH" and "free-text" protocols in the databases Medline/PubMed, SCOPUS, Web of Science, and Ovid/Embase, combining the terms ...
Thomson Paula - - 2012
This study investigated dissociative psychological processes and flow (dispositional and state) in a group of professional and pre-professional dancers (n=74). In this study, high scores for global (Mdn=4.14) and autotelic (Mdn=4.50) flow suggest that dancing was inherently integrating and rewarding, although 17.6% of the dancers were identified as possibly having ...
Kobylinski Kevin C KC Entomology Branch, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD 20910, USA. - - 2012
When ingested in a blood meal, ivermectin has been shown to reduce the survivorship of Anopheles gambiae in the laboratory and field. Furthermore, ivermectin mass drug administrations in Senegal have been shown to reduce the proportion of Plasmodium falciparum-sporozoite-containing An. gambiae. This study addresses whether ivermectin inhibits sporogony of P. ...
Ariansen Jennifer L JL Department of Chemistry and Neurobiology Curriculum, University of North Carolina at Chapel Hill, Chapel Hill NC, - - 2012
Dopamine projections that extend from the ventral tegmental area to the striatum have been implicated in the biological basis for behaviors associated with reward and addiction. Until recently, it has been difficult to evaluate the complex balance of energy utilization and neural activity in the striatum. Many techniques such as ...
Yildiz Sema - - 2011
The aim of this study was to evaluate the influence of passive maternal smoking on blood flow velocities in arteries of the fetal-placental-maternal circulation. A total of 79 pregnant women in their third trimester, including 33 passive smokers, 23 active smokers, and 23 nonsmoking controls, were enrolled in the study. ...
Schwope David M - - 2011
Δ⁹-Tetrahydrocannabinol (THC) is the most frequently observed illicit drug in investigations of accidents and driving under the influence of drugs. THC-glucuronide has been suggested as a marker of recent cannabis use, but there are no blood data following controlled THC administration to test this hypothesis. Furthermore, there are no studies ...
Garhöfer Gerhard - - 2011
BACKGROUND: Habitual smoking is a risk factor for a variety of vascular diseases, including ocular pathologies. In the current study, we set out to investigate whether the regulation of retinal vascular tone is impaired in habitual smokers. For this purpose, vascular reactivity was tested during flicker light induced vasodilatation in ...
Chambers David M - - 2011
The impact of cigarette smoking on volatile organic compound (VOC) blood levels is studied using 2003-2004 National Health and Nutrition Examination Survey (NHANES) data. Cigarette smoke exposure is shown to be a predominant source of benzene, toluene, ethylbenzene, xylenes and styrene (BTEXS) measured in blood as determined by (1) differences ...
Whitlow Thomas H - - 2011
We monitored curbside airborne particulate matter (PM) concentrations and its proinflammatory capacity during 3 weekends when vehicle traffic was excluded from Park. Ave., New York City. Fine PM concentration peaked in the morning regardless of traffic while ultrafine PM was 58% lower during mornings without traffic. Ultrafine PM concentration varied ...
Imai Yohsuke - - 2011
We investigated numerically the mechanism of margination of Plasmodium falciparum malaria-infected red blood cells (Pf-IRBCs) in micro-scale blood flow. Our model illustrates that continuous hydrodynamic interaction between a Pf-IRBC in the trophozoite stage (Pf-T-IRBC) and healthy red blood cells (HRBCs) results in the margination of the Pf-T-IRBC and, thus, a ...
Zattoni Andrea - - 2011
Reinjection of one ore more collected fractions of eluted samples is recognized as a useful procedure in analytical separation techniques, among which field-flow fractionation (FFF), to improve the actual separation of complex samples. Hollow-fiber flow FFF (HF5) is a micro-channel subset of flow FFF (F4), which has recently reached a ...
Brand Samuel - - 2011
We study a model granular suspension driven down a channel by an embedding fluid via computer simulations. We characterize the different system flow regimes and the stochastic nature of the transitions between them. For packing fractions below a threshold ϕ_{m}, granular flow is disordered and exhibits an Ostwald-de Waele-type power-law ...
Eames I - - 2011
Interfaces, across which fluid and flow properties change significantly, are a ubiquitous feature of most turbulent flows and are present within jets, plumes, homogeneous turbulence, oceans and planetary atmospheres. Even when the interfaces occupy a small volume fraction of the entire flow, they largely control processes such as entrainment and ...
Currie Geoffrey Michael - - 2011
This review examines the role and limitations of scintigraphic evaluation in acute lower gastrointestinal hemorrhage. A detailed discussion of methods for improving diagnostic outcomes is provided. Techniques and recommendations are offered for optimization of red blood cell scintigraphy for earlier detection and more accurate localization of acute lower gastrointestinal hemorrhage.
Yohannes G - - 2011
Field-flow fractionation (FFF) is one of the most versatile separation techniques in the field of analytical separation sciences, capable of separating macromolecules in the range 10(3)-10(15)gmol(-1) and/or particles with 1nm-100μm in diameter. The most universal and most frequently used FFF technique, flow FFF, includes three types of techniques, namely symmetrical ...
Calzolai Luigi - - 2011
We show that using asymmetric flow-field-flow fractionation and UV-vis detector it is possible to separate, characterize, and quantify the correct number size distribution of gold nanoparticle (AuNP) mixtures of various sizes in the 5-60nm range for which simple dynamic light scattering measurements give misleading information. The size of the collected ...
Kim Hack-Lyoung - - 2011
An elevated white blood cell (WBC) count is associated with nonalcoholic fatty liver disease (NAFLD); however, a leukocyte subtype that is involved in the pathogenesis of NAFLD is not known. This study was conducted to investigate the association between NAFLD and WBC subtype fractions (%) among healthy elderly Koreans. A ...
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