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Klahr Ana C AC Centre for Neuroscience, University of Alberta, P217 BSB, Edmonton, AB, T6G 2E9, - - 2014
Seizures are a frequent complication of brain injury, including intracerebral hemorrhage (ICH), where seizures occur in about a third of patients. Rodents are used to study pathophysiology and neuroprotective therapies after ICH, but there have been no studies assessing the occurrence of seizures in these models. Thus, we compared seizure ...
Sherk Kyle A KA 1Department of Health and Exercise Science, University of Oklahoma, Norman, Oklahoma. 2Hanger Orthotics and Prosthetics, Oklahoma City, Oklahoma. 3Health Science Center, University of Oklahoma, Oklahoma City, - - 2014
Ankle-foot orthoses (AFOs) and gait aids are commonly used by survivors of stroke to ambulate, but they have not been used as inclusion or exclusion criteria for physiological studies. The purpose of this study was to examine differences in neuromuscular function and blood flow characteristics between the lower limbs of ...
Yang Ning N Department of Neurology, the Fifth Affiliated Hospital of GuangZhou Medical University, 621# Harbour Road, GuangZhou, 510700 Guangdong Province, - - 2014
The presence of the A and B blood group antigens has been associated with risk of arterial thrombosis. The aim of the current study was to design a new simpler form of National Institutes of Health Stroke Scale (NIHSS) for use on admission, and assess the association of blood groups ...
Chueh J J Radiology, UMass Medical School, Worcester, MA, - - 2014
Improved recanalization rate and immediate flow restoration have been achieved by the latest clot retrieval (thrombectomy) systems in the acute ischemic stroke treatment. However, clot debris generated during mechanical thrombectomy can result in distal embolization. We hypothesise that the catheterization strategies (type and position of the suction catheter) affect the ...
Sattar A A Neurology, Medical College of Wisconsin, Milwaukee, WI, - - 2014
Cerebral angiographic revascularization grading is the primary method for measuring the angiographic success of acute ischemic stroke (AIS) endovascular therapy and is one of the strongest predictors for clinical outcome. Of the many reported scales, the modified Treatment in Cerebral Ischemia (mTICI) scale is the preferred grading scale for assessment ...
Behravan Effat E Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, - - 2014
Cerebral ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. This leads to cerebral hypoxia and thus to the death of neuronal cells or stroke. The limited number of medicines currently available for patients following ischemic stroke and insufficient data on ...
Niego Be'eri B Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, - - 2014
Plasmin, the principal downstream product of tissue-type plasminogen activator (tPA), is known for its potent fibrin-degrading capacity but is also recognized for many non-fibrinolytic activities. Curiously, plasmin has not been conclusively linked to blood-brain barrier (BBB) disruption during recombinant tPA (rtPA)-induced thrombolysis in ischemic stroke. This is surprising given the ...
Zheng Shuyan S Key Laboratory of Smart Drug Delivery Ministry of Education, School of Pharmacy Fudan University, Shanghai, 201203, - - 2014
Ischemic stroke accounts for 80% strokes and originates from a reduction of cerebral blood flow (CBF) after vascular occlusion. For treatment, the first action is to restore CBF by thrombolytic agent recombinant tissue-type plasminogen activator (rt-PA). Although rt-PA benefits clinical outcome, its application is limited by short therapeutic time window ...
Park Sin-Young - - 2014
[This corrects the article on p. 104 in vol. 23, PMID: 24737945.].
Jin Xinchun - - 2014
Tissue plasminogen activator (tPA) thrombolysis, remains the only United States Food and Drug Administration(FDA) approvedtreatmentfor acute ischemia stroke. However, the use of tPA has been profoundly constraineddue to its narrow therapeutic time window and the increased risk of potentially deadly hemorrhagic complications. TPA-associated hemorrhagic transformation (HT) often occurs as a ...
Ding Qiao Q Department of Neurology, Guangdong Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department, National Key Discipline, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, - - 2014
Neurogenesis and angiogenesis play important roles in functional recovery after ischemic stroke. When cerebral ischemia occurs, axon regeneration can compensate for the loss of apoptotic neurons in the ischemic area. The formation of new blood vessels ameliorates the local decrease in blood supply, enhancing the supply of oxygen and nutrients ...
Liu Qi Q School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, 1954, Huashan Road, Shanghai, 200030, - - 2014
The study of hemodynamic and vascular changes following ischemic stroke is of great importance in the understanding of physiological and pathological processes during the thrombus formation. The photothrombosis model is preferred by researchers in stroke study for its minimal invasiveness, controllable infarct volume and lesion location. Nevertheless, there is a ...
Favilla Christopher G CG From the Departments of Neurology (C.G.F., M.M., X.L., S.E.K., J.H.G., J.A.D.), Physics and Astronomy (R.C.M., M.N.K., D.L.M., A.G.Y.), and Radiology (J.A.D.), University of Pennsylvania, Philadelphia, PA; Institute of Physics, University of Campinas, Campinas, Brazil (R.C.M.); and ICFO-Institut de Ciències Fotòniques, Castelldefels, Barcelona, Spain - - 2014
A primary goal of acute ischemic stroke (AIS) management is to maximize perfusion in the affected region and surrounding ischemic penumbra. However, interventions to maximize perfusion, such as flat head-of-bed (HOB) positioning, are currently prescribed empirically. Bedside monitoring of cerebral blood flow (CBF) allows the effects of interventions such as ...
Young Phillip Matthew PM From the *Department of Diagnostic Radiology, Mayo Clinic, Rochester, MN; †Siemens Healthcare, Rochester, MN; ‡Division of Cardiovascular Surgery, Mayo Clinic, Rochester, MN; §Siemens Healthcare, Erlangen, Germany; and ∥Siemens Corporate Research, Princeton, - - 2014
Four-dimensional flow is a magnetic resonance technology that has undergone significant technical improvements in recent years. With increasingly rapid acquisition times and new postprocessing tools, it can provide a tool for demonstrating and visualizing cardiovascular flow phenomena, which may offer new insights into disease. We present an interesting clinical case ...
Kim Seong-Sik SS Graduate School of Physical Therapy, Sahmyook University, Republic of - - 2014
[Purpose] The purpose of this study was to investigate the effect of Action Observational Training (AOT) on cerebral hemodynamic changes, including cerebral blood flow velocity (CBFV) and cerebral blood flow volume (CBFvol) in healthy subjects and stroke survivors. [Subjects] This study had a cross-sectional design. Seven healthy subjects and six ...
Min Li-Juan LJ Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University Graduate School of Medicine, Tohon, Ehime, - - 2014
Stroke is a leading cause of death and disability; however, meta-analysis of randomized controlled trials of blood pressure-lowering drugs in acute stroke has shown no definite evidence of a beneficial effect on functional outcome. Accumulating evidence suggests that angiotensin II type 1 receptor blockade with angiotensin II type 2 (AT2) ...
Gibson Lorna M LM Division of Clinical Neurosciences, Western General Hospital, Edinburgh, - - 2014
The interface between cerebrovascular disease (CVD) and epilepsy is complex and multifaceted. Late-onset epilepsy (LOE) is increasingly common and is often attributed to CVD, and is indeed associated with an increased risk of stroke. This relationship is easily recognizable where there is a history of stroke, particularly involving the cerebral ...
Esposito Elga E Department Neurology & Stroke, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, - - 2014
Hypothermia is a promising therapeutic option for stroke patients and an established neuroprotective treatment for global cerebral ischemia after cardiac arrest. While whole body cooling is a feasible approach in intubated and sedated patients, its application in awake stroke patients is limited by severe side effects: Strong shivering rewarms the ...
Walcott Brian P BP 1] Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA [2] Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, - - 2014
Perturbations in cerebral blood flow and abnormalities in blood vessel structure are the hallmarks of cerebrovascular disease. While there are many genetic and environmental factors that affect these entities through a heterogeneous group of disease processes, the ultimate final pathologic insult in humans is defined as a stroke, or damage ...
Zirak Peyman P ICFO-Institut de Ciències Fotòniques, Mediterranean Technology Park, 08860 Castelldefels, Barcelona, - - 2014
ABSTRACT. The ultimate goal of therapeutic strategies for ischemic stroke is to reestablish the blood flow to the ischemic region of the brain. However, currently, the local cerebral hemodynamics (microvascular) is almost entirely inaccessible for stroke clinicians at the patient bed-side, and the recanalization of the major cerebral arteries (macrovascular) ...
Marcelo Aileen A Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, - - 2014
Cerebral angiogenesis is an important process for physiological events such as brain development, but it also occurs in pathological conditions such as stroke. Defined as the generation of new blood vessels from preexisting vasculature, angiogenesis after ischemic stroke is important to limit the subsequent neuronal injury and death, as well ...
Greenberg David A DA Buck Institute for Research on Aging, Novato, CA, - - 2014
Angiogenesis, the sprouting of new capillaries from existing blood vessels, accompanies clinical and experimental stroke and is focused particularly in the salvageable ischemic border zone. As this endogenous angiogenic response correlates positively with clinical prognosis, a more complete understanding of the underlying molecular mechanisms and timing of these events may ...
Dentali Francesco F Department of Clinical and Experimental Medicine, University of Insubria, Varese, - - 2013
It has been well known for many years that the ABO blood group has a major influence on hemostasis, through its influence on von Willebrand factor and, consequently, factor VIII plasma levels. Although the relationship between non-O blood type and the risk of venous thromboembolism is nowadays also well established, ...
Lee Jung Myung JM Division of Cardiology, Department of Internal Medicine, Research Institute of Radiological Science, Yonsei University Medical College, Seoul, - - 2013
The structural and functional characteristics of left atrial appendage (LAA) in patients with atrial fibrillation (AF) with previous stroke remain incompletely elucidated. This study investigated whether a larger LAA orifice is related to decreased LAA flow velocity and stroke in nonvalvular AF. The dimension, morphology, and flow velocity of LAA ...
Lin W - - 2013
External counterpulsation (ECP) is a novel method to increase cerebral blood flow, which may benefit acute ischaemic stroke patients. Our aim was to identify whether the hemodynamic effect of ECP is associated with cerebral vasoreactivity to breath-holding. Thirty-seven recent ischaemic stroke patients with large artery steno-occlusive disease were recruited together ...
Benders Manon J - - 2013
To perform a feasibility and safety study with recombinant human erythropoietin (rhEPO) in neonates with perinatal arterial ischemic stroke. Neonates with a magnetic resonance imaging-confirmed perinatal arterial ischemic stroke (n = 21) were treated with 1000 IU/kg rhEPO immediately after diagnosis and at 24 and 48 hours after the first ...
Tennant Kelly A - - 2013
Stroke usually affects people with underlying medical conditions. In particular, diabetics are significantly more likely to have a stroke and the prognosis for recovery is poor. Because diabetes is associated with degenerative changes in the vasculature of many organs, we sought to determine how hyperglycemia affects blood flow dynamics after ...
Jickling Glen C - - 2013
Hemorrhagic transformation (HT) is a common complication of ischemic stroke that is exacerbated by thrombolytic therapy. Methods to better prevent, predict, and treat HT are needed. In this review, we summarize studies of HT in both animals and humans. We propose that early HT (<18 to 24 hours after stroke onset) ...
Liu Jialing - - 2013
The brain vasculature has been increasingly recognized as a key player that directs brain development, regulates homeostasis, and contributes to pathological processes. Following ischemic stroke, the reduction of blood flow elicits a cascade of changes and leads to vascular remodeling. However, the temporal profile of vascular changes after stroke is ...
Cortijo Elisa - - 2013
Selection of best responders to reperfusion therapies could be aided by predicting the duration of tissue-at-risk viability, which may be dependant on collateral circulation status. We aimed to identify the best predictor of good collateral circulation among perfusion computed tomography (PCT) parameters in middle cerebral artery (MCA) ischemic stroke and ...
Poittevin Marine - - 2013
Disruption of cerebral blood flow after stroke induces cerebral tissue injury through multiple mechanisms that are not yet fully understood. Smooth muscle cells (SMCs) in blood vessel walls play a key role in cerebral blood flow control. Cerebral ischemia triggers these cells to switch to a phenotype that will be ...
Wang Winfred C - - 2013
In sickle cell disease, a common inherited haemoglobin disorder, abnormal haemoglobin distorts red blood cells, causing anaemia, vaso-occlusion and dysfunction in most body organs. Without intervention, stroke affects around 10% of children with sickle cell anaemia (HbSS) and recurrence is likely. Chronic blood transfusion dilutes the sickled red blood cells, ...
Sawada Hironobu - - 2013
SMTP-7 (Stachybotrys microspora triprenyl phenol-7), a small molecule that promotes plasminogen activation through the modulation of plasminogen conformation, has excellent therapeutic activity against cerebral infarction in several rodent models. Detailed evaluations of SMTP-7 in a primate stroke model are needed for effective, safe drug development. Here we evaluated SMTP-7 in ...
Weise Gesa - - 2013
Previous studies have highlighted the enormous potential of cell-based therapies for stroke not only to prevent ischemic brain damage, but also to amplify endogenous repair processes. Considering its widespread availability and low immunogenicity human umbilical cord blood (HUCB) is a particularly attractive stem cell source. Our goal was to investigate ...
McLeod D D - - 2013
Perfusion computed tomography is becoming more widely used as a clinical imaging tool to predict potentially salvageable tissue (ischemic penumbra) after ischemic stroke and guide reperfusion therapies. The study aims to determine whether there are important changes in perfusion computed tomography thresholds defining ischemic penumbra and infarct core over time ...
Sharma Vijay K - - 2014
Cerebrovascular ultrasonography is the only modality that provides real-time information about blood flow in various cervicocerebral arteries. Continuous information can be obtained over extended periods with high resolution and excellent spatial display. Hemodynamic changes in the cerebral circulation due to various physiological or pathological states can be monitored reliably. The ...
Lenglet Sébastien - - 2013
Matrix metalloproteinases (MMP) comprise a family of at least 25 zinc-dependent endopeptidases that play a pivotal role in the physiopathology of the mammalian central nervous system. In the first phases after stroke, the dysregulation of MMPs has been described to increase acute neurovascular disruption and cerebral injury. In particular, MMP-mediated ...
Mokrushin Anatoly A - - 2013
Blood-borne events play a major role in post bleeding disturbances of the neuronal network. However, very little is known about the early effects of blood plasma, leucocytes, and the red blood cells on the AMPA and NMDA-mediated synaptic responses in the onset of experimental intracranial hemorrhage (ICH). In this study, ...
Winship Ian R - - 2013
Collateral circulation provides an alternative route for blood flow to reach ischemic tissue during a stroke. Blood flow through the cerebral collaterals is a critical predictor of clinical prognosis after stroke and response to recanalization, but data on collateral dynamics and collateral therapeutics are lacking. Here, we investigate the efficacy ...
Guo Zhen-Ni - - 2013
Carotid or cerebral artery stenosis resulting in low perfusion is a major cause of ischemic stroke. Understanding the unique hemodynamic features in each patient undergoing a stroke-in-progress (SIP) and the correlation between progression and cerebral blood flow (CBF) status would help in the diagnosis and treatment of individual patients. We ...
Yassi Nawaf - - 2013
Intracerebral hemorrhage is a serious potential complication of stroke thrombolysis. We investigated the optimal computed tomography perfusion (CTP) parameter to predict cerebral parenchymal hematoma (PH) in acute ischemic stroke. Patients with hyperacute ischemic stroke had whole-brain CTP and follow-up computed tomography/MRI to identify hemorrhagic transformation. The association of the 3 ...
Pan Jiawei - - 2013
This study aimed to perform an evaluation of 4 perfusion computed tomographic (PCT) parameters (relative cerebral blood flow, cerebral blood volume, mean transit time [MTT], and delay time [DT]) in a series of patients with acute ischemic stroke to find optimal parameters to predict infarct core and penumbra. Twenty-six patients ...
Prince Ethan A EA Division of Interventional Radiology, Department of Diagnostic Imaging, Warren Alpert Medical School of Brown University, Providence, Rhode - - 2013
Acute ischemic stroke is a leading cause of death and the leading cause of disability in the United States. Cerebral neuronal death begins within minutes after threshold values of blood oxygen saturation are crossed. Prompt restoration of oxygenated blood flow into ischemic tissue remains the common goal of reperfusion strategies. ...
Lagunju I A - - 2013
Chronic blood transfusion (CBT) diminishes the risk of primary and secondary stroke in sickle cell disease (SCD). We appraised CBT and assessed its feasibility as an option for stroke prevention in a setting of limited resources. All new cases of SCD seen in the Paediatric Hematology/Neurology units of the University ...
Bielec G G Department of Swimming, Gdansk University of Physical Education and Sport, Gdansk, - - 2013
Short duration repeated maximal efforts are often used in swimming training to improve lactate tolerance, which gives swimmers the ability to maintain a high work rate for a longer period of time. The aim of the study was to examine the kinematics of swimming and its relation to the changes ...
Teng Fei - - 2013
Recombinant tissue plasminogen activator (rt-PA) is the only pharmacological treatment approved for thrombolysis in patients suffering from ischemic stroke, but its administration aggravates the risk of hemorrhagic transformations. Experimental data demonstrated that rt-PA increases the activity of poly(ADP-ribose)polymerase (PARP). The aim of the present study was to investigate whether PJ34, ...
Hsu Kao-Chih KC Department of Physical Medicine & Rehabilitation Tri-Service General Hospital National Defense Medical Center, Taipei Taichung Veterans General Hospital Taichung - - 2013
We present a right-hemispheric stroke patient with complex regional pain syndrome (CRPS). Symptoms of CRPS developed in conjunction with a corresponding elevation of the contralateral thalamic flow when the glycosylated hemoglobin values were high (16.1% and 13.4%), twice observed as migration from the bottom to the top location of the ...
Salinet Angela S M - - 2013
We tested two hypotheses: (1) neurovascular coupling is impaired after acute ischemic stroke, (2) subcomponent analysis of cerebral blood flow velocity can reveal significant differences between acute ischemic stroke and healthy controls. This was explored through the comparison of nineteen acute ischemic stroke patients with healthy controls. Recordings of cerebral ...
Garcia Andrea - - 2013
Ischemic stroke affects over 15 million patients per year and is a leading cause of death worldwide. Currently available treatments are indicated for less than 5% of patients. Stimulation of the facial nerve has been proposed as a possible new treatment of ischemic stroke that acts by increasing blood flow ...
Li Yao Y Shanghai Jiao Tong University, School of Biomedical Engineering, 800 Dongchuan Road, Shanghai 200240, - - 2013
Stroke is a worldwide medical emergency and an important issue in stroke research is looking for the early pathophysiological markers which can predict the severity of brain injury. Decreased cerebral blood flow (CBF) has been serving as the most important indicator of ischemic stroke. Particular attention is paid to study ...
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