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Crews William S WS Jr 2205 Highway 121, Bedford, TX 76021; - - 2014
Objectives: To examine whether a liver transplant patient, who was not taking an angiotensin-converting enzyme inhibitor and developed two episodes of hypotension with systolic pressure in the 50s within minutes of starting an RBC transfusion, may have had a disturbance in the production and metabolism of bradykinin and des-Arg(9)-BK. Methods: ...
Krause Benjamin W BW Neuroimaging Research Program, Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, - - 2014
This study examined the relationship of γ-aminobutyric acid (GABA) and glutamate levels from the anterior and posterior cingulates (AC and PC) with cerebral blood flow (CBF) at rest. (1)H magnetic resonance spectroscopy measurements in the AC and PC and pseudo-continuous arterial spin labeling data were acquired from 10 healthy controls. ...
Sigurdsson Sigurdur T - - 2013
The lower limit of autoregulation of cerebral blood flow (CBF) can be modulated with both angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARB). The influence of bradykinin antagonism on ARB-induced changes was the subject of this study. CBF was measured in Sprague-Dawley rats with laser Doppler technique. The blood ...
Teixidó Meritxell - - 2013
Less than 2% of all potential neurotherapeutics cross the blood-brain barrier (BBB). Here we sought to build a construct with the capacity to cross this barrier, to behave as a chemical delivery system, and, once inside the central nervous system (CNS), to be transformed and then act as an enzyme ...
Shen Yi - - 2012
Bacteria inhabit a wide variety of environments in which fluid flow is present, including healthcare and food processing settings and the vasculature of animals and plants. The motility of bacteria on surfaces in the presence of flow has not been well characterized. Here we focus on Pseudomonas aeruginosa, an opportunistic ...
Beausang John F - - 2012
Polarized total internal reflection fluorescence microscopy (polTIRFM) can be used to detect the spatial orientation and rotational dynamics of single molecules. polTIRFM determines the three-dimensional angular orientation and the extent of wobble of a fluorescent probe bound to the macromolecule of interest. This protocol describes how to construct sample chambers ...
Sakota Daisuke - - 2012
Optical properties of flowing blood were analyzed using a photon-cell interactive Monte Carlo (pciMC) model with the physical properties of the flowing red blood cells (RBCs) such as cell size, shape, refractive index, distribution, and orientation as the parameters. The scattering of light by flowing blood at the He-Ne laser ...
Venturelli Roberto - - 2012
With the overall goal being a better understanding of the sensing environment from the local perspective of a situated agent, we studied uniform flows and Kármán vortex streets in a frame of reference relevant to a fish or swimming robot. We visualized each flow regime with digital particle image velocimetry ...
Omori Toshihiro - - 2012
The dynamics of a capsule and a biological cell is of great interest in chemical engineering and bioengineering. Although the dynamics of a rigid spheroid is well understood by Jeffery's theory, that of a spheroidal capsule remains unclear. In this Letter, the motion of a spheroidal capsule or a red ...
Wang Chong C Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, - - 2012
Atherosclerotic plaques localize to regions of flow disturbance, i.e. bifurcations, branch points and regions of high curvature. Shear stress in these regions can be multi-directional due to complex flow patterns such as time-varying vortices. However, commonly used in vitro flow models are incapable of changing flow orientation to any direction ...
Haward Simon J - - 2012
We employ the techniques of microparticle image velocimetry and full-field birefringence microscopy combined with mechanical measurements of the pressure drop to perform a detailed characterization of the extensional rheology and elastic flow instabilities observed for a range of wormlike micellar solutions flowing through a microfluidic cross-slot device. As the flow ...
Qazi Shahzada Junaid Shreef - - 2012
Orientational alignment in a dilute dispersion of kaolinite particles has been investigated in a flow pattern that combines both shear and elongational stress, namely flow at a jet created by a 2 mm diameter nozzle inserted in a 6 mm diameter pipe. Spatially resolved, X-ray diffraction with synchrotron radiation permits ...
Cannon James - - 2011
With their unique long cylindrical shape, carbon nanotubes may one-day form nozzles for nano-scale printing or flow into a chamber. Since the scale of the flowing molecules is similar to the diameter of the nanotubes, molecular vibration, orientation and density become influenced by the confinement during flow. We have studied ...
de Castilhos Cristina D - - 2011
OBJECTIVES: To analyze the effect of blood collection and storage conditions on activity of α-galactosidase A, arylsulfatase B and α-glucosidase. DESIGN AND METHODS: Blood was collected in EDTA, heparin, or direct spotting on filter paper and stored at different temperatures (-20, 4, 25 and 37°C) and storage times (3, 10, ...
Paim Rafaela M M - - 2011
Triatomines are hematophagous insects in all post-embryonic life stages. They are vectors of Trypanosoma cruzi, the causative agent of Chagas disease. Their vectorial ability is influenced by their feeding performance, which varies greatly among species. Recent work showed that inhibition of the coagulation process in the anterior midgut (crop) environment ...
Thomson P C - - 2011
Background: Hemodialysis catheter thrombosis is associated with loss of catheter patency, catheter-related bacteremia and sepsis. To limit these risks, many renal units use heparin as a catheter-locking solution. In this study we investigate the effect of different concentrations of heparin catheter lock solution on systemic anticoagulation in an investigator-blinded randomized ...
Martinez Manuel - - 2011
: To report early blood exchange transfusion in malignant pertussis and a favorable clinical outcome. : A pediatric intensive care unit in a tertiary hospital in Geneva, Switzerland. : A descriptive case report. : An 8-wk-old girl was diagnosed with malignant pertussis (extreme leukocytosis, seizures, pneumonia, and secondary severe hypoxic ...
Bauman M E - - 2011
BACKGROUND:: The low molecular weight heparin effect in children is monitored using the anti-factor Xa level. Venipuncture is recommended; however, central venous catheter blood sampling is often necessary. Heparin infused through central venous catheters may contaminate central venous catheter blood samples, preventing reliable anti-factor Xa level measurement. Simultaneous anti-factor Xa/partial ...
Kopp Ruedger - - 2011
Extracorporeal membrane oxygenation can achieve sufficient gas exchange in severe acute respiratory distress syndrome. A highly integrated extracorporeal membrane oxygenator (HEXMO) was developed to reduce filling volume and simplify management. Six female pigs were connected to venovenous HEXMO with a total priming volume of 125 ml for 4 hours during ...
Dowling Matthew B - - 2011
Blood loss at the site of a wound in mammals is curtailed by the rapid formation of a hemostatic plug, i.e., a self-assembled network of the protein, fibrin that locally transforms liquid blood into a gelled clot. Here, we report an amphiphilic biopolymer that exhibits a similar ability to rapidly ...
Lee Da Young - - 2011
Blood compatible graphene/heparin conjugate is simply formulated through noncovalent interaction between chemically reduced graphene and heparin. Charge repulsion of negatively charged heparin on graphene plates renders hydrophobic graphene to be solublized in aqueous media without any precipitation or aggregation even after 6 months. Unfractioned heparin (UFH) with higher molecular weight ...
Gómez-Ochoa Pablo - - 2011
We describe the use of ultrasonography-guided percutaneous splenic injection of agitated saline and heparinized blood for the diagnosis of portosystemic shunts (PSS) in 34 dogs. Agitated saline mixed with 1 ml of heparinized autologous blood was injected into the spleen of 34 sedated dogs under sonographic guidance. The transducer was ...
Napolitano Lena M - - 2011
Marked variability in transfusion practice exists in cardiac surgical patients, with consumption of approximately 20% of the worldwide allogeneic blood supply. Observational studies have reported an association between red blood cell transfusion and adverse outcome, including pulmonary complications, in cardiac surgery. Tuinman and colleagues report that transfusions were associated with ...
Maurer Jürgen - - 2011
Heparin, a linear glycosaminoglycan, is used in different forms in anticoagulation treatment. Protamine, a highly positive charged peptide containing about 32 amino acids, acts as an antagonist for heparin to restore normal blood coagulation. The complex formation of protamine with heparin was analyzed by a combination of analytical ultracentrifugation and ...
Baufreton C - - 2010
The role of complement activation on the cerebral vasculature after cardiopulmonary bypass (CPB) is unclear. The goal of the study was to assess whether heparin-coated CPB reduces complement activation, and influences cerebral blood flow velocities (CBFV). Twenty-four patients undergoing coronary surgery were randomly allocated to non-coated (NC-group) or heparin-coated (HC-group) ...
van Berkel Miranda - - 2010
Abstract Background: Heparin binds positively charged electrolytes. In blood gas syringes, electrolyte-balanced heparin is used to prevent a negative bias in electrolyte concentrations. The potential pre-analytical errors introduced by blood gas syringes are largely unknown. Here, we evaluate electrolyte concentrations in non-anticoagulated blood compared with concentrations measured in electrolyte-balanced blood ...
Kaneshiro Bliss - - 2011
The objective of this study was to compare blood loss resulting from surgical termination of pregnancy up to 12 weeks of gestation between women receiving anticoagulation therapy and healthy controls. Women using heparin, low-molecular-weight heparin or warfarin requesting surgical abortion were enrolled and prospectively matched with nonanticoagulated controls. The primary ...
Gharehbaghi M M - - 2010
Exchange transfusion is performed using many different combinations of blood components. No single component is unequivocally the best. The purpose of this study was to determine the efficacy and adverse events of exchange transfusion (ECT) with whole blood and reconstituted blood in neonatal hyperbilirubinaemia. The medical charts of all neonates ...
Abbyad Paul - - 2010
We have developed a microfluidic approach to study the sickling of red blood cells associated with sickle cell anemia by rapidly varying the oxygen partial pressure within flowing microdroplets. By using the perfluorinated carrier oil as a sink or source of oxygen, the oxygen level within the water droplets quickly ...
Sugiura Tokio - - 2010
To study the effect of exchange transfusion on cytokine profiles in a patient with transient myeloproliferative disorder and hepatic fibrosis in which cytokines were measured before and after exchange transfusion. A newborn female was diagnosed with Down syndrome phenotypically and on karyotyping. Laboratory data showed a high leukocyte count with ...
Heyd Rodolphe - - 2010
We have developed hot-wire anemometry applying the 3omega method. The approach is based on the same heat transfer process as traditional anemometry, but substituting the constant current by a sinusoidal current and using synchronous detection to measure the conductive-convective exchange coefficient and the gas flow rate. Our theoretical model is ...
Kim Gi-Beum - - 2010
Intravascular oxidation is a respiratory assist method used to treat acute respiratory distress syndrome (ARDS). However intravascular oxidation through higher gas exchange is needed for successful clinical applications. In this study, an attempt was made to improve the gas exchange of an intravascular lung assist device by decreasing the level ...
Borland Colin D R CD Department of Medicine, Hinchingbrooke Hospital, Huntingdon PE29 6NT, UK. - - 2010
Lung diffusing capacity for nitric oxide (DLNO) is used to measure alveolar membrane conductance (DMNO), but disagreement remains as to whether DMNO=DLNO, and whether blood conductance (thetaNO)=infinity. Our previous in vitro and in vivo studies suggested that thetaNO<infinity. We now show in a membrane oxygenator model perfused with whole blood ...
Chuenchitra Thippawan - - 2010
The lymphocyte proliferation assay (LPA) is a technique to determine T-lymphocyte functions in vitro. The standard LPA using peripheral blood mononuclear cells (PBMC) separated from heparinized blood requires a large blood sample, time consuming and expensive. It is more useful if acid citrate dextrose (ACD) blood could be used not ...
Jaeckel Rhett - - 2010
Homozygous sickle cell carriers have an increased perioperative mortality. Some indications may justify an exchange blood transfusion to reduce the proportion of haemoglobin S. The advantages of general blood transfusion in a perioperative setting have not been proven and thus remain controversial. It is not clear whether reducing the proportion ...
Yang Bor-Wen - - 2010
Agents that alter the dynamics of hemostasis form an important part in management of conditions such as atherosclerosis, cerebrovascular disease, and bleeding diatheses. In this study, we explored the effects of heparin and tranexamic acid on the efficiency of blood coagulation. Using optical tweezers, we evaluated the pN-range micro-interaction between ...
Saito Akira - - 2010
The prognosis of patients with an acute accumulation of pathogenic or toxic substances in their body fluids--a condition that severely affects survival--can be significantly improved by blood purification. The most appropriate blood purification method and the duration for which it should be used must be selected on the basis of ...
Oduor M M National Blood Transfusion Services, Kenya, Ministry of Medical Services, P.O. Box 29804-00202, Nairobi, - - 2009
Provision of safe and adequate supplies of blood is dependent on a well organised blood transfusion service with dedicated well-trained manpower and resources for the service. To provide an overview of the evolution of blood transfusion services in Kenya, from the 1980s to date. Various Government of Kenya publications and ...
Maina John N - - 2009
The Ostrich, Struthio camelus is the largest extant bird. The arrangement of the airway and the vascular components of the parabronchus of its lung were investigated by 3D serial section reconstruction. Modestly developed atrial muscles, shallow atria, paucity of infundibulae with preponderant origination of the air capillaries (ACs) from the ...
Li Bi-juan - - 2010
HDN attributed to the rare Rh variants has become more and more significant caused by anti-D, but the compatible blood is usually very difficult to obtain when exchange transfusion is required. We treated a 10-hour neonate of O, D + C + c - E - e+ blood group with ...
Mongan Paul D - - 2009
BACKGROUND: This study determined individual organ blood flows and global hemodynamic, oxygen delivery and consumption parameters after normovolemic exchange transfusions with the hemoglobin based oxygen carrier (HBOC)-201 in a lightly anesthetized swine model. METHODS: The exchange transfusions were performed as a stepped reduction in blood volume to attain volume exchanges ...
Bailey Damian M - - 2009
BACKGROUND AND PURPOSE: High-altitude headache is the primary symptom associated with acute mountain sickness, which may be caused by nitric oxide-mediated activation of the trigeminovascular system. Therefore, the present study examined the effects of inspiratory hypoxia on the transcerebral exchange kinetics of the vasoactive molecules, nitrite (NO(2)(*)), and calcitonin gene-related ...
Terblanche John S - - 2010
Air flow rates may confound the investigation and classification of insect gas exchange patterns. Here we report the effects of flow rates (50, 100, 200, 400 ml min(-1)) on gas exchange patterns in wild-caught Glossina morsitans morsitans from Zambia. At rest, G. m. morsitans generally showed continuous or cyclic gas ...
Cao Suyi S Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, MD 21287, - - 2009
Partial exchange transfusion with a cell-free hemoglobin (Hb) polymer during transient middle cerebral artery occlusion (MCAO) reduces infarct volume but fails to increase blood flow, as might be expected with the induced decrease in hematocrit. In ischemic brain, endothelin antagonists are known to produce vasodilation. In nonischemic brain, pial arterioles ...
Yelgaonkar V N - - 2009
Pure terphthalic acid (PTA) is produced by the oxidation of paraxylene in an oxidation reactor of a PTA plant. Since the reaction is exothermic, the temperature rises above 210 degrees C. Vapours formed in the reactor are passed through a series of heat exchangers and the cooled liquid is fed ...
Li Xin X Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR 97239, USA. - - 2009
Human myocardial (1)H(2)O T(1)-weighted dynamic contrast-enhanced MRI data were acquired during the brief first-pass period after injection of a very small gadolinium diethylenetriaminepenta-acetate (GdDTPA(2-)) dose. The shutter-speed pharmacokinetic effects of both transendothelial and transcytolemmal equilibrium water exchange processes were investigated. Our results indicate that even for such a short acquisition ...
Lucato Jeanette Janaina Jaber - - 2009
To evaluate and compare the efficiency of humidification in available heat and moisture exchanger models under conditions of varying tidal volume, respiratory rate, and flow rate. Inspired gases are routinely preconditioned by heat and moisture exchangers to provide a heat and water content similar to that provided normally by the ...
Samanta Sandip - - 2009
OBJECTIVES: Acute intravascular hemolysis after exchange transfusion with glucose 6-phosphate dehydrogenase-deficient blood has been reported; however, it is not routine to screen donor blood for glucose 6-phosphate dehydrogenase deficiency while performing exchange transfusion. We hypothesized that exchange transfusion with glucose 6-phosphate dehydrogenase-deficient blood would lead to a less-than-expected decrease in ...
Spidlen Josef J Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia, - - 2008
The lack of software interoperability with respect to gating due to lack of a standardized mechanism for data exchange has traditionally been a bottleneck, preventing reproducibility of flow cytometry (FCM) data analysis and the usage of multiple analytical tools. To facilitate interoperability among FCM data analysis tools, members of the ...
Palhano Fernando L - - 2009
Transthyretin (TTR) is a 127-residue homotetrameric beta-sheet-rich protein that transports thyroxine in the blood and cerebrospinal fluid. The deposition of fibrils and amorphous aggregates of TTR in patients' tissues is a hallmark of TTR amyloid disease. Familial amyloidotic polyneuropathy is a hereditary form of TTR amyloidosis that is associated with ...
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