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Sykes S D - - 2013
There are fetal sex-specific differences in the balance between angiotensin (Ang) II and Ang-(1-7) in the maternal circulation during pregnancy. To determine whether at 15 weeks' gestation plasma levels of Ang II and Ang-(1-7), as well as levels of prorenin and Ang-converting enzyme (ACE), predicted the development of gestational hypertension ...
Antonios Tarek F T - - 2013
BACKGROUND: Preeclampsia is a major cause of maternal and neonatal mortality and morbidity. The incidence of preeclampsia seems to be rising because of increased prevalence of predisposing disorders, such as essential hypertension, diabetes, and obesity, and there is increasing evidence to suggest widespread microcirculatory abnormalities before the onset of preeclampsia. ...
Wilson Danielle L - - 2013
Sleep-disordered breathing (SDB) is reported commonly during pregnancy and is associated with an increased risk of adverse maternal and fetal outcomes, but the majority of these data are based upon self-report measures not validated for pregnancy. This study examined the predictive value of screening questionnaires for SDB administered at two ...
Sananès Nicolas - - 2013
OBJECTIVE: To evaluate the utility of first trimester cervical ultrasonography in predicting preterm delivery by separate analysis of measurements of cervical and isthmus length. METHODS: Cohort study based on data collected prospectively on singletons between 1 July 2011 and 1 February 2013. Mean cervical, isthmus and cervico-isthmic complex length were ...
Souka Athena P - - 2013
OBJECTIVES: To define the optimal gestational age in the third trimester, early (30 to 33 + 6 weeks) vs late (34 to 37 weeks), for performing an ultrasound examination for fetal biometry in order to predict birth weight deviations: small for gestational age (SGA≤5(th) centile) and large for gestational age (LGA≥95(th) centile) neonates. METHODS: ...
Speer Paul D - - 2013
Objective To determine if the length of fetal long bones (LB) at mid-trimester ultrasound is predictive of small-for-gestational-age (SGA) newborns at term delivery.Methods Retrospective evaluation of 6,781 women between 18 and 24 weeks' gestation at Magee-Womens Hospital (MWH). Gestational age (GA) was confirmed by first- or second-trimester ultrasound and patient's ...
Malek-Mellouli Monia - - 2013
Background: Assessment of early pregnancy is indicated in women with suspected abnormalities. It is based on biochemical assessment and on trans vaginal sonography . aim: To identify clinical, biological and ultrasonographic parameters that are predictive of spontaneous pregnancy resolution. methods: A prospective observational study was performed interesting women with a ...
Akbas Pinar Tipi - - 2013
ABSTRACT Objective: This study aims to compare the serum total L-carnitine concentrations of obese and non-obese pregnant women and to identify the role of L-carnitine in both maternal and fetal weight gain during pregnancy. Methods: This study reviews 118 healthy women with singleton term pregnancy (≥37 weeks). The characteristics of ...
Chaabane K - - 2013
aim: To determine the effect of misdiagnosis of macrosomia on maternal and perinatal outcomes. methods : We conducted a retrospective study ,between January 2007 and December 2008 of women (n = 464) who delivered singleton neonates with actual birth weight over 4000g and in whom fetal weight was estimated, by ...
Londero Ambrogio P - - 2013
Abstract Introduction: Our aim was to state the role of first trimester pregnancy-associated plasma protein A (PAPP-A)-multiple of the median (MoM) value as a predictor for breech presentation at term of pregnancy. Materials and methods: In this retrospective study, we present data for 1100 singleton full-term deliveries that took place ...
Borna Sedigheh S Department of Obstetrics & Gynecology, Vali-e-asr Hospital, Tehran University of Medical Sciences, Tehran, - - 2013
To investigate the clinical advantage of several prognostic factors for predicting preterm delivery. Eighty and six patients with a singleton pregnancy admitted to Vali-Asr hospital underwent genetic amniocentesis between the 15th and 23th weeks were included in this study. Maternal serum C-reactive protein (CRP), transvaginal sonographic measurement of cervical length ...
- - 2013
OBJECTIVES: The evaluation of hypoxia index (HI) in the prediction of abnormal fetal heart rate at delivery in uncomplicated pregnancies. MATERIAL AND METHODS: The study group included 148 pregnant patients at term (69 patients with and 79 without brain sparing effect). The value of C/U ratio and HI was determined. ...
Kallioniemi Hanna - - 2013
OBJECTIVE: We aimed to study vaginal fluid phosphorylated insulin-like growth factor binding protein-1 (phIGFBP-1) testing in early pregnancy to predict spontaneous preterm delivery (PTD). METHODS: Vaginal and cervical swab samples were collected from 5180 unselected women during the first-trimester (mean gestational age 13.1 weeks) ultrasound screening. PhIGFBP-1 was measured in vaginal ...
Miller Jena L - - 2013
OBJECTIVES: The frequency of fetal anomalies in women with pregestational diabetes correlates with their glycemic control. This study aimed to assess the predictive performance of first trimester fetal nuchal translucency (NT), ductus venosus (DV) Doppler, and hemoglobin A1c (HbA1c) to predict fetal anomalies in women with pregestational diabetes. STUDY DESIGN: ...
Bahado-Singh Ray O - - 2013
OBJECTIVE: To perform first trimester maternal serum metabolomic analysis and compare results in aneuploid versus Down syndrome (DS) pregnancies. STUDY DESIGN: This was a case control study of pregnancies between 11+0 and 13+6 weeks. There were 30 DS cases and 60 controls in which first trimester maternal serum was analyzed. ...
Boucoiran Isabelle - - 2013
Objectives To determine whether the parameters used in first-trimester screening for aneuploidies contribute significantly to the prediction of birth weight.Methods In this retrospective cohort study (n = 4110), nuchal translucency (NT), free β-chorionic gonadotropin (fβ-hCG), and pregnancy-associated plasma protein-A (PAPP-A) blood concentrations were measured between 11 + 0 and 13 + 6 weeks. Multiple pregnancies, chromosomal anomalies, major ...
Malek-Mellouli Monia - - 2013
Background: Women having pregnancies of unknown location (PUL) can be defined as those having positive pregnancy test when no pregnancy is visualized on transvaginal ultrasound (TVS). Aim: To identify diagnostic parameters which are predictive of ectopic pregnancies in women with early pregnancies of unknown location. Methods: We undertook a prospective ...
Chaabane Kais - - 2013
Identifying newborns who weight 4000 g or more is important because birth of macrosomic fetuses is associated with adverse peripartum outcomes. Ultrasound is widely used for this purpose Our objective was to evaluate the diagnostic value of sonographic measurement of fetal abdominal circumference (AC) over 350 mm for the prediction ...
Seilanian Toosi Farrokh - - 2013
A true estimation of gestational age (GA) plays an important role in quality maternity care and scheduling the labor date. This study aimed to evaluate the normal fetal kidney length (KL) and its correlation with GA. A cross-sectional study on 92 pregnant women between 8th and 10th week of gestation ...
Saxena Aditi R AR Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. - - 2013
First trimester Pregnancy Associated Plasma Protein A (PAPP-A) levels, routinely measured for aneuploidy screening, may predict development of preeclampsia. This study tests the hypothesis that first trimester PAPP-A levels correlate with soluble fms-like tyrosine kinase-1 (sFlt-1) levels, an angiogenic marker associated with preeclampsia, throughout pregnancy. sFlt-1 levels were measured longitudinally ...
Yalç─▒nkaya Ender E IVF Center, Kocaeli University Faculty of Medicine, Kocaeli, - - 2013
To investigate the biochemical markers such as nitric oxide (NO), malondialdehyde (MDA) and reduced glutathione (GSH), indicators of the oxidative status of the follicle, to predict the outcome of in vitro fertilization. Follicular aspirates of dominant follicles were collected during oocyte retrieval. Biochemical analyses of NO, MDA and GSH were ...
Lédée N - - 2012
BACKGROUND: Previous experiments have shown that granulocyte colony-stimulating factor (G-CSF), quantified in the follicular fluid (FF) of individual oocytes, correlates with the potential for an ongoing pregnancy of the corresponding fertilized oocytes among selected transferred embryos. Here we present a proof of concept study aimed at evaluating the impact of ...
Boucoiran Isabelle - - 2012
Objective To determine the accuracy of placental growth factor (PlGF), soluble fms-like tyrosine kinase-1 (sFlt-1), and inhibin A in singleton and multiple-gestation pregnancies for predicting preeclampsia (PE) and small for gestational age (SGA).Study Design A prospective cohort nested in a randomized controlled trial of antioxidant supplementation for the prevention of PE. Plasma ...
Beccaglia M - - 2012
In bitches and queens, the ultrasonographic measurement of extrafoetal and foetal structures allows the evaluation of gestational age and the prediction of the parturition term for an extended period of time. The aim of this study was to investigate whether the accuracy of parturition date prediction is affected by the ...
Stout M J MJ Washington University in Saint Louis, Department of Obstetrics and Gynecology, 660 S. Euclid Ave, Saint Louis, MO 63110, USA. - - 2013
Markers of placental dysfunction are used for risk prediction of adverse obstetric outcomes including preeclampsia and growth restriction. Although medically indicated preterm birth is often distinguished from spontaneous preterm birth, we hypothesize that similar placental dysfunction may underlay all preterm birth. We aimed to investigate whether first trimester placental protein ...
Broer Simone L SL Department of Reproductive Medicine, University Medical Center Utrecht, Utrecht, The Netherlands. - - 2013
BACKGROUND Although ovarian reserve tests (ORTs) are frequently used prior to IVF treatment for outcome prediction, their added predictive value is unclear. We assessed the added value of ORTs to patient characteristics in the prediction of IVF outcome. METHODS An individual patient data (IPD) meta-analysis from published studies was performed. ...
Yan Junhao - - 2012
This retrospective observational study was performed to determine the predictive value of midluteal serum progesterone measurement on the subsequent pregnancy outcome in women with unexplained recurrent miscarriage after referral. This study involved women with unexplained recurrent miscarriage attending the recurrent miscarriage clinic between January 1992 and March 2011. A total ...
Mei-Dan Elad - - 2012
Abstract Objective: To examine whether plasma levels of aspartate transaminase (AST) and alanine transaminase (ALT) during the first 20 weeks of pregnancy can predict preeclampsia in the second half of pregnancy. Methods: The study population included 15010 registered births. Receiver operating characteristic (ROC) curve analysis was used to describe the ...
Barber M A - - 2012
We conducted a prospective observational study of 306 asymptomatic women at 20-22 weeks of pregnancy to compare 3-dimensional ultrasound measurements of cervical volume with 2-dimensional ultrasound measurements of cervical length to evaluate the performance of cervical volume as a predictor of pre-term delivery, compared with the current standard, cervical length. ...
Tongprasert Fuanglada - - 2012
Abstract Objective: To compare the levels of maternal serum alpha-fetoprotein (AFP), unconjugated estriol (uE3) and free beta-human chorionic gonadotropin (free β-hCG) between pregnancies with fetal Hb Bart's disease and unaffected pregnancies. Methods: 148 pregnancies at risk of fetal Hb Bart's disease scheduled for cordocentesis at 18 to 22 weeks were ...
Cahill Alison G - - 2012
The objective of this study was to estimate the predictive ability of electronic fetal monitoring (EFM) patterns immediately prior to delivery for acidemia at term birth. This was a 4-year retrospective cohort study of 5388 consecutive singleton, nonanomalous gestations of 37 weeks or longer. The primary exposure was the EFM ...
Odiari Ebelechukwu A - - 2012
What is the effect of pravastatin on antiphospholipid antibody (aPL) modulation of human first trimester trophoblast function? Pravastatin does not prevent the effects of aPL on human first trimester trophoblast cell function. Antiphospholipid syndrome (APS) is associated with recurrent pregnancy loss and late pregnancy complications, such as pre-eclampsia, owing to ...
McElrath Thomas F - - 2012
OBJECTIVE: The purpose of this study was to examine whether longitudinally sampled maternal angiogenic concentrations predict preeclampsia. STUDY DESIGN: Plasma sFlt-1 and placental growth factor (PlGF) concentrations in healthy pregnant women were quantified at 10, 17, 25, and 35 weeks' gestation. Preeclampsia was diagnosed with criteria from the American College ...
Mesa H - - 2012
The objective of this study was to evaluate correlated responses in conceptus development and traits physiologically relevant for placental function in swine from a selection experiment that resulted in differences in placental weight (PW) and efficiency (PE = birthweight/placental weight). Generation 3, second parity females from two lines with a ...
Blank Miri - - 2012
OBJECTIVES: We evaluated the presence of anti-glycan antibodies (aGA) in patients with antiphospholipid syndrome (APS), and associations between aGA and clinical features of the disease. METHODS: Sera from APS patients and healthy controls were analyzed for aGA levels by ELISA. Analysis of the association of specific aGA with clinical manifestations ...
Toledano Yoel - - 2012
Because pregnancy and estrogens both induce pituitary lactotroph hyperplasia, we assessed the expression of pituitary cell cycle regulators in two models of murine pituitary hyperplasia. Female mice were assessed during nonpregnancy, pregnancy, day of delivery, and postpartum. We also implanted estradiol (E(2)) pellets in female mice and studied them for ...
Cho Eujin - - 2012
Pigmentary demarcation lines are abrupt transition lines between the areas of deeper pigmentation and the areas of lighter, normal pigmentation. Type B pigmentary demarcation lines involve the posterior medial portion of the lower extremities and are more commonly associated with pregnancy. We present a case of pigmentary demarcation lines of ...
van Drongelen Joris - - 2012
The vascular response to pregnancy has been frequently studied in mesenteric artery models, by investigating endothelial cell (EC) and smooth muscle cell (SMC) dependent responses to mechanical (flow-mediated vasodilation, myogenic reactivity, and vascular compliance) and pharmacological stimuli (G-protein coupled receptor responses: Gq(EC), Gs(SMC), Gq(SMC)). It is unclear to what extent ...
Prins Jelmer R - - 2012
IL6 is a multifunctional cytokine with pivotal roles in the inflammatory response and in directing T cell differentiation in adaptive immunity. IL6 is widely expressed in the female reproductive tract and gestational tissues, and exerts regulatory functions in embryo implantation and placental development, as well as the immune adaptations required ...
Dickmann Leslie J LJ Department of Pharmacokineticsand Drug Metabolism, - - 2013
There is considerable evidence that pregnancy changes the disposition of drugs in an enzyme- and gestational stage-specific manner. On the basis of probe drug studies, the activity of CYP3A4 and CYP2D6 increases and CYP1A2 decreases during human pregnancy. However, no studies of CYP2B6 activity during human pregnancy have been conducted. ...
Rada Cara C - - 2012
The maternal cardiovascular system undergoes hemodynamic changes during pregnancy via angiogenesis and vasodilation to ensure adequate perfusion of the placenta. Improper vascularization at the maternal-fetal interface can cause pregnancy complications and poor fetal outcomes. Recent evidence indicates that small conductance Ca(2+)-activated K(+) channel subtype 3 (SK3) contributes to vascular remodeling ...
Kalu C A - - 2012
Background: It has been recognized that preterm labor is related to short cervical length and that poor progress in labor is a major indication for cesarean section at term. We therefore hypothesize that long cervix is not associated with increased risk of cesarean delivery during labor at term. Objectives: The ...
Benoit Joshua B - - 2012
Sphingosine is a structural component of sphingolipids. The metabolism of phosphoethanolamine ceramide (sphingomyelin) by sphingomyelinase (SMase), followed by the breakdown of ceramide by ceramidase (CDase) yields sphingosine. Female tsetse fly is viviparous and generates a single progeny within her uterus during each gonotrophic cycle. The mother provides her offspring with ...
Hsiao Elaine Y - - 2012
A variety prenatal insults are associated with the incidence of neurodevelopmental disorders such as schizophrenia, autism and cerebral palsy. While the precise mechanisms underlying how transient gestational challenges can lead to later life dysfunctions are largely unknown, the placenta is likely to play a key role. The literal interface between ...
Emera Deena - - 2012
Transposable elements (TEs) are known to provide DNA for host regulatory functions, but the mechanisms underlying the transformation of TEs into cis-regulatory elements are unclear. In humans two TEs--MER20 and MER39--contribute the enhancer/promoter for decidual prolactin (dPRL), which is dramatically induced during pregnancy. We show that evolution of the strong ...
Majed Batoule H - - 2012
Prostacyclin (PGI(2)) is a member of the prostanoid group of eicosanoids that regulate homeostasis, hemostasis, smooth muscle function and inflammation. Prostanoids are derived from arachidonic acid by the sequential actions of phospholipase A(2), cyclooxygenase (COX), and specific prostaglandin (PG) synthases. There are two major COX enzymes, COX1 and COX2, that ...
Stika Catherine S - - 2012
Previously established as a chemotherapeutic agent for decades, methotrexate has been adapted for use as a medical therapy for unruptured ectopic pregnancies. Its mechanism of action, competitive inhibition of folate-dependent steps in nucleic acid synthesis, effectively kills the rapidly dividing ectopic trophoblast. However, the same action on normal cells is ...
Blois Sandra M - - 2012
Mouse and human pregnancy-specific glycoproteins (PSG) are known to exert immunomodulatory functions during pregnancy by inducing maternal leukocytes to secrete anti-inflammatory cytokines that promote a tolerogenic decidual microenvironment. Many such anti-inflammatory mediators also function as proangiogenic factors, which, along with the reported association of murine PSG with the uterine vasculature, ...
Srirattana Kanokwan - - 2012
Abstract Trichostatin A (TSA) has previously been used in somatic cell nuclear transfer (SCNT) to improve the cloning efficiency in several species, which led our team to investigate the effects of TSA on the full-term development of bovine SCNT and gaur-bovine interspecies SCNT (gaur iSCNT; gaur somatic cells as donors ...
Ladyman Sharon R - - 2012
Hyperphagia during pregnancy, despite rising concentrations of the satiety hormone leptin, suggests a state of leptin resistance develops. This study investigated the satiety response and hypothalamic responses to leptin during pregnancy in the mouse. Pregnant (day 13) and nonpregnant mice received an intraperitoneal (i.p.) injection of either leptin or vehicle ...
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