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Brown C Ann - - 2008
The relation between maternal heart rate variability (HRV) and fetal behavior was examined in hypertensive and normotensive pregnant women. A total of 40 mother-fetal pairs (n = 20 normotensive mothers; n = 20 hypertensive mothers) at 33-41 weeks' gestation were observed using a standardized procedure lasting approximately 50 min. It ...
Sumana Gurunath - - 2008
OBJECTIVE: Non-cirrhotic portal hypertension (NCPH) is a common cause of portal hypertension in developing countries, especially Asia. Recent data have shown near-normal reproductive function and good pregnancy outcome for NCPH compared with cirrhosis. The aim of the present study was to evaluate complications during pregnancy and pregnancy outcome in women ...
Buemi Michele - - 2008
The pathophysiological mechanisms underlying preeclampsia, a serious complication of pregnancy, are largely unknown. Since, on the other hand, the various risk factors are known, primary and secondary prevention with pre- and inter-pregnancy counseling should be undertaken, and a follow-up should be conducted to evaluate any long-term organic complications. There is ...
Signore Caroline - - 2008
OBJECTIVE: Our objective was to investigate whether serum concentrations of a novel anti-angiogenic factor, soluble endoglin (sEng), could predict placental abruption. METHODS: In a nested case-control study of nulliparous pregnancies, we examined levels of sEng in serum collected prospectively from 31 women who later developed placental abruption and from 31 ...
Yin T T - - 2008
OBJECTIVE: To test the hypothesis that obstructive sleep apnoea (OSA) is more common in pregnancies complicated by hypertensive disease and fetal growth restriction. STUDY DESIGN: An observational study comparing pregnant women with these two complications with normal pregnant women and non-pregnant women in two UK maternity hospitals. Each participant completed ...
Ntusi Ntobeko B A - - 2009
BACKGROUND: Peripartum cardiomyopathy (PPCM) is a disorder of unknown aetiology in which heart failure due to left ventricular dysfunction occurs between the last month of pregnancy and first five months post-partum. Theories abound concerning the specific cause and risk factors for PPCM, but none have been accepted universally. The primary ...
Troisi Rebecca - - 2008
The objective of the study was to determine whether blood pressure increases are associated with maternal angiogenic factors in uncomplicated and preeclamptic pregnancies. Associations of blood pressure increases from mid- to late pregnancy with maternal serum concentrations of soluble fms-like tyrosine kinase receptor (sFlt1), soluble endoglin (sEng), and placental growth ...
Irani R A - - 2008
During normal pregnancy, the renin-angiotensin system (RAS) plays a vitally important role in salt balance and subsequent well-being of mother and fetus. In this balance, one must consider not only the classical renal RAS but also that of the uteroplacental unit, where both maternal and fetal tissues contribute to the ...
- - 2008
(1) The list of adverse effects of selective serotonin reuptake inhibitor (SSRI) antidepressants in pregnant women and their newborns continues to grow; (2) It was already known that, when taken towards the end of pregnancy, SSRIs could cause spontaneously resolving neonatal disorders, particularly neurological problems; (3) A case-control study has ...
Erbagci Ibrahim - - 2008
OBJECTIVE: To present various ophthalmologic disorders in a clinical series of hemolysis, elevated liver enzymes and low platelet count (HELLP) syndrome cases. METHODS: This is a prospective clinical study performed between 2002 and 2005. One hundred seven HELLP patients attended in either Departments of Ophthalmology or Obstetrics and Gynecology, Medical ...
Barton John R - - 2008
Women with a history of previous preeclampsia are at increased risk of preeclampsia and other adverse pregnancy outcomes in subsequent pregnancies. The magnitude of this risk is dependent on gestational age at time of disease onset, severity of disease, and presence or absence of preexisting medical disorders. The objective in ...
Van Landingham M - - 2009
OBJECTIVE: To evaluate and identify the risk factors associated with the pathogenesis of congenital hydrocephalus in a large specific population. METHODS: An International Classification of Diseases (ICD)-9 database search of patients with congenital hydrocephalus treated at the University of Mississippi Medical Center between 1998 and 2007 was performed. All recruited ...
López-Jaramillo Patricio - - 2008
Preeclampsia, a pregnancy-exclusive hypertensive disorder, is the major cause of maternal and perinatal mortality, with a greater importance in developing countries. The role of inflammation in the pathogenesis of preeclampsia has been the object of recent studies by our group. We have described elevated levels of inflammatory markers (tumor necrosis ...
Sandrim Valeria C - - 2008
Deficient NO formation has been implicated in hypertensive disorders of pregnancy. However, no previous study has compared the circulating nitrite concentrations in healthy pregnant women with those found in hypertensive disorders of pregnancy. Moreover, 2 antiangiogenic factors produced in the placenta (soluble fms-like tyrosine kinase-1 and soluble endogline) may affect ...
Andrus Sarah S - - 2010
Preeclampsia is a syndrome characterized by hypertension, proteinuria and edema in a pregnant female after 20 weeks of gestation, including occurring in the postpartum period. Delivery of the infant is usually considered the definitive treatment for preeclampsia. Preeclampsia in a prior pregnancy is associated with an increased risk of recurrence ...
Villers Margaret S - - 2008
OBJECTIVE: The purpose of this study was to identify morbidity that is associated with sickle cell disease (SCD) in pregnancy. STUDY DESIGN: The Nationwide Inpatient Sample from the Healthcare Cost and Utilization Project of the Agency for Healthcare Research and Quality for the years 2000-2003 was queried for all pregnancy-related ...
Savona-Ventura C - - 2008
Gestational diabetes is often compounded by hypertensive disease of pregnancy. Women diagnosed as suffering from gestational diabetes were subdivided into two groups: those found to be suffering from some form of hypertension during their pregnancy [n = 78]; and those who did not develop hypertension [n = 345]. The maternal ...
Misković Berivoj - - 2008
The aim of this study was to determine if insertion-deletion polymorphism of angiotensin-converting enzyme is a risk factor for the development of preeclampsia. Sixty women with preeclampsia and 50 normotensive pregnant women were included in this study. Preeclampsia was defined as blood pressure >140/90 mmHg in a previously normotensive women ...
Mikolajczyk Rafael T - - 2008
The lower risk of preeclampsia observed in parous women has prompted a hypothesis that cardiovascular adaptation from a first pregnancy has ongoing benefits which contribute to a reduced risk of preeclampsia in the second pregnancy. However, how the interpregnancy interval affects mean arterial pressure (MAP) as an indicator of cardiovascular ...
Shan Hui Yi - - 2008
Preeclampsia is a serious complication during pregnancy that includes potentially life-threatening risks to the mother and fetus. It may be challenging to distinguish this from other causes of rapidly escalating hypertension, especially in women with end-stage renal disease, because current diagnostic criteria for preeclampsia cannot be easily applied. We report ...
Abe Toyofumi - - 2008
OBJECTIVES: To examine women with renal transplants who became pregnant, and delivered at our hospital. METHODS: Twenty-six women who had undergone renal transplantation between 1977 and 2002 became pregnant, and delivered at Osaka University Hospital. Complete medical records of twenty of them were retrieved and retrospectively analyzed. RESULTS: Overall, twenty-nine ...
Fong Tze-Vun - - 2008
BACKGROUND/AIMS: Esophageal varices bleeding is a fatal complication of portal hypertension. The model for end-stage liver disease (MELD) has been used as a tool to predict mortality risk in cirrhotic patients. It is currently unknown if MELD score can be applied to predicting late esophageal varices rebleeding. The predictive ability ...
Palei Ana C T - - 2008
OBJECTIVES: To compare the circulating levels of matrix metalloproteinase (MMP)-2, MMP-9, tissue inhibitors of metalloproteinase (TIMP)-1, TIMP-2, and the MMP-9/TIMP-1 and MMP-2/TIMP-2 ratios in preeclampsia and gestational hypertension with those found in normotensive pregnancies. DESIGN AND METHODS: We studied 83 pregnant women (30 healthy pregnant women with uncomplicated pregnancies, 26 ...
Salgado Sujatha S - - 2008
OBJECTIVE: To determine the frequency of placental infarcts and its effects on the fetal outcome in pregnancies complicated by hypertension. STUDY DESIGN: Case control. PLACE AND DURATION OF STUDY: Obstetrics Unit of North Colombo Teaching Hospital, Ragama, Sri Lanka, from January 2003 to January 2004. PATIENTS AND METHODS: Placentae of ...
Druzin Maurice L - - 2008
PURPOSE OF REVIEW: Hypertensive disorders of pregnancy, particularly the preeclampsia/eclampsia syndrome, remain the leading causes of worldwide pregnancy-related maternal and neonatal mortality and morbidity. This group of conditions are a 'riddle wrapped in a mystery inside an enigma' to quote Winston Churchill. We are fortunate to have contributions from leading ...
Zhang Yinghong - - 2008
To clarify the role of TAFI in hypertensive disorders in pregnancy, 22 subjects, including 10 with pre-eclampsia (PE) and 12 with gestational hypertension were examined for the levels of TAFI and thrombin-antithrombin (TAT) complex. Thirty normal pregnant women served as controls. ELISA was employed for the detection. The results showed ...
Vinnars Marie-Therese MT Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet, Stockholm, Sweden. - - 2008
The aim of the present study was to evaluate the histopathology in placentas from patients with severe preeclampsia with and without hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome. An additional aim was to compare the prevalence of infants born small for gestational age in the 2 groups. The ...
Bainbridge S A - - 2008
Hyperuricemia is a common finding in preeclamptic pregnancies evident from early pregnancy. Despite the fact that elevated uric acid often pre-dates the onset of clinical manifestations of preeclampsia, hyperuricemia is usually considered secondary to altered kidney function. Increased serum uric acid is associated with hypertension, renal disease and adverse cardiovascular ...
Rasmussen Svein - - 2008
We assessed whether fetal growth restriction without pregnancy-induced hypertension (PIH) is associated with the different clinical subgroups of PIH in the subsequent pregnancy. We also assessed the maternal and paternal contributions to this effect. Pairs of first and second, second and third, third and fourth, and fourth and fifth births ...
Poon Leona C Y - - 2008
This study aimed to determine the performance of screening for preeclampsia (PE) by maternal medical history and mean arterial pressure (MAP) at 11(+0) to 13(+6) weeks. In 5590 women with singleton pregnancies attending for routine care at 11(+0) to 13(+6) week's gestation we recorded maternal variables and measured the MAP. ...
Maynard Sharon E - - 2008
OBJECTIVE: Placental soluble fms-like tyrosine kinase-1 may contribute to the pathogenesis of preeclampsia. Here we describe alterations in serum angiogenic factor levels in women with multiple gestation pregnancies, a major preeclampsia risk factor. STUDY DESIGN: We collected serial serum specimens from 101 pregnant women at high preeclampsia risk between 22 ...
Diehl Courtenay L - - 2008
OBJECTIVE: This study was undertaken to validate a self-administered questionnaire in verifying the diagnosis of preeclampsia, eclampsia, or toxemia in a group of women with a greater than 20-year history of preeclampsia. STUDY DESIGN: Questionnaires were mailed to a random sample of 144 women who received a diagnosis of any ...
Onyiriuka, A N; ;
In this case-control study, we examined the perinatal outcome in 272 pregnancies complicated by hypertension and compared the result with that of 816 control cases. The overall prevalence of hypertensive disorders in pregnancy (HDP) was 7.2%. There was significantly higher perinatal mortality rate (PMR) of 110.3 per 1000 deliveries in ...
Onyiruika, A N; ;
This prospective study aimed at examining the effect of maternal hypertension in pregnancy on rate of preterm delivery and anthropometric indices in the resultant newborn infants. The gestational ages and anthropometric indices of 265 live-born babies of hypertensive mothers (BHM) were determined and the results compared with those of 804 ...
van Rijn Bas B - - 2008
BACKGROUND: Altered maternal inflammatory responses play a role in the development of preeclampsia and the hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome. We examined whether allelic variants of the innate immune receptors Toll-like receptor 4 (TLR4) and nucleotide-binding oligomerization domain 2 (NOD2), that impair the inflammatory response to ...
Ghanem Firas A - - 2008
The decision to treat elevated arterial pressure in pregnancy depends on the risk and benefits imposed on the mother and the fetus. Treatment for mild-to-moderate hypertension during pregnancy may not reduce maternal or fetal risk. Severe hypertension, on the other hand, should be treated to decrease maternal risk. Methyldopa and ...
El Guindy Alaa A - - 2008
OBJECTIVES: To assess the effects of applying a tight vs. a less tight control of mild chronic essential or gestational non-proteinuric hypertension in pregnancy. METHODS: A randomized trial was conducted in 2006-2007 in the University of Ain Shams, Egypt. Eligible participants (n=125) were randomly assigned to either tight or less ...
Longo-Mbenza B - - 2008
BACKGROUND: To assess whether the frequency pf pregnancy-induced hypertension is low, and vegetables intake and physical activity are protective against pregnancy-induced hypertension onset among rural women from Democratic republic of Congo. METHOD: This hospital-based and longitudinal study was carried out within the rural hospital of Kimpese, DR Congo were monitored ...
Mütze Sabine - - 2008
Preeclampsia is specific to pregnancy and is still a leading cause of maternal and perinatal mortality and morbidity, affecting about 3% of women, but the underlying pathogenetic mechanisms still remain unclear. Immune maladaptation, placental ischemia and increased oxidative stress represent the main components discussed to be of etiologic importance, and ...
Franceschini Nora - - 2008
Pregnancy increases plasma cystatin C, but levels are much higher in preeclampsia. Previous studies have not quantified preeclampsia risk with varying cystatin C concentrations or adjusted for confounders. We performed a case-control study of 100 preeclampsia cases and 100 random pregnancies uncomplicated by hypertension (controls). All women were free of ...
LaMarca Babbette D - - 2008
Preeclampsia is new-onset hypertension with proteinuria during pregnancy. The initiating event in preeclampsia has been postulated to involve reduced placental perfusion, which leads to widespread dysfunction of the maternal vascular endothelium. The main objective of this brief review was to highlight some of the recent advances in our understanding of ...
Kim Shin-Young - - 2008
Preeclampsia is a major cause of maternal and perinatal mortality and morbidity. The etiology of preeclampsia remains unclear. Recently, it was shown that misregulation of fms-like tyrosine kinase-1 (Flt-1) in the peripheral blood mononuclear cells of pregnant women results in over-expression of the soluble splice variant of Flt-1, sFlt-1, producing ...
Luoto Riitta R Tampere School of Public Health, University of Tampere, Tampere, - - 2008
To assess role of systolic hypertension during pregnancy in long-term mortality. A total of 4,090 Finnish women who delivered in the period from 1954 to 1963 were followed up for an average of 44 years. Mortality data were obtained from the Finnish cause-of-death registry. Cox-proportional hazard models were used for ...
Emonts Patrick P Department of Obstetrics and Gynaecology, University of Liège, CHR Citadelle, Liège, Belgium. - - 2008
To derive a prediction index based on the most salient patient history, laboratory, and clinical parameters for identifying women at high risk for developing preeclampsia (PE). Nonpregnant women with a history of PE (n = 101) were compared with nonpregnant parous women with a history of one or more successful ...
Lok Christine A R CA Department of Obstetrics and Gynaecology, Academic Medical Center, Amsterdam, The Netherlands. - - 2008
Microparticles (MP) are pro-coagulant vesicles derived from various cells. Evidence is accumulating that MP are of pathophysiological relevance in autoimmune, cardiovascular, and thromboembolic diseases and inflammatory disorders. Therefore, their role in the development of preeclampsia was investigated and MP from preeclamptic patients influenced endothelial-dependent vasodilatation. Knowledge about changes in circulating ...
Gallery E D M ED Department of Renal Medicine, Royal North Shore Hospital, St Leonards, NSW, Australia. - - 2008
Hypertension due to a reninoma (suspected on the basis of biochemical and clinical features, and exquisite sensitivity of hypertension to angiotensin-converting enzyme [ACE] inhibition, but not visible on imaging) was cured by laparoscopic nephrectomy. Treatment was followed by an uneventful pregnancy.
Paula Letícia Germany LG Programa de Pós-graduação em Clínica Médica e Ciências da Saúde (Nefrologia), Faculdade de Medicina/Hospital São Lucas, Pontificia Universidade Católica do Rio Grande do Sul., Porto Alegre, RS, Brazil. - - 2008
To evaluate associations between maternal serum uric acid (UA) levels, maternal status, and fetal outcome. Maternal UA, urinary protein-creatinine ratio (P/C), blood pressure (BP), gestational age at delivery, and birth weight were evaluated in hypertensive pregnant women (n = 58). These were divided into two groups: high UA (> or ...
Kraemer Bernhard B University Hospital for Women, Tuebingen, Germany. - - 2008
Takayasu's arteritis is a chronic, idiopathic, inflammatory disease of the arteries, which primarily involves the aorta, its main branches such as the brachiocephalic, carotid, subclavian, vertebral, and renal arteries, as well as the coronary and pulmonary arteries. It has been suggested that pregnancy, although not usually associated with an exacerbation ...
Póvoa A M AM Department of Gynecology and Obstetrics, Hospital Sao Joao-EPE, Faculdade de Medicina da Universidade do Porto, Portugal. - - 2008
To estimate the prevalence of maternal hypertensive disorders in Portugal and to assess their impact on obstetric outcomes. A national survey on hypertension in pregnancy was conducted in Portuguese public maternity wards and included 6726 pregnancies. Six percent of women presented with a hypertensive disorder during pregnancy or puerperium: 1.5% ...
Roberts Christine L CL Clinical and Population Perinatal Health Research, The Kolling Institute of Medical Research, University of Sydney, Sydney, Australia. - - 2008
To assess the accuracy of hypertensive disorders of pregnancy reporting in birth and hospital discharge data compared with data abstracted from medical records. Data from a validation study of 1200 women provided the 'gold standard' for hypertension status. The validation data were linked to both hospital discharge and birth databases. ...
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