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Magnussen Elisabeth B - - 2009
OBJECTIVE: To study the association of hypertensive pregnancy disorders with modifiable risk factors for cardiovascular and metabolic diseases and to estimate the feasibility for early detection and prevention. METHODS: This was a prospective study of 15,065 women with a first singleton birth between 1967 and 1995, who later participated in ...
Rath Werner - - 2009
Hypertensive disorders of pregnancy (HDP) are among the leading causes of maternal and fetal morbidity and mortality. New guidelines and findings from clinical trials must be taken into account so that the diagnosis and treatment of HDP can be optimized. Current guidelines, Cochrane reviews, metaanalyses, and randomized, controlled trials were ...
Huisman Monique A - - 2010
OBJECTIVE: The purpose of this study was to investigate possible altered chorionic vascularization patterns that are seen already in the first trimester of pregnancies that are complicated by hypertensive disorders or intrauterine growth restriction (IUGR) in the third trimester of pregnancy. STUDY DESIGN: After chorionic villous sampling, surplus of villi ...
Sahu Suchanda - - 2009
Pregnancy-induced hypertension (PIH) is a common medical complication of pregnancy with a high incidence. The study comprised of 30 normal and 30 PIH cases in their third trimester of pregnancy and the following estimations were done: Serum Malondialdehyde level (MDA), Vitamin E, triglycerides (TG), total cholesterol (TC), HDL-cholesterol (HDL-C) and ...
Aggarwal Pardeep Kumar - - 2009
OBJECTIVE: Preeclampsia, a pregnancy-specific syndrome characterized by hypertension and proteinuria, has a familial tendency and is an important cause of maternal and neonatal mortality. Abnormal endothelin-1 synthesis and/or release can explain abnormalities seen in preeclampsia. We prospectively evaluated whether endothelin-1 levels are increased in preeclampsia, to verify if placenta is ...
Yoder Scott R - - 2009
Hypertension in women of childbearing age is a challenging medical problem with increasing prevalence. Essential hypertension remains the most common diagnosis in young women. Reproductive goals and possible teratogenic effects must be considered when initiating therapy. Hypertensive disorders of pregnancy are frequent causes of maternal/fetal morbidity and mortality, the most ...
Tinsley John H - - 2009
Preeclampsia (PE), a pregnancy-specific hypertensive syndrome, is one of the leading causes of premature births as well as fetal and maternal death. There is strong evidence that maternal immune system activation, of which Toll-like receptors (TLRs) play a major role, contributes to the development of PE. Viral infections, sensed by ...
Kharb Simmi - - 2009
Preeclampsia occurs approximately in 10% of pregnancies and remains a leading cause of maternal and neonatal mortality and morbidity worldwide, particularly in developing countries. The condition is usually diagnosed in late pregnancy by the presence of hypertension with proteinuria and/ or edema. Prevention of any disease process requires knowledge of ...
Habli Mounira - - 2009
OBJECTIVE: To evaluate subsequent pregnancy outcome and impact of gestational age at onset of HELLP on long-term prognosis after HELLP over an average follow-up of 5 years STUDY DESIGN: One hundred twenty-eight patients with a history of HELLP filled out questionnaires and sent their medical records. Hemolysis, elevated liver enzymes, ...
Ndao C T - - 2009
In tropical countries, malaria and hypertension are common diseases of pregnancy. They have physiopathologic similarities such as placental ischemia, endothelial dysfunction, and production of proinflammatory cytokines. Recent findings suggested their possible link. The authors conducted a case-control study to explore the relation between malaria and hypertension at Guediawaye, a hypoendemic ...
Paternoster Delia Maria - - 2010
PURPOSE: The aim of this article is to describe two cases of pulmonary hypertension during pregnancy to highlight the major issues associated with the obstetric and anesthesiological management of such patients who, despite the medical advice, decided to continue their pregnancy and gave birth to healthy babies. METHODS AND RESULTS: ...
Akolekar Ranjit - - 2009
OBJECTIVE: To investigate the potential value of maternal plasma inhibin A in first-trimester screening for preeclampsia (PE). METHOD: The concentration of inhibin A at 11-13 weeks was measured in samples from 121 pregnancies that developed PE, 87 cases of gestational hypertension (GH) and 208 normal controls. The distributions of inhibin ...
Tiscia Giovanni - - 2009
Inherited or acquired thrombophilias have been largely explored as a cause of pregnancy complications. However, pathogenesis of obstetric complications, as fetal loss and pregnancy-related hypertensive disorders is still partly unexplained. Recently, a common haplotype (M2) within the annexin A5 (ANXA5) gene has been described as a risk factor in recurrent ...
Meloni Paolo P Department of General Surgery Pietro Valdoni, Policlinico Umberto I, La Sapienza University, Rome, - - 2009
Previous studies have suggested an association between low levels of first trimester serum Pregnancy Associated Plasma Protein-A (PAPP-A) and the occurrence of hypertension in pregnancy (PIH). The purpose of this study was to determine the predictive value of maternal PAPP-A levels in the identification of women at risk of PIH. ...
Callaway Leonie Kaye LK Royal Brisbane and Women's Hospital, Obstetric Medicine, E Floor, Clinical Sciences Building, Herston, Australia. - - 2009
Overweight and obesity have a strong association with the development of hypertensive disorders of pregnancy. However, the mechanisms underpinning this relationship are not clear. Obesity is associated with insulin resistance, endothelial dysfunction, hypertension dyslipidaemia, inflammatory upregulation, alteration in immune function and prothrombotic changes. These changes may contribute to the development ...
Bracho-Valdés Ismael I Departamento de Fisiología y Farmacología, Escuela Superior de Medicina del IPN, Casco de Santo Tomás, - - 2009
The progression of pregnancy is associated with attenuation in vasopressor response to adrenergic agonists. In pregnancy-induced hypertension this attenuation is reverted. It is not known if this reversion involves alpha-1 adrenoceptor expression. In this work we propose that in pregnant rats with subrenal aortic coarctation there are changes in the ...
Wilson Melissa L - - 2009
We sought to determine whether polymorphisms in the transforming growth factor (TGF)-beta3 gene are associated with risk of pregnancy-induced hypertension (PIH) in case-control mother-baby dyads. Patients (n = 136) and control subjects (n = 169) were recruited from our hospital. We genotyped 4 TGF-beta3 polymorphisms and examined association with PIH ...
Tinsley John H - - 2009
Hypertensive disorders of pregnancy, including preeclampsia (PE), affect approximately 7-10% of pregnancies in the US. Clinical and experimental studies strongly suggest that the maternal immune system plays a role in the development of these disorders; however, few therapeutic options exist aside from delivery. Using a deoxycorticosterone acetate (DOCA)/salt-low renin rat ...
Buyukbayrak Esra Esim - - 2009
Essential thrombocythaemia (ET) is a disease characterized by an increased platelet count, megakaryocytic hyperplasia and a hemorrhagic or thrombotic tendency. Pregnancy in patients with ET can have a favorable outcome. However, ET has also been reported to complicate pregnancy by recurrent abortions, intrauterine death, and fetal growth retardation due to ...
Poon L C Y - - 2010
The study aimed to develop prediction algorithms for hypertensive disorders based on multivariate analysis of factors from the maternal history and compare the estimated performance of such algorithms in the prediction of early preeclampsia (PE), late-PE and gestational hypertension (GH) with that recommended by the National Institute for Clinical Excellence ...
Wang Alice - - 2009
Preeclampsia, a systemic syndrome of pregnancy clinically characterized by new onset of proteinuria and hypertension, is associated with significant morbidity and mortality to both mothers and fetuses. The pathogenesis of preeclampsia has been enigmatic; this review will focus on understanding the origins of this disorder. Preeclampsia originates in the placenta, ...
Leeners Brigitte - - 2009
OBJECTIVE: To investigate the motivation for motherhood in women with hypertensive diseases in pregnancy. METHODS: A questionnaire was sent to 2600 women with hypertensive diseases in pregnancy and 1233 controls. Diagnoses from medical records were differentiated according to the International Society for the Study of Hypertension in Pregnancy criteria. After ...
Pal G K - - 2009
The early prediction of pregnancy-induced hypertension (PIH), a common morbid disorder of pregnancy is unsatisfactory. Therefore, in the present study we have investigated the role of spectral analysis of heart rate variability (HRV) in the early prediction of PIH. Spectral analysis of HRV was performed in three groups of subjects ...
Chaffin David G - - 2009
We assessed the effect of antihypertensive therapy guided by impedance cardiography on maternal and fetal outcomes in pregnancies at risk for hypertensive complications. We performed a retrospective review of the outcomes of 318 singleton pregnancies with chronic hypertension or prior preterm delivery due to preeclampsia whose antihypertensive therapy was guided ...
Dawson Shelagh I - - 2009
BACKGROUND: Studies demonstrate an association between high but non-diabetic blood glucose levels and cardiovascular morbidity and mortality. Pregnancy alters glucose metabolism and results in a continuum of glucose tolerance, it is not known whether this continuum is associated with a continuum of risk of CVD in later life. OBJECTIVES: To ...
Lykke Jacob A - - 2009
Minimal data exist concerning the relationship between hypertensive pregnancy disorders and various subsequent cardiovascular events and the effect of type 2 diabetes mellitus on these. In a registry-based cohort study, we identified women delivering in Denmark from 1978 to 2007 with a first singleton (n=782 287) and 2 first consecutive ...
Bracho-Valdes Ismael - - 2009
The progression of pregnancy is associated with attenuation in vasopressor response to adrenergic agonists. In pregnancy-induced hypertension this attenuation is reverted. It is not known if this reversion involves alpha-1 adrenoceptor expression. Objective. In this work we propose that in pregnant rats with subrenal aortic coarctation there are changes in ...
Vadhera Rakesh B - - 2009
Hypertensive disorders in pregnancy constitute one of the most frequent medical complications during gestation. Unfortunately, maternal and perinatal mortality remains significant worldwide in this population. Not infrequently, patients with severe preeclampsia will need parenteral agents to achieve rapid blood pressure control to avoid end-organ damage. During the last decades, new ...
Lindheimer Marshall D - - 2009
The American Society of Hypertension is publishing a series of Position Papers in their official journals throughout the 2008-2009 years. The following Position Paper originally appeared: JASH. 2008;2(6):484-494. Hypertension complicates 5% to 7% of all pregnancies. A subset of preeclampsia, characterized by new-onset hypertension, proteinuria, and multisystem involvement, is responsible ...
van Disseldorp Jeroen - - 2010
OBJECTIVE: To investigate whether women pregnant after a poor response in IVF have pregnancy-induced hypertension and preeclampsia more frequently than women with pregnancies after a normal response in IVF. Poor response to ovarian stimulation for IVF reflects advanced ovarian aging, which may be associated with early vascular aging. This may ...
Poon Leona C Y - - 2009
This study aimed to establish a method of screening for pregnancy hypertension by a combination of maternal variables, including mean arterial pressure, uterine artery pulsatility index, pregnancy-associated plasma protein-A, and placental growth factor in early pregnancy. The base-cohort population constituted of 7797 singleton pregnancies, including 34 case subjects who developed ...
Callaway Leonie Kaye - - 2009
Overweight and obesity have a strong association with the development of hypertensive disorders of pregnancy. However, the mechanisms underpinning this relationship are not clear. Obesity is associated with insulin resistance, endothelial dysfunction, hypertension dyslipidaemia, inflammatory upregulation, alteration in immune function and prothrombotic changes. These changes may contribute to the development ...
Ebeigbe P N - - 2009
The presence of proteinuria in pregnancy induced hypertension has been shown to increase maternal and perinatal morbidity and mortality. Hence early and accurate screening for proteinuria with prompt management holds one of the keys to reducing the morbidity and mortality associated with the disease. To examine the options for detection ...
Marik Paul E - - 2009
This article reviews 4 categories of hypertensive disorders of pregnancy: chronic hypertension, gestational hypertension, preeclampsia, and preeclampsia superimposed on chronic hypertension. It focuses on the diagnosis and management of preeclampsia with emphasis on the pharmacologic management of blood pressure during pregnancy. Preeclampsia is one of the most common medical disorders ...
McCoy Stacey - - 2009
PURPOSE: Pharmacotherapeutic options for the treatment of preeclampsia are reviewed. SUMMARY: Risk factors for the development of preeclampsia include microvascular diseases, such as diabetes mellitus; vascular and connective tissue disorders; hypertension; antiphospholipid antibody syndrome; and nephropathy. Several pathophysiological factors contribute to the development of the preeclamptic state, including vasospasm onset, ...
Willner Julia B - - 2009
A 32-year-old multigravida woman had 3 pregnancies complicated by hypertensive disease, requiring iatrogenic preterm delivery. Middle aortic syndrome was diagnosed when uncontrolled hypertension persisted postpartum, and was treated with aortic stent-graft placement. A pregnancy subsequent to the endovascular repair was uneventful, culminating in repeated cesarean section at term.
Anitha C J - - 2009
This study was conducted to find out the anthropometric, biosocial and obstetric predictors of birthweight in Kerala. The study sample consisted of 599 consecutive liveborn babies delivered at SAT Hospital, Medical College, Thiruvananthapuram and their mothers in November 2001. Details of maternal history, anthropometry, and biosocial and demographic factors were ...
Tranquilli Andrea L - - 2009
Calcium-Channel Blockers (CCBs), or calcium antagonists, are a heterogeneous group of drugs that produce cardiovascular effects by preventing the influx of calcium ions through L-type voltage-dependent calcium channels in specialized electrical system and conduction tissue cells, like myocardial and vascular smooth muscle cells. In recent years, CCBs have found their ...
Rytlewski Krzysztof - - 2009
BACKGROUND: Hypertension is one of the most frequent complications of pregnancy. Due to high risk of morbidity and mortality in both mothers and children, it is necessary to continuously monitor the pregnancy, principally with biophysical methods. Particularly, doppler velocimetry of the materno-fetal circulation proves useful. THE AIM of the study ...
Nakayama Tomohiro - - 2009
Essential hypertension (EH) accounts for 80-90% of hypertension, and pregnancy-induced hypertension (PIH) is responsible for hypertension during pregnancy. Both considered multifactorial disorders. While both have many features in common, conditions and causes of these diseases have yet to be clarified. Since both diseases are associated with hypertension, the genetic backgrounds ...
Cheng Ming-Huei - - 2009
Preeclampsia, a pregnancy-specific syndrome of hypertension and proteinuria, is one of the leading causes of perinatal morbidity and mortality. Although the initiating factor is unknown, a clearer picture regarding the network mechanisms of preeclampsia has begun to emerge during the past few years. The pathogenesis of preeclampsia can be described ...
Moreira L B - - 2009
Hypertension in pregnancy is an emerging sex-specific risk factor for cardiovascular disease and may lead to more severe hypertension after pregnancy. The objectives of this study were to investigate the frequency of pregnancy-related hypertension among patients referred to a hypertension clinic and its association with the severity of hypertension and ...
Lindheimer Marshall D - - 2008
Hypertension complicates 5% to 7% of all pregnancies. A subset of preeclampsia, characterized by new-onset hypertension, proteinuria, and multisystem involvement, is responsible for substantial maternal and fetal morbidity and is a marker for future cardiac and metabolic disease. This American Society of Hypertension (ASH) position paper summarizes the clinical spectrum ...
Sinelli M T - - 2008
Sartans are selective type 1 angiotensin II receptor antagonists that are used for treatment of arterial hypertension. We report a case of severe renal failure required dialysis after the use of olmesartan in the last month of pregnancy. Exposure to sartans during the last period of gestation seems to be ...
Pettersson Andreas - - 2008
Altered levels of pregnancy hormones have been suggested to initiate testicular cancer prenatally in the male fetus. The placenta is the main source of pregnancy hormones, and pregnancy hypertension and preeclampsia are associated with placental malfunction, including altered levels of hormones such as estrogen and human chorionic gonadotropin. We therefore ...
Buhimschi Irina A IA Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520-8063, USA. - - 2008
The cause of preeclampsia remains unknown and the diagnosis can be uncertain. We used proteomic-based analysis of urine to improve disease classification and extend the pathophysiologic understanding of preeclampsia. Urine samples from 284 women were analyzed by surface-enhanced laser desorption/ionization. In the exploratory phase, 59 samples were used to extract ...
Mistry Hiten D - - 2008
Preeclampsia is pregnancy-specific, affecting 2% to 7% of women, and is a leading cause of perinatal and maternal morbidity and mortality. Preeclampsia may also predispose the fetus to increased risks of adult cardiovascular disease. Selenium, acting through the selenoprotein glutathione peroxidases, has critical roles in regulating antioxidant status. Recent reports ...
Sandrim Valeria C - - 2008
AIMS: Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene have been inconsistently associated with preeclampsia. We compared genotype and haplotype frequencies of three eNOS gene polymorphisms in normotensive and hypertensive pregnancies. METHODS: Genotypes and haplotypes for eNOS polymorphisms (T-786C, Glu298Asp and intron 4 b/a) were determined in 326 pregnant ...
Gupta Arvind - - 2008
PURPOSE: In a retrospective study of patients with preeclampsia and patients with pregnancy-induced hypertension (PIH) who delivered at term, the association of retinopathy with various clinical and laboratory manifestations and fetal birth weight was evaluated. METHODS: Medical records of patients with preeclampsia and patients with PIH who delivered at term ...
Brown C Ann - - 2008
The relation between maternal heart rate variability (HRV) and fetal behavior was examined in hypertensive and normotensive pregnant women. A total of 40 mother-fetal pairs (n = 20 normotensive mothers; n = 20 hypertensive mothers) at 33-41 weeks' gestation were observed using a standardized procedure lasting approximately 50 min. It ...
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