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Silasi Michelle - - 2010
Preeclampsia is a common complication of pregnancy with potentially devastating consequences to both the mother and the baby.It is the leading cause of maternal deaths in developing countries. In developed countries it is the major cause of iatrogenic premature delivery and contributes significantly to increasing health care cost associated with ...
Cowans N J - - 2010
OBJECTIVE: The objective of this study was to examine first-trimester maternal serum placental growth factor (PlGF) levels in pregnancies which later develop hypertensive and growth complications. METHODS: In this case-control study, PlGF levels were measured by AutoDELFIA immunoassay platform. There were 47 cases of at least one of the following ...
Suri Vanita - - 2010
Takayasu's syndrome is a chronic inflammatory arteriopathy of unknown origin which primarily affects women of reproductive age. We report the course and outcome of 37 pregnancies in 15 women with Takayasu arteritis during the period 1999-2008. A retrospective analysis of 9 years was carried out in a tertiary hospital in ...
Allais Gianni - - 2010
Most epidemiological studies demonstrate that women suffering from migraine note a significant improvement in their headaches during pregnancy. Both headache specialists and gynecologists commonly hold that migraine does not involve any risks to either the mother, or the fetus. Despite this, recent studies into the medical complications of pregnancy in ...
Fruscalzo Arrigo - - 2010
OBJECTIVE: Pregnancy-related hypertensive disorders (PRHDs) are a leading cause of maternal and perinatal morbidity and mortality in developed countries. This study investigated a possible association of PRHDs with menstrual abnormalities. MATERIALS AND METHODS: We contacted all women with PRHDs who delivered in our clinic between 2004 and 2007 as well ...
Lazdam Merzaka M Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, - - 2010
Offspring born to mothers with hypertensive pregnancy have higher childhood blood pressure. We hypothesized this relates to prenatally programmed differences in the underlying vascular pathophysiology of the offspring and that these would be most apparent in those born preterm because of severe hypertension. We carried out a 20-year follow-up study ...
Varaldo Emanuela - - 2010
Prenatal diagnosis of pheocromocytoma, although rare, is important as it allows a reduction in both maternal mortality and foetal loss. Pheocromocytoma operated on in the first trimester of pregnancy with survival of both patient and foetus is rare in literature. Our case was operated on with success after a correct ...
Roberts James M JM Department of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, - - 2010
Oxidative stress has been proposed as a mechanism linking the poor placental perfusion characteristic of preeclampsia with the clinical manifestations of the disorder. We assessed the effects of antioxidant supplementation with vitamins C and E, initiated early in pregnancy, on the risk of serious adverse maternal, fetal, and neonatal outcomes ...
Danso Kwabena A - - 2010
OBJECTIVE: To assess the challenges associated with the diagnosis, management, and prevention of hypertensive disease during pregnancy in low-income countries, following the success of the Magpie Trial. METHODS: Descriptive review of the literature from 1990 to 2009 on the diagnosis, management, and prevention of hypertensive disease in pregnancy. RESULTS: In ...
Nasrin B - - 2010
Pregnancy induced hypertension (PIH) is a major complication of pregnancy and is associated with high maternal and perinatal morbidity and mortality. The aim of this study was to investigate the possible causal association of PIH with maternal serum PAPP-A and urinary protein-creatinine ratio (UPCr) as well as to evaluate the ...
Taçoy Gülten - - 2010
Idiopathic pulmonary arterial hypertension (IPAH) is characterized by a progressive increase in pulmonary vascular resistance, which may lead to right ventricular failure and death. Major cardiovascular and pulmonary alterations occur during pregnancy and therefore worsen or increase the complications of pulmonary arterial hypertension (PAH). A patient diagnosed with IPAH after ...
Dehaeck Ulrike - - 2010
OBJECTIVE: Ambulatory BP monitoring (ABPM) has been proposed as a logical approach to overcoming many of the problems associated with clinical BP measurement. The extent of its use in diagnosing hypertension in pregnancy is unknown. The objective of this study was to identify the practices surrounding use of ABPM by ...
Saxena Aditi R AR Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women's Hospital, 221 Longwood Ave, RFB-2, Boston, MA 02115, USA. - - 2010
Pregnancies complicated by new-onset hypertension are associated with increased sensitivity to angiotensin II, but it is unclear whether this sensitivity persists postpartum. We studied pressor response to infused angiotensin II in 25 normotensive postpartum women in both high- and low-sodium balance. Ten women had a history of hypertensive pregnancy (5 ...
Akolekar Ranjit R Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, Denmark Hill, London, - - 2011
In patients with preeclampsia maternal plasma concentration of plasminogen activator inhibitor-2 (PAI-2) is reduced. The objective of the study was to determine if the altered levels of PAI-2 precede the onset of the disease. Plasma PAI-2 was measured at 11-13 weeks of gestation in 119 pregnancies that developed preeclampsia, 85 ...
Tanbe Alain F - - 2010
Normal pregnancy is associated with significant vascular remodeling in the uterine and systemic circulation in order to meet the metabolic demands of the mother and developing fetus. The pregnancy-associated vascular changes are largely due to alterations in the amount/activity of vascular mediators released from the endothelium, vascular smooth muscle and ...
Sibai Baha M - - 2010
Gestational hypertension and gestational diabetes mellitus are the most frequent obstetric disorders during pregnancy. The rates of both disorders are expected to increase as a result of delayed pregnancy at a later maternal age, the epidemic of obesity and the increased frequency of using assisted reproductive technology in women with ...
Lindheimer Marshall D - - 2010
Hypertension complicates 5% to 7% of all pregnancies. A subset of preeclampsia, characterized by new-onset hypertension, proteinuria, and multisystem involvement, is responsible for substantial maternal and fetal morbidity and is a marker for future cardiac and metabolic disease. This American Society of Hypertension (ASH) position paper summarizes the clinical spectrum ...
Richter J J Department of Obstetrics and Gynecology, University Hospitals Leuven, B-3000 - - 2010
Hypertensive disorders are frequent during pregnancy and are related with an important morbidity and mortality worldwide. In this review we aim to provide the reader with a comprehensive overview of the clinical aspects of and the diagnostic tools used in the primary assessment and the (long term) follow-up of preeclampsia. ...
Langenveld Josje - - 2010
Early onset hypertensive disorders of pregnancy are associated with adverse maternal and neonatal outcome. The risk of recurrence influences parents' choices on subsequent pregnancies and the counseling obstetrician, but evidence so far has been limited. We performed the first systematic review on the risk of recurrence of hypertensive disorders that ...
Avni B - - 2010
The objective of this study was to examine whether aortic stiffness, as assessed by pulse wave analysis, could reliably discriminate between normal and hypertensive pregnancies. One hundred pregnant women were studied: five with severe pre-eclampsia, 27 with gestational hypertension, 14 with chronic hypertension and 54 with normal pregnancy. Central hemodynamic ...
Haq Ambreen Naveed - - 2010
This is a unique case of hyperreactio luteinalis associated with partial HELLP syndrome, chronic superimposed hypertension, and intrauterine growth restriction. The cysts were managed conservatively. A caesarean section was performed at 34 weeks due to the deterioration of liver function tests, and intrauterine growth restriction. Multiple tissue biopsies of the ...
Buyukbayrak Esra Esim - - 2010
Essential thrombocythaemia (ET) is a disease characterized by an increased platelet count, megakaryocytic hyperplasia and a hemorrhagic or thrombotic tendency. Pregnancy in patients with ET can have a favorable outcome. However, ET has also been reported to complicate pregnancy by recurrent abortions, intrauterine death, and fetal growth retardation due to ...
Champagne Katéri Agnès - - 2010
Obstructive sleep apnoea (OSA) affects 11 per cent of pre-menopausal women though it often remains undetected. Women may present differently than men, and the classic findings of snoring, witnessed apnoeas and sleepiness may not be observed. Factors which predispose to OSA include polycystic ovarian syndrome, obesity, retromicrognathia, and hypothyroidism. OSA ...
Olayemi Oladapo - - 2010
Hypertensive disorders of pregnancy are an important cause of maternal mortality in this environment, it accounts for about 20% of all maternal deaths in pregnancy in Nigeria. This study aims to determine the effect of the length of sexual cohabitation on the development of hypertension in pregnancy in a Nigerian ...
Wiedemann Annette - - 2010
PROBLEM: Pregnancy-induced hypertension (PIH) affects up to 15% of all pregnancies. Disturbed placentation is one factor associated with PIH. Leptin and peroxisome proliferator activator receptors (PPAR) seem to play an important role in placentation, fetal development, and blood pressure regulation. Therefore, we investigated polymorphisms in the genes encoding leptin, the ...
Kamat Runa - - 2011
To evaluate the flow mediated vasodilatation of brachial artery in women at risk of development of pregnancy induced hypertension. We enrolled 81 pregnant women at less than 20weeks of gestation. Flow mediated vasodilatation (FMD) was assessed twice in pregnancy. The FMD at different gestations were compared between subjects who developed ...
Liu Li-Ping - - 2010
PROBLEM: The aim of this study was to evaluate how fetal monocyte activation and maternal anti-fetal antigen-specific antibody-secreting cells (ASC) affect the severity of hypertensive disorder complicating pregnancy (HDCP). METHOD OF STUDY: Forty-six healthy third-trimester pregnant women and 20 patients with gestational hypertension, 20 with mild pre-ecalmpsia and another 20 ...
Cankar Ksenija - - 2010
PURPOSE: The pathophysiology of the pregnancy-induced hypertension is still poorly understood, especially with regard to the central autonomic nervous system control and peripheral vascular factors. METHODS: Our study therefore aimed to investigate simultaneously the responses of blood pressure, heart rate, heart rate variability (HRV), and laser-Doppler (LD) flux to local ...
Snabboon Thiti - - 2010
Although hypertension occurring during pregnancies is not uncommon and its prognosis is generally excellent, some of its unusual causes can lead to catastrophic consequences, especially in undiagnosed cases. Here, we report a pregnant woman who presented with hypertension in her early pregnancy. It was subsequently found to be caused by ...
DeKoninck P L J - - 2010
BACKGROUND: Spontaneous liver rupture during pregnancy is extremely rare, and often associated with hypertensive disorders. Maternal outcomes are poor and morbidity is high. CASE: A 27-year-old women (G1P0), pregnant with monochorionic-monoamniotic twins, developed extensive abdominal pain while she was electively admitted at 32 weeks for fetal pulmonary maturation. Diagnosed with ...
Deli? Ratko - - 2010
OBJECTIVE: This study was undertaken to investigate the usefulness of standard biochemical and hematological parameters measurement at third trimester of pregnancy for the individual prediction of preeclampsia. METHODS: A retrospective designed study included 113 patients with preeclampsia and a control group of 95 normal, uncomplicated pregnancies. Patients were recruited in ...
Odibo Anthony O - - 2010
OBJECTIVE: Our objective is to evaluate for potential associations between chorionic villus sampling (CVS) and hypertensive disorders of pregnancy. METHODS: Using our genetic database, we compared the rates of hypertensive disorders between women who underwent CVS at 10-13 and 6/7 weeks with those seen for other indications at similar gestational ...
Goland Sorel - - 2010
BACKGROUND: Pulmonary hypertension carries significant maternal and fetal risk during pregnancy and the postpartum period. As maternal mortality is high, specific targeted therapy for pulmonary hypertension may be required during pregnancy. CASES: We describe 2 pregnant patients who presented with severe secondary pulmonary arterial hypertension during their last trimester. They ...
Luitjes Susanne He - - 2010
Hypertensive disease in pregnancy remains the leading cause of maternal mortality in the Netherlands. Seventeen percent of the clinical pregnancies are complicated by hypertension and 2% by preeclampsia. The Dutch Society of Obstetrics and Gynaecology (NVOG) has developed evidence-based guidelines on the management of hypertension in pregnancy and chronic hypertension. ...
Ogland Bjorn - - 2010
To compare cord blood concentrations of total adiponectin in the offspring of pregnancies with and without preeclampsia. Using a Luminex analyzer, cord blood adiponectin was measured in 182 singleton pregnancies with preeclampsia and compared to adiponectin measured in 511 singleton pregnancies without preeclampsia. Adiponectin levels in cord blood increased with ...
Bogdarina Irina - - 2010
Adverse events in pregnancy may 'programme' offspring for the later development of cardiovascular disease and hypertension. Previously, using a rodent model of programmed hypertension we have demonstrated the role of the renin-angiotensin system in this process. More recently we showed that a maternal low protein diet resulted in undermethylation of ...
Mohanraj Pushparaj P Department of Obstetrics and Gynecology All India Institute of Medical Sciences, New Delhi, - - 2010
A 35 year woman G2P0A1L0 at 16 weeks period of gestation, underwent termination of pregnancy for a fetus having a large lumbosacral meningomyelocele and Arnold chairi II malformation. She was a known treated case of tuberculoma of the brain who was not on any antiepileptics, and had been seizure free ...
De Greeff Annemarie A King's College London, Division of Reproduction and Endocrinology, St. Thomas' Hospital, London, United - - 2010
To assess the accuracy of the Dinamap ProCare 400 in pregnancy and preeclampsia, according to the British Hypertension Society protocol. Ethical approval was obtained. Forty-five women were recruited at two large teaching hospitals. Nine sequential same arm measurements were taken from each woman alternating between the Dinamap and mercury sphygmomanometry. ...
Côté Anne-Marie AM Department of Nephrology, University of Sherbrooke, Sherbrooke, PQ, - - 2010
In hypertensive pregnancy, to compare 24hr creatinine clearance (CrCl) with formulae-derived renal function (Cockcroft-Gault (CG) or Modified Diet in Renal Disease (MDRD)). Retrospective review (198 women, 63% preeclampsia) using paired t-test (significant p < 0.008) and intraclass correlation coefficients (acceptable >0.70) to compare 24hr and CG CrCl. The 24hr CrCl ...
Sugathadasa B H K R BH Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Sri - - 2010
To investigate −2548 G/A polymorphism of LEP gene, plasma leptin and soluble leptin receptor in preeclampsia/pregnancy induced hypertension. Sixty-two patients and 63 controls (normal pregnancies) studied in the third trimester. Leptin and soluble leptin receptor measured by enzyme immunosorbent assay and −2548 G/A polymorphism by polymerase chain reaction followed by ...
Waness Abdelkarim A Department of Internal Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia. - - 2010
IgA nephropathy is fairly prevalent in Saudi Arabia. In this paper we examine the natural history of pregnancies and their impact on renal function in Saudi females affected by this condition. We followed a series of 12 patients, documented to have IgA nephritis by kidney biopsy, during their gestation. We ...
Sep Simone S Department of Obstetrics and Gynecology, University Medical Centre Maastricht, Maastricht, The Netherlands. - - 2010
To summarize reported evidence on the performance and clinical usefulness of prediction tests for recurrent hypertensive disease in pregnancy. A literature search was conducted in MEDLINE/PubMed and EMBASE. Test characteristics were extracted for relevant reports. Thirty-three of 4,311 articles found met the inclusion criteria. Twenty-four potential predictors were identified. Pre-pregnant ...
Geifman-Holtzman Ossie O Department of Obstetrics & Gynecology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA. - - 2010
We assessed hTERT mRNA levels in normal versus preeclamptic placental samples, examining hTERT expression levels in different clinical manifestations of hypertensive disorder of pregnancy. We performed a single-site, prospective case-control study of hTERT mRNA levels in placentas from term and preterm pregnancies with hypertensive disorders compared with unaffected pregnancies. Placental ...
Bennett Wendy L WL Department of Medicine, Division of General Internal Medicine, The Johns Hopkins University School of Medicine, 2024 E. Monument Street, Room 2-611, Baltimore, MD 21205, USA. - - 2010
To determine whether women who had a delivery after bariatric surgery have lower rates of hypertensive disorders in pregnancy compared with women who had a delivery before bariatric surgery. Retrospective cohort study. Claims data for 2002-6 from seven insurance plans in the United States. 585 women aged 16-45 who had ...
Feng Chong - - 2011
To investigate the expression of calprotectin, the receptor of advanced glycation end products (RAGE) and tumor necrosis factor-α (TNF-α) in hypertensive disorders in pregnancy as well as the significance of their expression. The research assessed levels of plasma calprotectin and TNF-α using the enzyme-linked immunosorbent assay, and expression of calprotectin, ...
Magee Laura A - - 2009
The hypertensive disorders of pregnancy are a leading cause of maternal mortality and morbidity. Complications are not limited to preeclampsia but also complicate both preexisting hypertension and isolated gestational hypertension. Blood pressure (BP) management is important but is only one aspect of management of the hypertensive disorders of pregnancy, which ...
Morikawa Mamoru - - 2009
PURPOSE OF REVIEW: The outcome of pregnancy in patients with isolated proteinuria is believed to be favorable. However, whether women with isolated proteinuria are at risk for progressing to preeclampsia has not been extensively studied. RECENT FINDINGS: The amount of proteinuria is thought to increase in the early third trimester, ...
Tomi? Vajdana - - 2009
Hypertensive disorders are among the most common complications in pregnancy and a major cause of perinatal morbidity and mortality. The aim of this study was to investigate the risk factors and adverse perinatal outcomes of pregnancies in mothers with hypertensive disorders, as well as the adequacy of prenatal care during ...
Okawara Masaki - - 2009
OBJECTIVES: The purpose of this paper is to elucidate the roles of phospholipase A(2) (PLA(2)), cyclooxygenase-2 (COX-2), and prostaglandin I(2) (PGI(2)) synthase in pregnancy induced hypertension (PIH). METHODS: In placentas from normal pregnant women and pregnant women with severe PIH, the enzyme expression of PLA(2), COX-2, and PGI(2) synthase was ...
Huda Shahzya S - - 2009
The hypertensive disorders of pregnancy include gestational hypertension and preeclampsia, both de novo and superimposed on chronic hypertension. These disorders occur frequently among pregnant woman and are important contributors to maternal and perinatal mortality and morbidity worldwide. In this review, we will focus on recent developments in the prediction and ...
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