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Ergin Rahime Nida RN Department of Gynecology and Obstetrics, Bahcesehir University, Istanbul, - - 2014
Systemic lupus erythematosus (SLE) is an autoimmune disease that classically manifests itself with fever, arthralgia, and rash, predominantly in women of childbearing age. The autoimmunity is against nuclear and cytoplasmic components; therefore, any organ system can be affected, and the clinical presentation spectrum is wide. Although rare, de novo SLE ...
George Eric M EM University of Mississippi, Medical - - 2014
The heme oxygenase system has long been believed to act largely as a housekeeping unit, converting pro-oxidant free heme from heme protein degradation into the benign bilirubin for conjugation and safe excretion. Recently, however, heme oxygenase have emerged as important regulators of cardiovascular function, largely through the production of their ...
Onkar Deepali D Associate Professor, Department of Anatomy, NKP Salve Institute of Medical Sciences and Research Centre , Nagpur, India - - 2014
Central nervous system anomalies are often severe and are the most common indications for therapeutic abortions. Ultrasound examination helps to identify and evaluate them well before birth. Present study was undertaken to evaluate the incidence of central nervous system anomalies in utero by ultrasound and to confirm them by autopsy ...
Tkachenko Oleksandra O Division of Renal Diseases and Hypertension, University of Colorado Denver, Denver, Colorado, - - 2014
Normal pregnancy is associated with sodium and water retention, which results in plasma volume expansion prior to placental implantation. The explanation offered for these events is that pregnancy 'resets' both volume and osmoreceptors. The mechanisms for such an enigmatic 'resetting' in pregnancy have not previously been explained. However, recent human ...
Conrad Kirk P KP 1University of Florida College of - - 2014
During the 1st trimester of human pregnancy, the maternal systemic circulation undergoes remarkable vasodilation. The kidneys participate in this vasodilatory response resulting in marked increases in renal plasma flow (RPF) and glomerular filtration rate (GFR). Comparable circulatory adaptations are observed in conscious gravid rats. Administration of the corpus luteal hormone, ...
Vyas Varsha V Department of Anaesthesia, Padmashree Dr. D. Y Patil Hospital and Research Centre, Navi Mumbai Maharashtra, - - 2014
Systemic lupus erythematosus (SLE) is an autoimmune disease most frequently found in women of child bearing age and may co-exist with pregnancy. Disease exacerbation, increased foetal loss, neonatal lupus and an increased incidence of pre-eclampsia are the major challenges. Its multisystem involvement and therapeutic interventions like anticoagulants, steroids and immunosuppressive ...
Akgun Hulya H Department of Pathology, Erciyes University Medical Faculty, Kayseri, - - 2014
This prospective study was designed to compare ultrasound and autopsy findings on fetal urinary system malformations in second trimester terminations of pregnancy (TOPs) to evaluate the degree of agreement of such findings. From January 2003 to October 2012, a total of 308 second trimester TOPs were performed because of fetal ...
Cabral Rita R Coimbra University, Hospital Center, Dermatology Department, Coimbra, Portugal, MD, Resident in the Dermatology Department, Coimbra University Hospital Center- Coimbra, - - 2014
Pemphigoid gestationis is a rare, autoimmune blistering dermatosis of pregnancy. No increase in fetal or maternal mortality has been demonstrated, but a greater prevalence of premature and small-for-gestationalage babies has been reported. Topical and systemic corticosteroids and antihistamines are the manstay of treatment. The authors report a case of a ...
Gülşen Ismail I Department of Neurosurgery, School of Medicine, Yüzüncü Yıl University, Van, - - 2014
Gliosarcoma is a rare tumor of the central nervous system and it constitutes about 1 to 8% of all malignant gliomas. In this report we are presenting a recurrent gliosarcoma case during a pregnancy in a 30-year-old woman. This is the first report presenting gliosarcoma in the pregnancy.
Hussein Wael W Division of Nephrology, Stanford University Medical Center, Stanford, California, - - 2014
Renal dysfunction during pregnancy is a common and serious complication. Understanding normal physiology during pregnancy provides a context to further describe changes in pregnancy that lead to renal dysfunction and may provide clues to better management. Hormonal changes during pregnancy allow for increased blood flow to the kidneys and altered ...
Meccariello Rosaria R 0000-0003-2174-1118 Dipartimento di Scienze Motorie e del Benessere, Università di Napoli Parthenope, via Medina 40, 80133 Napoli, - - 2014
The endocannabinoid system (ECS) is an evolutionarily conserved master system deeply involved in the central and local control of reproductive functions in both sexes. The tone of these lipid mediators-deeply modulated by the activity of biosynthetic and hydrolyzing machineries-regulates reproductive functions from gonadotropin discharge and steroid biosynthesis to the formation ...
Laway Bashir A BA Department of Endocrinology, Sher I Kashmir Institute of Medical Sciences, Soura Srinagar, Jammu and Kashmir, - - 2013
Pregnancy is associated with normal physiological changes in endocrine system that assists fetal survival as well as preparation of labor. The pituitary gland is one of the most affected organs in which major changes in anatomy and physiology take place. Due to overlapping clinical and biochemical features of pregnancy, sometimes ...
Vaccaro Mario - - 2013
We present a case of a woman with a 14-year history of rheumatoid arthritis, who showed simultaneously and gradually appearing, annular, erythematous, itchy patches and exacerbation of the joint symptoms, of one month duration, after pregnancy. Clinical and histologic features led us to the diagnosis of erythema multiforme. While it ...
Grissom Nicola M - - 2013
Maternal obesity during pregnancy increases the risk for offspring obesity, in part through effects on the developing brain. Previous research has shown that perinatal consumption of highly palatable foods by the mother can influence the development of offspring taste preferences and alter gene expression within the central nervous system (CNS) ...
Kota Sunil Kumar - - 2013
Successful outcome of pregnancy depends upon genetic, cellular, and hormonal interactions, which lead to implantation, placentation, embryonic, and fetal development, parturition and fetal adaptation to extrauterine life. The fetal endocrine system commences development early in gestation and plays a modulating role on the various physiological organ systems and prepares the ...
Chawla Sushil S Classified Specialist (Obstetrics & Gynaecology), INHS Asvini, Colaba, Mumbai, - - 2013
The eyes are our window to the world and offer us an island of vision in the sea of darkness. Equally, the eyes are also a window to peep into what is going on in the milieu interior. Pregnancy is a natural state of physiological stress for the body. Each ...
Katsuragi S - - 2013
We report a case of acute aortic dissection (Stanford type B) that occurred in pregnant woman at 34-week gestation. She had no systemic characteristics of Marfan syndrome, however she exhibited a mutation of FBN1, Arg 545 Cys, which has been found to correlate with ectopia lentis but not with aortic ...
Samra Khawla Abu KA Department of Ophthalmology, Ross Eye Institute, Buffalo, NY, - - 2013
Pregnancy represents a real challenge to all body systems. Physiological changes can involve any of the body organs including the eye and visual system. The ocular effect of pregnancy involves a wide spectrum of physiologic and pathologic changes. The latter might be presenting for the first time during pregnancy such ...
Papatheodorou A - - 2013
Vitrification has been successfully applied in the cryopreservation of oocytes and embryos. It can be achieved either by direct (open system) or indirect (closed system) contact with liquid nitrogen. Unlike embryo vitrification, few reports have been published regarding oocyte vitrification in closed systems. In order to validate the effectiveness of ...
George Eric M EM Department of Physiology and Biophysics, Center for Excellence in Cardiovascular Research, The University of Mississippi Medical Center, Jackson, Mississippi, - - 2013
Emerging evidence supports an important role for the heme oxygenase system in the maintenance of a healthy pregnancy. This review attempts to collect these wide-ranging data and summarize the recent progress in the field. New studies looking at heme oxygenase depletion in a variety of animal models have demonstrated that ...
Mahmoud Hussam H Department of Civil and Environmental Engineering, College of Engineering, Colorado State University, Fort Collins, CO 80523, - - 2013
Preterm birth is the primary contributor to perinatal morbidity and mortality, with those born prior to 32 weeks disproportionately contributing compared to those born at 32-37 weeks. Outcomes for babies born prematurely can be devastating. Parturition is recognized as a mechanical process that involves the two processes that are required ...
Unsworth Jeffrey David - - 2013
We present a case which describes a 29-year-old woman with systemic lupus erythematosus who was treated aggressively with cytotoxic immunosuppression. Five years later and approximately 12 weeks pregnant, she is confirmed as having carcinoma of the tongue. Not wishing to consider termination of her pregnancy, she underwent surgical resection, which ...
Tomsin K K Faculty of Medicine & Life Sciences, Hasselt University, Diepenbeek, - - 2013
In pregnancy, both maternal vascular tone and cardiac function are considered key players to reach a normal outcome for both mother and child. This complex story of maternal hemodynamics is intensely discussed in current scientific literature, however the role of the maternal veins has been strongly underestimated. We developed and ...
Pereira José Carlos JC - - 2012
Willis-Ekbom's disease (WED), formerly called restless legs syndrome, is more common in pregnant than in non-pregnant women, implying that the physiological and biochemical changes during pregnancy influence its development. During pregnancy, many hormone levels undergo significant changes, and some hormones significantly increase in activity and can interfere with other hormones. ...
Lomax L - - 2012
Objectives: To estimate the agreement between prenatal ultrasonography observations at 16 - 21 gestational weeks and fetal autopsy findings in pregnancies terminated because of fetal anomalies.Study Design: This 4½ year retrospective study includes consecutive fetuses that were terminated because of fetal malformation and/or chromosomal anomaly diagnosed in the second trimester. Only fetuses ...
Pinheiro M B - - 2012
Preeclampsia (PE) is a multi-system disorder of human pregnancy characterized by hypertension and proteinuria. Although its pathogenesis is not fully understood, predisposition to endothelial dysfunction is thought to play a crucial part. Normotensive pregnancy is associated with increases in coagulation factor levels and decreases in the natural anticoagulation, leading to ...
Thom Robyn P - - 2012
Congenital hydronephrosis, defined as congenital dilatation of one or more components of the renal collecting system, is detected in 1-2% of all pregnancies. The majority of antenatally detected hydronephrosis is non-obstructive and either resolves or stabilizes. Management of persistently severe cases may include surgical intervention, the only available treatment. Recent ...
Denny Kerina J - - 2012
The complement system is a key component of innate host defence that, under normal conditions, is responsible for the opsonization and destruction of potential pathogens. However, inappropriate or excessive activation of complement can have a detrimental effect on the host and has been implicated in the pathophysiology of numerous disease ...
Robson Andrew - - 2012
Uterine spiral artery remodeling is required for successful human pregnancy; impaired remodeling is associated with pregnancy complications, including late miscarriage, preeclampsia, and fetal growth restriction. The molecular triggers of remodeling are not known, but it is now clear that there are "trophoblast-independent" and "trophoblast-dependent" stages. Uterine natural killer (uNK) cells ...
Biron-Shental Tal - - 2012
Abstract Objective: Fetal cells represented by extravillous trophoblasts (EVT) obtained from the cervix are an important source for non-invasive prenatal diagnosis (NIPD) in early pregnancies. Endoreduplication is a duplication of chromosomes without mitosis, leading to polyploidy that might represent increased cellular metabolic activity. In this study, we estimated the normal ...
Pritchard Stephanie - - 2012
During pregnancy, cells from each fetus travel into the maternal circulation and organs, resulting in the development of microchimerism. Identification of the cell types in this microchimeric population would permit better understanding of possible mechanisms by which they affect maternal health. However, comprehensive analysis of fetal cells has been hampered ...
El-Badri Nagwa S - - 2012
Gender differences in stem cell population have recently been identified. Blood and tissue samples from women showed consistent elevation of hematopoietic stem cell populations, mesenchymal stem cell populations and endothelial progenitor cells compared to men of similar ages. We and others have shown an increase in hematopoietic stem cell population ...
Fraser Rupsha - - 2012
During human pregnancy, natural killer (NK) cells accumulate in the maternal decidua, but their specific roles remain to be determined. Decidual NK (dNK) cells are present during trophoblast invasion and uterine spiral artery remodelling. These events are crucial for successful placentation and the provision of an adequate blood supply to ...
Choolani Mahesh - - 2012
Delaying childbirth increases the proportion of advanced maternal age pregnancies. This increases the number of pregnancies requiring invasive prenatal testing. Prenatal diagnosis of chromosomal aneuploidies and monogenic disorders requires fetal cells obtained through invasive procedures (i.e. chorionic villus sampling and amniocentesis). These procedures carry a risk of fetal loss, which ...
Bondarenko Gennadiy I GI Wisconsin National Primate Research Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53715-1299, - - 2012
Throughout the reproductive cycle and into early pregnancy, the normal endometrium undergoes changes in a range of leukocytes, epithelia, stromal fibroblasts, and vascular structures caused by intersecting effects of hormone balance and embryo implantation. The direct investigation in humans of reproductive tract responses during normal and physiologically altered cycles is ...
Peterson S E - - 2012
Fetal cells (microchimerism) are acquired by women during pregnancy. Fetal microchimerism persists decades later and includes cells with pluripotent capacity. Persistent microchimerism has the capacity for both beneficial and detrimental maternal health consequences. Both miscarriage and termination of pregnancy can result in fetal microchimerism. We sought to determine whether cellular ...
Kara Rina J - - 2012
Fetal cells enter the maternal circulation during pregnancies and can persist in blood and tissues for decades, creating a state of physiologic microchimerism. Microchimerism refers to acquisition of cells from another individual and can be due to bidirectional cell traffic between mother and fetus during pregnancy. Peripartum cardiomyopathy, a rare ...
Kim Kijeong - - 2012
Regular exercise has been shown to be beneficial to the brain functions, but little is known about the effects of exercise during pregnancy on the long-term memory function of the mothers. The objective of this study was to determine the effects of swimming during pregnancy on long-term memory function in ...
Lissauer David - - 2012
Tolerance of the semiallogeneic fetus presents a significant challenge to the maternal immune system during human pregnancy. T cells with specificity for fetal epitopes have been detected in women with a history of previous pregnancy, but it has been thought that such fetal-specific cells were generally deleted during pregnancy as ...
Santolaya Jacobo L JL Department of Obstetrics and Gynecology, University of Medicine and Dentistry New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA. - - 2012
A maternal serum biomarker profile analysis was performed to determine potential indicators of acute rejection of pregnancy following in-utero cell-based treatments in pre-immune embryos. We used an established non-human primate model for in-utero stem cell therapy at 38-42 days from fertilization. The maternal serum concentrations of nine candidate biomarkers for acute ...
Kacerovsky Marian - - 2012
Abstract OBJECTIVE: We sought to evaluate the distribution of scavenger receptor for hemoglobin positive (CD163(+)) cells in the placenta and fetal membranes from pregnancies complicated by preterm prelabor rupture of membranes with respect to the presence and absence of histological chorioamnionitis. METHODS: Sixty-two women with singleton pregnancies with a gestational ...
Spencer Patrick S - - 2012
Implantation is a major landmark in life. It involves the correct apposition of the embryo in the maternal endometrium. The cellular environment influences placenta development, and direct contact of the fetus with maternal tissues is achieved through decidual cells. At the decidua, and at systemic level, the correct balance of ...
Dal Canto Mariabeatrice - - 2012
To assess retrospectively the developmental potential of different types of cumulus cell-oocyte complexes (COCs) derived from IVM cycles. IVM cycles were performed in natural cycles or after HCG, FSH, or FSH/HCG priming. COCs recovered were morphologically characterized in different types: compact (CC) or expanded (EC) cumulus mass but including an ...
John Rosalind R School of Biosciences, Cardiff University, - - 2012
The chorioallantoic placenta is the defining organ of eutherians that has enabled prolonged intrauterine gestation. As such, normal placental development and function are essential for mammalian reproductive success. Reflecting the key role of this organ in providing nutrients to the embryo, the characteristic cell type that forms substantial parts of ...
Nassar Dany - - 2012
Skin wound healing is a complex regenerative process involving various cell types. We recently investigated whether fetal microchimeric cells (FMCs) acquired during gestation contribute to maternal wound healing and used fetal microchimerism to investigate the recruitment of distant endothelial progenitor cells in skin wounds. Our study showed that fetal progenitor ...
Almasry Shaima M - - 2012
Studying in detail different histomorphological and pathological findings in placental stem and terminal villi of appropriate for gestational age (AGA) and idiopathic intrauterine growth restricted (IUGR) fetuses, then analyzing their correlation to the neonatal birth weight and to the some morphological features of the placenta. Fifty full-term human placentae of ...
Merz Waltraut M - - 2012
Abstract Aims: To investigate fetomaternal hemorrhage (FMH) rate and quantity in the second trimester of pregnancies with fetal anomalies and to assess the impact of invasive prenatal and termination procedures. Methods: Blood samples from women before termination of pregnancy were collected and analyzed by dual-color flow cytometry. Various clinical parameters ...
Rodriguez M - - 2012
Preeclampsia is a common disease of pregnancy characterized by the presence of hypertension and commitment of many organs, including the brain, secondary to generalized endothelial dysfunction. Its etiology is not known precisely, but it involved several factors, highlighting the renin angiotensin system (RAS), which would have an important role in ...
Tse Doris B - - 2012
Abstract If maternal atopy and environmental exposure affect prenatal Th cell development, the maternal and fetal immune systems should display common Th1/Th2 phenotypes. To test this hypothesis, we studied maternal and neonatal blood samples from mothers with total serum IgE <300 IU/mL. Basal levels of IFN-γ, IL-4, and eotaxin in ...
Gantert Markus - - 2012
Infections during pregnancy can adversely affect the development of the fetal brain. This may contribute to disease processes such as schizophrenia in later life. Changes in the (cyto-) architecture of the anterior cingulate cortex (ACC), particularly in GABA-ergic interneurons, play a role in the pathogenesis of schizophrenia. We hypothesized that ...
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