Search Results
Results 1 - 50 of 547
1 2 3 4 5 6 7 8 9 10 >
Luo Yanmin Y Department of Biochemistry, N Texas March of Dimes Birth Defects Center, University of Texas Southwestern Medical Center, Dallas, TX, 75390-9038, - - 2014
Persistent hypoxia caused by shallow invasion and poor placental perfusion may underlie the pathophysiology of preeclampsia, a leading cause of maternal and neonatal morbidity and mortality. Previously, we found that estrogen-related receptor γ (ERRγ) serves a critical and O2-dependent role in differentiation of human trophoblasts in culture and expression of ...
Dumesic Daniel A DA Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, - - 2014
The maternal-fetal environment plays an important role in developmental programming of adult disease. Metabolic and hormonal dysfunction during human fetal development accompanies gestational diabetes as a common occurrence in mothers with polycystic ovary syndrome (PCOS), while human fetal androgen excess from congenital adrenal hyperplasia or virilizing tumors precedes PCOS-like symptoms ...
Xu Zhangye Z Department of Obstetrics and Gynecology, 1st Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, - - 2014
To evaluate the role for LXA4 in the pregnancy. We detected the changes of LXA4 and LXA4 biosynthetic enzymes in the mice's pregnancy, blocked LXA4 signaling pathway, managed LXA4 level, and treated LPS-induced mouse abortion model to systematically determine how LXA4 impact pregnancy. The concentrations of LXA4 in serum and ...
Burd Irina I Integrated Research Center for Fetal Medicine, Gynecology and Obstetrics, Johns Hopkins School of Medicine, Baltimore, MD 21287. Electronic address: - - 2014
Intrauterine inflammation is associated with preterm birth and can lead to fetal neuroinflammation and neurobehavioral disorders in newborns. Dendrimers can intrinsically target and deliver drugs for the treatment of neuroinflammation. We explore whether hydroxyl polyamidoamine (PAMAM) dendrimer (G4-OH)-based nanomedicines can be delivered to the fetus by intra-amniotic administration, in a ...
Clark David A DA McMaster University Department of Medicine, Health Sciences Center, Room 3H1E, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1; Department of Immunology, Faculty of Medicine, and Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Toronto General Research Institute, Canada. Electronic address: - - 2014
It has been suggested that the differences between placentation in humans and rodents, such as mice, are sufficient to render human pregnancy unique and to justify ignoring data generated using mice. Detailed examination of the placenta-decidua interaction and decidual NK cell composition in humans, and mice, show that the principles ...
Wang Wen-Juan WJ Reproduction Medical Center, Yantai Yuhuangding Hospital, Qingdao University School of Medicine, 20 Yuhuangding East Road, Yantai 264000, P. R. - - 2014
Could adoptive transfer of pregnancy-induced CD4+CD25+ regulatory T cells (Tregs) reverse the increase in abortion rate caused by interleukin 17 (IL-17) in the CBA/J × BALB/c mouse model? The effects of exogenous IL-17 on increased abortion rate, as well as decreased transforming growth factor (TGF)-β and IL-10 expression, are reversed ...
Bonney Elizabeth A EA E Bonney, Obstetrics, Gynecology and Reproductive Sciences, University of Vermont College of Medicine, Burlington, United - - 2014
This review is an example of the use of an animal model to try to understand the immune biology of pregnancy. A well-known model of recurrent spontaneous pregnancy loss is put in clinical, historical and theoretical context, with emphasis on T cell biology.
Takeshita Ai A Department of Integrated Structural Biosciences, Division of Veterinary Science, Graduate School of Life and Environmental Science, Osaka Prefecture University, Osaka 598-8531, - - 2014
The complement system is one component of innate immunity that could participate in fetal loss. We have already reported that adipsin, a complement activator in the alternative pathway, is stably expressed in the placenta and that an increase in this expression is related to spontaneous abortion. However, complement inhibitor Crry ...
Pedroni Silvia M A SM Tommy's Centre for Maternal and Fetal Health, The University of Edinburgh, Queen's Medical Research Institute, Edinburgh, United Kingdom; MRC Centre for Reproductive Health, The University of Edinburgh, Queen's Medical Research Institute, Edinburgh, United - - 2014
Maternal obesity is linked with increased adverse pregnancy outcomes for both mother and child. The metabolic impact of excessive fat within the context of pregnancy is not fully understood. We used a mouse model of high fat (HF) feeding to induce maternal obesity to identify adipose tissue-mediated mechanisms driving metabolic ...
Hernandez-Andrade Edgar E Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, and Detroit, Michigan, USA; Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, - - 2013
Throughout gestation, changes in maternal and fetal Doppler parameters in pregnant mice, similar to those obtained in human fetuses, were detected using high-frequency ultrasound with a 55-MHz linear probe. In the uterine arteries (UtA), fetal umbilical artery (UA) and fetal ductus venosus (DV) peak systolic velocity increased (UtA, p = 0.04; UA, ...
Hill Alexandria J AJ The University of Texas Medical Branch, Galveston, TX, Department of Obstetrics and Gynecology. Electronic address: - - 2013
Fetal alcohol syndrome (FAS) is the most common cause of non-genetic mental retardation. Oxidative stress is one of the purported mechanisms. NADPH oxidase (NOX) is an enzyme involved in the production of reactive oxygen species (ROS). Our objective was to evaluate NOX in the fetal brain of a well-validated mouse ...
Haricharan S - - 2013
Pregnancy-associated breast cancers (PABCs) are tumors diagnosed during pregnancy or up to 5 years following parturition, and are usually high-grade, connective tissue-rich, and estrogen receptor (ER)/progesterone receptor-negative. Little is known about the cellular origin of PABCs or the mechanisms by which PABCs are initiated. Using the RCAS retrovirus to deliver ...
Koh Kwi Hye - - 2013
Substrates of a major drug-metabolizing enzyme CYP2D6 display increased elimination during pregnancy, but the underlying mechanisms are unknown in part due to a lack of experimental models. Here, we introduce CYP2D6-humanized (Tg-CYP2D6) mice as an animal model where hepatic CYP2D6 expression is increased during pregnancy. In the mouse livers, expression ...
Rattanapinyopituk Kasem - - 2013
Exposure to nanoparticles during pregnancy is a public concern, because nanoparticles may pass from the mother to the fetus across the placenta. The purpose of this study was to determine the possible translocation pathway of gold nanoparticles across the maternal-fetal barrier as well as the toxicity of intravenously administrated gold ...
Hauk Vanesa V Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, IQUIBICEN-CONICET, Buenos Aires, - - 2014
Impaired pregnancy in non-obese diabetic (NOD) mice was related to limited vascular remodeling and autoimmune background. Vasoactive intestinal peptide (VIP) has anti-inflammatory and immunosuppressant effects, so we explored its ability to modulate the immune microenvironment at the early maternal-placental interface and improve pregnancy in NOD mice. Implantation sites were isolated ...
Brown Lucia Y - - 2013
Non-chromosomal pregnancy failure is a common but poorly understood phenomenon. Because recent data have suggested that epigenetic abnormalities such as abnormal placental DNA methylation may play a role in human pregnancy failure, we undertook experiments designed to test whether decidual and/or placental DNA methylation abnormalities are present in a mouse ...
Lee Nora - - 2013
Polyspecific organic cation (OC) transporters play important roles in disposition of clinically used drugs, including drugs used during pregnancy. Pregnancy is known to alter the expression of drug-metabolizing enzymes and transporters, but its specific effect on OC transporters has not been well defined. Using quantitative PCR and LC-MS/MS targeted proteomics, ...
Kumar Senthil R - - 2013
Fetal microchimerism (FMC) has been described to have a range of effects on health and disease. Y-chromosomal DNA has been detected in Golden Retrievers suggesting persistent FMC. In that report, nine dogs had evidence of microchimerism without prior pregnancy. To further understand this finding, a dam with prior male live ...
Staff Anne Cathrine - - 2013
Acute atherosis (Aa) affects uteroplacental spiral arteries in 20-40% of cases of preeclampsia. Its hallmark is lipid-filled, CD68-positive foam cells. It usually develops in the decidua (the pregnancy endometrium) at the distal ends of arteries that are often unremodelled in their proximal segments. Aa resembles the early stages of atherosclerosis, ...
Gasperowicz M - - 2013
Human birth weight does not scale linearly with the weight of the placenta: placental mass (PM) is proportional to the fetal mass (FM) raised to the scaling exponent of 0.75 (PM ∼ FM(0.75)) [1,2]. The mouse is a common model for studying genetic and physiological backgrounds of placental development, function and pathologies. ...
Lee Hyung-Yul - - 2013
AMP-activated protein kinase (AMPK) is stimulated in embryos during diabetic pregnancy by maternal hyperglycemia-induced embryo oxidative stress. Stimulation of AMPK disrupts embryo gene expression and causes neural tube defects (NTD). Metformin, which may be taken during early pregnancy, has been reported to stimulate AMPK activity. Thus, the benefits of improved ...
Chien Yu - - 2013
Normal pregnancy is supported by increased levels of progesterone (P4), which is secreted from ovarian luteal cells via enzymatic steps catalyzed by P450scc (CYP11A1) and HSD3B. The development and maintenance of the corpora lutea during pregnancy, however, are less well understood. Here we use Cyp11a1 transgenic mice to delineate the ...
Saadoun Samira - - 2013
Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the CNS and affects women of childbearing age. Most patients with NMO have circulating Abs, termed NMO-IgG, against the astrocytic water channel protein aquaporin-4. In the CNS, NMO-IgG causes complement-mediated astrocyte damage, inflammatory cell infiltration, and myelin loss. In this study, ...
Sun Xiaofei - - 2013
Increases in emergency room visits due to abuse of designer drugs, popularly known by the street names "K2" and "Spice," are a cause for social, judicial, and clinical concerns. The psychoactive components in these herbal drugs mainly consist of different synthetic cannabinoids, and users of these street drugs are primarily ...
Kudo Yoshiki - - 2013
Munn et al. made a scientific observation of major biological importance. For the first time they showed that in the mammal the fetus does survive an immune attack mounted by the mother, and that the mechanism responsible for the survival depends on the fetus and placenta 'actively' defending itself from ...
Zhang Cong C Centre de recherche en reproduction animale, Université de Montréal, Saint-Hyacinthe, Québec, - - 2013
Successful pregnancy requires coordination of an array of signals and factors from multiple tissues. One such element, liver receptor homolog-1 (Lrh-1), is an orphan nuclear receptor that regulates metabolism and hormone synthesis. It is strongly expressed in granulosa cells of ovarian follicles and in the corpus luteum of rodents and ...
Freitag Nancy N Charité Center 12 Internal Medicine and Dermatology, Reproductive Medicine Research Group, Universitätsmedizin Berlin, 13353 Berlin, - - 2013
Preeclampsia (PE) is a pregnancy-specific disorder characterized by sudden onset of hypertension and proteinuria in the second half of pregnancy (>20 wk). PE is strongly associated with abnormal placentation and an excessive maternal inflammatory response. Galectin-1 (Gal-1), a member of a family of carbohydrate-binding proteins, has been shown to modulate ...
Albornoz Eduardo A - - 2013
Background: Maternal thyroid hormones play a fundamental role in appropriate fetal development during gestation. Offspring that have been gestated under maternal hypothyroidism suffer cognitive impairment. Thyroid hormone deficiency during gestation can significantly impact the central nervous system (CNS) by altering the migration, differentiation, and function of neurons, oligodendrocytes, and astrocytes. ...
Plaks Vicki V Department of Anatomy, University of California, San Francisco, CA 94143, - - 2013
The pregnancy complication preeclampsia (PE), which occurs in approximately 3% to 8% of human pregnancies, is characterized by placental pathologies that can lead to significant fetal and maternal morbidity and mortality. Currently, the only known cure is delivery of the placenta. As the etiology of PE remains unknown, it is ...
Kasum Miro - - 2013
Spontaneous forms of the ovarian hyperstimulation syndrome (sOHSS) are nearly always reported between 8 and 14 weeks of pregnancy and also with follicle-stimulating hormone (FSH) producing pituitary adenoma. The syndrome has been previously reported in rare instances of increased production of human chorionic gonadotrophin (hCG) such as multiple pregnancies, hydatiforme ...
Gooi Jonathan H - - 2013
Pregnancy is associated with a progressive remodeling of the uterine artery. This adaptation is influenced by local and systemic pregnancy-dependent factors. We recently demonstrated that the peptide hormone relaxin mediates uterine artery remodeling in late pregnant rats. The objective of this study in relaxin gene knockout (Rln(-/-)) mice was to ...
Christensen K E - - 2013
Genetic variants in one-carbon folate metabolism have been identified as risk factors for disease because they may impair the production or use of one-carbon folates required for nucleotide synthesis and methylation. p.R653Q (1958G>A) is a single nucleotide polymorphism in the 10-formyltetrahydrofolate (formylTHF) synthetase domain of the trifunctional enzyme MTHFD1; this ...
Jaiswal Mukesh Kumar - - 2013
The objective of the present study is to investigate the role of heat shock proteins (Hsps) in preimplantation embryonic development and uterine receptivity during lipopolysaccharide (LPS)-induced pregnancy loss. Mice treated with PBS or LPS on day 0.5 of pregnancy was used to collect embryos and uterus on days 1.5 to ...
Kaur Pushpinder - - 2013
Epigenetic events establish a particular gene expression signature for each cell type during differentiation and fertilization. Disruption of these epigenetic programs in response to environmental stimuli during prenatal exposure dysregulates the fetal epigenome, potentially impacting susceptibility to disease later in life (the fetal basis of adult disease). Maternal dietary modifications ...
Burk Raymond F RF Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. - - 2013
Selenoprotein P (Sepp1) is taken up by receptor-mediated endocytosis for its selenium. The other extracellular selenoprotein, glutathione peroxidase-3 (Gpx3), has not been shown to transport selenium. Mice with genetic alterations of Sepp1, the Sepp1 receptors apolipoprotein E receptor-2 (apoER2) and megalin, and Gpx3 were used to investigate maternal-fetal selenium transfer. ...
McRae Jennifer L - - 2013
CD39 (NTPDase1), a critical immune and vascular ecto-nucleotidase, hydrolyses pro-inflammatory and pro-thrombotic nucleotides (adenosine-5'-triphosphate (ATP) and adenosine diphosphate) to adenosine. In humans, CD39 is the dominant ecto-nucleotidase in placental trophoblastic tissues and modulates ATP-dependent trophoblastic functions. CD39 is an integral component of regulatory T cells (Treg), which are central to ...
Grindler Natalia M - - 2013
Obesity is associated with ovulatory disorders, decreased rates of conception, infertility, early pregnancy loss, and congenital abnormalities. Poor oocyte quality and reduced IVF success have also been reported in obese women. Recent attempts to understand the mechanism by which these defects occur have focused on mitochondria, essential organelles that are ...
Elsarraj Hanan S HS Department of Pathology and Laboratory Medicine, The University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, - - 2013
In this report, we have shown that miR146b promotes the maintenance of pregnancy-derived mammary luminal alveolar progenitors. MiR146b expression was significantly higher in the mammary glands of pregnant and lactating mice than in virgin mice. Furthermore, miR146b levels were significantly higher in mouse mammary glands exposed to the sex hormones, ...
Malek Antoine - - 2013
During human pregnancy, the maternal immune system develops and changes, providing protection for the growing placenta and fetus. These protective changes provide mechanisms allowing two genetically different individuals to interact with each other without allograft rejection. In addition to normal pregnancy, some pregnancies may develop under immunologic diseases, during which ...
Favaron Phelipe O - - 2013
ABSTRACT: BACKGROUND: Stereology is an established method to extrapolate three-dimensional quantities from two-dimensional images. It was applied to placentation in the mouse, but not yet for other rodents. Herein, we provide the first study on quantitative placental development in a sigmodontine rodent species with relatively similar gestational time. Placental structure ...
Rocas Delphine - - 2013
We report the case of a 33-year-old pregnant woman. The third-trimester ultrasound scan during pregnancy revealed fetal bilateral ventricular dilatation, macrosomia and a transverse diameter of the cerebellum at the 30(th) centile. A brain MRI scan at 31 weeks of gestation led to a diagnosis of hypoplasia of the cerebellar ...
Gundlach Karsten K H - - 2013
INTRODUCTION: A very famous paper by Sam Pruzansky, published in 1969, was entitled "Not all dwarfed mandibles are alike". This is the topic of this paper: to describe the shape and discuss the possible pathogenesis of an extremely rare congenital dysplasia found in a unilaterally hypoplastic mandible, namely the isolated ...
Bobek Gabriele - - 2013
Endothelial dysfunction as a result of dysregulation of anti-angiogenic molecules secreted by the placenta leads to the maternal hypertensive response characteristic of the pregnancy complication of preeclampsia. Structural abnormalities in the placenta have been proposed to result in altered placental perfusion, placental oxidative stress, cellular damage and inflammation and the ...
Cho Kwang Ho - - 2013
The human fetal anterior commissure was easily observed connecting the bilateral external capsules in frontal sections via hematoxylin and eosin staining at 7-8 weeks of gestation. However, after 12 weeks of gestation, the terminal area became difficult to identify because complicated looping fibers developed in the bilateral temporal lobes. The ...
Kaspersen Maja D - - 2013
Most of the human herpesviruses can be found in semen, although the reported prevalence varies considerably between individual studies. The frequent presence of herpesvirus in semen raises the question whether sexual transmission of the virus could have an impact on human reproduction. Only few studies have associated seminal shedding of ...
Greco Adelaide - - 2013
Ultrasound is a valuable non-invasive tool used in obstetrics and gynecology to monitor the growth and well being of the human fetus. The laboratory mouse has recently emerged as an appropriate model for fetal and perinatal studies because morphogenetic processes in mice exhibit adequate homology to those in humans, and ...
Lu Shan - - 2013
The normal intrauterine fluid environment is essential for embryo implantation. In hydrosalpinx patients, the implantation and pregnancy rates are markedly decreased after IVF-embryo transfer, while salpingectomy could significantly improve the pregnancy rates. The leakage of hydrosalpinx fluid into the endometrial cavity was supposed to be the major cause for impaired ...
Schmid Bernd C BC Department of Gynaecological Oncology, Royal Adelaide Hospital, Adelaide, SA 5000, - - 2013
Human chorionic gonadotropin (hCG) is useful in evaluating and monitoring early pregnancy as well as trophoblastic disease. Here we describe the management of women with elevated serum human chorionic gonadotropin in a case of a 51-year-old female who was unsuccessfully treated for ectopic pregnancy. She was subsequently diagnosed with pituitary ...
Goldsmith Laura T - - 2013
Elucidating the role(s) of relaxin in women has been greatly hampered by its species specificity. Suitable experimental models of relaxin action in women are limited. We established a non-human primate model of early human pregnancy to study the effects of relaxin in vivo and used three well characterized in vitro ...
Haricharan Svasti S Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United - - 2013
While a first pregnancy before age 22 lowers breast cancer risk, a pregnancy after age 35 significantly increases life-long breast cancer risk. Pregnancy causes several changes to the normal breast that raise barriers to transformation, but how pregnancy can also increase cancer risk remains unclear. We show in mice that ...
1 2 3 4 5 6 7 8 9 10 >