Search Results
Results 201 - 250 of 586
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Denison F C - - 2010
Maternal obesity is associated with increased morbidity and mortality for both mother and offspring. The mechanisms underlying the increased risk associated with maternal obesity are not well understood. In non-pregnant populations, many of the complications of obesity are thought to be mediated in part by inflammation and its sequelae. Recent ...
Walsh Judi - - 2010
Since Cranley's conceptualization in 1981, which produced a useful measure to investigate the construct, maternal-fetal relationships have most often been referred to as maternal-fetal, antenatal or prenatal "attachment". However, critical analysis of the literature suggests that this relationship is not an attachment relationship at all, as Bowlby and Ainsworth first ...
Thompson John M D - - 2010
Maternal nutritional status before and during pregnancy is important for the growth and development of the fetus. The effects of pre-pregnancy nutrition (estimated by maternal size) are well documented. There is little information in today's Western society on the effect of maternal nutrition during pregnancy on the fetus. The aim ...
Hocher Berthold - - 2010
It was suggested that fetal sex may substantially affect maternal glycemic control during pregnancy in genetically susceptible mothers. The peroxisome proliferator-activated receptor gamma2 (PPARgamma2) Pro12Ala polymorphism is known to affect glycemic control and may act in a sex-specific manner. This polymorphism is thus an attractive candidate to test this hypothesis ...
Mortensen Kristian Havmand - - 2010
BACKGROUND: Spontaneous pregnancy rarely occurs in women with Turner syndrome, and poor maternal outcomes are prominent in these women. CASES: We report two women with 45,X Turner syndrome who had a total of four spontaneous pregnancies. Maternal and fetal outcomes were good despite maternal comorbidities. Cesarean deliveries were performed in ...
Zielinsky Paulo - - 2010
Fetal ductus arteriosus constriction is a clinical disorder that occurs as a result of inhibition of the prostaglandin synthesis pathway, and has long been associated to maternal intake of nonsteroidal antiinflammatory drugs in late pregnancy. As a consequence of an increased right ventricular pressure, with tricuspid regurgitation and heart failure, ...
Lee C Y W - - 2010
Obesity is an important public health issue not only in the general population, but also among pregnant women. Maternal obesity is associated with potential risks and complications for both the mother and the fetus. In this review, an update on the reproductive risks of maternal obesity and the role of ...
Cramer J S - - 2010
Temporal variations in the sex ratio, or the ratio of boys to girls at birth, have been widely studied and variously attributed to social changes, conditions of war, and environmental changes. Recently, Mathews et al. ["You are what your mother eats: Evidence for maternal preconception diet influencing fetal sex in ...
Wouldes Trecia A TA Department of Psychological Medicine, University of Auckland, New Zealand. t.wouldes@auckland.ac.nz - - 2010
In recent decades there has been an increase in the methadone dosages prescribed for opioid dependent women during pregnancy. Using prospective longitudinal data from a cohort of 32 methadone exposed and 42 non-methadone exposed infants, this study examined the relationship between maternal methadone dose during pregnancy and a range of ...
- - 2010
OBJECTIVE: To determine whether higher maternal body mass index (BMI), independent of maternal glycaemia, is associated with adverse pregnancy outcomes. DESIGN: Observational cohort study. SETTING: Fifteen centres in nine countries. POPULATION: Eligible pregnant women. METHODS: A 75-g 2-hour oral glucose tolerance test (OGTT) was performed between 24 and 32 weeks ...
Chen Tianhui - - 2010
Little is known about correlates of first-trimester pregnancy hormones as in most studies maternal hormones have been measured later in gestation. We examined the associations of maternal characteristics and child sex with first-trimester maternal concentrations of four hormones implicated in breast cancer: human chorionic gonadotropin (hCG), alpha-fetoprotein (AFP), insulin-like growth ...
Dipietro Janet A - - 2010
The earliest relationship does not begin with birth. Pregnant women construct mental representations of the fetus, and feelings of affiliation or "maternal-fetal attachment" generally increase over the course of gestation. While there is a fairly substantial literature on the development and moderation of psychological features of the maternal-fetal relationship, including ...
Paumgartten Francisco J R - - 2010
The relevance of fetal abnormalities noted at maternally toxic doses is a long-standing issue regarding the interpretation of findings of segment II studies. A number of diseases and conditions during pregnancy are known to adversely affect embryo/fetal development, and along this line many scientists believe that any marked disturbance of ...
Palmer Christina G S - - 2010
Prenatal/obstetric complications are implicated in schizophrenia susceptibility. Some complications may arise from maternal-fetal genotype incompatibility, a term used to describe maternal-fetal genotype combinations that produce an adverse prenatal environment. A review of maternal-fetal genotype incompatibility studies suggests that schizophrenia susceptibility is increased by maternal-fetal genotype combinations at the RHD and ...
Leiss Jack K JK Center for Health Research, Constella Group, Durham, NC, USA. - - 2010
We sought to advance understanding of linkage error in U.S. maternally linked datasets and how the error might affect results of studies based on the linked data. North Carolina birth and fetal death records for 1988-1997 were maternally linked (n=1,030,029). The maternal set probability, defined as the probability that all ...
Hewitt Amy J - - 2010
BACKGROUND: Ethanol neurobehavioural teratogenicity is a leading cause of developmental mental deficiency, in which the hippocampus is a target site of injury. The multi-faceted mechanism of ethanol teratogenicity is not completely understood. This study tested the hypothesis that chronic ethanol exposure (CEE), via chronic maternal ethanol administration, increases cytochrome P450 ...
Nelson Scott M SM Division of Developmental Medicine, Reproductive and Maternal Medicine, Faculty of Medicine, University of Glasgow, Glasgow, UK. - - 2010
Obesity among pregnant women is highly prevalent worldwide and is associated in a linear manner with markedly increased risk of adverse outcome for mother and infant. Obesity in the mother may also independently confer risk of obesity to her child. The role of maternal metabolism in determining these outcomes and ...
Gasem Turki - - 2009
OBJECTIVE: The study evaluated the maternal and fetal outcome in 64 pregnancies complicated by HELLP syndrome. METHODS: A retrospective analysis of the medical records was performed of patients with HELLP syndrome managed at this tertiary Obstetric unit between January 1996 and December 2005, who were admitted for preeclamsia/eclampsia and had ...
Walters Merrie Rebecca - - 2009
Maternal obesity is associated with pregnancy complications and birth defects. Infants born to obese mothers may be at greater risk for childhood and adult obesity. Preconception planning with women of childbearing age should include information on the potential effects of obesity during pregnancy.
Pérez R - - 2009
The transplacental exchange of moxidectin after maternal or fetal intravenous (i.v.) administration was studied using the chronically catheterized fetal sheep model. Nine pregnant Suffolk Down sheep of 65.7 +/- 5.9 kg body weight (bw) were surgically prepared to insert polyvinyl catheters in the fetal femoral artery and vein and amniotic ...
Matsuzawa Yasuo - - 2010
Guillain-Barr? syndrome (GBS)-complicating pregnancy is rare; and it is generally believed that it carries a high maternal risk. We reported a case of good maternal and fetal outcomes of predominantly sensory GBS (generalized pain and numbness, mild deep sensory ataxia, positive serum IgM anti-GalNAcGD1a antibody)-complicating pregnancy after intravenous immunoglobulin treatment.
Huda Shahzya S - - 2010
Rates of obesity have increased exponentially worldwide to almost epidemic proportions. This is associated with a marked increase in adverse maternal and perinatal outcomes and subsequent burden on health care resources. In particular, maternal obesity is linked to numerous metabolic complications including subfertility, gestational diabetes, hypertensive disorders of pregnancy and ...
Goedhart Geertje - - 2010
Maternal psychosocial problems may affect fetal growth through maternal cortisol. This large prospective cohort study examined among 2810 women (1) the association of maternal cortisol levels with offspring birthweight and small for gestational age (SGA) risk and (2) the mediating role of maternal cortisol on the relation between maternal psychosocial ...
Micali Nadia - - 2009
The aim of this paper was to review the literature on the biological effects of a maternal eating disorder (ED) (and relevant comorbidities) in pregnancy on mothers and in particular on the foetus. We also aimed to highlight possible mechanisms of risk for long-term consequences in the offspring. Relevant literature ...
Xu Hairong - - 2009
Preeclampsia (PE) accounts for about one-quarter of the cases of maternal mortality and ranks second among the causes of pregnancy-associated maternal deaths in Canada and worldwide. The identification of an effective strategy to prevent PE is a priority and a challenge for research in obstetrics. Progress has been hampered by ...
Schlotz Wolff W MRC Epidemiology Resource Centre, University of Southampton, Southampton SO17 1BJ, UK. - - 2010
Maternal nutrition during pregnancy has been linked with fetal brain development and psychopathology in the offspring. We examined for associations of maternal folate status and dietary intake during pregnancy with brain growth and childhood behavioural difficulties in the offspring. In a prospective cohort study, maternal red blood cell folate (RCF) ...
Sakamoto Mineshi - - 2010
Mercury (Hg) and other heavy metal profiles, namely, lead (Pb), arsenic (As), cadmium (Cd), and selenium (Se) were investigated in maternal and umbilical cord (cord) red blood cells (RBCs) at parturition in Japanese population. Correlation coefficients of Hg, Pb, As, Cd, and Se between maternal and cord RBCs were 0.91, ...
Nelson Scott M - - 2010
We examined in a prospective longitudinal pregnancy cohort the influence of advancing gestation and baseline maternal adiposity on antim?llerian hormone (AMH) and determined whether maternal hormones (insulin, leptin, adiponectin, E(2), and sex hormone-binding globulin) correlate with alterations in AMH. We demonstrate that first-trimester AMH is associated negatively with maternal adiposity, ...
Bouchlariotou Sofia - - 2009
Phenylketonuria (PKU) is an autosomal recessive inborn error of phenylalanine (Phe) metabolism resulting from deficiency of phenylalanine hydroxylase (PAH). Most forms of PKU are caused by mutations in the PAH gene. Untreated PKU is associated with an abnormal phenotype, which includes growth failure, seizures, global developmental delay and severe intellectual ...
Symonds Michael E - - 2009
Changes in maternal diet at different stages of reproduction can have pronounced influences on the health and well-being of the resulting offspring, especially following exposure to an obesogenic environment. The mechanisms mediating adaptations in development of the embryo, placenta, fetus and newborn include changes in the maternal metabolic environment. These ...
Hocher Berthold - - 2009
BACKGROUND: Recent evidence from very rare human diseases suggests that variation in the fetal genome can modify maternal physiology during pregnancy. Here, we tested the hypothesis that fetal sex as a major genetic variant of the fetal genome may affect maternal physiology during pregnancy in genetically susceptible pregnant women. METHODS: ...
Denguezli Walid - - 2009
AIM: To assess the effect of maternal diet during pregnancy on the risk of delivering a large for gestational baby (macrosome). METHODS: A food intake survey of 350 healthy pregnant Tunisian women, 52 in group macrosomia and 298 in group control. Only term (> or =37 completed Weeks of gestation) ...
Pham Vi - - 2009
During human pregnancy, a circulating form of insulin-regulated aminopeptidase (IRAP EC 3.4.11.3), often termed oxytocinase or placental leucine aminopeptidase (PLAP), is present in plasma. It is proposed that circulating IRAP plays an important role in regulating the circulating levels of oxytocin and/or vasopressin during pregnancy. We assessed the reproductive and ...
Rodriguez Alina - - 2010
OBJECTIVE: This study aimed to replicate and extend previous work showing an association between maternal pre-pregnancy adiposity and risk for attention deficit hyperactivity disorder (ADHD) symptoms in children. METHODS: A Swedish population-based prospective pregnancy-offspring cohort was followed up when children were 5 years old (N = 1,714). Mothers and kindergarten ...
Unterberger A - - 2009
A sub-optimal intrauterine environment alters the trajectory of fetal development with profound effects on life-time health. Altered methylation, a proposed epigenetic mechanism responsible for these changes, has been studied in non-primate species but not nonhuman primates. We tested the hypotheses that global methylation in fetal baboon demonstrates organ specificity, gestational ...
Van Leeuwen P P Department of Biomagnetism, Witten/Herdecke University, 44799 Bochum, Germany. - - 2009
Pregnant mothers often report a special awareness of and bonding with their unborn child. Little is known about this relationship although it may offer potential for the assessment of the fetal condition. Recently we found evidence of short epochs of fetal-maternal heart rate synchronization under uncontrolled conditions with spontaneous maternal ...
Schrader Matthew - - 2009
The evolution of matrotrophy introduces the potential for genomic conflicts between mothers and embryos. These conflicts are hypothesized to accelerate the evolution of reproductive isolation and to influence the evolution of life-history traits, reproductive structures, and genomic imprinting. These hypotheses assume offspring can influence the amount of maternal investment they ...
Boama Vincent - - 2009
The Millennium Development Goals (MDGs) set very high targets for women's reproductive health through reductions in maternal and infant mortality, among other things. Reductions in maternal mortality and morbidity can be achieved through various different approaches, such as the confidential review of maternal deaths, use of evidence-based treatments and interventions, ...
Rhind S M - - 2009
Fetal tissue concentrations of endocrine disrupting compounds (EDCs), and their relationship to maternal tissue concentrations, are largely unknown, in any species. In particular, the patterns of accumulation in the respective tissues following increased rates of environmental exposure are little known. This study was designed to determine fetal and maternal tissue ...
Gasem Turki - - 2009
Objective. The study evaluated the maternal and fetal outcome in 64 pregnancies complicated by HELLP syndrome. Methods. A retrospective analysis of the medical records was performed of patients with HELLP syndrome managed at this tertiary Obstetric unit between January 1996 and December 2005, who were admitted for preeclamsia/eclampsia and had ...
Anderson Frank W J - - 2009
Women continue to die from pregnancy-related causes at an alarming rate. Maternal mortality was first called a neglected epidemic in 1985, but to date, no significant improvements have been realized. Great disparity exists as lifetime risk of dying from pregnancy is 1 in 26 in Africa, 1 in 7300 in ...
Ho Simone S M - - 2009
AIMS: This article aims to review the literature published to date on the types, current use, the biomechanical effects and adverse effects of maternity support belts for low back pain during pregnancy, to identify future research directions. BACKGROUND: Lumbar/pelvic support belts are frequently recommended for the prevention and treatment of ...
Wu Danny - - 2009
The term fetal surgery is used widely for fetal intervention during pregnancy; maternal-fetal surgery may be more appropriate, because all these invasive procedures also affect the mother. Although there is no direct benefit to the mother from these procedures, the risk to her is for a purely altruistic purpose. It ...
Ali E Y - - 2009
Anaemia affects almost two-thirds of pregnant women in developing countries; it is associated with poor maternal and perinatal outcomes. Anaemia during pregnancy, through many endocrine alterations might influence maternal and fetal environment. This study was conducted to investigate the anthropometric, biochemical and hormonal profiles in paired maternal and cord blood ...
Wolf Jason B - - 2009
Maternal effects can play an important role in a diversity of ecological and evolutionary processes such as population dynamics, phenotypic plasticity, niche construction, life-history evolution and the evolutionary response to selection. However, although maternal effects were defined by quantitative geneticists well over half a century ago, there remains some confusion ...
Gordon, John David
The purpose of these studies was to assess the pharmacokinetics, metabolism and fetal effects of valproic acid (VPA) in pregnant sheep. Following i.v. bolus administration, the disposition of VPA was best described by a biexponential function with a t½β of 2.13 ± 0.49 h in maternal serum and 3.37 ± ...
Beloosesky Ron - - 2009
OBJECTIVE: Maternal infection or inflammation may induce fetal inflammatory responses and potentially fetal brain injury. We sought to determine whether prophylactic n-acetylcysteine (NAC), a known antiinflammatory, may modulate the fetal cytokine response to maternal lipopolysaccharide (LPS). STUDY DESIGN: Pregnant Sprague Dawley rats (20/21 days = 0.95 gestation; n = 35) ...
Ibrahim H N - - 2009
The outcome of pregnancy in kidney donors has generally been viewed to be favorable. We determined fetal and maternal outcomes in a large cohort of kidney donors. A total of 2102 women have donated a kidney at our institution; 1589 donors responded to our pregnancy surveys; 1085 reported 3213 pregnancies ...
Cole Zoe A ZA The MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, Untied - - 2009
Maternal nutrition is a potentially important determinant of intrauterine skeletal development. Previous studies have examined the effects of individual nutrients, but the pattern of food consumption may be of greater relevance. We therefore examined the relationship between maternal dietary pattern during pregnancy and bone mass of the offspring at 9 ...
Wang Zhenhua - - 2009
Exposure to an adverse intrauterine environment increases the risk of cardiovascular disease later in adult life. However, the time course relationship between prenatal hypoxia and the onset of atherosclerosis in offspring remains unknown. The purpose of this study is to evaluate the role of reduced fetal oxygen supply on early ...
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