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Shah Amy A Department of Obstetrics & Gynecology, University of California, Los Angeles, CA 90095, - - 2011
Preexisting aortic disease can worsen during pregnancy as physiologic hemodynamic changes evolve. At a large academic institution, a patient with a remote history of vasculitis presented with a second trimester pregnancy with increasing aortic dilatation and aortic insufficiency. Extensive obstetric discussions encompassed maternal cardiac risks from continuing the pregnancy and ...
Avise John C - - 2010
We construct a verbal and graphical theory (the "fecundity-limitation hypothesis") about how constraints on the brooding space for embryos probably truncate individual fecundity in male-pregnant and female-pregnant species in ways that should differentially influence selection pressures for multiple mating by males or by females. We then review the empirical literature ...
Drea Christine M - - 2011
Female ring-tailed lemurs (Lemur catta) are Malagasy primates that are size monomorphic with males, socially dominate males, and exhibit a long, pendulous clitoris, channeled by the urethra. These masculine traits evoke certain attributes of female spotted hyenas (Crocuta crocuta) and draw attention to the potential role of androgens in lemur ...
Bloom Michael S - - 2011
Trace exposures to metals may affect female reproductive health. To assess the relation between trace concentrations of blood metals and female fecundity, 99 non-pregnant women discontinuing contraception for the purpose of becoming pregnant were prospectively followed. Participants completed a baseline interview and daily diaries until pregnant, or up to 12 ...
Akolekar Ranjit - - 2010
To examine the performance of a mass spectrometry-based detection platform using three Y-chromosome sequences for fetal sex determination from circulating cell-free fetal DNA (ccffDNA) in maternal blood in the first trimester of pregnancy. We extracted ccffDNA for the determination of fetal sex from stored maternal plasma obtained at 11 to ...
Thomal Janaina Thais - - 2010
Because the maternal environment can affect several physiological functions of the newborn, the aim of the present study was to examine the impact of sleep restriction during pregnancy on renal morphology and function in young offspring. Female 3-month-old Wistar rats were divided in 2 experimental groups: C (control) and SR ...
Fanson Kerry V - - 2010
Canada lynx face some unique breeding restrictions, which may have implications for population viability and captive management. The goal of this study was to improve our understanding of basic reproductive physiology in Canada lynx. Using fecal hormone metabolite analysis, we established normative patterns of fecal estrogen (fE) and progestagen (fP) ...
Rodins Karl - - 2011
We present a novel case of pyogenic granuloma occurring within a port-wine stain in two sequential pregnancies at different sites. There was no history of precipitating events such as trauma. We discuss why a pyogenic granuloma may occur within a port-wine stain and how pregnancy may increase the likelihood of ...
Sarangi S - - 2010
Exposure to methyl isocyanate and other toxic gases in Bhopal, India, on December 3, 1984 resulted in thousands of acute deaths, pregnancy loss and long-term effects. From 1985 to 2007, we conducted successive surveys of vital status and health to determine whether the exposure of parents to toxic gases in ...
Curtis J Thomas - - 2010
Monogamous animals face an interesting dilemma: if and when to terminate a nonproductive relationship. To address this issue, we asked whether reproductive compatibility is a criterion for maintaining a monogamous pair-bond between mates. Prairie voles (Microtus ochrogaster), are small rodents that form long-term, monogamous pair-bonds evidenced by a strong preference ...
Palkar Prajakta S - - 2010
Recent work indicates that PPARalpha is required for perfluorooctanoic acid (PFOA)-induced postnatal lethality resulting from prenatal exposure. The present study tested the hypothesis that relatively modest activation of PPARalpha during prenatal development will cause postnatal lethality, similar to that observed with PFOA, a relatively low affinity PPARalpha agonist. Female wild-type ...
Adachi I - - 2010
Although the Tsushima leopard cat (Prionailurus bengalensis euptilurus) is one of the most endangered mammals in Japan, its reproductive physiology and endocrinology have been not elucidated. The objective was to establish the non-invasive monitoring of reproductive endocrinology in a female Tsushima leopard cat and to identify the types of fecal ...
Bauer Samuel - - 2010
OBJECTIVE: This study investigates fluoxetine (FLX) exposure as an etiology for altered gestational length and adverse pregnancy outcomes. STUDY DESIGN: Two experiments were performed exposing mice to drinking water (H(2)O) or H(2)O+FLX. Primary outcomes included gestational length, litter size, and live birth rate. In experiment 1, time-mated dams were monitored ...
Pellegrino Miriam - - 2010
WNT4 signaling pathways represent an important step in the multi-faceted process of mammalian gonadal differentiation and the development of internal genitalia. WNT4 protein controls the cytoplasmatic stability of specific transcriptional coactivator beta catenin during both embriogenesis and adult homeostasis. The biological significance of WNT4 consists in determining the final female ...
Inawaka Kunifumi - - 2010
This study was conducted to evaluate the effects of procymidone (PCM) on development of male rabbit fetal external genitalia. PCM was administered once daily by gavage at dose levels of 0 (control) and 125mg/kg/day to pregnant rabbits from gestation day 6 through 28 and fetal external genitalia was observed in ...
Li Yim J F T - - 2010
A 17-year-old female was treated with botulinum toxin (botulinum toxin type A, Allergan) for a left convergent squint. She returned 1 week after her second injection and informed us that she found out she was pregnant 3 days after the second injection. After a long worrying 9 months, her pregnancy ...
Green Daniel M DM Department of Epidemiology and Cancer Control, St Jude Children's Research Hospital, 262 Danny Thomas Way, Mail Stop 735, Memphis, TN 38105-2794, USA. - - 2010
This study was undertaken to evaluate the effect of prior treatment with radiation therapy or chemotherapy for unilateral Wilms tumor (WT) diagnosed during childhood on pregnancy complications, birth weight, and the frequency of congenital malformations in live-born offspring. We reviewed pregnancy outcomes among female survivors and partners of male survivors ...
Paczolt Kimberly A - - 2010
Male pregnancy in seahorses, pipefishes and sea dragons (family Syngnathidae) represents a striking reproductive adaptation that has shaped the evolution of behaviour and morphology in this group of fishes. In many syngnathid species, males brood their offspring in a specialized pouch, which presumably evolved to facilitate male parental care. However, ...
Zhang Heng - - 2010
Fenvalerate, a widely used pyrethroid insecticide, has been associated with poor semen quality. As yet, little is known about the effects of prenatal fenvalerate exposure on testicular development. The present study investigated the effects of prenatal fenvalerate exposure on testicular development and spermatogenesis. The pregnant mice were administered fenvalerate (30 ...
Katsumata Etsuko - - 2010
The reproductive endocrinological characteristics of beluga, killer whale, spotted seal and bottlenose dolphin were evaluated and used in conjunction with applied reproductive research to enhance captive breeding programs. Results from 8 y of biweekly serum progesterone determination in a female beluga indicated that sexual maturity occured at approximately age 13, ...
Sakr Carine J CJ Department of Occupational Medicine and Environmental Health, Yale University School of Medicine, New Haven, CT, USA. - - 2010
Several adverse pregnancy outcomes were reported among female laboratory workers in a North American aluminum smelter. To determine whether these outcomes were associated with any occupational exposure at the plant, a cross-sectional survey was undertaken. Rates of miscarriage, premature singleton birth, and major congenital anomaly occurring during employment were compared ...
Groth K - - 2010
BACKGROUND: Pregnancies after organ transplantation and under immunosuppressive treatment are associated with slightly elevated risks for obstetric and post-natal complications but can usually be managed well. However, little is known about the effects of intrauterine exposure (IUE) to immunosuppressants in the growing and adult offspring. One major issue is the ...
Kauffman Alexander S AS Dept. of Reproductive Medicine, University of California, San Diego, La Jolla, CA, 92093, United States. - - 2010
In female mammals, reproduction is tightly regulated by energy status and food availability. Although acute energetic challenges inhibit female reproductive behavior and gonadotropin secretion, less attention has been given to the effects of short-term energetic challenge on pregnancy and gestation. Furthermore, species differences in pregnancy physiology necessitate more detailed analyses ...
Dunn Elizabeth - - 2010
Preterm delivery occurs in approximately 10% of all pregnancies. Prenatal exposure to synthetic glucocorticoids (sGCs) reduces the incidence of respiratory distress syndrome (RDS) in these babies. Therefore, administration of multiple courses of sGCs became common practice. Animal and human studies have demonstrated that multiple courses of sGCs can have long-term ...
Yoshida Takashi - - 2010
We studied two mating systems for a large-scale breeding colony of cynomolgus monkeys: (i) a 3-day timed system that keeps one female and one male together in a cage for 3 days beginning 11 days after menstruation, and (ii) a 7-day timed system beginning 9 days after menstruation. Regardless of ...
Veras Mariana Matera - - 2010
In recent years, numerous studies showed that exposure to environmental air pollutants affected reproductive functions and, in particular, produced adverse effects on pregnancy outcomes, fertility, and fetal health. Epidemiological studies demonstrated that exposure to ambient levels of air pollutants are associated with low birth weight, intrauterine growth retardation, prematurity, neonatal ...
Mitsunaga Fusako - - 2010
Non-invasive fetal sex determination is required for biomedical studies, in which some sexual difference would be expected in fetal events, in order to make a choice of male or female fetus. To detect male fetal DNA of the sex-determining region Y gene (SRY) in maternal macaque plasma, nested real-time PCR ...
Roellig Kathleen - - 2010
The concept of superfetation, a second conception during pregnancy, has been controversial for a long time. In this paper we use an experimental approach to demonstrate that female European brown hares (Lepus europaeus) frequently develop a second pregnancy while already pregnant and thereby increase their reproductive success. After a new, ...
Corson Lin L Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA. - - 2010
Multiple studies have suggested that prenatal exposure to either allergens or air pollution may increase the risk for the development of allergic immune responses in young offspring. However, the effects of prenatal environmental exposures on adult offspring have not been well-studied. We hypothesized that combined prenatal exposure to Aspergillus fumigatus ...
Baraté P P International Centre for Reproductive Health (ICRH), Department of Obstetrics and Gynaecology, Ghent University, - - 2010
More than two decades after the launch of the Safe Motherhood Initiative (Nairobi 1987) , maternal health in many developing countries has shown little or no improvement. Year after year, more than half a million mothers continue to die in silence. The specificities of the complex cross-cutting issue only partly ...
Clay A Moss - - 2010
Despite the importance of the western white-bearded wildebeest (Connochaetes taurinus mearnsi) to the Serengeti-Mara ecosystem, surprisingly little is known about the reproductive physiology of this keystone species. A longitudinal, non-invasive endocrine study was conducted on female wildebeest captured from the Serengeti-Mara migration and maintained for approximately 16 months in large ...
Lemos M F L - - 2010
Endocrine Disruptor Compounds (EDCs) have been largely studied concerning their effects on vertebrates. Nevertheless, invertebrates as targets for these chemicals have been neglected and few studies are available. Specifically for edaphic invertebrates, data concerning the effects of EDCs is residual. Influences of EDCs on the reproduction systems of these organisms, ...
Mull Christopher G - - 2010
This study characterizes the seasonal reproductive cycle of female round stingrays (Urobatis halleri) in an open coastal site at Seal Beach, CA and a protected estuary at the Seal Beach National Wildlife Refuge (SBNWR). Female round stingrays were sampled from August 2004 to July 2006, and assessed for reproductive parameters ...
Pucheu-Haston Cherie M - - 2009
The T-helper 2 (T(H)2) bias associated with pregnancy may predispose the pregnant mother to the development or exacerbation of allergic disease. To determine the effects of pregnancy on pre-existing maternal sensitization, we sensitized BALB/c mice before breeding by two intratracheal aspiration (IA) exposures to the fungal allergen, Metarhizium anisopliae crude ...
Lilley Thomas - - 2010
The steroid environment encountered by a foetus can strongly affect its post-natal physiology and behaviour. It has been proposed that steroid concentrations experienced in utero could be estimated from adults by measuring their second-to-fourth digit length ratio (2D:4D). However, there is still little direct evidence that intra-uterine steroid levels affect ...
Jensen Jeffrey T JT Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR 97239, USA. - - 2010
The study was conducted to determine whether a phosphodiesterase (PDE) 3 inhibitor has potential as a novel contraceptive in primates. Regularly cycling adult female cynomolgus macaques of proven fertility (n=16) were treated for 7 months with placebo (controls) or the PDE3 inhibitor ORG 9935 as a daily food treat (150 ...
Melamed Nir - - 2009
OBJECTIVE: To estimate the association between fetal sex and pregnancy outcome in dichorionic twin pregnancies and the effect of male and female fetuses on their opposite-sex co-twin. METHODS: This was a retrospective study of all dichorionic twin pregnancies at a tertiary hospital from 1995 to 2006. Pregnancies were classified into ...
Chaouat Gérard - - 2009
This paper reports a summary of our comparative analysis of the uterine expression of interleukin-23 (IL-23), IL-27 and TWEAK in the CBA/J femalexDBA/2 male mouse mating combination, a model of immune-mediated early pregnancy loss. Compared with the MHC-identical CBA/JxBALB/c mating combination, which yields successful pregnancies, immunohistochemistry and qPCR in uterine ...
Mitrano Presciliana - - 2010
The objective of this study is to evaluate pregnancy's action on glycosaminoglycans (GAGs) profile in bladder and urethra of female adult rats. Twenty adult female rats were divided into four groups: control, day 10 pregnancy, day 20 pregnancy, and day 5 after delivery. Sulfated GAGs content were determined by densitometry. ...
Silva Erick J R - - 2009
The present study was conducted to evaluate the effects of the administration of a hydroalcohol extract of Calendula officinalis L. flowers (HAE) on the reproductive function of Wistar rats. Four groups of adult male rats were treated orally with HAE at doses of 0, 0.25, 0.5 and 1.0 g/kg for ...
Kawaguchi Hiroaki - - 2009
The aim of this study was to investigate the effect of exposure period and dose of diethylstilbestrol (DES), which has strong estrogenic activity, on pregnancy in rats. All rats with observed vaginal plugs or sperm in vaginal smear tests after mating were divided into 3 groups: those fed a normal ...
Petry Clive J CJ Department of Paediatrics, University of Cambridge, Cambridge, U.K. - - 2010
We have hypothesized that variation in imprinted growth-promoting fetal genes may affect maternal glucose concentrations in pregnancy. To test this hypothesis we evaluated the effects of fetal disruption of murine H19(Delta13) on maternal glucose concentrations in pregnancy. Experimental mice were pregnant females that had inherited the disrupted H19(Delta13) from their ...
Pallud Johan - - 2009
Advances in the understanding of the natural history of diffuse low-grade gliomas and the optimization of their therapeutic management have allowed an improvement of their prognosis. Therefore, more and more young women harboring such gliomas now envision a pregnancy. However, relationships between gliomas and pregnancy are poorly known. We performed ...
Sato Tamio - - 2009
The aim of this study was to analyze the effects of synthetic para-nonylphenol isomers administered chronically throughout pregnancy and lactation on the reproductive system of mouse pups. The two synthetic isomers used in this study showed higher (3E22NP) or lower (44NP) estrogen receptor (ER) binding activity on in vitro yeast ...
Mader Sarah L SL Oregon Health and Science University, Department of Anesthesiology and Perioperative Medicine, Portland, OR, - - 2009
In order to efficiently generate genetically engineered mouse (GEM) fetuses or neonates of a specified age range, researchers must develop strain-specific strategies, including reliable early pregnancy detection. The authors evaluated pregnancy indices (pregnancy rate, plug rate, pregnant plugged rate, first litter size and body weight) in two GEM breeding colonies: ...
Mu??oz C - - 2009
This study investigated the effects of different planes of nutrition in early pregnancy (EP) and mid-pregnancy (MP) of crossbred ewes on carcass characteristics of male offspring and reproductive performance of female offspring. During EP (d 1 to 39 after synchronized mating) ewes were allocated 60% (low, L-EP), 100% (medium, M-EP), ...
French Jeffrey A JA Department of Psychology and Callitrichid Research Center, University of Nebraska at Omaha, 6001 Dodge St., Omaha, NE 68182, USA. - - 2010
Maternal hormones can dramatically modify offspring phenotypes via organizational actions on morphological and behavioral development. In placental mammals, there is the possibility that some portion of hormones in maternal circulation may be derived from fetal origin. We tested the possibility that maternal androgens in pregnant female marmosets reflected, in part, ...
Gonzalez Gabriel G Department of Genetics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, - - 2009
Dicer encodes a riboendonuclease required for microRNA biosynthesis. Dicer was inactivated in Müllerian duct mesenchyme-derived tissues of the reproductive tract of the mouse, using an Amhr2-Cre allele. Although Amhr2-Cre; Dicer conditional mutant males appeared normal and were fertile, mutant females were infertile. In adult mutant females, there was a reduction ...
Zimran Ari - - 2009
BACKGROUND: The principal manifestations of type 1 Gaucher disease (GD) (increased risk of bleeding, anaemia, splenomegaly, hepatomegaly and bone disease) are likely to affect females during reproductive events such as menarche and menstruation; fertility, pregnancy, parity, delivery and lactation; and menopause. In order to determine the optimal management of female ...
Sharkey Don - - 2009
Increasing adiposity predisposes to the development of the metabolic syndrome, in part, through adipose tissue dysregulation and inflammation. In addition, offspring nutrient-restricted (NR) in utero can exhibit an increased risk of early-onset insulin resistance and obesity, although the mechanisms remain unclear. We aimed to: 1) define adipose tissue ontogeny of ...
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