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Results 251 - 300 of 1682
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Hanita O - - 2012
Early pregnancy failure is a common pregnancy complication. In clinical practice, the time delay to distinguish viable from nonviable pregnancy is often distressing to patients and doctors. A highly sensitive and specific biomarker that accurately discriminates between viable and nonviable pregnancy would be useful for early intervention. Progesterone has been ...
Gervasi Maria-Teresa - - 2012
Intra-amniotic inflammation is traditionally defined as an elevation of amniotic fluid interleukin (IL)-6. Previous case control studies have suggested an association between an elevated midtrimester amniotic fluid IL-6 and preterm delivery, although such an association has been recently challenged. Intra-amniotic inflammation can also be defined by an elevation of the ...
Rausch Mary E ME Department of Obstetrics and Gynecology, Center for Human Reproduction, North Shore University Hospital, Manhasset, New York, USA. - - 2012
Unless an ectopic pregnancy is visible by ultrasound, diagnosis can be a challenge. Differentiating ectopic pregnancies from intrauterine pregnancies can be impossible without intervention or follow-up. This poses a clinical dilemma to the practitioner given the inherent danger to the mother of tubal rupture of an ectopic pregnancy versus the ...
Olausson Hanna H MRC Human Nutrition Research, The Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, - - 2012
Pregnancy and lactation are times of additional demand for Ca. Ca is transferred across the placenta for fetal skeletal mineralisation, and supplied to the mammary gland for secretion into breast milk. In theory, these additional maternal requirements could be met through mobilisation of Ca from the skeleton, increased intestinal Ca ...
Gu Hui - - 2012
The discovery of placental microRNAs (miRNAs) in maternal serum has opened up new possibilities for noninvasive prenatal diagnosis. However, the expression of miRNAs in the serum of pregnant women with fetuses with neural tube defects (NTDs) has not been characterized. In this paper, we explored serum miRNAs as potential biomarkers ...
Richardson A - - 2012
Abstract AIMS: The study was concerned with the medical management of ectopic pregnancy; specifically, (i) whether there is a significant increase in follow-up duration when the serum βhCG is greater than 3000iu/l and (ii) an association between the serum βhCG concentration at presentation and the need for a repeat dose ...
Pecks Ulrich - - 2012
PROBLEM: To address the question of whether the high levels of oxidative modified low-density lipoproteins (oxLDL) in pregnancy are opposed by an appropriate humoral autoimmune response providing anti-oxLDL autoantibodies in maternal serum of healthy women throughout gestation. METHOD OF STUDY: Blood was taken from 33 patients at four different time ...
Zong Lu - - 2012
Objective. To investigate the expression and changes of high-temperature requirement A1 (HtrA1) during pregnancy and the use of this value in predicting preeclampsia. Method. Serum samples were collected from pregnant mothers at different gestational weeks, and double-antibody sandwich enzyme-linked immunosorbent assay was employed to describe the changes in HtrA1 in ...
Cowans N J - - 2012
Objectives: To compare the DELFIA Xpress and Quantikine ELISA placental growth factor (PlGF) immunoassay platforms by analysing the same set of early first-trimester maternal serum samples from cases with trisomy 21 and euploid controls. Methods: Thirty-seven trisomy 21 cases and 243 euploid control serum samples, drawn at 8(+0) to 10(+6) ...
Ferreira A F A - - 2012
The objective of this study was to determine if the maternal serum levels of visfatin in the first trimester of pregnancy are altered in cases that develop preeclampsia (PE) and whether the levels are related to placental perfusion reflected in uterine artery pulsatility index (PI). Serum visfatin and uterine artery ...
Ashoor Ghalia - - 2012
Objective: It was the aim of this study to examine the possible effects of maternal and fetal characteristics on the fetal fraction in maternal plasma cell-free DNA (cfDNA) at 11-13 weeks' gestation. Methods: In a nested case-control study, cfDNA was extracted from maternal plasma obtained before chorionic villous sampling from ...
Negi Reena - - 2012
BACKGROUND & AIMS: Pre-eclampsia is associated with oxidative stress in the maternal circulation. The aim of the study was to access the oxidative stress status by quantification of byproducts generated during lipid peroxidation; deficient antioxidant activity and inadequate trace elements during oxidative damage in the umbilical cord blood of pre-eclamptic/eclamptic ...
Perez-Ferre N - - 2012
Aim: To evaluate the associations of maternal serum 25-Hydroxyvitamin D (25-OH-D) status with glucose homeostasis and obstetric and newborn outcomes in women screened for gestational diabetes mellitus (GDM).Methods: 266 women were screened for GDM at 24-28 week of gestation during the months with maximal sunlight exposure in Spain (June to ...
Tong Stephen - - 2012
: To determine whether serum macrophage inhibitory cytokine-1, pregnancy-associated plasma protein-A (PAPP-A), anandamide, or β-human chorionic gonadotropin (hCG) measured in an asymptomatic population in the middle of the first trimester with a viable fetus predicts subsequent miscarriage. : We undertook a prospective cohort study at Mercy Hospital for Women between ...
Vasudeva Akhila - - 2012
We present a case of recurrent pregnancy loss associated with unusual constellation of utoimmunity-related features such as hypertension, severe hrombocytopenia, hypothyroidism and persistent high titers of perinuclear antineutrophilic cytoplasmic antibodies. Her clinical features did not fit into a particular diagnosis of vasculitides, systemic lupus erythematosis (SLE) or other known autoimmune ...
Mayor Pedro - - 2012
In this study, the period of pregnancy of nine collared peccary females has been monitored through the analysis of serum progesterone and estradiol-17β profiles. Serum concentrations of progesterone increased by Day 4 after conception, reaching concentrations of 33.4±5.6ng/mL on Day 10. Between Days 10 and 130 progesterone values were maintained ...
Casikar Ishwari - - 2012
Background: In the 21(st) century, tubal ectopic pregnancies (EPs) are diagnosed earlier in their natural history due to transvaginal ultrasound technology. More women are haemodynamically stable and therefore can be offered non-invasive outpatient management with systemic Methotrexate (MTX). However there is no evidence that MTX is necessary in all these ...
Heazell Alexander E P - - 2012
Metabolomics offers a powerful holistic approach to examine the metabolite composition of biofluids to identify disruptions present in disease. We used ultra performance liquid chromatography-mass spectroscopy on the maternal serum obtained in the third trimester to address the hypothesis that pregnancies ending in poor outcomes (small for gestational age infant, ...
Zeljkovic Aleksandra - - 2012
Pregnancy is associated with alterations in low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses, but the exact pattern of these variations remains controversial. This study investigates longitudinal changes of plasma LDL and HDL particles distributions during the course of normal pregnancy, as well as associations of maternal LDL and HDL ...
Strom Charles M - - 2012
To determine the sensitivity and specificity of hyperglycosylated hCG (hhCG) measurements for the diagnosis of clinical pregnancies in the IVF setting and how soon post embryo transfer (ET) a pregnancy can be detected using an ultrasensitive (hhCG) assay. To determine if a single, early hhCG measurement can discriminate between biochemical ...
Bowman C J - - 2012
Embryo-fetal biodistribution of a maternally administered humanized IgG2 in rats was evaluated by enzyme-linked immunosorbent assay in dose response and time course studies. Fetal and maternal plasma IgG2 levels increased with dose from 10 to 300mg/kg but fetal:maternal ratio decreased with increasing dose. Plasma IgG2 levels decreased in fetal rat ...
Tongprasert Fuanglada - - 2012
OBJECTIVE: To compare the levels of maternal serum free β-hCG and PAPP-A between pregnancies with fetal homozygous α-thalassemia-1 disease and unaffected pregnancies. MATERIALS AND METHODS: One hundred and forty eight pregnancies at risk for fetal homozygous α-thalassemia-1 disease scheduled for cordocentesis at 18 to 22 weeks were recruited into the ...
Derbent Aysel Uysal - - 2012
Abstract Objective: To evaluate first and second trimester maternal serum markers in pregnancies complicated with inherited thrombophilias. Methods; A case-control study was conducted in 50 pregnancies complicated with hereditary thrombophilia and 100 control pregnancies. Results: Each woman with inherited thrombophilia received low molecular weight heparin (LMWH) throughout her pregnancy. Gravidity, ...
Breukelman S P - - 2012
The aim of this analysis was to determine whether pregnancy loss (PL) after embryo transfer (ET) in cattle was related to maternal progesterone (P4) concentrations during and shortly after ET, and maternal bovine pregnancy-associated glycoprotein-1 (bPAG-1) concentrations in plasma at days 25-35 of gestation. Embryos (n=260) were produced either in ...
Sifakis Stavros - - 2012
Abstract Objective: To investigate whether the maternal serum concentration of human Placental Growth Hormone (PGH) at 11-13 weeks' gestation is altered in pregnancies that deliver small for gestational age (SGA) neonates. Methods: Maternal serum concentration of PGH was measured in 60 cases that subsequently delivered SGA neonates in the absence ...
Imudia Anthony N - - 2012
OBJECTIVE: To assess the impact of elevated peak serum E(2) levels (EPE(2); defined as levels >90th percentile) on the day of hCG administration during controlled ovarian hyperstimulation (COH) for IVF on the likelihood for small for gestational age (SGA), preeclampsia (PreE), and preterm delivery (PTD) in singleton pregnancies. DESIGN: Retrospective ...
Beta Jarek - - 2012
Abstract Objective: To examine the potential value of maternal serum level of ferritin in the first trimester of pregnancy in the prediction of spontaneous early preterm delivery. Methods: Maternal serum concentration of ferritin at 11-13 weeks' gestation was measured in a case-control study of singleton pregnancies delivering phenotypically normal neonates, ...
Fresno L - - 2012
Amniotic fluid exerts a protective function and is an essential component for foetal development and maturation during pregnancy. However, little is known about the exact physiological functions of foetal fluids in this process as well as their biochemical composition in cats. In the present study, the biochemical composition of amniotic ...
El Sherbiny Walid S - - 2012
INTRODUCTION: Placental protein 13 (PP13) is a protein expressed only in the placenta. It is involved in gluing the placenta to the uterus and remodeling the maternal arteries to expand them. Women who subsequently develop preterm preeclampsia have low first trimester maternal serum. AIM OF WORK: The aim of this ...
Di Lorenzo G - - 2012
OBJECTIVE: To evaluate the detection of pregnancy hypertensive disorders by integrating maternal history, serum biomarkers and uterine artery Doppler in the first trimester. METHODS: We prospectively recruited 2118 women that underwent an 11-13 weeks aneuploidy screening. We gathered information on maternal history, uterine artery Doppler and serum biomarkers (PAPP-A, PlGF, ...
Straughen Jennifer K JK Department of Family Medicine and Public Health Sciences, The Wayne State University School of Medicine, Detroit, MI, - - 2012
Soluble fms-like tyrosine kinase 1 (sFlt1) is an antiangiogenic protein that is associated with a number of disorders of placental angiogenesis. It has been hypothesized that disruption of placental angiogenesis may contribute to the pathophysiology of preterm delivery (PTD). However, the relationship of PTD risk to variation in sFlt1 levels ...
Moghaddam Banaem Lida - - 2012
Aim:  The aim of this study was to determine the relationship between maternal serum C-reactive protein (CRP) levels in the first 20 weeks of pregnancy and later occurrence of preterm premature rupture of membranes and preterm birth. Material and Methods:  A prospective cohort study that measured maternal serum CRP levels in ...
Kæstel Pernille - - 2012
Vitamin A deficiencies in pregnancy may impair the health of the mother and the growth, development, and later health of her offspring. However, the understanding of the variability of micronutrient status markers during pregnancy is limited. We measured serum retinol and β-carotene and the acute phase proteins C-reactive protein (CRP) ...
Sezer Selda Demircan - - 2012
Purpose: The aim of this study was to compare maternal and umbilical cord serum levels of the angiogenic and anti-angiogenic factors in early- and late-onset pre-eclamptic pregnancies as well as in normal pregnancies, which might have significant importance in the etiology of pre-eclampsia. Materials and Methods: This prospective case-control study ...
Gremlich S - - 2012
Successful implantation is still the limiting step in IVF. We hypothesized that maternal plasma concentrations of certain cytokines at the time of embryo transfer could predict the likelihood of successful implantation and pregnancy. sIL-2R, IL-6, LIF, and MMP2 concentrations were measured in plasma from 160 IVF patients (natural and stimulated ...
Sakamoto Mineshi - - 2012
Fish is a major source of harmful methylmercury (MeHg) and beneficial docosahexaenoic acid (DHA) in the developing brain. In this study, we investigated the correlations among maternal and umbilical cord (cord) MeHg and DHA levels at parturition, and mercury (Hg) concentration in 1-cm incremental segments hair samples which grew during ...
Rull Kristiina - - 2012
Context:Recurrent miscarriage (RM) (at least three consecutive pregnancy losses) occurs in 1-3% of fertile couples. No biomarkers with high predictive value of threatening miscarriage have been identified.Objective:We aimed to profile whole-genome differential gene expression in RM placental tissue and to determine the protein levels of identified loci in maternal sera ...
Canisso I F - - 2013
Premature luteal demise or luteal insufficiency is not well characterised as a cause of pregnancy loss in domestic species, including horses. In this report, a mare inseminated with cooled-transported semen at our facility returned for a routine pregnancy diagnosis at 15 days post ovulation. Ultrasonography per rectum revealed endometrial oedema ...
Spiliotis I - - 2012
The skeletal muscle proteins, dysferlin (DYSF) and myoferlin (MYOF) have been demonstrated by mass spectrometry to be present in the apical syncytiotrophoblast of the human placenta, where they may play a role in membrane repair. Immunohistochemistry and immunoblotting were performed on placental samples to localize and quantify DYSF and MYOF ...
Zhao Zhen - - 2012
The use of serum human chorionic gonadotropin (hCG) and progesterone to identify patients with ectopic pregnancy (EP) has been shown to have poor clinical utility. Pregnancy-associated circulating microRNAs (miRNAs) have been proposed as potential biomarkers for the diagnosis of pregnancy-associated complications. This proof-of-concept study examined the diagnostic accuracy of various ...
Míková Blanka - - 2012
Background. Dialysis patients are at high risk of cardiovascular complications. Pregnancy-associated plasma protein A (PAPP-A) as well as sRAGE (soluble receptor for advanced glycation end products) are new biomarkers related to cardiovascular disease. The aim of our study was to describe their intra- and inter-individual variability. Methods. The studied group ...
Scholl P F PF Johns Hopkins University, Bloomberg School of Public Health, Department of Environmental Health Sciences, 615 N. Wolfe St., Baltimore, MD 21205-2200, USA. - - 2012
Characterization of normal changes in the serum proteome during pregnancy may enhance understanding of maternal physiology and lead to the development of new gestational biomarkers. In 23 Nepalese pregnant women who delivered at term, two-dimensional difference in-gel electrophoresis (DIGE) was used to assess changes in relative protein abundance between paired ...
Chapinal N - - 2012
The objective was to examine the associations of peripartum concentrations of nonesterified fatty acids (NEFA), β-hydroxybutyrate (BHBA), and calcium with milk production in early lactation and pregnancy at the first artificial insemination (AI) across different management systems. Fifty-five Holstein freestall dairy herds located across the United States and Canada were ...
Daponte Alexandros - - 2012
Anti-Chlamydial trachomatis (anti-CT) responses, particularly anti-heat shock 60 (Hsp60), antibodies confer a higher risk of ectopic pregnancy. With emerging evidence supporting the pivotal role of interleukin-1β (IL-1β) and IL-8 in the immunopathogenesis of CT-specific tubal obstruction, we determined anti-CT Hsp60 antibody reactivity and serum concentrations of IL-1β and IL-8 in ...
Quant Hayley - - 2012
Background. In patients with new onset seizures during pregnancy, it can be challenging to differentiate between eclampsia and other etiologies. Soluble fms-like tyrosine kinase (sFlt1) is an antiangiogenic protein that is elevated in preeclampsia and eclampsia. Case. A multiparous woman presented at 22 weeks gestation with seizures. The initial presentation ...
Rohra D K - - 2012
Background. We hypothesized that pre-eclampsia (PE) can be predicted early in primiparas by measuring serum levels of soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF). Methods. All normotensive primiparas attending the antenatal clinics of Aga Khan University Hospital and Aga Khan Hospital for Women, Karachi, Pakistan without any ...
Crochet John R - - 2012
Progesterone is produced by the corpus luteum until completion of the luteal-placental shift at approximately 6-10 weeks following last menstruation. Studies have shown that first trimester progesterone levels are predictive of pregnancy viability, and some authors support a level of 5 ng/mL as an absolute threshold to indicate viability. A ...
Köşüş Aydin - - 2012
To determine whether assisted reproductive technology (ART) itself or polycystic ovary syndrome (PCOS) as a cause of infertility has any effect on first trimester serum screening results. First trimester serum screening results of ART pregnancies of women with PCOS (IVF-P group) were compared with those of women who underwent ART ...
Kim Jee Hyun - - 2012
This study was performed to assess the prognostic value of serum hCG, progesterone, and inhibin A levels measured at 11 days post-ET for predicting pregnancy outcome in women participating in IVF. Between May 2005 and April 2008, sera were obtained from 70 infertile women who underwent IVF-ET at 11 days ...
Abdul-Hussein Meena M - - 2012
To explore the diagnostic value and measurement of serum CA-125, the single measurement of progesterone (P), ß-HCG, and estradiol (E2) in the early diagnosis of ectopic pregnancy. Serum levels of CA-125, progesterone, ß-HCG and estradiol were measured by Enzyme Linked Immuno Sorbent Assay (ELISA) techniques in 40 symptomatic women with ...
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