An ultrastructural study of the features and distribution of collagen fibrils was performed in the endometrium of virgin and pregnant (2nd to 11th day) mice. Collagen-containing structures were observed in the cytoplasm of fibroblasts on the 2nd day of pregnancy. Treatment of tissues with lanthanum nitrate established that these structures ...

The study describes dermis development in fetal porcine skin between 40 d GA and birth. The first fibroblast arrangement occurs about 47 d GA, while between 60-65 d GA the first fibres are visible. They can be identified as collagen about 67 d GA, somewhat later the dermis shows 2 ...

During pregnancy the collagen content of the human uterus increases sevenfold and the elastin content increases fourfold to fivefold. The stable pyridinoline cross-link is found in uterine collagen at a level of 0.11 mol per mole of collagen. The same ratio, or a higher one, is found at the end ...

The concentration of collagen in the human uterine cervix decreases during pregnancy. This change contributes to the ripening process, which facilitates cervical dilatation during labor. It has been suggested that cervical collagen is partly degraded at term and after delivery. In order to evaluate this hypothesis we investigated the proportion ...

Morphological and developmental characteristics of the rhesus monkey nasopalatine duct system and associated primary palatal structures are described along with functional and phylogenetic considerations. Examination of five adult palates and coronal sections of 13 fetal palates together with dissections of a sixth adult specimen and of a 119-day-old fetal palate ...

Specimens from the uterine wall were obtained from 16 patients at 31 to 40 weeks of pregnancy: 10 underwent surgical procedures for a hypertensive disorder and six for abnormality of the birth canal or faulty presentation. Collagen types I, III, and V and fibronectin antibodies were used for immunohistologic studies. ...

During the course of gestation, changes in the metabolism and chemical composition of the cervical connective tissue occur. The concentrations of collagen, proteoglycan and hyaluronate in the cervix decrease with time of pregnancy, while there is a small but significant increase in tissue hydration. The collagen network loses its dense, ...

Previous investigations of vocal fold lamina propria in adult human larynx have revealed a highly specific organization and distribution of the connective fibres. The authors tried to elicit the developmental characteristics of that process using a material of foetal larynxes, ranging in foetal age from 13 to 23 weeks. The ...

An 18-year old Japanese woman with folded skin in the forehead and scalp was found to have an underly Brachycephaly with peculiar hair lines, broad and sparse eyebrows, bilateral epicanthi, and decreased neck-shoulder angles were found, as well as reticular pigmentation of fingers and toes. Routine laboratory data and endocrine ...

Superficial wounds in a Yorkshire pig were treated with a semiocclusive polyurethane film dressing (PUD) or left open. The number and types of microflora present in the wounds each day was determined by a scrub technique, selective media, and the spiral plating system. In wounds covered with the PUD, the ...

Interrupted serial sections of the foot region from 14 human fetuses, crown-rump (CR) lengths between 32 and 240 mm, were studied, using HE, PAS, Alcian blue, Gomori's trichrome and von Kossa stains. Cartilage canals carrying vascular connective tissue from the perichondrium entered the talus by 68-mm. The centre of ossification ...

This report evaluates a rare case of craniofacial microsomia in a partially developed, malformed heteropagus conjoined twin. In this instance, several major components of the craniofacial complex were involved: bones, cartilage, teeth, salivary glands, auditory apparatus, cerebrum, cranial nerves, and ocular neuroepithelium. In addition, cervical vertebrae and appendicular long bones ...

Connective tissue in biopsy specimens taken from the lower part of the uterine cervix in 40 pregnant women at various gestational ages was compared to that in similar biopsy specimens from 15 nonpregnant women. The concentrations of collagen, sulfated glycosaminoglycans, and hyaluronic acid decreased during pregnancy. At the gestational age ...

Using neutrons activation analysis, the changes in concentrations of Cu, Zn and Mn in hair during pregnancy are studied. Scalp and pubic hair samples from both non-pregnant and pregnant female subjects were analysed. The results of this preliminary study are presented. Cu, Zn and Mn levels in scalp hair obtained ...

Thorough evaluation of all twin pregnancies is necessary if prenatal diagnosis of conjoined twins is to be made more often. Application of sonography, amniography, and amniocentesis is helpful in formulating prognosis, details of delivery, and subsequent assessment. Two-dimensional echocardiography, radionuclide scanning, computed tomography, and sonography are recently developed techniques for ...

Proteoglycans (PGs) are closely associated with cartilage calcification. We have examined the hypertrophic zone of rat epiphyseal cartilage, in which calcification is occurring, using the high-iron diamine-thiocarbohydrazide-silver proteinate (HID-TCH-SP) method for sulfated glycosaminoglycans, an immunoferritin method specific for chondroitin sulfate A, and the tannic acid-ferric chloride (TA-Fe) method to stain ...

The advent of new and effective methods for the neonatal evaluation and treatment of conjoined twins has greatly increased the importance of prenatal diagnosis of this complication. Ultrasonography has become the method used most commonly to diagnose and evaluate multiple pregnancies. All ultrasonographers should be familiar with the signs associated ...

The most widely used knee mechanisms for through-knee amputees can be characterized as three principal types of design. These types are metal side bars with heavy duty joints, conventional knee mechanisms for above-knee amputees and special polycentric linkage mechanisms for through-knee amputees. An investigation in Sweden in 1979 showed that ...

Partly purified somatomedin prepared from adult human plasma stimulated [3H]thymidine and [35S]sulphate uptake into human cartilage. At a final concentration of 0.1 U/ml somatomedin the uptake of [3H]thymidine into fetal cartilage at 18 weeks of gestation was 162 +/- 23% compared with controls. Somatomedin also increased the incorporation of [35S]sulphate ...

Contents and types of asbestos in fireproofing insulation materials sprayed on ceilings of 127 buildings throughout the U.S. were studied. Asbestos was found to be present in more than 50% of the buildings and chrysotile was the main component identified. Frequency distribution of airborne fiber concentrations was lognormal. During renovation ...

The proteoglycans of the cynomolgus monkey corneal stroma were isolated and characterized by using a combination of physiochemical and biochemical methods. Proteoglycans were biosynthetically radiolabeled by incubating whole corneas in medium containing [35S]sulfate and either [3H]serine or [3H]mannose as precursors. Macromolecules were extracted from the corneal stromas with 4 M ...

The case is presented of conjoined twins diagnosed prenatally by ultrasound. Recognition of this obstetric problem allows for rational planning of the pregnancy and delivery, including delivery by cesarean section in an institution equipped with pediatric surgical and neonatal intensive care facilities. Prenatal sonography further allows for investigation of the ...

The sweat gland primordium appeared as a solid bud from the ental side of the epithelial cords of the growing hair follicles in the CRL 36 cm-fetus from the primary hair follicles and in the CRL 64 cm-fetus from the secondary ones. In the CRL 68 cm-fetus the glands were ...

Forty pregnant women attending the high-risk and normal obstetric clinics were evaluated for parietal scalp hair stage ratios during the second and/or third trimesters. In seven of the ten high risk patients from whom hair samples were obtained on two occasions, there was an observed fall in anagen hair percentages. ...

The collagen concentration in rat uterine cervix was less on day 18 of pregnancy than in the non-pregnant animal but did not diminish further as pregnancy proceeded. The solubility of cervical collagen in warm acetic acid (0.5 mol/l) was increased on day 22 compared with days 19, 20 and 21 ...

We subcutaneously injected collagen wound dressing (CAS) extracts equivalent to the area covering human body surface by 35 and 70%, respectively, into mouse dams from days 6 to 15 of pregnancy. No toxicity was observed in dams and no external, skeletal and visceral anomalies related to CAS treatment were observed ...

The effect of acupuncture on the grasp reflex caused by mechanical vibrations of fingers produced by a cylinder-type vibrator (120 Hz) was studied in healthy man. As the hand grasped the vibrator during vibration, the volar surface of all fingers was simultaneously stimulated, resulting in a gradually increased force of ...

The descriptive epidemiology of conjoined twinning in the United States was investigated using data from the Birth Defects Monitoring Program (BDMP), a nationwide congenital malformations surveillance system that monitors discharge diagnoses associated with a third of the births in the United States. This is the largest recorded series concerning conjoined ...

Spontaneous and experimentally induced twinning and conjoined placentation were studied in Swiss-Webster (SW) mice. Conjoined placentation was noticed at a rate of 0.4% for twins and 0.06% for triplets. Placentally conjoined embryos were either symmetrical or asymmetrical. A single spontaneous monozygotic conjoined twin was observed among 2,000 blastocysts cultured in ...

It has been confirmed that glycosaminoglycan is associated with collagen and other constituents of the anulus fibrosus. In cells, it appears to be present on the rough endoplasmic reticulum and is removed by hyaluronidase digestion and thus may consist of chondroitin sulphate. In pericellular material it appears as fibrils and ...

In the fetus with 9 cm CRL the ventricular groove was made up of two lips and a floor. The mucosa consisted of a Lamina epithelialis and a Lamina propria mucosae. The basal zone of the Lamina epithelialis was uneven in the floor of the groove and showed wedge-shaped evaginations ...

In the fetal stage of 9 cm CRL 4 order omasal laminae are present. With increasing age they increase greatly in size and conical papillae are seen projecting from their sides into the lumen. At 27 cm CRL stage sporadic smooth muscle cells in the interlaminar spaces, representing the first ...

1. The occurrence of mineralised tendons in the wing and pelvic limb of the domestic fowl was studied radiographically in adults and in growing birds from hatching to 182 d. 2. Mineralised tendons were found to occur in all the adults in the dorsal and plantar tarsometatarsus and variably in ...

Seventy-four acetabula from a total of 140 normal human fetuses, obtained from abortions and deaths in the prenatal period, were used. The fetuses ranged from 9.1 to 40 cm in crown-rump length and are believed to be between 12 weeks and term. Acetabula were decalcified embedded in paraffin or celloidin, ...

Scanning electron microscopy demonstrates an extensive and highly organized network of collagen in the left ventricle of all species examined. This system is arbitrarily divisible into three major components: a collagen weave network that surrounds groups of myocytes; an extensive array of collagen struts measuring 120 to 150 nm in ...

The effect of parity of maternal hair chromium and the changes during pregnancy were investigated. Hair samples were collected from nulliparous and multiparous women and longitudinally from pregnant women. Chromium was determined by flameless atomic absorption. Mean hair chromium in multiparous women was low when compared with nulliparous women of ...

Conjoined twins of the xiphopagus type have been separated 24 hours after spontaneous delivery. Indication for early intervention was impending rupture of a large omphalocele as well as deterioration of one severely malformed twin who did not survive surgery, whereas the other one showed normal development up to 15 months ...

The first known case of conjoined acardiac monsters in a twin pregnancy is reported. The conjoined monsters shared a single abdominal-thoracic artery and a primitive single-chambered heart. The placenta was monoamniotic with two umbilical cords. A classification of acardia as well as a discussion of possible mechanisms leading to the ...

Glycosaminoglycans and collagen were measured in dried samples of human amnion from pregnancies with and without premature rupture of the membranes. The major sulphated glycosaminoglycans were dermatan and chondroitin sulphates. The concentration of sulphated glycosaminoglycans decreased significantly towards term in both groups of patients (with, r=--0.720, and without, r=-0.631, premature ...

The response of human fetal costal cartilage (gestational age 12--25 weeks) to plasma containing somatomedin activity has been examined in vitro. Uptake of both 3H-thymidine and 35S-sulfate into the cartilage was increased; the increase in 35S-sulfate uptake was relatively constant (mean = 198% of basal, N = 25) throughout the ...

The developmental changes of collagen and mucopolysaccharides in the semilunar values of the mouse were studied during the embryonic, fetal and postnatal period. The valvular collagen was investigated using Van Gieson and Sirius red-polarization microscopy methods. These procedures showed that the establishment of the fibrosa layer of the cusps does ...

In previous studies, we have shown that female sex hormones given in dosages corresponding to plasma levels in the last trimester of pregnancy retard collagen accumulation in early phases of experimental granulation tissue formation. Results of incorporation experiments using radioactive proline reported in this article indicate that this hormone treatment ...

Little is known at the present time about the molecular basis and mechanisms of morphogenesis. The present study is an attempt to determine what influence the extracellular matrix has on the initial outgrowth of the limb bud. Stage -12 to -18 chick embryo lateral plates were examined in relation to ...

In 16 patients with thermal injury, no difference in bacterial clearing was noted when wounds were dressed with cadaver homograft skin, porcine skin, either mesh or sheet, and with amnion. Because of cost and ease we prefer fresh porcine skin for second- and third-degree burns.

The intensity of respiration of the body fragments of the planarian after its division anteriorly and posteriorly to the pharynx was studied. After division anteriorly to the pharynx regeneration takes place. During regeneration of the anterior fragment respiration increases in the first day after the operation and at the differentiation ...

Obstetric, morphopathologic, neonatal, and surgical features of 36 reported cases of xiphopagus conjoined twins were correlated and reveal: (1) a 6% incidence of prenatal diagnosis; (2) a 36% rate of dystocia; (3) a 19% incidence of stillbirths; (4) variation in the extent of fusion; (5) a high rate of occurrence ...

To test the hypothesis that chromium deficiency may be cumulative with age and increasing parity, hair chromium levels were measured in 432 women at delivery. Although the levels in general were lower than those found in nonpregnant women there was no correlation between hair chromium level and age or number ...

The later stages of development (16-40 weeks in utero) of the periotic duct and its adjacent areas in the human fetus indicate that the critical stages of development occur in four specific time related stages over a six-week period (20-26 weeks). First, the petrous apex ossifies to separate th inferior ...

Medial meniscectomy and the creation of "bucket-handle" lesions of the medial meniscus induce mild to moderate osteoarthrotic changes in the knee joints of mature rabbits. The osteoarthrotic lesions studied by gross inspection and histological sections, almost exclusively involve the medial tibial articular cartilage. The pathologic changes begin superficially, pass to ...

This is a follow-up study to an experiment on stress and wound healing which suggested a possible relationship between exposure to heat or cold stressors prior to wounding and reduced ability of the skin to retain the outline of an excised square cutout. The apparent gaping of wounds in stressed ...