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Saleri R R Dipartimento di Scienze Medico-Veterinarie,Università di Parma,Via del Taglio - - 2014
The mechanism of action of leptin in pregnant breeding sows, in which hyperphagia is managed through dietary strategies, is yet to be clarified. The aim of this study was to monitor leptin concentrations and their interactions with lactogenic hormones in Large White×Landrace breeding multiparous sows (n=15). All sows showed a ...
VandeVoort Catherine A CA California National Primate Research Center, University of California, Davis, California; Department of Obstetrics and Gynecology, University of California, Davis, California. Electronic address: - - 2014
To determine if binge ethanol consumption before ovulation affects oocyte quality, gene expression, and subsequent embryo development. Binge levels of ethanol were given twice weekly for 6 months, followed by a standard in vitro fertilization cycle and subsequent natural mating. National primate research center. Adult female rhesus monkeys. Binge levels of ethanol, ...
Argañaraz Me M Laboratorio Investigaciones en Reproducción Animal (LIRA), Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET, San Miguel de Tucuman, Argentina; Cátedra de Biología Celular y Molecular, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán, San Miguel de Tucuman, - - 2014
South American camelids show high embryo loss rate, during the first 60 days of pregnancy. One of the factors which may be related to this situation is that over 98% of the embryos implant in the left uterine horn (LUH) even though both ovaries contribute similarly to ovulation. There is scarce ...
Hitit M M Selcuk University, Konya, - - 2014
A set of genes that display differential expression levels in the reproductive tract could serve as beneficial markers of endometrial receptivity. SERPINA14 is present in the uterus during pregnancy and suppresses lymphocyte accumulation. Osteopontin is the ligand of integrin β3 and enables trophoblast communication during implantation. Leukemia inhibitory factor (LIF) ...
Ozel C C Selcuk University, Konya, - - 2014
Phospholipase A2 (PLA2) is involved in the synthesis of prostaglandins (PG) as it releases arachidonic acid from the membrane phospholipids to be a precursor for cyclooxygenase enzymes. Therefore, it is critically important during luteolysis and at the time of maternal recognition of pregnancy. The embryo must attenuate endometrial PGF2α production, ...
Yao Yuan Y Department of Laboratory Medicine, Southwest Hospital, Third Military Medical University, Chongqing 400038, - - 2014
Objective: In this study, we aimed to search for noninvasive predictive biomarkers for prenatal diagnosis of Down's syndrome (DS). Methods: Maternal serum samples from five DS-affected pregnant women and five DS-unaffected women were analyzed by 2D gel electrophoresis and MALDI-TOF mass spectrometry to screen for potential predictive biomarkers of DS. ...
Stach Sonia Christina Leme SC Department of Obstetrics and Gynecology, São Paulo University Medical School, - - 2014
Group B Streptococcus (GBS), Klebsiella spp. and Pseudomonas spp. are important etiological agents of neonatal infections in Brazil. There is a lack of data in the literature regarding the specific transport of immunoglobulin G (IgG) against these pathogens in multiple pregnancies. Maternal (n=55) and umbilical cord (n=110) blood samples were ...
Ephraim Richard - - 2014
BackgroundHypertensive disorders of pregnancy are important causes of morbidity and mortality. The levels of calcium (Ca2+) and magnesium (Mg2+) in pregnancy may implicate their possible role in pregnancy-induced hypertension. This study assessed serum Ca2+ and Mg2+ levels in women with PIH (pregnancy-induced hypertension) and PE (pre-eclampsia), compared to that in ...
Tsai Yi-Ru YR Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital, Change Gung University, Kaohsiung, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Change Gung University, Kaohsiung, - - 2014
To assess whether progesterone elevation is the only factor in determining outcomes of in vitro fertilization (IVF). Retrospective cohort study. Infertility clinic at Kaohsiung Chang Gung Memorial Hospital, Taiwan. One thousand five hundred eight women undergoing a total of 1,508 IVF cycles. None. Clinical pregnancy and live-birth rates. Patients were classified ...
Fort Marta M Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Jordi Girona, 18, 08034 Barcelona, Catalonia, - - 2014
Cobalt is an essential trace element but may cause toxic effects upon occupational or environmental exposure. Women accumulate more cobalt than men at similar exposure levels which may be related to higher metabolic iron loss. During pregnancy these losses are much stronger but their influence on cobalt intake has not ...
Watkins Deborah J DJ Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, United - - 2014
Phenols and parabens are used in a multitude of consumer products resulting in ubiquitous human exposure. Animal and in vitro studies suggest that exposure to these compounds may be related to a number of adverse health outcomes, as well as potential mediators such as oxidative stress and inflammation. We examined ...
Uzunlar Ozlem O Obstetrics and Gynecology Department, Zekai Tahir Burak Women Health Training and Research Hospital, Ankara, Turkey, - - 2014
The aim of this study was to estimate the level of liver fatty acid binding protein (LFABP) in women with preeclampsia. A case-control study was conducted in 90 pregnant women who were divided into the following three groups: normal pregnancy (n = 30), mild-moderate preeclampsia (n = 30), and severe preeclampsia (n = 30). Maternal blood ...
Hohwü Lena L Section for General Practice, Institute of Public Health, Aarhus University, Aarhus, Denmark. Electronic address: - - 2014
Animal and human studies suggest that programing of the hypothalamic-pituitary-adrenal (HPA) axis may be involved in the development of obesity, but human studies of biological indicators of HPA axis activity are lacking. We studied the association between levels of the stress hormone cortisol during pregnancy and overweight offspring during childhood ...
Milhorn Denise D Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, - - 2014
It is unclear if the point-of-care (POC) Clinitest hCG device is subject to high-dose hook interference from physiological concentrations of intact human chorionic gonadotropin (hCG), β-core fragment of hCG (hCGβcf), and hCG free β-subunit (hCGβ) found in urine during pregnancy. We used a simulation model to address this question and ...
Wagner C L CL Medical University of South Carolina Children's Hospital, Charleston, SC, USA. Electronic address: - - 2014
There have been observational reports that maternal vitamin D status at baseline and not closest to delivery is a better predictor of pregnancy outcomes, suggesting that a cascade of events is set into motion that is not modifiable by vitamin D supplementation during later pregnancy. To address this issue, in ...
Hallstensen Randi Fykse RF Division of Internal Medicine, Nordland Hospital, Bodø, - - 2014
Eculizumab is a humanized IgG2/4 chimeric anti-complement C5 antibody used to treat patients with paroxysmal nocturnal hemoglobinuria (PNH) or atypical hemolytic uremic syndrome. The aim of this study was to evaluate whether or not the complement activity in newborns from pregnant women who receive eculizumab is impaired. A novel eculizumab-C5 ...
Ballendine Stephanie A SA Dept. of Physiology, University of Saskatchewan, GB33, Health Sciences Building, 107 Wiggins Rd, Saskatoon, SK S7N5E5, - - 2014
Research suggests that maternal immune activation (MIA) during pregnancy increases the risk of neurodevelopmental disorders including schizophrenia and autism in the offspring. Current theories suggest that inflammatory mediators including cytokines and chemokines may underlie the increased risk of these disorders in humans. For example, elevated maternal interleukin-8 (IL-8) during pregnancy ...
Amelkina Olga O Department of Reproduction Biology, Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany. Electronic address: - - 2014
In the present study, we aimed to histologically stage and characterize the structural life span of the CL in the domestic cat. Moreover, the intraluteal levels of progesterone and estrogens were determined throughout the pregnant and nonpregnant (pseudopregnant, PP) luteal phases. On the basis of observed histomorphology of CL, the ...
Sakumoto Ryosuke R Animal Physiology Research Unit, National Institute of Agrobiological Sciences, Ibaraki 305-0901, - - 2014
To determine functional differences between the corpus luteum (CL) of the estrous cycle and pregnancy in cows, gene expression profiles were compared using a 15 K bovine oligo DNA microarray. In the pregnant CL at days 20-25, 40-45 and 150-160, the expressions of 138, 265 and 455 genes differed by a ...
Kremer Andreas E AE Tytgat Institute for Liver and Intestinal Research and Department of Hepatology & Gastroenterology, Academic Medical Center, University of Amsterdam, Amsterdam The Netherlands; Department of Medicine I, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, - - 2014
Intrahepatic cholestasis of pregnancy (ICP) is defined by pruritus, elevated total fasting serum bile salts (TBS) and transaminases, and an increased risk of adverse fetal outcome. An accurate diagnostic marker is needed. Increased serum autotaxin correlates with cholestasis-associated pruritus. We aimed to unravel the diagnostic accuracy of autotaxin in ICP. ...
Dochez Vincent V Department of Obstetrics and Gynecology, Centre Hospitalier Departemental, 85000, La Roche sur Yon, - - 2014
Primary hyperparathyroidism (pHPT) during pregnancy is rare and associated with increased morbidity and mortality for both mother and fetus. This review aims to draw together recent thinking on pregnancy and pHPT. We have performed a Pubmed (Medline(®)) search with no time limit using "primary hyperparathyroidism", "pregnancy" or "management" as keywords. ...
Tian Chun-Fang CF Department of Obstetrics and Gynecology, Shenzhen Seventh People's Hospital, Shenzhen, Guangdong 518081, P.R. - - 2014
Chorioamnionitis is common in females with prematurely ruptured fetal membranes (PROM). The current diagnosis of PROM and preterm PROM (PPROM) is based on vaginal fluid analysis. The present study investigated the value of serum β-human chorionic gonadotropin (β-hCG) and interleukin-1 (IL-1) levels in diagnosing chorioamnionitis. In total, 150 term-pregnancy patients ...
Kimiaee Parichehr P *Department of Gynecologic and Obstetrics, Mahdiyeh Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran; †Mahdiyeh Hospital, Shahid Beheshti University of Medical Sciences; ‡Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences; §Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran; and ∥Prevention of Psychosocial Injuries Research Centre, Ilam University of Medical Sciences, Ilam, - - 2014
The aim of this study was to reach a publicly applicable marker, using the increasing or decreasing trend of different forms of β-human chorionic gonadotropin (β-hCG) during the first 28 days after molar pregnancy evacuation. The present retrospective cohort study investigated all of the documents of patients with hydatidiform mole ...
Mitrovic Slobodanka Lj SLj Faculty of Medical Science, Kragujevac, Serbia, Department of Pathology, Clinical Center Kragujevac, Kragujevac, Serbia. - - 2014
Choriocarcinoma is the most aggressive, malignant form of gestational trophoblastic disease and has varying incidence, increasing in patients older than 40 years. It usually develops after a malignant alteration in a molar pregnancy, but rarely after an abortion or normal or ectopic pregnancies. The most common localization is the uterus, ...
Chowdary Pratima P Katharine Dormandy Haemophilia Centre and Thrombosis Unit, Royal Free Hospital, London, - - 2014
Low molecular weight heparin (LMWH) given to inhibit coagulation and reduce the risk of thrombosis, is typically monitored by anti-Xa assay. However, anti-Xa levels may not necessarily provide an accurate measure of coagulation inhibition. Moreover, pregnancy is associated with hypercoagulability, which may compromise the efficacy of LMWH. We looked at ...
Nwaru Bright I BI Allergy and Respiratory Research Group, Centre for Population Health Sciences, University of - - 2014
Maternal nutritional status during pregnancy has been reported to be associated with childhood asthma and atopic disease. The Avon Longitudinal Study of Parents and Children has reported associations between reduced umbilical cord Fe status and childhood wheeze and eczema; however, follow-up was short and lung function was not measured. In ...
Lin Xian-Hua XH Key Laboratory of Reproductive Genetics, Ministry of Education, Zhejiang University, Hangzhou, People's Republic of China; Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University, Hangzhou, People's Republic of - - 2014
To examine epithelial Na(+) channel (ENaC) expression in endometrium of overweight/obese women with polycystic ovary syndrome (PCOS) during the window of implantation, and to explore the mechanism linking leptin-mediated reduction of γ-ENaC to low endometrial receptivity. Controlled, prospective, clinical, experimental study. University-based infertility center. Blood and endometrium samples were collected ...
Haghmorad Dariush D Immunology Research Center, BuAli Research Institute, Department of Immunology and Allergy, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Student Research Committee, Mashhad University of Medical Sciences, Mashhad, - - 2014
Pregnancy suppressive effect on autoimmune diseases including Multiple Sclerosis and Rheumatoid Arthritis may result from high levels of sex steroids such as estrogen and estriol. This study was designed to reveal the molecular and cellular mechanisms underlying the effect of estrogen on MS alleviation. Female C57BL/6 mice were immunized with ...
Przygrodzkaa E E Department of Hormonal Action Mechanisms, Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Olsztyn, Poland; Molecular Biology Core Facility, Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Olsztyn, - - 2014
The studies on the acquisition of luteolytic sensitivity have been focused mainly on molecular changes induced in the luteal tissue after treatment with exogenous PGF2α or on physiological changes occurring during the estrous cycle. The comparison of changes leading to the acquisition of luteolytic sensitivity after Day 12 of the ...
Arya Ravi P RP Hepatitis Group, National Institute of Virology, Pune, - - 2014
Hepatitis E virus (HEV) causes high mortality among pregnant women. Pathogenesis of HEV, especially during pregnancy, is poorly understood. Our aim was to assess the role of Toll-like-receptors (TLRs) in hepatitis E patients with pregnancy (Antenatal care, ANC) or without pregnancy (non-ANC). The patient categories included acute-phase, non-ANC (n=46) and ...
Al-Balushi Mohammed S MS Departments of Microbiology & Immunology, Sultan Qaboos University, Muscat, - - 2014
Antiphospholipid antibodies fluctuate during a healthy normal pregnancy. This study aimed to investigate the levels of both immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies for cardiolipin and β2-glycoprotein (β2GP) among healthy pregnant women. This study was conducted between May 2010 and December 2012. A total of 75 healthy Omani ...
Jalkanen Anna A Division of Clinical Neurosciences, Turku University Hospital, PL 52, 20521, Turku, Finland, - - 2014
During pregnancy, alterations take place in mother's immune system with the goal of maintaining a successful pregnancy, and delivering healthy offspring. Immune alterations include activation of the innate immune system and dampening of cell-mediated adaptive immunity. Due to these alterations, cell-mediated autoimmune diseases typically ameliorate during pregnancy. The objectives of ...
Huda Sabrina S Department of Paediatrics, Faculty of Dentistry, University of Toronto, Toronto, - - 2014
Background: A multitude of studies suggest an association between periodontal disease and adverse birth outcomes but the findings have been equivocal. Although the evidence is controversial, it is biologically plausible, and the key link maybe inflammation. Since periodontitis is at times either active or inactive, trying to correlate the presence ...
Martins-Júnior Helio A HA ThoMSon Mass Spectrometry Laboratory, Institute of Chemistry, University of Campinas (UNICAMP), Campinas, SP, - - 2014
The plasma levels of corticosteroids and sex steroids during pregnancy are key indicators of mammalian placental function and the onset of parturition. Steroid hormones are believed to be disturbed in pregnancies produced using assisted reproductive technologies (ARTs) due to placental dysfunction and the frequently observed lack of parturition signals. To ...
Miettinen Helena E HE Department of Medicine, Division of Internal Medicine, University of Helsinki, Biomedicum Helsinki, Helsinki, - - 2014
We examined serum cholesterol synthesis and absorption markers and their association with neonatal birth weight in obese pregnancies affected by gestational diabetes mellitus (GDM). Pregnant women at risk for GDM (BMI >30 kg/m(2)) were enrolled from maternity clinics in Finland. GDM was determined from the results of an oral glucose ...
Oztas Efser - - 2014
Abstract Aim: Our aim was to investigate whether any hematological changes readily detectable by simple complete blood count (CBC), as well as fasting and postprandial total serum bile acid (SBA) levels, have diagnostic values for the prediction of adverse pregnancy outcomes in intrahepatic cholestasis of pregnancy (ICP). Methods: A prospective, ...
Ulkumen Burcu Artunc BA Celal Bayar University, School of Medicine, Department of Obstetrics and Gynecology, Manisa, - - 2014
Abstract Objective: The aim of the present study was to evaluate changes in maternal serum Neutrophil Gelatinase-associated Lipocalin (NGAL) and procalcitonin (PCT) concentrations in preeclampsia. Material and method: This case-control study consisted of 40 preeclamptic and 40 healthy singleton pregnancies matched for age and body mass index. Serum NGAL and ...
Sakar Mehmet Nafi MN Department of Obstetrics and Gynecology, Suleymaniye Maternity Education and Research Hospital, Istanbul, - - 2014
Abstract Objective: Pregnancy induced hypertension is one of the most important cause of maternal-fetal morbidity and mortality. Pregnancy related hypertensive disorders are usually associated with diminished nitric oxide (NO) levels. We aimed to evaluate the role of serum NO levels and eNOS gene G894T polymorphism on hypertensive disorders of pregnancy. ...
Hong Sung Nam SN Department of Obstetrics and Gynecology, School of Medicine, Samsung Changwon Hospital, Sungkyungkwan University, Changwon, - - 2014
Impaired angiogenesis of the developing placenta in the early pregnancy is one etiology of preterm delivery. Vascular endothelial growth factor (VEGF) is a key regulator of normal angiogenesis. Leptin stimulates other angiogenic factors, including VEGF. In this study, we aimed to investigate whether levels of VEGF and leptin in amniotic ...
Chen Danqing - - 2014
BackgroundOffspring of pregnancy complicated with gestational diabetes (GDM) are at high risk for metabolic diseases. The mechanisms behind the association of intrauterine exposure to GDM and high risk of health problems in later life remain largely unknown. The aim of this study was to clarify the alteration in methylation levels ...
Huynh Lise L Family medicine resident at the University of Toronto in Ontario practising with the Toronto Western Hospital Family Health Team in the University Health - - 2014
To review the recent evidence behind the association of low levels (ie, below the fifth percentile) of pregnancy-associated plasma protein A (PAPP-A) with adverse perinatal outcomes and to integrate new findings with the recommendations made by the Society of Obstetricians and Gynaecologists of Canada in 2008. A review of recently ...
Jafrin W W Dr Wahida Jafrin, Assistant Professor, Department of Biochemistry, Mymensingh Medical College, Mymensingh, - - 2014
Pre-eclampsia is a disease which causes significant maternal and fetal morbidity and mortality, especially in the developing countries. Despite numerous studies, the etiology of pre-eclampsia has not yet been fully elucidated. Although several evidences indicate that various elements such as serum Magnesium, Calcium etc. might play an important role in ...
Cleys Ellane R ER Department of Biomedical Sciences, Colorado State University, Fort Collins, - - 2014
Despite reports that circulating levels of maternal serum exosomes increase during pregnancy and that placenta-specific microRNAs (miRNAs) have been identified in humans, little is known about exosomes and miRNAs during pregnancy in agriculture animals. In this study, we characterized the expression of 94 miRNAs in ovine placentomes at gestation day ...
Schneuer Francisco J FJ Clinical and Population Perinatal Health Research, Kolling Institute of Medical Research, University of Sydney, Sydney, NSW, - - 2014
Abstract Aims: To assess soluble endothelial cell-specific tyrosine kinase receptor (sTie-2) levels in the first trimester of pregnancy and its association with adverse pregnancy outcomes; and examine the predictive accuracy. Study Design: In this nested case-control study, serum sTie-2 levels were measured in 2,616 women with singleton pregnancies attending first ...
Franasiak Jason M JM Division of Reproductive Endocrinology, Department of Obstetrics, Gynecology and Reproductive Sciences, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey. Electronic address: - - 2014
To characterize the relationship between serum 25-hydroxy vitamin D (25-OH D) levels and implantation and clinical pregnancy rates in women who undergo a euploid blastocyst embryo transfer. This retrospective cohort study, conducted in an academic setting, included 529 cycles in which comprehensive chromosome screening was performed as part of routine ...
Nair Rohini R RR Department of Molecular & Human Genetics, Banaras Hindu University, Varanasi, - - 2014
The contribution of systemic S100A8 protein in menstrual cycle, pregnancy, and early pregnancy loss (EPL) is not known. Altered expression of S100A8 in maternal decidua is associated with recurrent early pregnancy loss. The objective of this study was to investigate the systemic level of S100A8 in different phases of menstrual ...
Christiansen S C SC Department of Endocrinology, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway; Unit for Applied Clinical Research, Institute for Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway. Electronic address: - - 2014
Some pregnancy complications are characterized by increased levels of cell-free fetal (cffDNA) and maternal DNA (cfmDNA), the latter may also be elevated during physical strain. This study aims at assessing the impact of exercise and metformin intervention in pregnancy, and to compare the levels of cell free DNA in pregnant ...
Bikov Andras - - 2014
Asthma is one of the most common conditions which complicate pregnancy. Pro- and anti-apoptotic mechanisms can be modulated by asthma accompanying pregnancy. Survivin, an anti-apoptotic protein has been implicated in the pathomechanism of asthma and also in the development of pathological pregnancies; however survivin has not been studied in pregnant ...
Berger Peter P Institute for Biomedical Aging Research, University of Innsbruck, Rennweg 10, A6020 Innsbruck, Austria. Electronic address: - - 2014
Pregnancy tests for human chorionic gonadotrophin (hCG) are used widely in hospital and home settings. Assays measuring hCG also have uses in prenatal screening and oncology. The output from three recent international workshops provides a framework for reliable measurement of hCG. Requirements for future hCG assays include use of clear ...
Cıkman Muzaffer Seyhan MS Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Education and Research Hospital, Altindag, Ankara, - - 2014
To determine whether inherited thrombophilia affects components of second trimester combined aneuploidy screening test. A case-control study was performed between 1 December 2010 and 1 February 2012, at a tertiary referral hospital. Singleton pregnancies with inherited thrombophilia that underwent second trimester (16-19(+6) week) combined aneuploidy screening test were included in ...
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