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Refaat Bassem - - 2014
Embryo implantation is a major prerequisite for the successful establishment of pregnancy. Ectopic implantation outside the intrauterine cavity and the development of ectopic pregnancy (EP) is a major cause of maternal morbidity and occasionally mortality during the first trimester. EP may be induced by failure of tubal transport and/or increased ...
Ephraim Richard - - 2014
BackgroundHypertensive disorders of pregnancy are important causes of morbidity and mortality. The levels of calcium (Ca2+) and magnesium (Mg2+) in pregnancy may implicate their possible role in pregnancy-induced hypertension. This study assessed serum Ca2+ and Mg2+ levels in women with PIH (pregnancy-induced hypertension) and PE (pre-eclampsia), compared to that in ...
Uzunlar Ozlem O Obstetrics and Gynecology Department, Zekai Tahir Burak Women Health Training and Research Hospital, Ankara, Turkey, - - 2014
The aim of this study was to estimate the level of liver fatty acid binding protein (LFABP) in women with preeclampsia. A case-control study was conducted in 90 pregnant women who were divided into the following three groups: normal pregnancy (n = 30), mild-moderate preeclampsia (n = 30), and severe preeclampsia (n = 30). Maternal blood ...
Sakumoto Ryosuke R Animal Physiology Research Unit, National Institute of Agrobiological Sciences, Ibaraki 305-0901, - - 2014
To determine functional differences between the corpus luteum (CL) of the estrous cycle and pregnancy in cows, gene expression profiles were compared using a 15 K bovine oligo DNA microarray. In the pregnant CL at days 20-25, 40-45 and 150-160, the expressions of 138, 265 and 455 genes differed by a ...
Dochez Vincent V Department of Obstetrics and Gynecology, Centre Hospitalier Departemental, 85000, La Roche sur Yon, - - 2014
Primary hyperparathyroidism (pHPT) during pregnancy is rare and associated with increased morbidity and mortality for both mother and fetus. This review aims to draw together recent thinking on pregnancy and pHPT. We have performed a Pubmed (Medline(®)) search with no time limit using "primary hyperparathyroidism", "pregnancy" or "management" as keywords. ...
Tian Chun-Fang CF Department of Obstetrics and Gynecology, Shenzhen Seventh People's Hospital, Shenzhen, Guangdong 518081, P.R. - - 2014
Chorioamnionitis is common in females with prematurely ruptured fetal membranes (PROM). The current diagnosis of PROM and preterm PROM (PPROM) is based on vaginal fluid analysis. The present study investigated the value of serum β-human chorionic gonadotropin (β-hCG) and interleukin-1 (IL-1) levels in diagnosing chorioamnionitis. In total, 150 term-pregnancy patients ...
Kimiaee Parichehr P *Department of Gynecologic and Obstetrics, Mahdiyeh Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran; †Mahdiyeh Hospital, Shahid Beheshti University of Medical Sciences; ‡Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences; §Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran; and ∥Prevention of Psychosocial Injuries Research Centre, Ilam University of Medical Sciences, Ilam, - - 2014
The aim of this study was to reach a publicly applicable marker, using the increasing or decreasing trend of different forms of β-human chorionic gonadotropin (β-hCG) during the first 28 days after molar pregnancy evacuation. The present retrospective cohort study investigated all of the documents of patients with hydatidiform mole ...
Mitrovic Slobodanka Lj SLj Faculty of Medical Science, Kragujevac, Serbia, Department of Pathology, Clinical Center Kragujevac, Kragujevac, Serbia. - - 2014
Choriocarcinoma is the most aggressive, malignant form of gestational trophoblastic disease and has varying incidence, increasing in patients older than 40 years. It usually develops after a malignant alteration in a molar pregnancy, but rarely after an abortion or normal or ectopic pregnancies. The most common localization is the uterus, ...
Chowdary Pratima P Katharine Dormandy Haemophilia Centre and Thrombosis Unit, Royal Free Hospital, London, - - 2014
Low molecular weight heparin (LMWH) given to inhibit coagulation and reduce the risk of thrombosis, is typically monitored by anti-Xa assay. However, anti-Xa levels may not necessarily provide an accurate measure of coagulation inhibition. Moreover, pregnancy is associated with hypercoagulability, which may compromise the efficacy of LMWH. We looked at ...
Nwaru Bright I BI Allergy and Respiratory Research Group, Centre for Population Health Sciences, University of - - 2014
Maternal nutritional status during pregnancy has been reported to be associated with childhood asthma and atopic disease. The Avon Longitudinal Study of Parents and Children has reported associations between reduced umbilical cord Fe status and childhood wheeze and eczema; however, follow-up was short and lung function was not measured. In ...
Al-Balushi Mohammed S MS Departments of Microbiology & Immunology, Sultan Qaboos University, Muscat, - - 2014
Antiphospholipid antibodies fluctuate during a healthy normal pregnancy. This study aimed to investigate the levels of both immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies for cardiolipin and β2-glycoprotein (β2GP) among healthy pregnant women. This study was conducted between May 2010 and December 2012. A total of 75 healthy Omani ...
Jalkanen Anna A Division of Clinical Neurosciences, Turku University Hospital, PL 52, 20521, Turku, Finland, - - 2014
During pregnancy, alterations take place in mother's immune system with the goal of maintaining a successful pregnancy, and delivering healthy offspring. Immune alterations include activation of the innate immune system and dampening of cell-mediated adaptive immunity. Due to these alterations, cell-mediated autoimmune diseases typically ameliorate during pregnancy. The objectives of ...
Huda Sabrina S Department of Paediatrics, Faculty of Dentistry, University of Toronto, Toronto, - - 2014
Background: A multitude of studies suggest an association between periodontal disease and adverse birth outcomes but the findings have been equivocal. Although the evidence is controversial, it is biologically plausible, and the key link maybe inflammation. Since periodontitis is at times either active or inactive, trying to correlate the presence ...
Martins-Júnior Helio A HA ThoMSon Mass Spectrometry Laboratory, Institute of Chemistry, University of Campinas (UNICAMP), Campinas, SP, - - 2014
The plasma levels of corticosteroids and sex steroids during pregnancy are key indicators of mammalian placental function and the onset of parturition. Steroid hormones are believed to be disturbed in pregnancies produced using assisted reproductive technologies (ARTs) due to placental dysfunction and the frequently observed lack of parturition signals. To ...
Miettinen Helena E HE University of Helsinki, Finland; - - 2014
We examined serum cholesterol synthesis and absorption markers and their association with neonatal birth weight in obese pregnancies affected by gestational diabetes mellitus (GDM). Pregnant women at risk for GDM (BMI>30 kg/m2) were enrolled from maternity clinics in Finland. GDM was determined from the results of an oral glucose tolerance ...
Oztas Efser - - 2014
Abstract Aim: Our aim was to investigate whether any hematological changes readily detectable by simple complete blood count (CBC), as well as fasting and postprandial total serum bile acid (SBA) levels, have diagnostic values for the prediction of adverse pregnancy outcomes in intrahepatic cholestasis of pregnancy (ICP). Methods: A prospective, ...
Ulkumen Burcu Artunc BA Celal Bayar University, School of Medicine, Department of Obstetrics and Gynecology, Manisa, - - 2014
Abstract Objective: The aim of the present study was to evaluate changes in maternal serum Neutrophil Gelatinase-associated Lipocalin (NGAL) and procalcitonin (PCT) concentrations in preeclampsia. Material and method: This case-control study consisted of 40 preeclamptic and 40 healthy singleton pregnancies matched for age and body mass index. Serum NGAL and ...
Sakar Mehmet Nafi MN Department of Obstetrics and Gynecology, Suleymaniye Maternity Education and Research Hospital, Istanbul, - - 2014
Abstract Objective: Pregnancy induced hypertension is one of the most important cause of maternal-fetal morbidity and mortality. Pregnancy related hypertensive disorders are usually associated with diminished nitric oxide (NO) levels. We aimed to evaluate the role of serum NO levels and eNOS gene G894T polymorphism on hypertensive disorders of pregnancy. ...
Hong Sung Nam SN Department of Obstetrics and Gynecology, School of Medicine, Samsung Changwon Hospital, Sungkyungkwan University, Changwon, - - 2014
Impaired angiogenesis of the developing placenta in the early pregnancy is one etiology of preterm delivery. Vascular endothelial growth factor (VEGF) is a key regulator of normal angiogenesis. Leptin stimulates other angiogenic factors, including VEGF. In this study, we aimed to investigate whether levels of VEGF and leptin in amniotic ...
Chen Danqing - - 2014
BackgroundOffspring of pregnancy complicated with gestational diabetes (GDM) are at high risk for metabolic diseases. The mechanisms behind the association of intrauterine exposure to GDM and high risk of health problems in later life remain largely unknown. The aim of this study was to clarify the alteration in methylation levels ...
Huynh Lise L Family medicine resident at the University of Toronto in Ontario practising with the Toronto Western Hospital Family Health Team in the University Health - - 2014
To review the recent evidence behind the association of low levels (ie, below the fifth percentile) of pregnancy-associated plasma protein A (PAPP-A) with adverse perinatal outcomes and to integrate new findings with the recommendations made by the Society of Obstetricians and Gynaecologists of Canada in 2008. A review of recently ...
Cleys Ellane R ER Department of Biomedical Sciences, Colorado State University, Fort Collins, - - 2014
Despite reports that circulating levels of maternal serum exosomes increase during pregnancy and that placenta-specific microRNAs (miRNAs) have been identified in humans, little is known about exosomes and miRNAs during pregnancy in agriculture animals. In this study, we characterized the expression of 94 miRNAs in ovine placentomes at gestation day ...
Schneuer Francisco J FJ Clinical and Population Perinatal Health Research, Kolling Institute of Medical Research, University of Sydney, Sydney, NSW, - - 2014
Abstract Aims: To assess soluble endothelial cell-specific tyrosine kinase receptor (sTie-2) levels in the first trimester of pregnancy and its association with adverse pregnancy outcomes; and examine the predictive accuracy. Study Design: In this nested case-control study, serum sTie-2 levels were measured in 2,616 women with singleton pregnancies attending first ...
Franasiak Jason M JM Division of Reproductive Endocrinology, Department of Obstetrics, Gynecology and Reproductive Sciences, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey. Electronic address: - - 2014
To characterize the relationship between serum 25-hydroxy vitamin D (25-OH D) levels and implantation and clinical pregnancy rates in women who undergo a euploid blastocyst embryo transfer. This retrospective cohort study, conducted in an academic setting, included 529 cycles in which comprehensive chromosome screening was performed as part of routine ...
Nair Rohini R RR Department of Molecular & Human Genetics, Banaras Hindu University, Varanasi, - - 2014
The contribution of systemic S100A8 protein in menstrual cycle, pregnancy, and early pregnancy loss (EPL) is not known. Altered expression of S100A8 in maternal decidua is associated with recurrent early pregnancy loss. The objective of this study was to investigate the systemic level of S100A8 in different phases of menstrual ...
Christiansen S C SC Department of Endocrinology, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway; Unit for Applied Clinical Research, Institute for Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway. Electronic address: - - 2014
Some pregnancy complications are characterized by increased levels of cell-free fetal (cffDNA) and maternal DNA (cfmDNA), the latter may also be elevated during physical strain. This study aims at assessing the impact of exercise and metformin intervention in pregnancy, and to compare the levels of cell free DNA in pregnant ...
Bikov Andras - - 2014
Asthma is one of the most common conditions which complicate pregnancy. Pro- and anti-apoptotic mechanisms can be modulated by asthma accompanying pregnancy. Survivin, an anti-apoptotic protein has been implicated in the pathomechanism of asthma and also in the development of pathological pregnancies; however survivin has not been studied in pregnant ...
Berger Peter P Institute for Biomedical Aging Research, University of Innsbruck, Rennweg 10, A6020 Innsbruck, Austria. Electronic address: - - 2014
Pregnancy tests for human chorionic gonadotrophin (hCG) are used widely in hospital and home settings. Assays measuring hCG also have uses in prenatal screening and oncology. The output from three recent international workshops provides a framework for reliable measurement of hCG. Requirements for future hCG assays include use of clear ...
Cıkman Muzaffer Seyhan MS Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Education and Research Hospital, Altindag, Ankara, - - 2014
To determine whether inherited thrombophilia affects components of second trimester combined aneuploidy screening test. A case-control study was performed between 1 December 2010 and 1 February 2012, at a tertiary referral hospital. Singleton pregnancies with inherited thrombophilia that underwent second trimester (16-19(+6) week) combined aneuploidy screening test were included in ...
Meddeb Sawsen S Department of Gynecology and Obstetrics, Farhat Hached University Hospital, Sousse, Tunisia; Research Laboratory in Quality of Maternal Health Care in Tunisia. Electronic address: - - 2014
Choriocarcinoma is a highly malignant trophoblastic neoplasm. Its association with ectopic pregnancy is very rare and usually with aggressive behavior. We report a new case arising in an interstitial pregnancy occurring in a 46-year-old woman. The patient was admitted for severe pelvic pain and abundant metrorrhagia. One month ago, she ...
Nalla Amarnadh A Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen; The Danish Diabetes Academy, Odense University Hospital, Odense; Center for Fetal Programming, - - 2014
Several studies have shown an increase in beta cell mass during pregnancy. Somatolactogenic hormones are known to stimulate proliferation of existing beta cells in rodents whereas the mechanism in humans is still unclear. We hypothesize that in addition to somatolactogenic hormones there are other circulating factors involved in beta cell ...
Marom-Haham Lilach - - 2014
Abstract Objective: Magnesium sulfate (MgSO4) administered to women at risk for preterm delivery decreases the risk of cerebral palsy in their children. However, the neuroprotective effect of MgSO4 has not been shown in twin gestations. Thus, the aim of this study was to determine the maternal serum levels of magnesium ...
Kamimura Kenya - - 2014
Intrahepatic cholestasis of pregnancy (ICP) is a cholestasis condition caused by elevated levels of serum bile acids that mainly occurs in the third trimester of pregnancy. Maternal symptoms include pruritus; elevation of transaminases, biliary enzymes, and bilirubin levels; and abnormal liver function tests. Fetal symptoms include spontaneous preterm labor, fetal ...
Jalkanen A A Division of Clinical Neurosciences, Turku University Hospital, Turku, - - 2014
Both pregnancy and high vitamin D concentration seem to generate a protective environment against multiple sclerosis (MS) relapses. Longitudinal case-control analysis of vitamin D concentrations during pregnancy and lactation of MS mothers is lacking. To examine serum 25-hydroxyvitamin-D3 levels of MS patients during and after pregnancy and compare these to ...
Zawiejska A A Department of Obstetrics and Women's Diseases, University of Medical Sciences, Poznan, - - 2014
Hypertensive disorders of pregnancy (HDPs) are associated with altered maternal metabolism, impaired perinatal outcome and increased risk for remote maternal complications. The aim of our study was to analyse associations between circulating levels of angiogenic factors and markers of oxidative stress and metabolic status in women with HDP. Forty-six women ...
Persechini Marie-Laure ML Department of Endocrinology and Metabolic Diseases, Pôle Cardio-Vasculaire et Métabolique, CHU Larrey, 24 Chemin de Pouvourville, TSA 30030, 31059, Toulouse Cedex 9, - - 2014
A decrease of insulin-like growth factor-I levels (IGF-I) has been reported during the first trimester of pregnancy in women with acromegaly before the secretion of placental growth hormone (GH) progressively increases IGF-1 concentration. To evaluate variations of concentrations of IGF-1, insulin-like growth factor (IGF)-binding protein-3 (IGF-BP3) and GH during the ...
Søstrup Birgitte B Department of Biomedical Sciences, Cellular and Molecular Medicine Section, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen; Centre for Fetal Programming, Danish Research Council for Strategic Research, - - 2014
Several studies have shown increased beta cell mass during pregnancy in both rodents and humans. Proliferation of existing beta cells seems to be the predominant mechanism in rodents, whereas the mechanism in humans is unclear. We hypothesized that neogenesis contributes to the increased beta cell mass in pregnancy and that ...
Lathi Ruth B RB Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford - - 2014
Hyperandrogenic conditions in women are associated with increased rates of miscarriage. However, the specific role of maternal testosterone in early pregnancy and its association with pregnancy outcome is unknown. The purpose of this study was to compare serum testosterone levels during early pregnancy in women with and without polycystic ovary ...
Thaler C J CJ Department and Outpatient Clinic for Gynaecology and Obstetrics, Hospital of the Ludwig Maximilian University of Munich, Großhadern Campus, Hormone & Fertility Centre Großhadern, Munich ; Department and Outpatient Clinic for Gynaecology and Obstetrics, Hospital of the Ludwig Maximilian University of Munich, City Centre Campus, Hormone & Fertility Centre City Centre, - - 2014
Folate metabolism affects ovarian function, implantation, embryogenesis and the entire process of pregnancy. In addition to its well-established effect on the incidence of neural tube defects, associations have been found between reduced folic acid levels and increased homocysteine concentrations on the one hand, and recurrent spontaneous abortions and other complications ...
Chen Yi-Pin YP Department of Gynecology, Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan County, - - 2014
To analyze the relationship between in vitro fertilization (IVF) pregnancy rate and basal serum hormone levels before patients begin an IVF course. In this retrospective study, we analyzed patients with anti-Müllerian hormone (AMH) data and IVF data from January 2009 to October 2012. Pregnancy rates were calculated by AMH and follicle ...
Takeda Akihiro A Department of Obstetrics and Gynecology, Gifu Prefectural Tajimi Hospital, Tajimi, Gifu, Japan. Electronic address: - - 2014
Cesarean scar pregnancy (CSP) is a rare potentially life-threatening form of ectopic gestation. However, optimal management has not yet been established. Furthermore, there are limited reports on the diagnostic value of three-dimensional computed tomographic angiography (3D-CTA) for the conservative management of this disorder. A 33-year-old woman (gravida 3, para 2), ...
Peng Hsiu-Huei HH Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou Medical Center and Chang Gung University College of Medicine, Kwei-Shan, Taoyuan, - - 2014
A twin pregnancy consisting of a complete hydatidiform mole with a coexisting normal fetus is extremely rare with an incidence of 1/22,000 to 1/100,000. The incidence of preterm delivery is high and few pregnancies reach near term with a viable fetus. A 34-year-old woman presented at 20 weeks of gestation with ...
Rabie Nader Z NZ Division of Maternal Fetal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 77205-77199, - - 2014
Evaluation of: Asvold BO, Vatten LJ, Tanbo TG, Eskild A. Concentrations of human chorionic gonadotrophin in very early pregnancy and subsequent pre-eclampsia: a cohort study. Hum. Reprod. 29(6), 1153-1160 (2014). A total of 2405 consecutive singleton pregnancies were followed to determine if early HCG levels were associated with the development ...
Köşüş Nermin N Fatih University, Ankara, - - 2014
Subcutaneous abdominal fat thickness (SCFT) is important for predisposition to metabolic and cardiovascular diseases. Our aim was to evaluate maternal SCFT and metabolic changes (such as insulin resistance and high inflammatory markers) during pregnancy. A total of 92 pregnant women between 24-28 weeks of gestation were enrolled in the study. ...
Zhang Joy Y JY Vitamin D Research Group, School of Food and Nutritional Sciences, University College Cork,Cork,Republic of - - 2014
Nutritional requirements for vitamin D during pregnancy have been inadequately described, and there are conflicting data on the impact of gestation on vitamin D status. In the present study, we conducted a longitudinal analysis of total and free (unbound) serum 25-hydroxyvitamin D (25(OH)D), vitamin D-binding protein (DBP) and albumin concentrations ...
Shankar H H All India Institute of Medical Sciences , Ansari Nagar, New Delhi , - - 2014
Pregnancy is accompanied by several haemodynamic, biochemical and haematological changes, which may lead to severe problems, if they are not suitably addressed. The current study highlights the haematological and biochemical differences observed in anaemic (AP) and non-anaemic primigravida (NAP), at their 2nd trimester, in a north Indian population. There were ...
van der Wijden Carla L CL Department of Public & Occupational Health and EMGO+ Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands; Department of Gynecology, Medisch Centrum Jan van Goyen, Amsterdam, The - - 2014
Childbearing is considered to be a significant risk factor for developing overweight and obesity. Physical activity might influence weight change via hormonal changes. To test the hypothesis that higher levels of moderate to vigorous intensity physical activity (MVPA) are positively associated with maternal insulin sensitivity, and reduce IGF-1, IGFBP-3, leptin ...
Mesens Tinne T Dept. Obstetrics & Gynaecology, Ziekenhuis Oost Limburg, Genk, Belgium. Electronic address: - - 2014
To evaluate in early and late preeclampsia a correlation of maternal venous Doppler flow characteristics with biochemical parameters in maternal serum and urine, or with gestational outcome. In this observational cross-sectional study, renal interlobar vein impedance index (RIVI) was measured according to a standardised protocol for combined electrocardiogram-Doppler ultrasonography in ...
Teofilo Marcella Martins Alves MM Nutritional Epidemiology Observatory, Department of Social and Applied Nutrition, Institute of Nutrition Josué de Castro, Rio de Janeiro Federal University, RJ, Brazil; Graduate Program in Nutrition, Institute of Nutrition Josué de Castro, Rio de Janeiro Federal University, RJ, - - 2014
Serum lipids have been associated with depression in the adult population; however, this association during pregnancy remains unclear. The aim of this study was to evaluate the association between serum lipids and depressive symptom scores during pregnancy. A prospective cohort of 238 pregnant women was followed at the 5th-13th, 20th-26th ...
Eleftheriades Makarios M Embryocare, Fetal Medicine Unit, Athens, Greece; Bioiatriki SA, Department of Ultrasound and Fetal Medicine, Athens, Greece; First Department of Pediatrics, University of Athens Medical School, Athens, Aghia Sophia Children's Hospital, Athens, Greece. Electronic address: - - 2014
To examine maternal serum concentrations of placental growth factor (PlGF) at 11-14 gestational weeks in pregnancies that developed gestational diabetes mellitus (GDM) and to create first trimester prediction models for GDM. Case control study including 40 GDM cases and 94 controls. PlGF, biophysical and biochemical markers and maternal-pregnancy characteristics were ...
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