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Julius Justin M JM Division of Pharmacy, The University of Texas MD Anderson Cancer Center, Houston, - - 2014
The objective of this study was to estimate maternal-fetal transplacental passage of granisetron in an ex vivo placental perfusion model. Term human placentas (N=8) were collected immediately after delivery. A single cotyledon from each placenta was perfused granisetron concentration to mimic systemic maternal peak plasma concentrations following either IV (50ng/mL) ...
Brownbill P P University of Manchester, Maternal & Fetal Health Research Group, Manchester, United - - 2014
Placental up-regulation of free fetal haemoglobin (fHbF) occurs in preeclamptic (PE) pregnancy. Heme oxygenase-1 (HO-1) is an important vasculoprotective enzyme in the catabolism of the associated heme porphyrin structure. We have previously shown that fHbF negatively influences the vasculoprotective capacity of the fetal circulation. Here we study fHbF levels in ...
Jia Xiaojiao X Department of Endocrinology, Hebei Medical University, Shijiazhuang, - - 2014
To explore serum vaspin, leptin, and adiponectin levels and their correlation with insulin resistance (IR) in pregnant women with and without gestational diabetes mellitus (GDM) and healthy non-pregnant women. A total of 262 individuals, including pregnant women with GDM (n = 86), those without GDM (n = 92), and age-matched healthy non-pregnant women (n = 84) ...
Valdés Gloria - - 2014
The opposing renin-angiotensin system (RAS) and kallikrein-kinin system (KKS) are upregulated in pregnancy and localize in the utero-placental unit. To test their participation as counter-regulators, circulating angiotensin II (AII) was exogenously elevated and the bradykinin B2 receptor (B2R) was antagonized in pregnant guinea-pigs. We hypothesized that disrupting the RAS/KKS balance ...
Moran M M Diagnostic Imaging, School of Medicine and Medical Science, University College Dubliln, Dublin, - - 2014
Pre-eclampsia (PET) and intrauterine growth restriction (IUGR), often associated with impaired placental function, are among the most common conditions contributing to increased perinatal mortality and morbidity. This study investigates if three dimensional power Doppler (3DPD) of the placenta and computerised analysis of placental calcification is different between PET/IUGR and normal ...
Galjaard Sander S KU Leuven Department of Development and Regeneration: Pregnancy, Fetus and Neonate, Gynaecology and Obstetrics, University Hospitals Leuven, Leuven, - - 2014
Fetal intima-media thickness (IMT) has been suggested as a marker of pre-clinical atherosclerosis, and maternal IMT could be altered through dynamic circumstances related to pregnancy. We investigated the feasibility of measurement of IMT at four pre-defined fetal and four pre-defined maternal arterial locations to determine vascular changes that could be ...
Parkington Helena C HC Monash University, - - 2014
While the impact of alcohol consumption by pregnant women on fetal neurodevelopment has received much attention, the effects on the cardiovascular system are not well understood. We hypothesised that repeated exposure to alcohol (ethanol) in utero would alter fetal arterial reactivity and wall stiffness, key mechanisms leading to cardiovascular disease ...
Batarse Rodolfo R Nephrology, Nephrology, Hypertension, Transplant Medicine, Rancho Mirage, United - - 2014
Management of the pregnant patient on peritoneal dialysis (PD) is potentially challenging because uterine enlargement may negatively affect catheter function and prescribed dwell volumes. Additional reports of the management of these patients are needed. Here, we describe a near-full-term delivery in a 27-year-old woman who had been on dialysis for ...
Grange Dorothy K DK Washington University School of Medicine, One Children's Place, NWT 9th Floor, St. Louis, MO 63110, - - 2014
For pregnant women with phenylketonuria (PKU), maintaining blood phenylalanine (Phe)<360μmol/L is critical due to the toxicity of elevated Phe to the fetus. Sapropterin dihydrochloride (sapropterin) lowers blood Phe in tetrahydrobiopterin (BH4) responsive patients with PKU, in conjunction with a Phe-restricted diet, but clinical evidence supporting its use during pregnancy is ...
Heller Michaela M North Dakota Fetal Alcohol Syndrome Center, Department of Pediatrics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North - - 2014
This study is a review of alcohol dispersion into and elimination from the fetal compartment. PubMed searches were conducted for all years and all languages for relevant papers. We also hand searched the reference list of papers and text books for additional references. Alcohol concentration is determined by body water ...
Sohlberg S S Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. Electronic address: - - 2014
Our primary aim was to investigate if women with early or late preeclampsia have different placental perfusion compared with normal pregnancies. A secondary aim was to investigate if placental perfusion changes with increasing gestational age in normal pregnancy. The study population included thirteen women with preeclampsia (five with early and ...
Cornette Jérôme J Division of Obstetrics and Prenatal Medicine, Department of Obstetrics and Gynecology, and the Department of Radiology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands; and the Department of Obstetrics and Gynecology, St Fransiscus Hospital, Rotterdam, The - - 2014
Uterine artery pseudoaneurysm has a pathognomonic ultrasound appearance. Its occurrence in pregnancy is life-threatening for both mother and fetus. We present an illustrative case and discuss management with selective uterine artery embolization during pregnancy. A 37-year-old pregnant woman presented with profuse painless vaginal blood loss at a gestational age of ...
Ueki Ryusuke R Department of Anesthesiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan, - - 2014
Placental transfer of volatile anesthetics is a critical issue in managing fetal distress during cesarean section under general anesthesia. Using dual perfused human placental cotyledons obtained from parturients undergoing elective cesarean section (n = 5), we investigated the effect of decreased fetal perfusion on placental clearance of sevoflurane and isoflurane. Keeping the ...
Seror Jérémy J Paris Diderot, Université Paris VII, Paris, France ; Department of Gynecology and Obstetrics, Beaujon-Bichat Hospital, AP-HP, Clichy, - - 2014
Hashimoto's thyroiditis is the principal aetiology of hypothyroidism with presence of anti-thyroperoxidase antibodies (anti-TPO). The association between anti-TPO and foeto-placental complications has been observed in previous studies. To go further in the understanding, the current study compares the level of anti-TPO in maternal blood and in the cord blood of ...
Brace Robert A RA - - 2013
Intramembranous absorption increases during intra-amniotic infusion of physiological saline solutions. The increase may be due partly to the concomitant elevation in fetal urine production as fetal urine contains a stimulator of intramembranous absorption. In this study, we hypothesized that the increase in intramembranous absorption during intra-amniotic infusion is due in ...
Aris Aziz A Department of Obstetrics and Gynecology, Clinical Research Centre of Sherbrooke University Hospital Centre, Sherbrooke (Quebec), Canada. Electronic address: - - 2013
We determined bisphenol A (BPA) concentrations of 61 pregnant women (PW), their fetuses and 26 nonpregnant women (NPW) in Eastern Townships of Canada; and evaluated potential correlations between maternal and fetal blood, and between peripheral blood and peritoneal fluid. In PW, BPA levels were ranged from non-detected to 4.46ng/ml and ...
Wagner Carol L CL Department of Pediatrics, Medical University of South Carolina, 173 Ashley Avenue, MSC 514, Charleston, - - 2013
The article by McManus et al that appears in this month's issue of Clinical Endocrinology entitled, "MATERNAL, UMBILICAL ARTERIAL AND UMBILICAL VENOUS 25-HYDROXYVITAMIN D AND ADIPOCYTOKINE CONCENTRATIONS IN PREGNANCIES WITH AND WITHOUT GESTATIONAL DIABETES" (1) extends the debate about the multifunctional role of vitamin D during pregnancy. Looking at the relationship ...
Gennari-Moser Carine - - 2013
A successful pregnancy requires an accommodating environment. Salt and water availability are critical for plasma volume expansion. Any changes in sodium intake would alter aldosterone, a hormone previously described beneficial in pregnancy. To date, it remains ambiguous whether high aldosterone or high salt intake is preferable. We hypothesized that increased ...
Jesudason Shilpanjali - - 2013
Pregnancy in ESRD is rare and poses substantial risk for mother and baby. This study describes a large series of pregnancies in women undergoing long-term dialysis treatment and reviews maternal and fetal outcomes. Specifically, women who had conceived before and after starting long-term dialysis are compared. All pregnancies reported to ...
Pašková A - - 2013
Steroids are important markers in pregnancy. Although estimating their levels separately in umbilical arterial (UA) and venous blood (UV) enable more precise insights into the functioning fetoplacental unit compared to using mixed umbilical blood (UM), selective aspiration of UA and UV is technically more demanding than collecting UM. We measured ...
Anbazhagan A - - 2013
It has been suggested that the origins of pre-eclampsia arise from the maternal venous system dysfunction. This study aimed to test this hypothesis by assessing hepatic perfusion in pre-eclampsia using three-dimensional (3D) ultrasound. The hepatic portal vein flow in 12 women with normal pregnancy and 11 women with pre-eclampsia was ...
Bajoria R - - 2013
Use of drugs that cross the placenta freely are currently avoided during pregnancy. We investigated whether cationic small unilamellar (SUV) liposomes of different lipid compositions could prevent the transfer and uptake of warfarin across human term placenta. Cationic liposomes encapsulated warfarin was prepared by using lecithin (F-SUV) or sterylamine (S-SUV) ...
McDonald Emily A - - 2013
Schistosomiasis affects approximately 40 million women of reproductive age and has been linked to elevated levels of circulating endotoxin in non-pregnant individuals. We have evaluated endotoxin levels in maternal, placental and newborn blood collected from women residing in Leyte, The Philippines. Endotoxin levels in both maternal and placental compartments in ...
Derwig I - - 2013
To investigate (a) if placental perfusion in the second trimester of pregnancy, measured by two non-invasive magnetic resonance imaging (MRI) techniques, is related to impedance to flow in the uterine arteries, as assessed by Doppler ultrasound; and (b) if these measures are associated with future gestational outcome. In 37 singleton ...
Nair Sreeja - - 2013
Abstract Goodpasture's syndrome complicating pregnancy is extremely rare and dialysis requiring anti GBM disease with renal recovery is uncommon. We report a case of a 23-year-old primi gravida who presented with Goodpasture's syndrome during thirteenth week of pregnancy. She was initiated on steroids and cytotoxic drugs along with intensive plasma ...
Tsesis Svetlana - - 2013
Abstract The purpose of this study was to examine whether changes in estrogen and progesterone levels observed during normal pregnancy influence blood glutamate levels. One-hundred and sixteen pregnant women were divided into three groups based on gestational age: group 1 included women in their first trimester, group 2 included women ...
Schaible A M - - 2013
Pregnancy is accompanied by major immunological changes to maintain both tolerance for the fetus and immune competence. Leukotrienes are powerful 5-lipoxygenase-derived inflammatory mediators and the characteristics of leukotriene-related diseases (e.g., asthma, allergic rhinitis) change during pregnancy. Here, we show that pregnancy affects leukotriene synthesis in human blood and leukocytes. 5-Lipoxygenase ...
Lun Fiona M F - - 2013
Epigenetic mechanisms play an important role in prenatal development, but fetal tissues are not readily accessible. Fetal DNA molecules are present in maternal plasma and can be analyzed noninvasively.METHODS: We applied genomewide bisulfite sequencing via 2 approaches to analyze the methylation profile of maternal plasma DNA at single-nucleotide resolution. The ...
Yorifuji Takashi - - 2013
Time spatial labeling inversion pulse (Time-SLIP) is a non-contrast magnetic resonance angiography (MRA) technique. No cases in which this technique was used during pregnancy have been reported. We report herein two cases with adenomyosis of the same size and location that underwent Time-SLIP MRA during pregnancy. In case 1, the ...
Kärkkäinen Henna - - 2013
BACKGROUND: The study sets out to examine differences in arterial stiffness and nocturnal blood pressure dipping as outcomes in women with gestational hypertension compared with healthy pregnant women during pregnancy and 3 months after delivery. METHODS AND RESULTS: We prospectively studied a cohort of 60 women during the third trimester of ...
Zarek J - - 2013
HMG-CoA reductase inhibitors (statins) are contraindicated during pregnancy. However, it has been suggested that the hydrophilic property of pravastatin prevents its placental transfer to the fetus, explaining neutral effects observed in controlled studies. Using the ex-vivo placental perfusion model, placental transfer of pravastatin (50 ng/ml) was determined. The mean maximum fetal ...
Cheung Katharine L KL Division of Nephrology, Stanford University, Palo Alto, CA, - - 2013
Pregnancy involves remarkable orchestration of physiologic changes. The kidneys are central players in the evolving hormonal milieu of pregnancy, responding and contributing to the changes in the environment for the pregnant woman and fetus. The functional impact of pregnancy on kidney physiology is widespread, involving practically all aspects of kidney ...
Fujita Kohei K Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan. - - 2013
To elucidate changes in endothelial function throughout the gestational period in normal pregnancy and its relationship with plasma soluble fms-like tyrosine kinase-1 (sFlt-1) levels. Endothelial function was evaluated by reactive hyperemia index (RHI) using Endo-PAT2000 and plasma sFlt-1 levels were measured simultaneously by ELISA. RHI gradually deteriorated with increasing gestational ...
Mao Caiping - - 2013
Intrauterine environments are linked to fetal renal development and postnatal health. Influence of salt diets during pregnancy on renal functions and renin-angiotensin system (RAS) were determined in the ovine fetus and offspring. Pregnant ewes were fed high-salt diet (HSD) or normal-salt diet (NSD) for two months during middle-later gestation. Fetal ...
Derwig I - - 2013
PURPOSE: To investigate whether, in the second trimester of pregnancy, placental T2 relaxation time (determined using magnetic resonance imaging (MRI)) is related to impedance to flow in the uterine arteries. METHODS: In 40 singleton pregnancies at 24-29 weeks' gestation, uterine artery pulsatility index (PI) was measured by Doppler ultrasound and ...
Hussein Hassan A - - 2013
The aim of this study was to verify the efficacy of color Doppler ultrasonography for diagnosis of degree and duration of uterine torsion in buffaloes. In Assiut province/Upper Egypt, 65 buffaloes (37 with uterine torsion, 28 with normal late pregnancy) were examined clinically and using Doppler ultrasonography. The Doppler indices ...
Gulraze Anjum - - 2013
We describe two cases of fetal goiter in women with no history of thyroid disease. Diagnosis of fetal goiter during antenatal care was made by ultrasound and MRI. Congenital hypothyroidism was confirmed by fetal blood sampling that was treated with weekly intra-amniotic injections of L-thyroxin. One fetus was initially treated ...
Aref Salah - - 2013
This study aimed to assess the von Willebrand factor (VWF) antigen levels and its proteolytic enzyme ADAMTS13 activity in preeclampsia. The study includes 10 non-pregnant women, 50 normal pregnancy, and 110 preeclamptic (PE) women at the same period of pregnancy. For all studied groups plasma ADAMTS13 activities were determined with ...
Duehlmeier R - - 2013
German black headed mutton (GBM) ewes are recognized as being highly susceptible to ovine pregnancy toxemia (OPT). The present trial was performed to evaluate whether a breed-dependent gestational diabetes mellitus-like insulin resistance during late pregnancy might be responsible for the high incidence of OPT in the GBM breed. Modified frequently ...
Zamanpoor Mansour - - 2013
Abstract Objective: to quantify circulating fetal DNA (fDNA) levels in the second and third trimesters of normal healthy pregnant individuals and pregnant women with the following clinical conditions: gestational diabetes mellitus (GDM), iron deficiency anemia and gestational hypertension (GHT). Methods: The SRY gene which is located on Y chromosome was ...
Gyselaers Wilfried - - 2013
Abstract This review summarizes current information on anatomical and physiological properties of the early gestational uteroplacental circulation, and implications of normal or abnormal functioning of the venous compartment. It is illustrated that these properties serve intra-uterine redistribution of blood flow, which is a crucial activity during different stages of trophoblastic ...
Brewster Shireen - - 2013
Background/Aims. Gestational diabetes mellitus (GDM) and milder gestational impaired glucose tolerance (GIGT) identify women who are at risk of developing cardiovascular disease. Endothelial dysfunction, as indicated by impaired flow-mediated dilatation (FMD) on brachial artery ultrasound, is an early marker of vascular disease. Thus, we sought to evaluate endothelial function in ...
Ibrahim Hisham Saleh - - 2013
Raised leptin levels have been reported in the placentae and serum of women with elevated blood pressure and proteinuria during pregnancy. The role of leptin in this however remains unknown. This study investigates the effect of leptin administration on systolic blood pressure (SBP) and proteinuria and serum markers of endothelial ...
Abu-Zaid Ahmed A College of Medicine, Alfaisal University, P.O. Box 50927, Riyadh 11533, Saudi - - 2013
Frequency of pregnancy among childbearing age women with end-stage renal disease (ESRD) undergoing long-term periodic dialysis ranges from 1% to 7%. Although pregnancy in dialysis women with ESRD is considered a largely high-risk pregnancy, occurrence of successful pregnancy is not impossible with success rates approaching 70%. Rates of successful pregnancy ...
Gooneratne S Ravi - - 2013
Three each of 3-year-old Angus and Simmental heifers, surgically modified to collect bile, were used to measure the effects of pregnancy and breed on bile flow, biliary copper and zinc excretion and plasma copper and zinc concentrations. Bile copper excretion was significantly higher at 7-mo of pregnancy when samples from ...
Garcia Segarra N - - 2012
A 22 year-old woman with tyrosinemia type I (HT1) married her first cousin who is heterozygous for the same FAH mutation for which the patient is homozygous. During her pregnancy she was treated with diet (prescribed tyrosine intake 300 mg/day), and nitisinone (60 mg/day). Median plasma tyrosine levels were 560 μmol/L (range: 375-838, n = 21) ...
van Santen Susanne - - 2012
Abstract Background: Iron deficiency is a commonly encountered problem in pregnancy and a frequently observed cause of pregnancy-associated anemia. We longitudinally assessed the iron regulatory hormone hepcidin during gestation and postpartum and related hepcidin to conventional indicators of iron status and inflammation. Methods: Thirty-one healthy pregnant women were included and ...
Schreurs Malou P H - - 2012
In preeclampsia, hyperlipidemia is enhanced compared to normal pregnancy that could adversely affect vascular function. In the cerebral vasculature, this could lead to dysregulation of cerebral blood flow and neurological complications. Here, we examined the effect of excessive hyperlipidemia, as seen in preeclampsia, on cerebral artery function and expression of ...
Rumer Kristen K KK Department of Obstetrics and Gynecology, University of Colorado, Aurora, CO 80045, - - 2013
Sialic acid immunoglobulin-like lectin (Siglec)-6 is a transmembrane receptor that binds sialyl-TN glycans and leptin. Among eutherian mammals, only human placentas express Siglec-6. Previous work has implicated Siglec-6 in preeclampsia (PE). Preeclampsia, a leading cause of maternal and perinatal morbidity and mortality, is characterized by placental abnormalities. This study provides ...
Magriples Urania U Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520, USA. - - 2013
To investigate the effect of race, body mass index (BMI), and weight gain on blood pressure in pregnancy and postpartum. Secondary analysis of pregnant women aged 14 to 25 who received prenatal care at a university-affiliated public clinic in New Haven, Connecticut and delivered singleton term infants (n = 418). ...
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