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Yiu Z Z N ZZ The Dermatology Centre, Salford Royal NHS Foundation Trust, University of Manchester, Manchester Academic Health Science Centre, Manchester M6 8HD, UK and Psoriasis-Center at the Department of Dermatology, Venerology and Allergology, University Medical Centre Schleswig-Holstein, Campus Kiel, Schittenhelmstr.7, 24105 Kiel, - - 2014
Abstract The effects of conventional systemic therapies for psoriasis on pregnancy outcomes, lactation, male fertility and mutagenicity are common concerns in the clinical setting. There is relatively little evidence to guide clinician and patient. Here, we review the safety profile of the commonly used conventional systemic therapies used for psoriasis ...
Müller-Deile Janina J Janina Müller-Deile, Mario Schiffer, Division of Nephrology and Hypertension, Department of Medicine, Hannover Medical School, 30625 Hannover, - - 2014
Proteinuria is a frequently detected symptom, found in 20% of pregnancies. A common reason for proteinuria in pregnancy is preeclampsia. To diagnose preeclampsia clinically and to get new insights into the pathophysiology of the disease it is at first essential to be familiar with conditions in normal pregnancy. Animal models ...
Carta Paolo P Nephrology unit, Careggi University Hospital, Florence, - - 2014
We report 3 cases of unplanned pregnancies in 2 recipients of kidney transplant from deceased donor treated with everolimus (the first patient had a second pregnancy). They were in good health without particular complications related to the immunosuppressive therapy. The patients were referred to our institution at the end of ...
Ozzello Daniel J DJ Department of Ophthalmology, University of Colorado, Aurora, - - 2014
To evaluate whether cost, insurance prior authorization, pregnancy considerations, and subspecialty practice lead to changes in therapeutic decisions among uveitis and retina specialists in the treatment of intermediate and posterior uveitis. Prospective cross-sectional study. A total of 934 uveitis and retina specialists across the United States were surveyed via e-mail ...
Helmy S S Department of Obstetrics and Gynecology, Medical University Vienna, Vienna, - - 2014
To investigate a possible correlation between the volume of the tubal ectopic pregnancy (EP) measured by vaginal-ultrasound (VUS) and methotrexate (MTX) therapy outcome. Data of EP volume measured by one expert-sonographer, viability, clinical symptoms, previous IVF/insemination, follow-up of β-hCG and progesterone levels, and treatment of EP was collected of 100 ...
Panduranga Prashanth P Departments of Cardiology, Royal Hospital, Muscat, - - 2014
Choosing the best anticoagulant therapy for a pregnant patient with a mechanical prosthetic valve is controversial and the published international guidelines contain no clear-cut consensus on the best approach. This is due to the fact that there is presently no anticoagulant which can reliably decrease thromboembolic events while avoiding damage ...
Pacheco Luis D LD *Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine †Department of Anesthesiology, Division of Surgical Critical Care, The University of Texas Medical Branch at Galveston, Galveston, - - 2014
Severe sepsis is a major cause of mortality among critically ill patients. Early recognition accompanied by early initiation of broad-spectrum antibiotics with source control and fluid resuscitation improves outcomes. Hemodynamic resuscitation starts with fluid therapy followed by vasopressors if necessary. Cases refractory to first-line vasopressors (norepinephrine) will require second-line vasopressors ...
Marsh Courtney A CA Clinical Assistant - - 2014
Obesity is associated with multiple adverse reproductive outcomes such as infertility, ovulation dysfunction, miscarriage, preeclampsia, gestational diabetes mellitus, preterm delivery, operative delivery, and fetal growth disorders. Although the prevalence of maternal obesity is increasing, it is unclear which method of weight loss is most effective before conception to improve reproductive ...
Falah Nadia N Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, - - 2014
Landmark early work has led to the nearly universal use of antenatal corticosteroids to accelerate fetal lung maturity with pregnancies complicated by impending preterm birth. Antenatal corticosteroids clearly reduce respiratory morbidity, death, and other adverse neonatal outcomes. Limited pregnant human pharmacokinetic data and some animal data give clinicians some information ...
Herrell Howard Ernest HE East Tennessee State University, Johnson City, TN, - - 2014
Nausea and vomiting of pregnancy affects nearly 75% of pregnant women. The exact cause is unknown. In most cases, it is a mild, self-limited condition that can be controlled with conservative measures and has no adverse fetal sequelae. About 1% of women develop hyperemesis gravidarum, which may result in adverse ...
Teh Wan Tinn WT Department of Obstetrics & Gynaecology, University of Melbourne and the Royal Women's Hospital, Parkville, VIC 3052, Australia ; Reproductive Services, Royal Women's Hospital, Parkville, VIC 3052, - - 2014
Future fertility is of paramount importance to younger cancer survivors. Advances in assisted reproductive technology mean that young women treated with radiation involving the uterus may require clinical guidance regarding whether to attempt a pregnancy themselves. We performed a review of the literature regarding radiation involving uterus (total body irradiation ...
Samuel Miriam M Guy's and St Thomas' NHS Foundation Trust, Westminster Bridge Road, London SE1 7EH, - - 2014
Introduction. There are few data regarding the tolerability, safety, or efficacy of antenatal atazanavir. We report our clinical experience of atazanavir use in pregnancy. Methods. A retrospective medical records review of atazanavir-exposed pregnancies in 12 London centres between 2004 and 2010. Results. There were 145 pregnancies in 135 women: 89 ...
Shastri Aravind T - - 2012
This report describes a case of premature closure in utero of the ductus arteriosus (DA) diagnosed postnatally in a baby with hydrops and cardiac failure. An echocardiogram 6 h postnatally showed marked dilation of the right atrium and right ventricle with marked hypertrophy and impaired function, elevated pulmonary pressures, a small ...
Berveiller Paul - - 2012
Chronic myeloid leukemia is a chronic myeloproliferative disorder of hematopoietic stem cells that occurs in 10% of cases in women of childbearing age. Treatment is mainly based on tyrosine kinase inhibitors such as imatinib, dasatinib, or nilotinib. However, the maternal and embryofetal safety of these drugs in pregnant women is ...
Sisodia Shantilal Mohanlalji - - 2012
ABSTRACT: Amniotic fluid embolism (AFE) is a rare, unforeseeable, unpreventable, and dreadful complication of pregnancy. Histological diagnosis is still the criterion standard for its detection because of the lack of any reliable clinical laboratory tests. The diagnosis of AFE has a close association with medicolegal aspects of obstetric death. Amniotic ...
Mayumi Miyuki - - 2012
We here report the first case of discordant Pena-Shokeir phenotype observed in monoamniotic twins. A 34-year-old woman, pregnant with twins, was referred at 10 weeks' gestation because one of the twins had increased nuchal translucency. Serial ultrasonographic examinations suggested that twin A may have had several other abnormalities, including pleural effusion ...
Gómez-Montes E - - 2012
Objectives To determine which combination of cardiac parameters provide the best prediction of postnatal coarctation of aorta (CoAo) in fetuses with cardiac asymmetry. Methods We selected all cases of ventricular and great vessels disproportion prenatally diagnosed in 2003-2010. Only normally grown liveborn fetuses with isolated cardiac asymmetry and with complete ...
Cutts Briony A - - 2012
The diagnosis and management of pulmonary embolism in pregnancy is difficult, because diagnostic procedures and the use of anticoagulants potentially can expose mother and fetus to adverse effects. This article reviews evidence for current best practice and emerging novel techniques for the diagnosis of pulmonary embolism in pregnancy and includes ...
Inoue Seiji - - 2012
Fontan operation is performed to provide palliation for patients with many forms of highly complex congenital heart disease that cannot support a biventricular circulation. Increasing numbers of women who have undergone these connections in childhood are now reaching their childbearing years, and some are becoming pregnant. The low flow and ...
Štimac Tea - - 2012
To determine the lamellar body count (LBC) cutoff value for fetal lung maturity and to evaluate the clinical usefulness of LBC in predicting the severity of neonatal respiratory distress syndrome (RDS). A prospective study was conducted from 2002 until 2010. LBC was estimated in uncentrifugated amniotic fluid samples using Cell-Dyn ...
Hung Chih-Chiang - - 2012
Hepatocellular carcinoma (HCC) occurring in pregnancy is very rare. The prognosis is usually poor because of unclear clinical presentation. A 30-year-old woman who suffered from HCC during pregnancy underwent hepatectomy twice, and resection for pulmonary metastasis once. A healthy infant was delivered after the first hepatectomy. Currently, she remains disease ...
Zhou Xi - - 2012
Introduction: To present a rare case of ovarian hyperstimulation syndrome (OHSS) following a spontaneous complete hydatidiform molar (CHM) pregnancy. Case: A 38-year-old woman underwent vacuum curettage for a CHM pregnancy. Seven days later, she was admitted to our hospital with the symptoms of OHSS. Transvaginal ultrasonography demonstrated enlarged multicystic ovaries, ...
Loubert Christian - - 2012
PURPOSE: The purpose of this Continuing Professional Development module is to review the physiology of maternal hypotension induced by spinal anesthesia in pregnant women, and the effects of fluids and vasopressors. PRINCIPAL FINDINGS: Maternal hypotension induced by spinal anesthesia is caused mainly by peripheral vasodilatation and is not usually associated ...
Kryczka Karolina - - 2012
Therapeutic management in pregnant patients with heart failure still remains a challenge, even though in most pregnant women with cardiac diseases an outcome is good. A 32-year-old woman, 17 weeks pregnant, was admitted to hospital with heart failure (HF) NYHA class III/IV. Echocardiography revealed enlarged LV, LVEF 13%, significant mitral ...
Ngatchou William - - 2012
The aim was to describe how to avoid technical difficulties during venous femoral cannula insertion for extracorporeal membrane oxygenation (ECMO) in a woman in late pregnancy. A 28-year old pregnant woman presented at 32 weeks of gestation after developing an acute respiratory distress syndrome (ARDS) of an unknown origin that ...
Pellegrinelli J M - - 2012
OBJECTIVE: Primary fetal pleural effusions are rare. If severe, thoracoamniotic shunting is needed. Our objective was to study the management and outcomes of pleural effusions in our unit. METHODS: Retrospective analysis of primary fetal hydrothorax between 1991 and 2010. RESULTS: Of 41 cases, 23 (56%) were hydropic, and 27 (66%) ...
Ferreira Dos Santos Luís - - 2012
We describe the case of a 37-year-old pregnant woman who presented at 29 weeks of gestation with syncope and shortness of breath caused by pulmonary embolism. Due to persistent hypotension thrombolytic therapy with tenecteplase was administered and the clinical and hemodynamic response was excellent, with no maternal or fetal hemorrhagic ...
Wang Page I - - 2012
The objectives of this article are to discuss the current evidence-based recommendations regarding the use of diagnostic imaging in the evaluation of pulmonary embolism, appendicitis, urolithiasis, and cholelithiasis during pregnancy. Diagnostic imaging should be performed during pregnancy only with an understanding of the maternal and fetal risks and benefits, the ...
Vimercati Antonella - - 2012
to compare ultrasound (US) and autopsy findings of fetal malformations in second trimester terminations of pregnancy to evaluate the degree of agreement between US and fetal autopsy. in this study, all second trimester termination of pregnancy between 2003-2010 were considered. US and autopsy findings were compared and all cases were ...
Nilofer Angadi Rajasab - - 2012
Univentricular heart or single ventricle heart is a rare and complex congenital heart disease (CHD). We report the successful management of a parturient with a single ventricle, and pulmonary stenosis. The univentricular heart is discussed in detail and the maternal and fetal outcome in pregnant women with CHD is reviewed.
Sinkovskaya Elena - - 2012
Objectives: The aim of this study was to establish normal values of fetal left brachiocephalic vein (LBCV) dimensions during normal pregnancy as well as to determine if routine assessment of the LBCV may help to identify fetuses with congenital abnormalities of this vessel. Methods: Fetal LBCV was assessed prospectively during ...
Dennis A T - - 2012
Acute pulmonary oedema in pregnant women is an uncommon but life-threatening event. The aims of this review are to address why pulmonary oedema occurs in pregnant women and to discuss immediate management. We performed a systematic literature search of electronic databases including MEDLINE, EMBASE and the Cochrane Library, using the ...
Ahmed Iftikhar - - 2012
Hydatid disease in pregnancy is a rare condition. Ruptured pulmonary hydatid cyst with pneumothorax during pregnancy is potentially serious for both the patient and the fetus. Diagnosis, treatment, and the mode of delivery of the infant all present complex problems related to this event. We describe here a case of ...
Zimmer Etan Z - - 2012
To present sonographic findings in early and late appearance of fetal Ebstein's anomaly. Fetal sonography was performed in 53 447 consecutive pregnant women at 14 to 16 weeks' gestation. Ebstein's anomaly was detected in eight fetuses, in four of them additional anomalies were observed. All eight pregnancies were terminated. In an additional ...
Peres Luiz Cesar - - 2012
Abstract Prenatal diagnosis at very early gestational age may disclose fetal anomalies, enough to support termination of pregnancy. This is, however limited by lack of details on ultrasound examination at such an early stage and hence the importance of post mortem examination to confirm and elaborate on these abnormalities. We ...
Giannella Luca - - 2012
Abstract During pregnancy, one of the possible complications is pneumonia. Early recognition as well as a timely and appropriate therapy is very important to prevent cardio-respiratory failure which may promote premature birth, low birth weight and miscarriage. In pregnancy, a chest X-ray is not contraindicated but may create a considerable ...
Lim Ken - - 2012
BACKGROUND: There have been contradictory reports on the risks of persistent pulmonary hypertension (PPHN) in infants exposed to SSRIs in utero. However, there has been no assessment of fetal pulmonary arterial dynamics in such pregnancies. AIMS AND SUBJECTS: To measure fetal right pulmonary artery (RPA) variables using Doppler ultrasound at ...
Occhiogrosso Mallay - - 2012
Two recent studies linking in utero exposure to selective serotonin reuptake inhibitors (SSRIs) with persistent pulmonary hypertension of the newborn (PPHN), a potentially serious but rare respiratory illness, have made clinicians and patients more reluctant to use SSRIs during pregnancy. However, additional clinical studies have associated maternal depression rather than ...
Leung Ann N - - 2012
Background: Pulmonary embolism (PE) is a leading cause of maternal mortality in the developed world. Along with appropriate prophylaxis and therapy, prevention of death from PE in pregnancy requires a high index of clinical suspicion followed by a timely and accurate diagnostic approach. Methods: To provide guidance on this important ...
Chu Chen - - 2012
To evaluate the fetal cardiac function in gestational diabetes mellitus (GDM) pregnancies under different maternal glycemic controls. Forty four GDM mothers received 78 fetal echocardiographic evaluations at three gestational periods (<28, 28-34 and ⩾34 weeks) and were divided into poorly-(DM1) and well-(DM2) controlled groups according to their glycemic control at ...
Jaïs Xavier - - 2012
Previous studies have reported mortality rates of up to 56% associated with pregnancy in pulmonary arterial hypertension (PAH) but the management of this disease has changed considerably in recent years. We compiled a multinational, prospective registry to examine the contemporary outcome of pregnancies in patients with PAH. During a 3-yr ...
Rimaitis Kęstutis - - 2012
Pregnancy in a woman with pulmonary hypertension carries a prohibitively high risk of maternal mortality, and pregnancy is contraindicated in such patients. Some women decide to continue with their pregnancy despite being aware of possible fatal maternal outcome. The management of pulmonary hypertension in pregnancy is a challenge and requires ...
Sanikop Channabasavaraj S - - 2012
Cardio circulatory changes associated with pregnancy result in a significant haemodynamic burden and lead to morbidity and even mortality in women with cardiac disease. We report a rare case of severe pulmonary stenosis who underwent elective caesarean section under general anaesthesia with satisfactory maternal and neonatal outcome.
Dib Chadi - - 2012
Reversible causes of miscarriage are many, but they affect only 1% of women who are trying to conceive. Herein, we describe the case of a 23-year-old woman who presented for evaluation of repeated miscarriages and was found to have hypoxemia and erythrocytosis. Further evaluation revealed hypoplastic right-heart syndrome with an ...
Kinney Michelle A O - - 2012
Maternal cardiovascular and pulmonary events during labor and delivery may result in adverse maternal and fetal outcome. Potential etiologies include primary cardiac events, pulmonary embolism, eclampsia, maternal hemorrhage, and adverse medication events. Remifentanil patient-controlled analgesia is an alternative when conventional neuraxial analgesia for labor is contraindicated. Although remifentanil is a ...
García-Díaz Lutgardo - - 2012
Giant placental chorioangiomas have been associated with a number of severe fetal complications and high perinatal mortality. We report a case of giant chorioangioma with fetal hydrops, additionally complicated by severe anemia, mild cardiomegaly with hyperdinamic heart circulation and maternal mirror syndrome. Intrauterine blood transfusion and amniodrainage was performed at ...
Babic Inas I Department of Obstetrics and Gynecology, King Faisal Specialist Hospital and Research Centre, MBC-52, PO Box 3354, Riyadh 11211, Kingdom of Saudi Arabia. - - 2012
Chyloascites or chyloperitoneum, which can be caused by different factors, is a process of eruption of one or many lymphatic vessels spontaneously. Malignant processes, inflammation or trauma can cause a sudden burst in a lymphatic vessel which will lead to a collection of milky fluid in any space of the ...
Nwaejike Nnamdi N Cardiothoracic Surgery Department, Papworth Hospital, Cambridge, - - 2012
Pneumothorax during pregnancy is uncommon. Recently ambulatory chest drainage has been advised to treat the pneumothorax and to cover the delivery period. This imposes restrictions on the mother with associated co-morbidity. The authors present a case of recurrent chest-tube resistant pneumothorax during pregnancy which had persisted for 4-weeks. To guide ...
Pastore Mayra B MB Department of Obstetrics/Gynecology, Perinatal Research Laboratories, University of Wisconsin-Madison, Madison, Wisconsin, - - 2012
The steroid hormone estrogen and its classical estrogen receptors (ERs), ER-α and ER-β, have been shown to be partly responsible for the short- and long-term uterine endothelial adaptations during pregnancy. The ER-subtype molecular and structural differences coupled with the differential effects of estrogen in target cells and tissues suggest a ...
Colleoni F - - 2011
Mitochondrial function is required to support energetically-demanding processes in the placenta. As such, a compromise in mitochondrial function could severely impact fetal growth and development. Respirometry is a highly useful method for studying mitochondrial function, but is not possible in freeze-thawed mitochondria, which become uncoupled. We have developed a novel ...
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