Search Results
Results 551 - 600 of 1102
< 7 8 9 10 11 12 13 14 15 16 17 >
Mills J L - - 1998
Previous studies indicate that fasting plasma glucose decreases during gestation, but the timing and extent are not consistent from study to study. We had an opportunity to examine this question in the normal pregnancy cohort of women studied in the Diabetes in Early Pregnancy Study. Subjects were monitored to identify ...
Wolfe L A - - 1998
The purposes of this review were twofold: to apply modern physicochemical principles to explain changes in acid-base regulation and the control of ventilation in human pregnancy; and to demonstrate the value of pregnancy as a model for the study of endocrine effects on physiological control systems. Application of P.A. Stewart's ...
Glynn B P - - 1998
OBJECTIVES: The aim of this study was to investigate the possibility that urocortin is the ligand that displaces corticotropin-releasing hormone from its binding protein in the maternal circulation during pregnancy and, if so, to determine whether urocortin, like corticotropin-releasing hormone, is synthesized in substantial quantities in the placenta. STUDY DESIGN: ...
Beigel Y - - 1998
BACKGROUND: The use of plasma-exchange therapy has increased the longevity of patients with homozygous familial hypercholesterolemia (HFH), and pregnancy in affected women is expected to become more common. We describe the clinical course, feasibility and risks of repeated pregnancies in patients with HFH treated by long-term plasma exchange. METHODS: We ...
Jazayeri A - - 1998
OBJECTIVE: To determine if umbilical cord plasma erythropoietin levels are elevated in pregnancies that continue beyond their expected date for delivery. METHODS: Erythropoietin was measured using an enzyme-linked immunosorbent assay in 124 appropriately grown newborns delivered from 37-43 weeks' gestation. Each woman had an uncomplicated labor and delivery course without ...
Havenaar E C - - 1998
Patients suffering from rheumatoid arthritis (RA) may experience a temporary reduction of disease symptoms during pregnancy. As indicated by the occurrence of RA-disease symptoms during pregnancy, three categories of patients were defined, namely, remission, relapse and unchanged. In all three categories changes in the plasma level and glycosylation of alpha1-acid ...
Riad L E - - 1998
The true elimination rate constant of a metabolite is calculated using a partial area difference analysis. A linear pharmacokinetic model which describes clearances of parent and metabolite is developed. The model makes no restrictions on the route of administration of the parent but requires time-invariant kinetics for both parent and ...
Van Peborgh P - - 1998
OBJECTIVE: Our aim was to evaluate the consequences of polyhydramnios on maternal plasma volume and maternal serum aldosterone and atrial natriuretic peptide (ANP) concentrations in monochorionic twin pregnancies complicated by twin-to-twin transfusion syndrome (TTTS). METHODS: The maternal plasma volume, ionograms as well as plasma ANP and aldosterone concentrations were compared ...
Krauss T - - 1998
OBJECTIVE: Circulating levels of endothelial cell adhesion molecules are elevated in women with preeclampsia. The aim of the present study was to determine levels of these molecules in the fetal circulation of normal pregnancies and pregnancies complicated by preeclampsia. STUDY DESIGN: Fetal plasma samples from the umbilical vein and peripheral ...
Lo Y M - - 1998
We have developed a real-time quantitative PCR assay to measure the concentration of fetal DNA in maternal plasma and serum. Our results show that fetal DNA is present in high concentrations in maternal plasma, reaching a mean of 25.4 genome equivalents/ml (range 3.3-69. 4) in early pregnancy and 292.2 genome ...
Sattar N - - 1998
BACKGROUND: Leptin, an adipose tissue-derived signalling factor encoded by the obese gene has been shown to be present as a 16-kDa protein in the blood of mice and humans. Resistance to leptin occurs in human obesity. Leptin has also been shown to associate with plasma insulin concentrations and there is ...
Rohr F J - - 1998
Lower than average concentrations of tyrosine could be a factor in the fetal damage produced by maternal phenylketonuria (PKU). Dietary supplementation with L-tyrosine has been inconsistent in these reported pregnancies. Consequently, we studied the response to supplementation with L-tyrosine in five maternal PKU pregnancies. Before supplementation the mean plasma tyrosine ...
Paarlberg K M - - 1998
OBJECTIVE: To determine normal values of total plasma fibronectin in all three gestational trimesters and to examine 1) whether total plasma fibronectin levels differ between normotensive, hypertensive, and preeclamptic women; and 2) whether total plasma fibronectin may serve as an early marker of pregnancy-induced hypertensive disorders. METHODS: Total plasma fibronectin ...
Holden D P - - 1998
OBJECTIVE: We investigated the change in the plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, in early-, mid-, and late-gestation normotensive pregnancies and in gestational age-matched preeclamptic pregnancies and compared the observed changes with changes in blood pressure. STUDY DESIGN: Blood pressure and peripheral plasma asymmetric ...
Ostlund E - - 1998
BACKGROUND: Disseminated intravascular coagulation (DIC) is a frequently observed complication in pregnant women. The laboratory diagnosis of DIC is difficult but the development in the detection of circulating soluble fibrin has improved the possibility. METHODS: A number of pregnant women (n= 175) with obstetric complications e.g. preeclampsia, hypertension, intrauterine growth ...
Bellart J - - 1998
OBJECTIVE: Changes in hemostatic system were evaluated in healthy pregnant women. METHODS: Blood was sampled in the 1st, 2nd and 3rd trimesters of gestation, during delivery and 3 days postpartum and plasma factors were measured using commercial tests. RESULTS: Thrombin-antithrombin III complexes, fibrinopeptide A and D-dimer were higher during pregnancy. ...
Suzuki S - - 1998
Platelet hemostatic capacity (PHC) was measured in blood from pregnant patients during all three trimesters using the PFA-100 system. Closure times were shorter with both cartridge systems during pregnancy, compared to non-pregnant controls, suggesting increased PHC. Thrombin/antithrombin (TAT) complex and prothrombin fragment 1 + 2 (F 1+2) levels were elevated ...
Mantagos S - - 1998
Biotin is an important vitamin for cellular function and growth and, therefore, essential for fetal development. The fetus is exclusively dependent on maternal biotin supply. Since biotin is not produced within the body, maternal biotin levels depend on dietary intake. In order to investigate the biotin status of the human ...
Kawai M - - 1997
The gestational profiles of leptin in plasma, adipose tissue and placenta were investigated in rats. Leptin in plasma and the adipose tissue of the maternal compartment increased as pregnancy advanced and remained high during the latter half of pregnancy (approximately 2-fold compared with the non-pregnant state), followed by a rapid ...
Greenberg S S - - 1997
This study tests the hypothesis that nitric oxide synthase (NOS) inhibition is linked to NG-nitro-L-arginine methyl ester (L-NAME)-mediated intrauterine growth retardation (IUGR) and fetal limb reduction deficits (LRD) in pregnant dams. Administration of L-NAME (1 mg/ml) or aminoguanidine (AG, 500 micrograms/ml) in the drinking water or intraperitoneal administration of L-N5-(1-iminoethyl)-ornithine ...
Tomson T - - 1997
We investigated the effect of pregnancy on the kinetics of lamotrigine (LTG), passage of LTG over the placenta and the excretion of the drug in breast milk. We used high-performance liquid chromatography to determine concentrations of LTG in plasma and in breast milk in a woman who was treated with ...
Al M D - - 1997
OBJECTIVE: To investigate whether succeeding pregnancies will affect the maternal and neonatal docosahexaenoic acid (DHA, 22:6n-3) status. DESIGN: Cross-sectional study. SUBJECTS: Women who were pregnant for the 1st to 7th time and took part in a longitudinal study to investigate the essential fatty acid status of pregnant women and their ...
Dickson K A - - 1997
Our aim was to determine the effect of maternal hyperthermia, both with and without maternal water deprivation, on fetal fluid balance. Seven pregnant ewes (131.8 +/- 1.0 days gestation) were studied during a control period and periods of maternal heating (MH, 42-44 degrees C for 8 h, water freely available), ...
Stokol T - - 1997
The pharmacokinetics of von Willebrand factor antigen (vWf:Ag) and factor VIII coagulant (FVIII:C) activity in dogs with von Willebrand Disease (vWD) and haemophilia A, respectively, were assessed after the administration of fresh frozen plasma (FFP) and cryoprecipitate. Loading doses necessary to attain target plasma concentrations of each factor were estimated ...
Hellstern P - - 1997
We established reference ranges for factor VII clotting activity (FVII:C), factor VII amidolytic activity (FVII:AM), and activated factor VII (FVIIa) in 102 healthy individuals. The reference ranges were 65-160 U/100 ml, 70-165 U/100 ml, and 30-170 mU/ml, respectively (2.5 and 97.5 percentiles). Freezing and thawing of the plasma samples had ...
Chiasson J L - - 1997
OBJECTIVE: To characterize the effect of pregnancy on glucose turnover and gluconeogenesis in healthy women and in women with well-controlled insulin-dependent diabetes mellitus (IDDM). DESIGN: Prospective clinical study. SETTING: Clinical research unit of the Hôtel-Dieu de Montréal hospital. PARTICIPANTS: Five healthy pregnant women and 6 pregnant women with IDDM. INTERVENTIONS: ...
Zeijdner E E - - 1997
During singleton pregnancy, maternal essential fatty acid (EFA) status decreases progressively. After multiple pregnancy it can be expected that the neonatal and maternal EFA status is even lower. To study whether the maternal EFA supply to the fetus is a limiting factor to the neonatal EFA status, we compared the ...
Smeaton T C - - 1997
A single bolus dose of theophylline (Th; 5 mg/kg) was administered through the abdominal catheter in nonpregnant and pregnant rats to measure unbound fraction (fu) of Th in pregnancy. After 90 min blood samples were collected. Plasma was extracted with a solvent system comprising chloroform and isopropyl alcohol (IPA) followed ...
Friedman S A - - 1997
OBJECTIVE: To determine the degree of fetal endothelial involvement in preeclampsia by measuring fetal plasma concentrations of cellular fibronectin. METHODS: In a prospective cohort study, fetal plasma was collected at delivery from the chorionic plate arteries and veins in a convenience sample of 28 pregnancies complicated by preeclampsia and in ...
Kato H - - 1997
Fetal levels of a representative lipid peroxide malondialdehyde (MDA) were measured as an index of oxidative stress in pregnancies complicated by preeclampsia (n = 19) and in normal pregnancy (n = 23). PO2, PCO2 and pH were also measured in umbilical venous blood obtained by cordocentesis. Plasma MDA levels rose ...
Kolben M - - 1997
Our purpose was to determine the levels in plasma of angiogenin in healthy pregnant women and to examine whether there are differences between uncomplicated pregnancies and patients with the syndrome of hemolysis, elevated liver enzymes, and low platelets, preeclampsia-eclampsia, and highly pathologic Doppler flow findings without additional complications. Angiogenin was ...
Comeglio P - - 1996
Pregnancy is considered as a hypercoagulable state and an increased incidence of thromboembolic phenomena has been reported in pregnant women. Relevant changes in the hemostatic mechanism have been reported during physiological pregnancy: briefly, increased levels of coagulation factors, enhanced thrombin generation and suppression of fibrinolysis are commonly found in women ...
Puza S - - 1996
Thrombotic thrombocytopenic purpura (TTP) is a disorder of unknown etiology affecting the microcirculation of multiple organ systems. Plasma therapy has significantly reduced the mortality rate; thus, an increased incidence of recurrence has been noted. Since corticosteroids, antiplatelet agents, and splenectomy do not prevent recurrences, monthly plasma infusion have been instituted ...
Tamura T - - 1996
OBJECTIVE: To evaluate the effect of angiotensin-converting enzyme (ACE) genotypes on pregnancy outcome, the incidence of pregnancy-induced hypertension, and changes in blood pressure (BP) during pregnancy; and the relationship between plasma ACE activities and plasma and erythrocyte zinc concentrations in each genotype. METHODS: The subjects (n = 191) were selected ...
Godfrey K M - - 1996
As insulin is a major fetal growth hormone, we have related the mother's nutrient intakes (assessed by a food frequency questionnaire) and other influences associated with fetal growth to the baby's concentrations of insulin and its propeptides in umbilical cord plasma. Among 391 term babies studied, those whose mothers had ...
Liapi C A - - 1996
High levels of corticotropin-releasing hormone (CRH) circulate in the plasma of pregnant women especially during the third trimester and even higher levels have been reported in abnormal pregnancies of various etiologies. One of these etiologies is pregnancy-induced hypertension (PIH). OBJECTIVE: To measure CRH blood levels with a sensitive method in ...
Irons D W - - 1996
OBJECTIVE: Our purpose was to determine whether human pregnancy alters the metabolic clearance and natriuretic effect of atrial natriuretic peptide. STUDY DESIGN: The metabolic clearance rate of atrial natriuretic peptide (ANP 99-126) was measured serially in nine normotensive primigravid women studied in early and late pregnancy and again 4 months ...
Sturgiss S N - - 1996
Pregnancy in healthy women is associated with increments in glomerular filtration rate (GFR) and effective renal plasma flow (ERPF). We hypothesized that the hyperfiltration of normal pregnancy attenuates or exhausts renal reserve. In 21 healthy females studied serially in early and late pregnancy and then on average 15 wk postpartum, ...
Schröcksnadel H - - 1996
OBJECTIVE: To examine levels of serum tryptophan and its degradation product kynurenine in uncomplicated pregnancy, according to the week of pregnancy and the concentrations of neopterin. METHODS: Plasma was analyzed from 45 healthy pregnant women (15 in each trimester), 15 healthy puerperas, and 20 nonpregnant controls. Tryptophan and kynurenine were ...
Johnson M R - - 1996
Recent data suggest that the ovarian peptide relaxin is responsible for the pregnancy-associated fall in plasma osmolality in the rat. In order to test whether relaxin has the same role during human pregnancy, plasma osmolality, electrolytes, urea and creatinine were measured in samples obtained at 10, 20 and 30 weeks ...
Steinberg F M - - 1996
A woman with primary lipoprotein lipase (LPL) deficiency developed marked hypertriglyceridemia, pancreatitis, eruptive xanthomas, and unusual palmar xanthomas during pregnancy. Hypotheses to account for the palmar xanthomas were that oxidative modification of triglyceride (TG)-rich lipoproteins occurred due to increased plasma residence time, or that their apolipoprotein E (apoE) content was ...
Roberts M - - 1996
Hyperfiltration precedes renal function loss in several nephropathies. Animal studies suggest this may be due to accompanying increases in transglomerular capillary hydrostatic pressure difference (delta P) and/or altered glomerular processing of macromolecules. Renal hemodynamics increase strikingly in human pregnancy. To test the hypothesis that these alterations are not potentially harmful, ...
Al M D - - 1996
OBJECTIVE: To study the relationships between the essential fatty acid (EFA) composition of maternal diet, maternal EFA status and the EFA status of healthy newborn infants. METHODS: A prospective longitudinal study was performed in which 176 pregnant women completed a food frequency questionnaire (FFQ) before 13, at 22, and at ...
Garland M - - 1996
The devastating impact of human immunodeficiency virus (HIV) infection during pregnancy has made the pharmacologic evaluation of potentially therapeutic agents of high priority. The results presented here are the maternal pharmacokinetics from a series of experiments to delineate more clearly the complex maternal-fetal pharmacokinetics and the effects of AZT in ...
Al Senaidy A M - - 1996
Plasma alpha- and gamma-tocopherol were monitored in pregnant women throughout healthy gestational periods and after delivery and were compared with that of non pregnant women. The mean plasma alpha-tocopherol and gamma-tocopherol concentrations in non pregnant Saudi women (15.2 +/- 1.3 and 1.8 +/- 0.2 mumol/l respectively) were found within normal ...
Spronsen, Francinus Johannes van
In this thesis, attention is paid to growth which may be impaired due the severe dietary Phe restriction; the possibility of distinction between patients with differences in PAH enzyme activity by direct measurement of the in-vivo phenylalanine hydroxylation; plasma Phe and Tyr concentrations in response to different distributions of the ...
Cunze T - - 1996
Fibronectin can be detected in the plasma and the extracellular matrix of the uterus of pregnant women. Studies so far have compared individual observations, whilst serial investigations during pregnancy, and during and after parturition have not been carried out. Plasma fibronectin levels were measured in 153 women with healthy pregnancies ...
Kandoussi A M - - 1996
Whole plasma from 6 normolipidemic chronic renal failure (CRF) patients undergoing hemodialysis treatment was passed through the anti-apolipoprotein (Apo) AI immunosorbent column connected to the anti-Apo B immunoaffinity column. Apo AI and B containing particles were analyzed for lipid and Apo contents. The results were compared with findings obtained in ...
Petraglia F - - 1996
Corticotropin-releasing hormone-binding protein (CRFBP) is a 37-kD protein of 322 amino acids, containing one putative N-glycosylation site and 11 cysteines, 10 of which remain in the mature molecule (298 amino acids) and result essential for the action. CRFBP protein gene has been cloned and mapped to the distal region of ...
Pekelharing H L - - 1995
The current prevalent view is that plasma lipoprotein(a) [Lp(a)] concentrations are under strong genetic control. Most dietary and drug interventions seem to have little or no effect on plasma Lp(a) levels. However, evidence for a possible regulatory rol e of hormones is accumulating, for instance, fluctuations of Lp(a) levels during ...
< 7 8 9 10 11 12 13 14 15 16 17 >