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Glover Vivette V Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, Du Cane Road, W12 0NN, London, UK, - - 2015
Many prospective studies have shown that if a mother is depressed, anxious or stressed while pregnant, this increases the risk for her child having a wide range of adverse outcomes including emotional problems, symptoms of attention deficit hyperactivity disorder (ADHD) or impaired cognitive development. Although genetics and postnatal care clearly ...
King Suzanne S Department of Psychiatry, McGill University, Montreal, QC, Canada, - - 2015
Animal studies of prenatal maternal stress permit random assignment of pregnant animals to stress and no-stress groups, and allow total control of the type, severity, and timing of the stressor in utero. Human studies have obvious constraints that make the use of experimental methods nearly impossible. Studying pregnant women who ...
Cohick Wendie S WS Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ, 08901-8520, USA, - - 2015
Fetal alcohol spectrum disorders affect a significant number of live births each year, indicating that alcohol consumption during pregnancy is an important public health issue. Environmental exposures and lifestyle choices during pregnancy may affect the offspring's risk of disease in adulthood, leading to the idea that a woman's risk of ...
Sarkar Dipak K DK Endocrinology Program and Department of Animal Sciences, Rutgers, The State University of New Jersey, 67 Poultry Farm Road, New Brunswick, NJ, 08901, USA, - - 2015
The idea that exposure to adverse environmental conditions and lifestyle choices during pregnancy can result in fetal programming that underlies disease susceptibility in adulthood is now widely accepted. Fetal alcohol exposed offspring displays many behavioral and physiological abnormalities including neuroendocrine-immune functions, which often carry over into their adult life. Since ...
Heller Debra S DS *Department of Pathology & Laboratory Medicine, Rutgers-New Jersey Medical School, Newark NJ †Department of Pathology, Division of Anatomic Pathology, University of Alabama at Birmingham, Birmingham, - - 2015
As the information obtained from previable fetal and stillbirth autopsies is used not only to explain the loss to the parents, but for future pregnancy planning, general pathologists need to be comfortable in dealing with these autopsies. The importance of an adequate fetal examination has been emphasized in a recent ...
Macdonald-Wallis Corrie C aMRC Integrative Epidemiology Unit at the University of Bristol bSchool of Social and Community Medicine, University of Bristol, Bristol cCentre for Statistical Methodology dDepartment of Medical Statistics, London School of Hygiene and Tropical Medicine, London eSchool of Medicine, University of Glasgow, Glasgow, - - 2015
Pregnancy is a period of considerable change in blood pressure, with an early pregnancy decrease followed by a late pregnancy rise. High blood pressure in pregnancy is associated with adverse perinatal outcomes for the mother and offspring. We aimed to define normal ranges of blood pressure across gestation. We used ...
Naruse Mie M Department of Epigenetics, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan School of Health Sciences, Tokai University, Bohseidai, Isehara, Kanagawa 259-1193, - - 2014
Sirh7/Ldoc1 [sushi-ichi retrotransposon homolog 7/leucine zipper, downregulated in cancer 1, also called mammalian retrotransposon-derived 7 (Mart7)] is one of the newly acquired genes from LTR retrotransposons in eutherian mammals. Interestingly, Sirh7/Ldoc1 knockout (KO) mice exhibited abnormal placental cell differentiation/maturation, leading to an overproduction of placental progesterone (P4) and placental lactogen ...
Gatzke Noah N Noah Gatzke is an emergency Nurse Practitioner at Health Sciences Centre, Adult ER, Winnipeg, MB. Laura Johnson is an instructor at the University of Manitoba, Faculty of Nursing, and a Nurse Practitioner Health Sciences Center Adult Emergency, Winnipeg, - - 2014
: Ectopic pregnancy (EP) is a leading cause of maternal morbidity and mortality. Rates of EP have declined, yet ethnic, socioeconomic, and age-related disparities persist. Improved ultrasound resolution, the use of emergency transvaginal ultrasounds, and improved lab sensitivity have enabled earlier diagnosis, which could further improve outcomes for patients with ...
Cabañas-Perianes Valentin V Department of Hematology, Virgen de la Arrixaca University Hospital, Murcia, - - 2014
Multiple myeloma (MM) is a hematologic neoplasm characterized by plasma tumor cell proliferation in the bone marrow. It's a rare malignancy before a 40-year-old and it is extremely uncommon during pregnancy. We report the case of a 37-year-old woman with a newly diagnosed IgG λ MM (Durie-Salmon stage IIIA, International ...
Cok Tayfun T Department of Obstetrics and Gynecology, School of Medicine, Baskent University, Ankara, - - 2014
Cesarean scar pregnancy (CSP) is a rare type of ectopic pregnancy, which occurs in previous cesarean section scar tissue, with an incidence of 1 in 1800-3000 pregnancies. Transvaginal ultrasound-guided local methotrexate (MTX) administration presents as a non-systemic option with possible better penetration to the pregnancy site. We present the management ...
Fyfe Trina M - - 2014
BackgroundThe purpose of this scoping review was to review the literature on healthcare provider provision of anti-D prophylaxis to RhD negative pregnant women in appropriate clinical situations in various healthcare settings.MethodsA scoping review framework was used to structure the process. The following databases were searched: CINAHL (EBSCO), EBM Reviews (OvidSP), ...
Prior Tomas T Centre for Fetal Care, Queen Charlotte's and Chelsea Hospital, London, UK; Institute for Reproductive and Developmental Biology, Imperial College London, London, - - 2014
Assessment of fetal haemodynamics, specifically umbilical and middle cerebral artery Doppler, can identify babies at increased risk of a subsequent diagnosis of intra-partum fetal compromise. The true growth potential of a fetus is difficult to predict, but recently a new definition, independent of fetal weight, using the cerebro-umbilical (C/U) ratio ...
Visiedo Francisco F Research Unit, Puerta del Mar University Hospital, Cádiz, - - 2014
Placental metabolism is an important mechanism for the regulation of fetal growth and long-term health of the newborns. In this study, we investigated the effects of maternal metabolic environment on human placental fatty acid and glucose metabolism. We used placental explants from uncomplicated pregnancies or pregnancies complicated with gestational diabetes ...
Viteri Oscar A OA Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, The University of Texas Health Science Center, Houston, - - 2014
Objectives Substance abuse in pregnancy remains a major public health problem. Fetal teratogenicity results from the effect of these substances during fetal development, particularly when used in combination. This review will focus on and attempt to clarify the existing literature regarding the association of substance abuse on the development of congenital ...
Jia Xiaofang - - 2014
Abstract Objective: To investigate selected fatty acid (FA) profiles in maternal whole blood during normal pregnancy and to evaluate their associations with term birth dimensions. Methods: We characterized nine major maternal blood FAs representing four FA families during the second and third trimester of pregnancy, and explored their associations with ...
Weissman Amir - - 2014
Abstract Aims: Sonographic estimation of fetal weight is a fundamental part of the routine obstetrical practice and may affect management decisions particularly in multiple gestations. The data available on the accuracy of sonographic estimation of fetal weight in triplets are very limited. In the present study we investigated the accuracy ...
Kadam Leena L Department of Physiology - - 2014
Abstract Peroxisome proliferator-activated receptor-gamma (PPAR-γ) belongs to the nuclear hormone receptor superfamily. Apart from being involved in lipid metabolism, like its other subtypes PPAR α and β, it is implicated to be crucial for successful placentation. While its role in extravillous trophoblast (EVT) differentiation has been studied, the involvement in ...
Seikku Laura L Department of Obstetrics and Gynecology, Helsinki University Central Hospital, - - 2014
High amniotic fluid erythropoietin (aEPO) concentration reflects chronic fetal hypoxia. Our aim was to study aEPO concentration in relation to neonatal outcome in pregnancies complicated by intrauterine growth restriction. Retrospective case series. Helsinki University Hospital, Finland. A total of 66 singleton pregnancies complicated by intrauterine growth restriction. Amniocentesis or amniotic ...
Ventura Walter W Fetal Medicine Unit, Instituto Nacional Materno Perinatal, Lima, - - 2014
To determine the contribution of uterine (UtA) and umbilical (UA) arteries Doppler examination at 28 weeks to predict adverse pregnancy outcomes in women who had increased resistance uterine artery in the early second trimester METHODS: Women with UtA mean pulsatility index (PI) above the 95(th) centile at 19-22 weeks of gestation ...
Schjoldager Janne Gram JG Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, 9 Ridebanevej, 1870, Frederiksberg C, - - 2014
Recently, we reported that preferential maternal-fetal vitamin C (vitC) transport across the placenta is likely to be impaired by prolonged maternal vitC deficiency. Maintenance of a basal maternal vitC supply at the expense of the fetus may impair fetal development; however, the knowledge of vitC's impact on intrauterine development is ...
Morton Jude S JS University of - - 2014
Preeclampsia is a disorder of pregnancy with a significant impact on maternal and fetal health. The complexity of this multifactorial condition has precluded development of effective therapies and, although many potential pathways have been investigated, the aetiology still requires clarification. Our group has investigated the scavenger, lectin-like oxidised LDL (LOX-1), ...
Dicke J M JM Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, - - 2014
The standard obstetric ultrasound examination includes documentation of arms and legs. The purpose of this study is to review the efficacy of ultrasound for the detection of limb anomalies, the type and incidence of associated malformations and pregnancy outcomes. All cases of polydactyly (POD), abnormal hand position (AHP), limb reduction ...
Barbara Piccoli Giorgina PG SS Nefrologia, Department of Clinical and Biological Sciences, ASOU San Luigi Gonzaga, University of Turin, - - 2014
The correlation between advanced or proteinuric CKD and adverse pregnancy outcomes is intuitive, although how early CKD affects pregnancy remains unknown. Glomerular hyperfiltration is a physiological response to pregnancy, correlated with outcomes in hypertension or collagen diseases. The aim of the study was correlate first trimester hyperfiltration with pregnancy outcomes ...
Whisner C M CM Division of Nutritional Sciences, Cornell University, Ithaca, - - 2014
Background:Modifiable risk factors during pregnancy, such as diet and weight gain, are associated with fetal birth weight but little is known about how these factors influence fetal fat acquisition in utero among pregnant adolescents.Objective:To determine whether maternal pre-pregnancy BMI (ppBMI), gestational weight gain (GWG) and dietary intake during pregnancy influence ...
Krawczynski Kamil - - 2014
Tightly coordinated, reciprocal embryo-maternal interactions affect gene expression during early pregnancy. Recently, microRNAs (miRNAs) have emerged as new players in the fine tuning of embryo development and implantation in mammals via posttranscriptional gene regulation mechanisms. Here, we integrated transcriptomic and computational approaches to profile miRNAs and miRNA synthesis/transport-related genes during ...
de Melo Juliana Oliveira JO University of São Paulo, School of Medicine, Laboratory of Renal Physiopathology, SP, - - 2014
This study aimed to verify the development of placental and systemic inflammation in rats exposed to fine particulate matter before or during pregnancy. Wistar rats were exposed to filtered air (control) or to a load of 600μg/m(3) of fine particles in the air. The gene expression of IL-1β, IL-4, IL-6, ...
Palomaki Ge G Department of Pathology and Laboratory Medicine, Women & Infants Hospital, Providence, Rhode Island; Alpert Medical School at Brown University, Providence, Rhode Island; Savjani Institute for Health Research, Windham, - - 2014
The proportion of circulating cell free (ccf) DNA derived from the feto-placental unit (fetal fraction or FF) correlates with test success and interpretation reliability. Some fetal disorders are associated with systematically lower FF, sometimes resulting in non-informative results. We analyzed results from pregnancies tested in a nested case/control study derived ...
Fügedi Gergely - - 2014
BackgroundThe endocannabinoid system plays a key role in female reproduction, including implantation, decidualization and placentation. In the present study, we aimed to analyze cannabinoid receptor 1 (CB1), CB2 and fatty acid amid hydrolase (FAAH) expressions and localization in normal and preeclamptic placenta, in order to determine whether placental endocannabinoid expression ...
Capone C A CA Department of Pediatrics, Division of Pediatric Cardiology, The Children's Hospital at Montefiore-Albert Einstein College of Medicine, Bronx, NY, - - 2014
Fetal supraventricular tachycardia (SVT), characterized by a fetal ventricular heart rate faster than 200 beats per minute (bpm), is often diagnosed during routine fetal heart monitoring or prenatal ultrasound examinations. Clinical guidelines for management of fetal SVT have not been determined in standardized trials, nor do we have a clear ...
Aromatario Mariarosaria M From the "Sapienza" University of Rome, Rome, - - 2014
Motor vehicle collisions are an important cause of blunt abdominal trauma in pregnant woman. Among the possible outcomes of blunt abdominal trauma, placental abruption, direct fetal trauma, and rupture of the gravid uterus are described. An interesting case of complete fetal decapitation with uterine rupture due to a high-velocity motor ...
Green Sarah B SB Sarah B. Green, Pharm.D., is Postgraduate Year 1 Pharmacy Practice Resident, WakeMed Health and Hospitals, Raleigh, NC; at the time of writing she was Intern, Drug Information, Department of Pharmacy, University of North Carolina Hospitals (UNCH), Chapel Hill. Ashley L. Pappas, Pharm.D., BCPS, is Pharmacy Specialist, Drug Information, Department of Pharmacy, UNCH. - - 2014
A review of case reports and other published data on fetal and neonatal outcomes associated with maternal use of bisphosphonate medications is presented. Bisphosphonates can persist in the bone matrix for years, even after therapy is discontinued, potentially resulting in fetal bisphosphonate exposure during pregnancy. Adverse effects of bisphosphonates on ...
Baska-Vincze Boglárka B Szent István University Equine Department and Clinic, Faculty of Veterinary Science Dóra major H-2225 ÜllÅ‘ - - 2014
In the equine practice, attempts have been made to examine the fetus in the second and third trimester of pregnancy but all of the available methods have limitations. Until now, transabdominal ultrasonography has been regarded as the most informative examination. This method allows us to measure fetal heart rate, fetal ...
Sato Y Y Department of Maternal Fetal Medicine, Osaka Prefectural Hospital Organization, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, - - 2014
Prenatal ultrasonography of a pregnant woman with a past history of total thyroidectomy for Graves' disease detected fetal tachycardia, fetal growth restriction and oligohydramnios at 30 weeks gestation. Because a high titer of thyroid-stimulating hormone receptor antibody was noted in maternal serum and the fetal goiter was detected on ultrasonography, ...
Weissmann-Brenner Alina A Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Hashomer, Affiliated With the Sackler Faculty of Medicine, Tel Aviv University, Ramat Gan, Israel. - - 2014
This series describes the sonographic characteristics and pregnancy outcomes of fetuses with abnormal insertion of the umbilical vein (UV) into the inferior vena cava (IVC). We conducted a retrospective study that described the sonographic features of 6 patients who underwent a routine anatomic scan during early pregnancy. Six patients had ...
Costa H F HF UNESP-FMVA-DAPSA, Aracatuba-SP - - 2014
Environmental influences such as nutritional restriction during early gestation in cattle may impair fetal development and compromise functions in adulthood. During the first trimester of gestation fetal gonads are formed. We hypothesised that either restriction or excess of nutrients ingested by cows during the first third of pregnancy interferes with ...
Robles M M INRA, UMR 1198 Biologie du Développement et Reproduction, Jouy en Josas, - - 2014
Modifications of maternal environment could alter fetal growth and development through the placenta and thus health in adulthood. The developmental origins of health and disease suggest that maternal nutrition during pregnancy may affect offspring development and subsequent energy metabolism. To understand the effect of common feeding practices during gestation, 24 ...
Rousseau-Ralliard D D INRA, UMR1198 BDR, Jouy-en-Josas, - - 2014
Pre-gestational type 1-diabetes (T1D) increases the risk of miscarriage and congenital malformations and programs the offspring to develop metabolic syndrome in adulthood. Management of maternal diabetes is essential during gestation but could be also highly important around the time of conception. Using a rabbit model, the effects of maternal T1D ...
Xiang R R JS Davies Epigenetics and Genetics Group, School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy Campus, Roseworthy, South Australia, - - 2014
The placenta, a major determinant of fetal growth in eutherians, facilitates maternal-fetal cross talk and mediates programming of postnatal phenotype via genetic and epigenetic mechanisms. However, magnitude and specificity of effects of maternal and paternal genomes on placental and fetal phenotype and their relationships are unclear. Using an outbred bovine ...
Rodrigues V H V VH University of Fortaleza (UNIFOR), Fortaleza, Ceará, - - 2014
Accelerated fetal growth may be observed in pregnancies from IVP embryos, which can be associated with increased concentration of sugar moieties (glucose, fructose) in the fetal plasma and related fluids (Bertolini et al. 2004 Reproduction 128, 341-354). The aim of this study was to compare the gene expression profiles of ...
Pratt Anita A Department of Perinatal Medicine, Pregnancy Research Centre, University of Melbourne, Parkville, VIC, 3052, - - 2014
Placental angiogenesis is critical to the success of human pregnancy. Angiogenesis is defined as the formation of new blood vessels from existing vasculature. Angiogenesis is necessary for the establishment of adequate placental perfusion, which is important for providing the optimum in utero environment to support fetal development. Defective placental angiogenesis ...
Maynard Matthew R MR Advanced Laboratory for Radiation Dosimetry Studies (ALRADS), J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, 32611-8300, - - 2014
One of the many objectives of the European Union's SOLO (Epidemiological Studies of Exposed Southern Urals Populations) project is to quantify the radiation dose-response following chronic in utero exposures to ionizing radiation. The project is presently conducting a pooled analysis of two cohorts of individuals born to exposed mothers-the Techa ...
Nassi Rossella R Endocrinology Unit, San Donato Hospital , Arezzo , Italy - - 2014
Abstract Cushing's syndrome is a rare condition in the general population and is even less common during pregnancy with only a few cases reported in literature. The diagnosis of Cushing's syndrome may be difficult during pregnancy because the typical features of the disorder and pregnancy may overlap. However, Cushing's syndrome ...
Marcellin L L Cochin Institute, Inserm U1016, CNRS 8104, Université Paris Descartes, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Port Royal - Hôpitaux Universitaires Paris Centre, Service de Gynécologie-Obstétrique II et Médecine de la Reproduction, Paris, France Université Paris Descartes, DHU Risques et Grossesse, Paris, France - - 2014
Are the fetal membranes of women affected with endometriosis similar to those from disease-free women? Decidua of women with endometriosis is able to generate endometriotic-like lesions in contact with the fetal membranes. Eutopic endometrium of women affected with endometriosis presents compromised properties. Endometrium undergoes decidualisation to accept and to further ...
Léger Juliane J Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, Service d'Endocrinologie Diabétologie Pédiatrique, Centre de Référence des Maladies Endocriniennes Rares de la Croissance, F-75019 Paris, - - 2014
Context: Untreated hypothyroidism is associated with a higher risk of adverse obstetric and neonatal outcomes. Pregnancy complications have yet to be evaluated in patients treated early for congenital hypothyroidism (CH). Objective: To investigate pregnancy outcomes and their determinants in a population-based registry of young adult women with CH. Design, setting ...
Adams Tracy M TM Stony Brook University Hospital, Stony Brook, NY. Department of Obstetrics and Gynecology Division of Maternal Fetal Medicine; Winthrop University Hospital Mineola, NY. Department of Obstetrics and Gynecology Division of Maternal Fetal Medicine. Electronic address: - - 2014
To determine the timing of administration of antenatal corticosteroids for indicated preterm births and to identify which indications are associated with the most optimal timing of administration. This was a retrospective cohort of patients who received antenatal corticosteroids in anticipation of indicated preterm birth between 2009 and 2012 at Winthrop ...
Geer Laura A LA Department of Environmental and Occupational Health Sciences, State University of New York, Downstate School of Public Health, Box 43, 450 Clarkson Avenue, Brooklyn, NY 11203-2533, USA. Electronic address: - - 2014
Amniotic fluid (AF) is a biological medium uniquely suited for the study of early exposure of the human fetus to environmental contaminants acquired by the mother before and during pregnancy. Traditional diagnostic applications of AF have focused almost exclusively on the diagnosis of genetic aberrations such as Trisomy-21 and on ...
Plamondon André A Applied Psychology and Human Development, University of Toronto, Toronto, Ontario, Canada; Fraser Mustard Institute for Human Development, University of Toronto, Toronto, Ontario, Canada. Electronic address: - - 2014
Experimental evidence in rodents shows that maternal stress during pregnancy (MSDP) negatively impacts spatial learning and memory in the offspring. We aim to investigate the association between MSDP (i.e., life events) and spatial working memory, as well as attention skills (attention shifting and attention focusing), in humans. The moderating roles ...
Balassiano Erika - - 2014
After spontaneous conception, the rate of miscarriage is more common in multiple rather than singleton pregnancies. However, the incidence of miscarriage is lower in in-vitro fertilization twin versus singleton pregnancies. Most patients have little understanding of pregnancy outcomes once they achieve a positive pregnancy test. This study investigated the relationship ...
Rabaglino Maria B MB From the Department of Animal Reproduction, Universidad Nacional de Rio Cuarto, Rio Cuarto, Cordoba, Argentina (M.B.R.); Department of Obstetrics and Laboratory of Neuroimmunology and Developmental Origins of Disease, University Medical Center Utrecht, Utrecht, The Netherlands (E.D.P.U.); Department of Ob/Gyn, Magee Womens Hospital, Pittsburgh, PA (A.J., W.A.H.); and D.H. Barron Reproductive and Perinatal Biology Research Program, Departments of Physiology and Functional Genomics and of Ob/Gyn, University of Florida, Gainesville (E.D.P.U., K.P.C.). brabaglino@ufl.edu - - 2014
Impaired uterine invasion by extravillous trophoblast in early gestation is implicated in the genesis of preeclampsia, a potentially lethal malady of human pregnancy. However, reasons for extravillous trophoblast dysfunction remain unclear because of virtual inaccessibility of early placental and uterine tissues from women who develop preeclampsia, and the absence of ...
Becker Jeroen H JH Department of Obstetrics and Gynecology, University Medical Centre Utrecht, Utrecht, the - - 2014
To study the predictive value of biphasic ST-events for interventions for suspected fetal distress and adverse neonatal outcome, when using ST-analysis of the fetal electrocardiogram (FECG) for intrapartum fetal monitoring. Prospective cohort study. Three academic hospitals in Sweden. Laboring women with a high-risk singleton fetus in cephalic position beyond 36 ...
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