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Dahlstrom Jane E JE 1Department of Anatomical Pathology, ACT Pathology, Canberra Hospital 2ANU Medical School, Canberra 3Department of Endocrinology, Canberra Hospital 4Department of Obstetrics and Gynaecology, Calvary Hospital 5John James Medical Centre, Deakin, - - 2014
A 26-year-old Indian lady G2P0 presented at 33 weeks gestation complaining of itch. Liver function tests revealed an elevated alkaline phosphatase (ALKP) of 2983 U/L (normal range 20-110) which on fractionation was a placental or placental-like isoenzyme. All other investigations, including fetal ultrasound, were normal. Labour was induced at 37 weeks ...
Cheung Annie N Y AN Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong - - 2014
Extensive use of ultrasound in early pregnancy has given rise to increased diagnostic dilemma, particularly the differential diagnosis of early complete mole, partial mole and abnormal nonmolar villous lesions. The rare entities of placental mesenchymal dysplasia, twin pregnancy with one complete mole further pose problems. Overdiagnosis of hydatidiform mole in ...
Faye-Petersen Ona Marie OM Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, - - 2014
There is mounting evidence that several placental pathologic entities associated with fetal intrauterine growth restriction and poor and recurrent pregnancy outcomes reflect disruption of mechanisms of immune tolerance normally operative during pregnancy. This presentation update will include an overview studies that have yielded evidence of the role of alloimmune mechanisms, ...
Petukhova N L NL ART Clinic "Test-tube babies" , Moscow , - - 2014
Abstract This study of infertile women prior in vitro fertilization (IVF) is focused at the genetic and acquired thrombophilia before the IVF program, the identification of the frequency of occurrence of thrombophilia in them, the impact of thrombophilia of the offensive, the course and outcome of pregnancies, to improve the ...
Glasier Anna A Department of Obstetrics and Gynaecology, University of Edinburgh , Edinburgh , Scotland - - 2014
Abstract Unintended pregnancy is an important public health problem worldwide. Unwanted pregnancies may end in induced abortion (legal or illegal, safe or unsafe) or in childbirth. In many parts of the world both can be life threatening. Even where both are safe, abortion is distressing for all concerned while unwanted ...
Cohen J J Department of Gynecology and Obstetrics, Hôpital Tenon, Assistance Publique des Hôpitaux de Paris Université Pierre et Marie Curie Paris 6, France - - - 2014
The main objective was to confirm with modern tools the former assertion that there is a vascular resistance gradient along the umbilical cord. We performed a prospective observational study in a population of women with third trimester monofetal and uncomplicated pregnancies during two months. Pulsatility Index and Resistance Index were ...
Visentin Silvia S Department of Woman's and Child's Health, Maternal-Fetal Medicine Unit, University of Padua School of Medicine, Padua, Italy (S.V., F.G., D.T., V.Z., G.A., E.C.); and Clinic of Obstetrics and Gynecology, Department of Experimental Clinical and Medical Sciences, University of Udine, Udine, Italy - - 2014
To investigate whether antenatal recognition of small-for-gestational-age (SGA) fetuses with normal maternal and fetal Doppler values delivered after 34 weeks' gestation is associated with changes in the risk of adverse maternal and neonatal outcomes. In this retrospective study, we included 313 singleton SGA fetuses and 313 appropriate-for-gestational-age control fetuses born ...
Bromley Bryann B Diagnostic Ultrasound Associates, PC, Boston, Massachusetts USA (B.B., T.D.S., Y.G., B.R.B.); Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts USA (B.B., B.R.B.); Departments of Obstetrics and Gynecology (B.B., T.D.S., Y.G., R.S.N., B.R.B.) and Radiology (B.B., T.D.S., B.R.B.), Brigham and Women's Hospital, Boston, Massachusetts USA; Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts USA (J.L.); and Harvard Vanguard Medical Associates, Boston Massachusetts USA (R.S.N.). - - 2014
The purpose of this study was to evaluate the importance of second-trimester "soft markers" for trisomy 21 after an 11- to 14-week aneuploidy screening scan. We conducted a retrospective cohort study of consecutive patients referred for measurement of the nuchal translucency (NT) as part of a screening protocol for aneuploidy. ...
Bromley Bryann B Diagnostic Ultrasound Associates, PC, Boston, Massachusetts USA (B.B., T.D.S., Y.G., B.R.B.); Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts USA (B.B., B.R.B.); Departments of Obstetrics and Gynecology (B.B., T.D.S., S.N., Y.G., B.R.B.) and Radiology (B.B., T.D.S., B.R.B.), Brigham and Women's Hospital, Boston, Massachusetts USA; Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts USA (J.L.); and Harvard Vanguard Medical Associates, Boston, Massachusetts USA (R.S.N.). - - 2014
The purpose of this study was to determine whether first-trimester aneuploidy screening sonography initially performed by credentialed sonographers was useful for detecting fetal anomalies between 11 and 14 weeks' gestation. We conducted a retrospective cohort study of consecutive patients referred to a private ultrasound facility between January 1, 2008, and ...
Al-Gubory Kaïs H - - 2014
Abstract Oxidative stress is associated with decreased female fertility and adversely affects prenatal development. Mammalian cells have developed a network of enzymatic and non-enzymatic antioxidant defence systems to prevent oxidative stress. Little attention has been paid to the antioxidative pathways in placentas of normal and disturbed pregnancies, leaving a gap ...
Shamsa A A Department of Obstetrics and Gynaecology, Westmead Hospital , Westmead, NSW , - - 2014
The aim of this study was to review the incidence, indication, management and complications of peripartum hysterectomy (PH) in a tertiary level hospital over a decade. A retrospective review of all cases of PH performed at Westmead Hospital, Western Sydney, 2003-2012, was undertaken. PH was defined as hysterectomy performed after ...
Sung Joyce F JF Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Colorado Denver, Aurora, - - 2014
Objective To determine whether hyperglycemic excursions detected by continuous glucose monitoring (CGM) correlate with birth weight percentile and other pregnancy outcomes, and whether CGM correlates better with these outcomes than a single glucose value from a 1-hour glucose challenge test (GCT). Study Design This was a prospective observational study of 55 pregnant ...
Shreffler Karina M KM Department of Human Development and Family Science, Oklahoma State University, 700 N. Greenwood Ave., Tulsa, OK, 74106, USA, - - 2014
How stable are women's pregnancy intentions across their reproductive lifespans? Are there demographic, social, or attitudinal characteristics that are associated with differing pregnancy intentions patterns? Patterns of intendedness across pregnancies were examined using a sample of 3,110 women ages 25-45 who have been pregnant at least twice from the National ...
Sananès Nicolas N Department of fetal medicine, Strasbourg teaching hospital, - - 2014
Abstract Objective: The monkey model is the best model to investigate some physiological response to the fetal transitory tracheal occlusion but it has never been described in macaca monkeys. The aim of this study was to evaluate the feasibility of fetal endoscopic tracheal occlusion (FETO) in a non-human primate model. ...
Aviram Amir A Rabin Medical Center, Helen Schneider Hospital for Women , Petah Tikva , Israel - - 2014
Abstract Objective: We aimed to evaluate whether pre-recognition of small for gestational age (SGA) at late preterm or term pregnancies, has an impact on pregnancy outcome. Methods: Retrospective analysis of SGA newborns, stratified to those with suspected or unsuspected IUGR according the sonographic estimated fetal weight (EFW), below the 10th ...
Titapant Vitaya V Division of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, - - 2014
The aim of this study was to explore the effects of prenatal fetal diagnoses of non-lethal anomalies on the psychological well-being of pregnant women throughout their pregnancy. Fifty-five pregnant women were asked to complete a questionnaire (the Spielberger State-Trait Anxiety Inventory) to assess their anxiety levels at multiple follow-up visits. ...
Kagan K O KO Department of Obstetrics and Gynaecology, University of Tuebingen, - - 2014
Purpose: To examine combined first trimester screening (FTS), noninvasive prenatal testing (NIPT) and a two-step policy that combines FTS and NIPT in screening for aneuploidy. Materials and Methods: Retrospective study involving 21 052 pregnancies where FTS was performed at the Praxis Praenatal.de in Duesseldorf, Germany. In each case, the sum risk ...
Pala H G HG Division of Perinatology, Department of Obstetrics and Gynecology, Celal Bayar University School of Medicine , Manisa , - - 2014
The aim of this study is to evaluate the relationship between three-dimensional (3D) ultrasound measurements of placenta at 11-13(6) weeks' gestation and maternal serum levels of pregnancy associated plasma protein-A (PAPP-A), free beta human chorionic gonadotrophin (fβhCG), Doppler parameters in early pregnancy. This prospective study consisted of 334 singleton pregnancies ...
Chang Abraham A Stanford Health Care, Palo Alto, CA, - - 2014
Systematically review the literature assessing outcomes of acute myeloid leukemia (AML) treatment during pregnancy. A Pubmed literature search (January 1969 to June 2014) for articles written about AML and pregnancy, and bibliographies/citations of previously published reviews. Articles written in the English language that administered active AML chemotherapy during pregnancy were ...
Stocker L J LJ University of Southampton, Faculty of Medicine, Academic Unit of Human Development and Health, - - 2014
To investigate the incidence of congenital lung malformations over the past 19 years. Congenital lung malformations (CLM) are a heterogeneous group of lung abnormalities. The antenatal diagnosis is important for fetal and neonatal management but there have been no studies examining whether the reported incidence of this abnormality is constant. ...
Fruscalzo A A Clinic of Obstetrics and Gynecology, DISM, AOU, "SM della Misericordia'" of Udine, P.le SM della Misericordia 15, 33100, Udine, Italy, - - 2014
Retinol (ROH) is an essential micronutrient required for normal fetal development and an essential molecule for antioxidant processes. To investigate the putative role of ROH as a marker of preeclampsia in early second trimester amniotic fluid (AF). Case-control study comparing the concentration of ROH and other antioxidants such as uric ...
Chen Lei-Shih LS Department of Health and Kinesiology, Texas A&M University, College Station, - - 2014
In the United States, prenatal genetic testing (PGT) for Autism Spectrum Disorders (ASD) is currently available via clinical genetic services. Such testing may inform parents about their unborn child's risk for ASD, prepare parents for the birth of an affected infant, and allow them to arrange for early interventions. Although ...
Quezada Maria Soledad MS Harris Birthright Research Centre for Fetal Medicine, King's College, London, - - 2014
To examine the performance of cell-free (cf)DNA testing for trisomies 21, 18 and 13 in a general population at 10-11 weeks' gestation. In 2,905 singleton pregnancies prospective screening for trisomies was performed by chromosome-selective sequencing of cfDNA in maternal blood at 10-11 weeks and by the combined test at 11-13 ...
Macdonald-Wallis Corrie C aMRC Integrative Epidemiology Unit at the University of Bristol bSchool of Social and Community Medicine, University of Bristol, Bristol cCentre for Statistical Methodology dDepartment of Medical Statistics, London School of Hygiene and Tropical Medicine, London eSchool of Medicine, University of Glasgow, Glasgow, - - 2014
Pregnancy is a period of considerable change in blood pressure, with an early pregnancy decrease followed by a late pregnancy rise. High blood pressure in pregnancy is associated with adverse perinatal outcomes for the mother and offspring. We aimed to define normal ranges of blood pressure across gestation. We used ...
Dumitrescu Adina A Department of Obstetrics, Gynecology and Reproductive Sciences (GWA, EDA), Center for Studies in Reproduction, University of Maryland School of Medicine, Baltimore, MD, 21201 and Departments of Obstetrics and Gynecology and Physiological Sciences (AD, GJP), Eastern Virginia Medical School, Norfolk, VA, - - 2014
We have previously shown that estrogen selectively suppresses growth of the fetal zone of the baboon fetal adrenal cortex, which produces the C19-steroid precursors, e.g. dehydroepiandrosterone sulfate (DHAS), that are aromatized to estrogen within the placenta. In the present study, we determined whether fetal adrenal expression of cell cycle regulators ...
Girardi G G 1] MRC Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK [2] Lupus Research Unit, The Rayne Institute, King's College London St Thomas' Hospital, London, - - 2014
In the current study, we have developed a magnetic resonance imaging-based method for non-invasive detection of complement activation in placenta and foetal brain in vivo in utero. Using this method, we found that anti-complement C3-targeted ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles bind within the inflamed placenta and foetal brain cortical ...
Rada Cara C CC Washington - - 2014
Proper placental perfusion is essential for fetal exchange of oxygen, nutrients, and waste with the maternal circulation. Impairment of utero-placental vascular function can lead to pregnancy complications, including preeclampsia and intrauterine growth restriction. Potassium channels have been recognized as regulators of vascular proliferation, angiogenesis, and secretion of vasoactive factors, and ...
Freud Lindsay R LR Department of Cardiology, Boston Children's Hospital, Harvard Medical - - 2014
To better understand the natural history and spectrum of fetal aortic stenosis (AS), we aimed to 1) determine the prenatal diagnosis rate of neonates with critical AS and a biventricular (BV) outcome; and 2) describe the findings at fetal echocardiography in prenatally diagnosed patients. A multi-center, retrospective study was performed ...
Quezada Maria Soledad MS Harris Birthright Research Centre of Fetal Medicine, King's College Hospital, London, - - 2014
To explore whether in pregnancies that are complicated by spontaneous preterm delivery fetal fraction of cell-free (cf)DNA in maternal plasma at 11-13 weeks' gestation is altered and if this measurement is useful in the prediction of preterm delivery. Fetal fraction of cfDNA was measured at 10(+0) -13(+6)  weeks' gestation in ...
Rolnik Daniel L DL Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, - - 2014
To examine whether maternal plasma concentration of total cell-free (cf) DNA and fetal fraction at 11-13 and 20-24 weeks' gestation in pregnancies that subsequently develop preeclampsia (PE) is different from those without this complication. Total cfDNA and fetal fraction were measured in 20 cases of early-PE, requiring delivery <34 weeks, 20 ...
Kerr Ashley - - 2014
It is well established that spontaneous conceptus loss in swine is associated with an imbalance of both angiogenic and immunological factors. Leptin (LEP), a metabolic hormone, has also been implicated in the promotion of angiogenesis. In this study, LEP and its long form receptor (OB-Rb) were evaluated during porcine pregnancy ...
Chaparro María M Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IP), and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD) , Americio 17, E 2°C, 28021 Madrid , Spain +34 913093911 ; +34 914022299 ; - - 2014
Introduction: Infliximab has been approved for the treatment of patients with inflammatory bowel diseases (IBD). However, data regarding its safety during pregnancy and breastfeeding are scarce. Areas covered: Relevant papers sourced from bibliographical searches (MEDLINE) up to June 2014 are reviewed. Infliximab, as adalimumab, crosses the placenta from the end ...
Clark Dayna R - - 2014
Listeria monocytogenes (Lm) is an intracellular bacterium with unique predisposition for systemic maternal infection during pregnancy and morbid consequences for the developing fetus. Given the high mortality associated with prenatal Lm infection, strategies for augmenting protective immunity during the exceedingly vulnerable period of pregnancy are urgently needed. Herein, protection conferred ...
Brock Rebecca L - - 2014
A systematic investigation of the role of prenatal partner support in perinatal maternal depression was conducted. Separate facets of partner support were examined (i.e., received support and support adequacy) and a multidimensional model of support was applied to investigate the effects of distinct types of support (i.e., informational, physical comfort, ...
Sharma Nirmal S NS From the *Division of Pulmonary, Critical Care, and Sleep Medicine, and the ** Department of Cardiothoracic Surgery, University of Alabama at Birmingham, Birmingham - - 2014
Extracorporeal membrane oxygenation (ECMO) use during pregnancy and the post-partum period is thought to be associated with an increased risk for maternal or fetal bleeding complications. We present our recent institutional experience in managing pregnant and post-partum patients with ECMO. We also performed a literature review of modern use of ...
de Andrade Ramos Bruna B Department of Pathology, Botucatu Medical School, São Paulo State University, UNESP, Botucatu, São Paulo, - - 2014
Microorganisms in the pregnant female genital tract are not always associated with pathology. The factors that influence the maternal response to microorganisms remain ill defined. We review the state of knowledge of microbe-host interactions in gestational tissues and highlight mechanisms that promote tolerance or pathogenesis. Tolerance to microorganisms is promoted ...
Bruwer Zandrè Z Genetic and Developmental Medicine Clinic, Sultan Qaboos University Hospital, Muscat, Sultanate of Oman, - - 2014
The incidence of congenital anomalies and/or genetic disorders in the Omani population has reached figures greater than double the global statistics. Preference for consanguineous unions together with the fact that termination of pregnancy in Muslim communities are largely avoided, have been highlighted as contributing factors. This overview identifies a third ...
Schleenvoigt B T BT Center for Infectious Diseases and Infection Control, Jena University Hospital, Erlanger Allee 101, 07740, Jena, Thuringia, FR Germany, - - 2014
Schistosomiasis is a widespread helminthic infection which sometimes may affect travelers to endemic areas. We report on a case of urogenital and placental schistosomiasis in a 28-year-old German woman who had been exposed to schistosomiasis in Lake Malawi one year earlier. She experienced painless macrohaematuria in her 21st week of ...
Eskild Anne A Department of Obstetrics and Gynecology and Institute of Clinical Medicine, University of Oslo, Akershus University Hospital, - - 2014
To study whether placental weight or placental to birthweight ratio are associated with Apgar score in the newborn five minutes after birth. Population based registry study. The Medical Birth Registry of Norway. All singleton live births during the period 1999-2008, a total of 522 360 births. The placental to birthweight ratios ...
Kirn Verena V Department of Obstetrics and Gynecology, University of Cologne, Kerpener Str. 34, 50931, Cologne, Germany, - - 2014
Since the routine screening program for cervical dysplasia by Pap smear was established in the early 1970s, the rate of cervical cancer has continually dropped. Even if a high percentage of cervical dysplasia shows spontaneous restitution, the only effective therapy for persisting cervical dysplasia is local ablation or excision which ...
Matsubara Shigeki S Department of Obstetrics and Gynecology, Jichi Medical University, Shimotsuke, Tochigi, - - 2014
The uterine incision site in cesarean section for placenta previa (PP) with low suspicion of abnormally invasive placentation is controversial. A lower uterine segment transverse incision may sometimes result in a "transplacental approach" when the placenta is present at this site, which may cause massive maternal hemorrhage. Neonates born from ...
Wong Luchin F LF Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT, United States; Department of Maternal-Fetal Medicine, Intermountain Healthcare, Salt Lake City, UT, United States. Electronic address: - - 2014
We sought to assess the relationship between a short interpregnancy interval (IPI) following a pregnancy loss and subsequent live birth and pregnancy outcomes. A secondary analysis of women enrolled in the Effects of Aspirin in Gestation and Reproduction trial with an hCG-positive pregnancy test and whose last reproductive outcome was ...
Díaz Marta M Hospital Sant Joan de Déu, University of Barcelona, Esplugues, - - 2014
Background: Prenatal growth restraint is associated with increased oxidative stress - as judged by mitochondrial dysfunction - in pregnancies complicated by preeclampsia or diabetes, but it is uncertain whether this is also the case in uncomplicated pregnancies. We assessed the link between fetal growth restraint and placental mitochondrial dysfunction, as ...
Savitri Ary I AI Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht,Utrecht,The - - 2014
Many Muslim women worldwide are pregnant during Ramadan and adhere to Ramadan fasting during pregnancy. In the present study, we determined whether maternal adherence to Ramadan fasting during pregnancy has an impact on the birth weight of the newborn, and whether the effects differed according to trimester in which Ramadan ...
Walsh Jennifer M JM UCD Obstetrics & Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin, - - 2014
Abstract Objective: Our objective was to determine if early pregnancy urinary metabolomic profiles could predict fetal adiposity and macrosomia. Methods: This is a prospective study of fifty healthy women in their second pregnancy. Fasting urine samples taken during early pregnancy were analyzed using NMR spectroscopy. Maternal glucose and insulin were ...
Hasegawa Junichi J Department of Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, - - 2014
Longitudinal and cross-sectional investigations using ultrasound examinations during pregnancy can be used to clarify the mechanisms and pathophysiology of abnormal fetal and placental development. Such sonoembryological assessments are useful as a method for clarifying the etiology of disease. In the present review, we describe current knowledge based on our experience ...
Jimbo Tomoka T Department of Obstetrics and Gynecology, Kyushu University Hospital, Fukuoka, - - 2014
Placental mesenchymal dysplasia (PMD) is a rare disease that may be difficult to distinguish from molar pregnancy. The disease is associated with major fetal complications, including Beckwith-Wiedemann syndrome, fetal growth restriction and intrauterine fetal death. Rarely, fetal hematological disorders and liver tumors also may occur. Two patients were referred to ...
Fukuda Takanori T Department of Obstetrics and Gynecology, Shonan Kamakura General Hospital, Kamakura City, - - 2014
A 32-year-old woman had bilateral tubal and intrauterine pregnancies after hyperovulation with clomiphene citrate and subsequent artificial insemination with husband's semen. Laparoscopic surgery revealed bilateral tubal pregnancies. Salpingectomy was performed on the left tube and linear salpingotomy was performed on the right tube. The postoperative course was uneventful. The patient ...
DeKoninck P P Fetal Medicine Unit, Department of Obstetrics and Gynaecology, University Hospitals Leuven, KU Leuven, Leuven, Belgium; Department of Development and Regeneration, Cluster Organ Systems, KU Leuven, Leuven, - - 2014
To report a recent update on fetuses with right-sided congenital diaphragmatic hernia (RCDH) in the era of fetal surgery. Retrospective review of prospectively collected data. Fetal treatment centres in Leuven and Barcelona. Consecutive cases of RCDH between 2002 and 2012. Data on prenatal imaging, genetic testing, pregnancy and neonatal outcomes ...
Ovesen P P Department of Obstetrics and Gynecology, Aarhus University Hospital, Skejby, 8200 Aarhus N, - - 2014
Abstract Objective: To estimate the association between gestational diabetes mellitus (GDM) and adverse pregnancy and neonatal outcomes in Denmark. Methods: A population-based cohort study including all singleton pregnancies in Denmark from 2004 to 2010 (n = 403,092). Maternal complications during pregnancy and delivery and fetal complications were classified according to ...
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