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Visentin Silvia S Department of Woman's and Child's Health, Maternal-Fetal Medicine Unit, University of Padua School of Medicine, Padua, Italy (S.V., F.G., D.T., V.Z., G.A., E.C.); and Clinic of Obstetrics and Gynecology, Department of Experimental Clinical and Medical Sciences, University of Udine, Udine, Italy - - 2014
To investigate whether antenatal recognition of small-for-gestational-age (SGA) fetuses with normal maternal and fetal Doppler values delivered after 34 weeks' gestation is associated with changes in the risk of adverse maternal and neonatal outcomes. In this retrospective study, we included 313 singleton SGA fetuses and 313 appropriate-for-gestational-age control fetuses born ...
Bromley Bryann B Diagnostic Ultrasound Associates, PC, Boston, Massachusetts USA (B.B., T.D.S., Y.G., B.R.B.); Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts USA (B.B., B.R.B.); Departments of Obstetrics and Gynecology (B.B., T.D.S., Y.G., R.S.N., B.R.B.) and Radiology (B.B., T.D.S., B.R.B.), Brigham and Women's Hospital, Boston, Massachusetts USA; Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts USA (J.L.); and Harvard Vanguard Medical Associates, Boston Massachusetts USA (R.S.N.). - - 2014
The purpose of this study was to evaluate the importance of second-trimester "soft markers" for trisomy 21 after an 11- to 14-week aneuploidy screening scan. We conducted a retrospective cohort study of consecutive patients referred for measurement of the nuchal translucency (NT) as part of a screening protocol for aneuploidy. ...
Bromley Bryann B Diagnostic Ultrasound Associates, PC, Boston, Massachusetts USA (B.B., T.D.S., Y.G., B.R.B.); Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts USA (B.B., B.R.B.); Departments of Obstetrics and Gynecology (B.B., T.D.S., S.N., Y.G., B.R.B.) and Radiology (B.B., T.D.S., B.R.B.), Brigham and Women's Hospital, Boston, Massachusetts USA; Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts USA (J.L.); and Harvard Vanguard Medical Associates, Boston, Massachusetts USA (R.S.N.). - - 2014
The purpose of this study was to determine whether first-trimester aneuploidy screening sonography initially performed by credentialed sonographers was useful for detecting fetal anomalies between 11 and 14 weeks' gestation. We conducted a retrospective cohort study of consecutive patients referred to a private ultrasound facility between January 1, 2008, and ...
Ugurlucan Funda Gungor FG Istanbul University Istanbul Medical School, Department of Obstetrics and Gynecology, Istanbul, - - 2014
To evaluate the feasibility of umbilical cord scanning during the second-trimester sonographic examination, we looked at the method of scanning, the findings, and the time spent. Five hundred forty-nine singleton pregnancies were evaluated at 18-23 weeks' menstrual age with two-dimensional sonography (US). Color Doppler US was used when needed. The ...
Matinnia Nasrin N Department of Community Health, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400, Serdang, Selangor, Malaysia, - - 2014
Pregnancy- and childbirth-related fears are common psychological concerns and the primary reasons for requesting caesarean section (CS). We aimed to examine the content of maternal fear and the associated demographic factors in a sample of Iranian primigravidae. A randomly selected sample of primigravidae (n = 342) was recruited in four health care ...
Croft Adam P AP Department of Renal Immunobiology, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, - - 2014
Pregnancy in patients with anti-neutrophil cytoplasm antibody-associated vasculitis is reportedly associated with a high risk of fetal and maternal complications. Here we describe the outcome of pregnancies in patients with granulomatosis with polyangiitis and microscopic polyangiitis at five centers in the United Kingdom using a retrospective case review of all ...
Wassenaar Trudy M TM Molecular Microbiology and Consultants, Zotzenheim, - - 2014
Novel findings in microbiology question the long-standing paradigm that a healthy pregnancy implies a sterile uterus. It now seems that the placenta is frequently colonized with bacteria, and a placental microbiome has been identified. Recent literature findings are summarized here, and an attempt is made to separate pathological bacterial presence ...
Hudeček Robert R Department of Obstetrics and Gynaecology, Masaryk University and University Hospital Brno , Brno, Czech Republic - - 2014
Background: An ectopic pregnancy within a Cesarean scar represents a rare type of extrauterine pregnancy in which the fertilized egg nidates in the myometrium of the uterine wall within a scar left from a previous Cesarean delivery. An unrecognized growing Cesarian scar pregnancy may result in uterine rupture, uncontrollable metrorrhagia, ...
Salzberg Kelsey W KW 401 Parnassus Ave, San Francisco, CA 94143, USA. - - 2014
We report the case of a 34-year-old woman who was diagnosed with pemphigus vulgaris (PV) during pregnancy. The patient presented with widespread blistering dermatitis and associated burning and pruritus. At 6 weeks' gestation the patient was admitted to the hospital to expedite her diagnosis and initiate treatment. A skin biopsy ...
Wilson R Douglas RD Calgary - - 2014
To provide obstetrical and genetic health care practitioners with guidelines and recommendations for prenatal screening, diagnosis, and obstetrical management of fetal open and closed neural tube defects (OCNTD). This review includes prenatal screening and diagnostic techniques currently being used for the detection of OCNTD including maternal serum alpha fetoprotein screening, ...
Genc Mine M Department of Obstetrics and Gynecology, Sifa University School of Medicine, Izmir, - - 2014
Placenta percreta is a rare complication potentially fatal to fetus and the mother. We present here a 41-year-old female patient who underwent curettage for incomplete abortion at 6(th) week of pregnancy. She had persistent vaginal bleeding for 2 months after the curettage, for which she was treated with hysterectomy. Preoperative ...
White S S Department of Dermatology, University of Texas Medical Branch, Galveston, TX, - - 2014
The pregnancy-specific skin disorders are pruritic, inflammatory eruptions. The current classification by Ambros-Rudolph et al. includes four entities: pemphigoid gestationis (PG), polymorphic eruption of pregnancy (PEP), atopic eruption of pregnancy (AEP), and intrahepatic cholestasis of pregnancy (ICP). Although these disorders are all characterized by intense pruritus during pregnancy, they can ...
Rab Attila A Telki Hospital, Telki, - - 2014
Abstract Objective: The gene expression of transforming growth factor beta-1 (TGF-β1) in human placental samples obtained from pregnancies with small for gestational age fetuses (SGA) was compared to those of normal pregnancies. Methods: In 2011 placental samples from 101 pregnancies with SGA and from 140 normal pregnancies were obtained for ...
Sun Libo - - 2014
Neonatal mortality reduction in China over past two decades was reported from nationwide sampling surveys, however, how high risk pregnancy affected neonatal outcome is unknown. The objective of this study was to explore relations of pregnancy complications and neonatal outcomes from a regional birth population. In a prospective, cross-sectional survey ...
Payne Matthew S - - 2014
This study tested if second trimester amniotic fluid cytokine levels, Ureaplasma sp. colonisation and sexual activity predict preterm birth and explain the differential preterm birth rates in Chinese compared to Australian women. Amniotic fluid was collected by amniocentesis (Chinese 480, Australian 492). Cytokines were measured by multiplex assay and Ureaplasma ...
Shin Jung-A JA Department of Anatomy, School of Medicine, Ewha Womans University, Seoul, - - 2014
Background: Normal fetal development requires adequate folate levels during pregnancy. Although folate metabolic enzymes have important roles in the maintenance of normal fetal development, the location of folate metabolic enzymes, methionine synthase (MTR) and 5,10-methylenetetrahydrofolate reductase (MTHFR), has not been previously examined. Methods: We investigated the expression of MTR and ...
Li Jian J Department of Clinical Medicine, Medical college of Hunan Normal University, Changsha 410006, - - 2014
Background/Aims: Diabetes is well-known to influence endothelial function. Endothelial function and blood flow regulation might be different in diabetic and non-diabetic pregnancy. However, the impact of umbilical blood flow regulation in gestational diabetes on fetal development is unknown so far. Methods: In a prospective birth cohort study, we analyzed the ...
Al-Gubory Kaïs H - - 2014
Abstract Oxidative stress is associated with decreased female fertility and adversely affects prenatal development. Mammalian cells have developed a network of enzymatic and non-enzymatic antioxidant defence systems to prevent oxidative stress. Little attention has been paid to the antioxidative pathways in placentas of normal and disturbed pregnancies, leaving a gap ...
Shamsa A A Department of Obstetrics and Gynaecology, Westmead Hospital , Westmead, NSW , - - 2014
The aim of this study was to review the incidence, indication, management and complications of peripartum hysterectomy (PH) in a tertiary level hospital over a decade. A retrospective review of all cases of PH performed at Westmead Hospital, Western Sydney, 2003-2012, was undertaken. PH was defined as hysterectomy performed after ...
Liorni Ilaria I CNR Consiglio Nazionale delle Ricerche, Istituto di Elettronica e di Ingegneria dell'Informazione e delle Telecomunicazioni IEIIT (CNR National Research Council of Italy, Institute of Electronics, Computer and Telecommunication Engineering), Piazza Leonardo da Vinci, Milano, Italy; Dipartimento di Elettronica, Informazione e Bioingegneria DEIB (Department of Electronics, Information and Bioengineering), Politecnico di Milano, Piazza Leonardo da Vinci, Milano, - - 2014
In this paper, fetal exposure to uniform magnetic fields (MF) with different polarizations is quantified at 50 Hz. Numerical computations were performed on high-resolution pregnant models at 3, 7, and 9 months of gestational age (GA), that distinguish a high number of fetal tissues. Fetal whole-body and tissue-specific induced electric fields ...
Sung Joyce F JF Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Colorado Denver, Aurora, - - 2014
Objective To determine whether hyperglycemic excursions detected by continuous glucose monitoring (CGM) correlate with birth weight percentile and other pregnancy outcomes, and whether CGM correlates better with these outcomes than a single glucose value from a 1-hour glucose challenge test (GCT). Study Design This was a prospective observational study of 55 pregnant ...
Shreffler Karina M KM Department of Human Development and Family Science, Oklahoma State University, 700 N. Greenwood Ave., Tulsa, OK, 74106, USA, - - 2014
How stable are women's pregnancy intentions across their reproductive lifespans? Are there demographic, social, or attitudinal characteristics that are associated with differing pregnancy intentions patterns? Patterns of intendedness across pregnancies were examined using a sample of 3,110 women ages 25-45 who have been pregnant at least twice from the National ...
Sananès Nicolas N Department of fetal medicine, Strasbourg teaching hospital, - - 2014
Abstract Objective: The monkey model is the best model to investigate some physiological response to the fetal transitory tracheal occlusion but it has never been described in macaca monkeys. The aim of this study was to evaluate the feasibility of fetal endoscopic tracheal occlusion (FETO) in a non-human primate model. ...
Aviram Amir A Rabin Medical Center, Helen Schneider Hospital for Women , Petah Tikva , Israel - - 2014
Abstract Objective: We aimed to evaluate whether pre-recognition of small for gestational age (SGA) at late preterm or term pregnancies, has an impact on pregnancy outcome. Methods: Retrospective analysis of SGA newborns, stratified to those with suspected or unsuspected IUGR according the sonographic estimated fetal weight (EFW), below the 10th ...
Titapant Vitaya V Division of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, - - 2014
The aim of this study was to explore the effects of prenatal fetal diagnoses of non-lethal anomalies on the psychological well-being of pregnant women throughout their pregnancy. Fifty-five pregnant women were asked to complete a questionnaire (the Spielberger State-Trait Anxiety Inventory) to assess their anxiety levels at multiple follow-up visits. ...
Kagan K O KO Department of Obstetrics and Gynaecology, University of Tuebingen, - - 2014
Purpose: To examine combined first trimester screening (FTS), noninvasive prenatal testing (NIPT) and a two-step policy that combines FTS and NIPT in screening for aneuploidy. Materials and Methods: Retrospective study involving 21 052 pregnancies where FTS was performed at the Praxis Praenatal.de in Duesseldorf, Germany. In each case, the sum risk ...
Pala H G HG Division of Perinatology, Department of Obstetrics and Gynecology, Celal Bayar University School of Medicine , Manisa , - - 2014
The aim of this study is to evaluate the relationship between three-dimensional (3D) ultrasound measurements of placenta at 11-13(6) weeks' gestation and maternal serum levels of pregnancy associated plasma protein-A (PAPP-A), free beta human chorionic gonadotrophin (fβhCG), Doppler parameters in early pregnancy. This prospective study consisted of 334 singleton pregnancies ...
Chang Abraham A Stanford Health Care, Palo Alto, CA, - - 2014
Systematically review the literature assessing outcomes of acute myeloid leukemia (AML) treatment during pregnancy. A Pubmed literature search (January 1969 to June 2014) for articles written about AML and pregnancy, and bibliographies/citations of previously published reviews. Articles written in the English language that administered active AML chemotherapy during pregnancy were ...
Stocker L J LJ University of Southampton, Faculty of Medicine, Academic Unit of Human Development and Health, - - 2014
To investigate the incidence of congenital lung malformations over the past 19 years. Congenital lung malformations (CLM) are a heterogeneous group of lung abnormalities. The antenatal diagnosis is important for fetal and neonatal management but there have been no studies examining whether the reported incidence of this abnormality is constant. ...
Fruscalzo A A Clinic of Obstetrics and Gynecology, DISM, AOU, "SM della Misericordia'" of Udine, P.le SM della Misericordia 15, 33100, Udine, Italy, - - 2014
Retinol (ROH) is an essential micronutrient required for normal fetal development and an essential molecule for antioxidant processes. To investigate the putative role of ROH as a marker of preeclampsia in early second trimester amniotic fluid (AF). Case-control study comparing the concentration of ROH and other antioxidants such as uric ...
Chen Lei-Shih LS Department of Health and Kinesiology, Texas A&M University, College Station, - - 2014
In the United States, prenatal genetic testing (PGT) for Autism Spectrum Disorders (ASD) is currently available via clinical genetic services. Such testing may inform parents about their unborn child's risk for ASD, prepare parents for the birth of an affected infant, and allow them to arrange for early interventions. Although ...
Quezada Maria Soledad MS Harris Birthright Research Centre for Fetal Medicine, King's College, London, - - 2014
To examine the performance of cell-free (cf)DNA testing for trisomies 21, 18 and 13 in a general population at 10-11 weeks' gestation. In 2,905 singleton pregnancies prospective screening for trisomies was performed by chromosome-selective sequencing of cfDNA in maternal blood at 10-11 weeks and by the combined test at 11-13 ...
Macdonald-Wallis Corrie C aMRC Integrative Epidemiology Unit at the University of Bristol bSchool of Social and Community Medicine, University of Bristol, Bristol cCentre for Statistical Methodology dDepartment of Medical Statistics, London School of Hygiene and Tropical Medicine, London eSchool of Medicine, University of Glasgow, Glasgow, - - 2014
Pregnancy is a period of considerable change in blood pressure, with an early pregnancy decrease followed by a late pregnancy rise. High blood pressure in pregnancy is associated with adverse perinatal outcomes for the mother and offspring. We aimed to define normal ranges of blood pressure across gestation. We used ...
Dumitrescu Adina A Department of Obstetrics, Gynecology and Reproductive Sciences (GWA, EDA), Center for Studies in Reproduction, University of Maryland School of Medicine, Baltimore, MD, 21201 and Departments of Obstetrics and Gynecology and Physiological Sciences (AD, GJP), Eastern Virginia Medical School, Norfolk, VA, - - 2014
We have previously shown that estrogen selectively suppresses growth of the fetal zone of the baboon fetal adrenal cortex, which produces the C19-steroid precursors, e.g. dehydroepiandrosterone sulfate (DHAS), that are aromatized to estrogen within the placenta. In the present study, we determined whether fetal adrenal expression of cell cycle regulators ...
Girardi G G 1] MRC Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK [2] Lupus Research Unit, The Rayne Institute, King's College London St Thomas' Hospital, London, - - 2014
In the current study, we have developed a magnetic resonance imaging-based method for non-invasive detection of complement activation in placenta and foetal brain in vivo in utero. Using this method, we found that anti-complement C3-targeted ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles bind within the inflamed placenta and foetal brain cortical ...
Rada Cara C CC Washington - - 2014
Proper placental perfusion is essential for fetal exchange of oxygen, nutrients, and waste with the maternal circulation. Impairment of utero-placental vascular function can lead to pregnancy complications, including preeclampsia and intrauterine growth restriction. Potassium channels have been recognized as regulators of vascular proliferation, angiogenesis, and secretion of vasoactive factors, and ...
Freud Lindsay R LR Department of Cardiology, Boston Children's Hospital, Harvard Medical - - 2014
To better understand the natural history and spectrum of fetal aortic stenosis (AS), we aimed to 1) determine the prenatal diagnosis rate of neonates with critical AS and a biventricular (BV) outcome; and 2) describe the findings at fetal echocardiography in prenatally diagnosed patients. A multi-center, retrospective study was performed ...
Quezada Maria Soledad MS Harris Birthright Research Centre of Fetal Medicine, King's College Hospital, London, - - 2014
To explore whether in pregnancies that are complicated by spontaneous preterm delivery fetal fraction of cell-free (cf)DNA in maternal plasma at 11-13 weeks' gestation is altered and if this measurement is useful in the prediction of preterm delivery. Fetal fraction of cfDNA was measured at 10(+0) -13(+6)  weeks' gestation in ...
Rolnik Daniel L DL Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, - - 2014
To examine whether maternal plasma concentration of total cell-free (cf) DNA and fetal fraction at 11-13 and 20-24 weeks' gestation in pregnancies that subsequently develop preeclampsia (PE) is different from those without this complication. Total cfDNA and fetal fraction were measured in 20 cases of early-PE, requiring delivery <34 weeks, 20 ...
Kerr Ashley - - 2014
It is well established that spontaneous conceptus loss in swine is associated with an imbalance of both angiogenic and immunological factors. Leptin (LEP), a metabolic hormone, has also been implicated in the promotion of angiogenesis. In this study, LEP and its long form receptor (OB-Rb) were evaluated during porcine pregnancy ...
Chaparro María M Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IP), and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD) , Americio 17, E 2°C, 28021 Madrid , Spain +34 913093911 ; +34 914022299 ; - - 2014
Introduction: Infliximab has been approved for the treatment of patients with inflammatory bowel diseases (IBD). However, data regarding its safety during pregnancy and breastfeeding are scarce. Areas covered: Relevant papers sourced from bibliographical searches (MEDLINE) up to June 2014 are reviewed. Infliximab, as adalimumab, crosses the placenta from the end ...
Clark Dayna R - - 2014
Listeria monocytogenes (Lm) is an intracellular bacterium with unique predisposition for systemic maternal infection during pregnancy and morbid consequences for the developing fetus. Given the high mortality associated with prenatal Lm infection, strategies for augmenting protective immunity during the exceedingly vulnerable period of pregnancy are urgently needed. Herein, protection conferred ...
Brock Rebecca L - - 2014
A systematic investigation of the role of prenatal partner support in perinatal maternal depression was conducted. Separate facets of partner support were examined (i.e., received support and support adequacy) and a multidimensional model of support was applied to investigate the effects of distinct types of support (i.e., informational, physical comfort, ...
Sharma Nirmal S NS From the *Division of Pulmonary, Critical Care, and Sleep Medicine, and the ** Department of Cardiothoracic Surgery, University of Alabama at Birmingham, Birmingham - - 2014
Extracorporeal membrane oxygenation (ECMO) use during pregnancy and the post-partum period is thought to be associated with an increased risk for maternal or fetal bleeding complications. We present our recent institutional experience in managing pregnant and post-partum patients with ECMO. We also performed a literature review of modern use of ...
Keelan J A JA Perth, WA, Australia. Electronic address: - - 2014
Solithromycin is a 4th generation macrolide/fluoroketolide antibiotic that has potential applications in the treatment and prevention of intrauterine and fetal infections in pregnancy; it has also been reported to exert anti-inflammatory effects. The objective of the present study was to determine its ability to cross the human placenta and inhibit ...
de Andrade Ramos Bruna B Department of Pathology, Botucatu Medical School, São Paulo State University, UNESP, Botucatu, São Paulo, - - 2014
Microorganisms in the pregnant female genital tract are not always associated with pathology. The factors that influence the maternal response to microorganisms remain ill defined. We review the state of knowledge of microbe-host interactions in gestational tissues and highlight mechanisms that promote tolerance or pathogenesis. Tolerance to microorganisms is promoted ...
Bruwer Zandrè Z Genetic and Developmental Medicine Clinic, Sultan Qaboos University Hospital, Muscat, Sultanate of Oman, - - 2014
The incidence of congenital anomalies and/or genetic disorders in the Omani population has reached figures greater than double the global statistics. Preference for consanguineous unions together with the fact that termination of pregnancy in Muslim communities are largely avoided, have been highlighted as contributing factors. This overview identifies a third ...
Schleenvoigt B T BT Center for Infectious Diseases and Infection Control, Jena University Hospital, Erlanger Allee 101, 07740, Jena, Thuringia, FR Germany, - - 2014
Schistosomiasis is a widespread helminthic infection which sometimes may affect travelers to endemic areas. We report on a case of urogenital and placental schistosomiasis in a 28-year-old German woman who had been exposed to schistosomiasis in Lake Malawi one year earlier. She experienced painless macrohaematuria in her 21st week of ...
Eskild Anne A Department of Obstetrics and Gynecology and Institute of Clinical Medicine, University of Oslo, Akershus University Hospital, - - 2014
To study whether placental weight or placental to birthweight ratio are associated with Apgar score in the newborn five minutes after birth. Population based registry study. The Medical Birth Registry of Norway. All singleton live births during the period 1999-2008, a total of 522 360 births. The placental to birthweight ratios ...
Kirn Verena V Department of Obstetrics and Gynecology, University of Cologne, Kerpener Str. 34, 50931, Cologne, Germany, - - 2014
Since the routine screening program for cervical dysplasia by Pap smear was established in the early 1970s, the rate of cervical cancer has continually dropped. Even if a high percentage of cervical dysplasia shows spontaneous restitution, the only effective therapy for persisting cervical dysplasia is local ablation or excision which ...
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