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Quezada Maria Soledad MS Harris Birthright Research Centre of Fetal Medicine, King's College Hospital, London, - - 2014
To explore whether in pregnancies that are complicated by spontaneous preterm delivery fetal fraction of cell-free (cf)DNA in maternal plasma at 11-13 weeks' gestation is altered and if this measurement is useful in the prediction of preterm delivery. Fetal fraction of cfDNA was measured at 10(+0) -13(+6)  weeks' gestation in ...
Rolnik Daniel L DL Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, - - 2014
To examine whether maternal plasma concentration of total cell-free (cf) DNA and fetal fraction at 11-13 and 20-24 weeks' gestation in pregnancies that subsequently develop preeclampsia (PE) is different from those without this complication. Total cfDNA and fetal fraction were measured in 20 cases of early-PE, requiring delivery <34 weeks, 20 ...
Kerr Ashley - - 2014
It is well established that spontaneous conceptus loss in swine is associated with an imbalance of both angiogenic and immunological factors. Leptin (LEP), a metabolic hormone, has also been implicated in the promotion of angiogenesis. In this study, LEP and its long form receptor (OB-Rb) were evaluated during porcine pregnancy ...
Chaparro María M Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IP), and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD) , Americio 17, E 2°C, 28021 Madrid , Spain +34 913093911 ; +34 914022299 ; - - 2014
Introduction: Infliximab has been approved for the treatment of patients with inflammatory bowel diseases (IBD). However, data regarding its safety during pregnancy and breastfeeding are scarce. Areas covered: Relevant papers sourced from bibliographical searches (MEDLINE) up to June 2014 are reviewed. Infliximab, as adalimumab, crosses the placenta from the end ...
Clark Dayna R - - 2014
Listeria monocytogenes (Lm) is an intracellular bacterium with unique predisposition for systemic maternal infection during pregnancy and morbid consequences for the developing fetus. Given the high mortality associated with prenatal Lm infection, strategies for augmenting protective immunity during the exceedingly vulnerable period of pregnancy are urgently needed. Herein, protection conferred ...
Brock Rebecca L - - 2014
A systematic investigation of the role of prenatal partner support in perinatal maternal depression was conducted. Separate facets of partner support were examined (i.e., received support and support adequacy) and a multidimensional model of support was applied to investigate the effects of distinct types of support (i.e., informational, physical comfort, ...
Sharma Nirmal S NS From the *Division of Pulmonary, Critical Care, and Sleep Medicine, and the ** Department of Cardiothoracic Surgery, University of Alabama at Birmingham, Birmingham - - 2014
Extracorporeal membrane oxygenation (ECMO) use during pregnancy and the post-partum period is thought to be associated with an increased risk for maternal or fetal bleeding complications. We present our recent institutional experience in managing pregnant and post-partum patients with ECMO. We also performed a literature review of modern use of ...
Keelan J A JA Perth, WA, Australia. Electronic address: - - 2014
Solithromycin is a 4th generation macrolide/fluoroketolide antibiotic that has potential applications in the treatment and prevention of intrauterine and fetal infections in pregnancy; it has also been reported to exert anti-inflammatory effects. The objective of the present study was to determine its ability to cross the human placenta and inhibit ...
de Andrade Ramos Bruna B Department of Pathology, Botucatu Medical School, São Paulo State University, UNESP, Botucatu, São Paulo, - - 2014
Microorganisms in the pregnant female genital tract are not always associated with pathology. The factors that influence the maternal response to microorganisms remain ill defined. We review the state of knowledge of microbe-host interactions in gestational tissues and highlight mechanisms that promote tolerance or pathogenesis. Tolerance to microorganisms is promoted ...
Bruwer Zandrè Z Genetic and Developmental Medicine Clinic, Sultan Qaboos University Hospital, Muscat, Sultanate of Oman, - - 2014
The incidence of congenital anomalies and/or genetic disorders in the Omani population has reached figures greater than double the global statistics. Preference for consanguineous unions together with the fact that termination of pregnancy in Muslim communities are largely avoided, have been highlighted as contributing factors. This overview identifies a third ...
Schleenvoigt B T BT Center for Infectious Diseases and Infection Control, Jena University Hospital, Erlanger Allee 101, 07740, Jena, Thuringia, FR Germany, - - 2014
Schistosomiasis is a widespread helminthic infection which sometimes may affect travelers to endemic areas. We report on a case of urogenital and placental schistosomiasis in a 28-year-old German woman who had been exposed to schistosomiasis in Lake Malawi one year earlier. She experienced painless macrohaematuria in her 21st week of ...
Eskild Anne A Department of Obstetrics and Gynecology and Institute of Clinical Medicine, University of Oslo, Akershus University Hospital, - - 2014
To study whether placental weight or placental to birthweight ratio are associated with Apgar score in the newborn five minutes after birth. Population based registry study. The Medical Birth Registry of Norway. All singleton live births during the period 1999-2008, a total of 522 360 births. The placental to birthweight ratios ...
Kirn Verena V Department of Obstetrics and Gynecology, University of Cologne, Kerpener Str. 34, 50931, Cologne, Germany, - - 2014
Since the routine screening program for cervical dysplasia by Pap smear was established in the early 1970s, the rate of cervical cancer has continually dropped. Even if a high percentage of cervical dysplasia shows spontaneous restitution, the only effective therapy for persisting cervical dysplasia is local ablation or excision which ...
Matsubara Shigeki S Department of Obstetrics and Gynecology, Jichi Medical University, Shimotsuke, Tochigi, - - 2014
The uterine incision site in cesarean section for placenta previa (PP) with low suspicion of abnormally invasive placentation is controversial. A lower uterine segment transverse incision may sometimes result in a "transplacental approach" when the placenta is present at this site, which may cause massive maternal hemorrhage. Neonates born from ...
Wong Luchin F LF Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT, United States; Department of Maternal-Fetal Medicine, Intermountain Healthcare, Salt Lake City, UT, United States. Electronic address: - - 2014
We sought to assess the relationship between a short interpregnancy interval (IPI) following a pregnancy loss and subsequent live birth and pregnancy outcomes. A secondary analysis of women enrolled in the Effects of Aspirin in Gestation and Reproduction trial with an hCG-positive pregnancy test and whose last reproductive outcome was ...
Díaz Marta M Hospital Sant Joan de Déu, University of Barcelona, Esplugues, - - 2014
Background: Prenatal growth restraint is associated with increased oxidative stress - as judged by mitochondrial dysfunction - in pregnancies complicated by preeclampsia or diabetes, but it is uncertain whether this is also the case in uncomplicated pregnancies. We assessed the link between fetal growth restraint and placental mitochondrial dysfunction, as ...
Savitri Ary I AI Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht,Utrecht,The - - 2014
Many Muslim women worldwide are pregnant during Ramadan and adhere to Ramadan fasting during pregnancy. In the present study, we determined whether maternal adherence to Ramadan fasting during pregnancy has an impact on the birth weight of the newborn, and whether the effects differed according to trimester in which Ramadan ...
Walsh Jennifer M JM UCD Obstetrics & Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin, - - 2014
Abstract Objective: Our objective was to determine if early pregnancy urinary metabolomic profiles could predict fetal adiposity and macrosomia. Methods: This is a prospective study of fifty healthy women in their second pregnancy. Fasting urine samples taken during early pregnancy were analyzed using NMR spectroscopy. Maternal glucose and insulin were ...
Hasegawa Junichi J Department of Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, - - 2014
Longitudinal and cross-sectional investigations using ultrasound examinations during pregnancy can be used to clarify the mechanisms and pathophysiology of abnormal fetal and placental development. Such sonoembryological assessments are useful as a method for clarifying the etiology of disease. In the present review, we describe current knowledge based on our experience ...
Jimbo Tomoka T Department of Obstetrics and Gynecology, Kyushu University Hospital, Fukuoka, - - 2014
Placental mesenchymal dysplasia (PMD) is a rare disease that may be difficult to distinguish from molar pregnancy. The disease is associated with major fetal complications, including Beckwith-Wiedemann syndrome, fetal growth restriction and intrauterine fetal death. Rarely, fetal hematological disorders and liver tumors also may occur. Two patients were referred to ...
Fukuda Takanori T Department of Obstetrics and Gynecology, Shonan Kamakura General Hospital, Kamakura City, - - 2014
A 32-year-old woman had bilateral tubal and intrauterine pregnancies after hyperovulation with clomiphene citrate and subsequent artificial insemination with husband's semen. Laparoscopic surgery revealed bilateral tubal pregnancies. Salpingectomy was performed on the left tube and linear salpingotomy was performed on the right tube. The postoperative course was uneventful. The patient ...
DeKoninck P P Fetal Medicine Unit, Department of Obstetrics and Gynaecology, University Hospitals Leuven, KU Leuven, Leuven, Belgium; Department of Development and Regeneration, Cluster Organ Systems, KU Leuven, Leuven, - - 2014
To report a recent update on fetuses with right-sided congenital diaphragmatic hernia (RCDH) in the era of fetal surgery. Retrospective review of prospectively collected data. Fetal treatment centres in Leuven and Barcelona. Consecutive cases of RCDH between 2002 and 2012. Data on prenatal imaging, genetic testing, pregnancy and neonatal outcomes ...
Ovesen P P Department of Obstetrics and Gynecology, Aarhus University Hospital, Skejby, 8200 Aarhus N, - - 2014
Abstract Objective: To estimate the association between gestational diabetes mellitus (GDM) and adverse pregnancy and neonatal outcomes in Denmark. Methods: A population-based cohort study including all singleton pregnancies in Denmark from 2004 to 2010 (n = 403,092). Maternal complications during pregnancy and delivery and fetal complications were classified according to ...
Horgan Casie E - - 2014
Humans with Ehlers-Danlos Syndrome, a subtype of which is caused by abnormal decorin expression, are at increased risk of preterm birth due to preterm premature rupture of fetal membranes (PPROM). In the mouse model, the absence of decorin leads to fetal membrane abnormalities, preterm birth and dysregulation of decorin's downstream ...
Myngheer Nele N Department of Endocrinology, University Hospitals Leuven, Leuven, - - 2014
Sulfonylureas (SUs) are effective at controlling glycemia in permanent neonatal diabetes mellitus (PNDM) caused by KCNJ11 (Kir6.2) mutations. We report the case of a woman with PNDM who continued high doses of glibenclamide (85 mg/day) during her pregnancy. The baby was born preterm, and presented with macrosomia and severe hyperinsulinemic ...
Razon Yaron Y Heart Institute, Schneider Children Medical Center of Israel, Petah-Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: - - 2014
Right aortic arch (RAA) is usually associated with the presence of a significant congenital heart disease, usually a conotruncal defect, which determines the postnatal outcome. In the absence of such cardiac defects, the significance of RAA has not been determined. The aims of this study were to evaluate the significance ...
Ong Gregory S Y GS Department of Endocrinology and Diabetes (G.S.Y.O., S.J.B., E.M.L. and J.P.W.) and Department of General Medicine (G.S.Y.O.), Sir Charles Gairdner Hospital, Nedlands 6009 AUSTRALIA; Department of Clinical Biochemistry (N.C.H. and E.M.L.), PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre, Nedlands 6009 AUSTRALIA; School of Medicine and Pharmacology (J.P.W.), The University of Western Australia, Crawley 6009 - - 2014
Maternal hypothyroidism in early pregnancy is associated with adverse outcomes, but not consistently across studies. First trimester screening for chromosomal anomalies is routine in many centers and provides an opportunity to test thyroid function. To determine if thyroid function tests performed with first trimester screening predicts adverse pregnancy outcomes. Cohort ...
Shelton Melissa M MM University of South Florida, College of Nursing, Tampa, FL, USA - - 2014
A secondary pilot study was carried out as part of a larger parent study of thyroid function in pregnancy and postpartum. All women in the parent study (N = 631) had blood samples, demographic data, and measures of perceived stress and dysphoric moods collected between 16 and 26 weeks' gestation. ...
Brazão Vânia V College of Pharmaceutical Sciences of Ribeirão Preto (FCFRP), University of São Paulo, Av. do Café s/n, 14040-903 Ribeirão Preto, São Paulo, Brazil. Electronic address: - - 2014
Pregnancy is known to induce a transient depression of maternal cell-mediated immunity, to prevent rejection of the fetus, while at the same time it keeps adequate maternal host defense mechanisms to fight infection. Presently, the aim of this paper was to investigate a possible endocrine and immunologic alteration observed during ...
Krauspenhar Bruna B Graduate Program in Medicine and Health Sciences (Nephrology), School of Medicine, Institute of Biomedical Research, São Lucas Hospital, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil. Electronic address: - - 2014
Preeclampsia (PE), one of the leading gestational hypertensive diseases, is characterized by increased blood pressure (⩾140/90mmHg) and pathological proteinuria after 20weeks gestation. It is a complex, multifactorial syndrome with an unestablished etiology and cure. The search continues for a biomarker that could assist in the early prediction or diagnosis of ...
Bahr B L BL Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT, - - 2014
Preeclampsia (PE) and intrauterine growth restriction (IUGR) are two diseases that affect pregnant women and their unborn children. These diseases cause low birth weight, pre-term delivery, and neurological and cardiovascular disorders in babies. Combined they account for 20% of preterm deliveries. Pyruvate kinase M2 (PKM2) is a metabolism enzyme found ...
Skreden Marianne M 1Department of Public Health,Sports and Nutrition,University of Agder,PO Box 422,4604 - - 2014
To describe changes in consumption of different types of beverages from pre-pregnancy to early pregnancy, and to examine associations with maternal age, educational level and BMI. Cross-sectional design. Participants answered an FFQ at inclusion into a randomized controlled trial, the Fit for Delivery (FFD) trial, in median gestational week 15 ...
Uribe Mari Carmen MC Laboratorio de Biología de la Reproducción, Departamento de Biología Comparada, Facultad de Ciencias, Universidad Nacional Autónoma de México, Ciudad Universitaria, 04510, México, DF, - - 2014
Intraluminal gestation, as it occurs in viviparous goodeids, allows a wide diversity of embryo-maternal metabolic exchanges. The branchial placenta occurs in embryos developing in intraluminal gestation when ovarian folds enter through the operculum, into the branchial chamber. The maternal ovarian folds may extend to the embryonic pharyngeal cavity. A branchial ...
Chang Zenas Z Eunice Kennedy Shriver National Institute of Child Health and Human - - 2014
Objective: To describe the pregnancy course and outcome, and use of anakinra, a recombinant selective IL-1 receptor blocker, during pregnancy in patients with cryopyrin-associated periodic syndromes (CAPS), including familial cold auto-inflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS) and neonatal onset multi-system inflammatory disease (NOMID). Methods: Women currently enrolled in natural history ...
Adekola Henry H Department of Obstetrics and Gynecology, Hutzel Women's Hospital/Wayne State University School of Medicine, Detroit, MI, - - 2014
We describe the transvaginal sonographic findings in a patient with complete placenta previa and increased risk of preterm birth owing to a prior history of mid-trimester pregnancy loss in whom we observed a short cervix and prolapse of the placenta and fetal membranes into the endocervical canal. We believe that ...
Rallis Sofia S School of Psychology, Deakin University, Victoria, Australia. Electronic address: - - 2014
Perinatal distress has largely been conceptualised as the experience of depression and/or anxiety. Recent research has shown that the affective state of stress is also present during the perinatal period and thus may add to a broader understanding of perinatal distress. The aims of the present study were to investigate ...
Chen Chung-Hey CH PhD, RN, Professor, Institute of Allied Health Sciences and Department of Nursing, National Cheng Kung - - 2014
Pregnancy is a potentially stressful event. Prenatal stress alters maternal endocrine and immune systems, has been implicated in the etiology of prenatal complications or postnatal psychiatric disorders, and may adversely affect fetal health. The 30-item Pregnancy Stress Rating Scale (PSRS), initially developed in 1983 by Chen and colleagues, is the ...
Unterscheider Julia J Department of Obstetrics and Gynaecology, Royal College of Surgeons in Ireland, Dublin, - - 2014
Objective This study aims to compare recommendations from recently published national clinical guidelines for pregnancies complicated by fetal growth restriction (FGR). Materials and Methods Clinical guidelines informing best practice management of pregnancies with FGR issued by the American Congress of Obstetricians and Gynecologists, the Society of Obstetricians and Gynaecologists of Canada and ...
Chanprapaph Pharuhas - - 2014
Abstract Background: Multiple first trimester aneuploidy sonomarkers have been introduced recently. Objective: To evaluate the efficacy of first trimester sonomarkers in fetal aneuploidy detection without serum markers. Methods: There were entirely 280 fetuses with 11-13+6 weeks' gestation (crown-rump -length between 45-84 mm) enrolled to assess nuchal translucency thickness (NT), nasal ...
Cruz-Martinez Rogelio R Department of Fetal Medicine and Surgery, Children's and Women's Specialty Hospital, Querétaro, - - 2014
Congenital neck masses are associated with high perinatal mortality and morbidity secondary to airway obstruction due to a mass effect of the tumor with subsequent neonatal asphyxia and/or neonatal death. Currently, the only technique designed to establish a secure neonatal airway is the ex utero intrapartum treatment (EXIT) procedure, which ...
Armstrong-Wells Jennifer J University of Colorado School of Medicine/Children's Hospital Colorado, Department of Pediatrics (Neurology); University of Colorado School of Medicine, Department of Obstetrics & Gynecology. Electronic address: - - 2014
The maternal-fetal inflammatory response contributes to both preterm premature rupture of membranes (PPROM) and adverse neurological outcomes. Additionally, cytokines associated with fetal placental inflammation can be detrimental to brain development regardless of inciting infection. We investigated whether differential patterns of cytokine markers in maternal and fetal plasma samples reflect subtypes ...
Bazer Fuller W FW Department of Animal Science, Texas A&M University, College Station, Texas 77843. Electronic address: - - 2014
Uterine adenogenesis, a unique post-natal event in mammals, is vulnerable to endocrine disruption by estrogens and progestins resulting in infertility or reduced prolificacy. The absence of uterine glands results in insufficient transport of nutrients into the uterine lumen to support conceptus development. Arginine, a component of histotroph, is substrate for ...
Almeida Patrícia P Centro Hospitalar e Universitário de Coimbra, Coimbra, - - 2014
To evaluate the obstetric and perinatal outcomes evolution of triplet pregnancies. A prospective observational study was conducted in triplet pregnancies delivered over 16 years in a tertiary obstetric center with differentiated perinatal support. Evaluation of demographic factors, obstetric complications, gestational age at delivery, mode of delivery, birth weight and immediate ...
Gore Andrea C AC Division of Pharmacology & Toxicology, University of Texas at Austin, Austin, TX - - 2014
The prenatal brain develops under the influence of an ever-changing hormonal milieu that includes endogenous fetal gonadal and adrenal hormones; placental and maternal hormones; and exogenous substances with hormonal activity that can cross the placental barrier. This review discusses the influences of endogenous fetal and maternal hormones on normal brain ...
Mittal Ankita A Department of Obstetrics and Gynecology, Pt. B. D. Sharma Post Graduate Institute of Medical Sciences, Rohtak, 124001, Haryana, India, - - 2014
To evaluate the relationship between sonographic measurements of umbilical cord coiling index during late second trimester of pregnancy and perinatal outcome. This prospective study was conducted on two hundred pregnant women with uncomplicated, singleton pregnancy between 20 to 24 weeks of gestation. The antenatal umbilical coiling index (UCI) was calculated by ...
Brahmalakshmy B L BL Department of Obstetrics-Gynecology, Kasturba Medical College and Hospitals (A Constituent of Manipal University), Mangalore, 575001, - - 2014
There is significant increase in proportion of cases with previous cesarean delivery requiring obstetric care. The available literature fails to provide uniform opinion on each woman's characteristics to identify risk of uterine rupture while planning trial of labor after cesarean. To study the association of abnormal lower uterine segment with ...
Rodriguez A A Hospital de Sabadell, Corporació Sanitària Parc Taulí, Institut Universitari ParcTaulí-UAB, Sabadell, Catalonia, Spain; Universitat Autònoma de Barcelona, Campus d'Excelència Internacional Bellaterra, Catalonia, - - 2014
To investigate the association of maternal circulating 25-hydroxyvitamin D3 [25(OH)D3] concentration with pregnancy and birth outcomes. Prospective cohort study. Four geographical areas of Spain, 2003-2008. Of 2382 mother-child pairs participating in the INfancia y Medio Ambiente (INMA) Project. Maternal circulating 25(OH)D3 concentration was measured in pregnancy (mean [SD] 13.5 [2.2] ...
Taura Junki J Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, - - 2014
The effect of 2,3,4,7,8-pentachlorodibenzofuran (PnCDF) on the fetal pituitary-gonad axis was compared with that produced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in Wistar rats. Maternal treatment at gestational day (GD)15 with PnCDF and TCDD reduced the fetal expression at GD20 of pituitary luteinizing hormone (LH) and the testicular proteins necessary for steroidogenesis. The ...
Sanz-Salvador Lucía L L Sanz-Salvador, Obstetrics & Gynecology, Fundación para la Investigación Sanitaria y Biomédica (FISABIO), Valencia, - - 2014
Changes in bone density and in bone markers suggest that pregnancy is associated with deterioration of bone mass in the mother. The metabolism of calcium resets to allow the needs imposed by the building of the fetal skeleton. The fetus contributes in the process through the output of regulators from ...
Wong Luchin F LF University of Utah, Department of Obstetrics and Gynecology, Salt Lake City, UT; Intermountain Healthcare, Department of Maternal-Fetal Medicine, Salt Lake City, UT. Electronic address: - - 2014
To determine obstetric and neonatal outcomes of expectantly managed multi-fetal pregnancies complicated by early preterm premature rupture of membranes (PPROM) prior to 26 weeks. A retrospective cohort of all multi-fetal pregnancies complicated by documented PPROM occurring before 26 0/7 weeks and managed expectantly by a single Maternal-Fetal Medicine practice between ...
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