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Salles Gil F GF Department of Internal Medicine, University Hospital Clementino Fraga Filho, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, - - 2014
The well-known mid-trimester drop in blood pressure (BP) during normal pregnancy was recently questioned. To describe longitudinal changes in BP during healthy pregnancies and to investigate factors associated with no mid-trimester drop in BP. A prospective cohort with 158 healthy pregnant women was followed up in a public health care ...
de Assunção Renata Almeida RA Department of Obstetrics and Gynecology, Hospital das Clínicas, University of Sao Paulo, Brazil, São Paulo, SP, - - 2014
To examine the correlation between fetal myocardial performance index (MPI) and hemoglobin levels. Prospective study involving singleton pregnancies at risk of fetal anemia due to maternal anti-D alloimmune disease. Right and left ventricle MPI were evaluated by ultrasound up to 72 hours before cordocentesis. Zeta-score values for fetal MPI and hemoglobin ...
Milligan Natasha N Maternal-Fetal Medicine Division (Placenta Clinic), Department of Obstetrics & Gynaecology, Mount Sinai Hospital, University of Toronto, Ontario, - - 2014
Abstract Objectives: To determine the most reproducible method for the sonographic measurement of placental length. Methods: A prospective study of women with singleton pregnancies who underwent sonographic measurement of placental dimensions during mid-gestation. Two sonographers independently determined placental length using 3 different approaches (linear, curve-linear and panoramic) and placental thickness. ...
O'Tierney-Ginn Perrie P Center for Reproductive Health, MetroHealth Medical Center, Cleveland, - - 2014
Context: The sensitivity of the placenta to maternal insulin remains controversial. Early pregnancy may be a time of increased placental sensitivity to maternal insulin as insulin receptors are abundant on the syncytiotrophoblast in the first trimester, but are far fewer at term. Hypothesis: Maternal insulin secretory response in early, but ...
Mochimaru Aya A Perinatal Center for Maternity and Neonates, Yokohama City University Medical Center, Yokohama, - - 2014
The aim of this study was to elucidate the risk of poor pregnancy outcomes in women with adenomyosis by comparing their outcomes to those of women without uterine abnormalities. The subjects were 36 women diagnosed with adenomyosis before pregnancy who were managed at a tertiary care center between January 2002 ...
Ooi Poh Vei PV University Maternity Hospital, Limerick, Republic of - - 2014
Abstract Objective: This study sought to determine whether ultrasound assessment of fetal head circumference (FHC) at the onset of labor can predict the likelihood of operative delivery. Methods: We performed a prospective cohort study of 200 nulliparous women with singleton, cephalic, term pregnancies in an Irish Maternity Hospital. Transabdominal ultrasound ...
Mastrolia Salvatore Andrea SA Department of Obstetrics and Gynecology, Azienda Ospedaliero-Universitaria Policlinico di Bari, School of Medicine, University of Bari "Aldo Moro", Bari, - - 2014
Abstract Fetal goiter is an extremely rare complication of pregnancy, its incidence is 1 in 40 000 deliveries. Antithyroid maternal therapy is responsible for 10-15% of fetal congenital hypothyroidism, and can be considered as the most frequent underlying cause for this condition. The frequency of fetal goiter that is associated ...
Sengpiel Verena - - 2014
BackgroundHealth authorities in numerous countries recommend periconceptional folic acid supplementation to prevent neural tube defects. The objective of this study was to examine the association of dietary folate intake and folic acid supplementation during different periods of pregnancy with the risk of spontaneous preterm delivery (PTD).MethodsThe Norwegian Mother and Child ...
Parlier Anna Beth AB From the Center for Research, Division of Family Medicine, and the Department of Obstetrics and Gynecology, Mountain Area Health Education Center, Asheville, North - - 2014
To describe how effectively we provided adequate prenatal care and postpartum contraception to prevent repeat, unintended pregnancies to women using opiates or medication maintenance therapy (MMT) during pregnancy. We conducted a retrospective chart review of 94 women using opiates or MMT during 96 pregnancies while receiving prenatal care in the ...
Lildballe Dorte Launholt DL Klinisk Genetisk Afdeling, Aarhus Universitetshospital, Brendstrupgårdsvej 21 C, 8200 Aarhus N, Denmark. - - 2014
We aimed to determine the diagnostic efficiency of quantitative fluorescence polymerase chain reaction (QF-PCR) in a clinical setting where most of the analyses are performed on chorion villus samples from high-risk pregnancies as determined by combined first-trimester screening. A retrospective study on QF-PCR data from all pregnancies in the Central ...
Kus Martin S MS Medical Department, Submarine Squadron SIX, 9168 Second Street, Suite 202, Norfolk, VA - - 2014
The identification of ectopic pregnancy is the primary concern for pregnant patients with an indeterminate ultrasound (an empty uterus or gestational sac). The absence of free fluid and adnexal masses by ultrasound combined with the absence of ectopic risk factors are used to place women in a "low-risk" category. We ...
Conturso Roberto R Department of Obstetrics and Gynecology, Valduce Hospital, Como, - - 2014
Objective: To assess the sonographic visualization of the pericallosal arteries in normal fetuses at 11-13 weeks of gestation using 3D ultrasound. Methods: We prospectively enrolled women with a singleton pregnancy undergoing ultrasound at 11-13 weeks of gestation. A 3D volume with high-definition power Doppler was acquired starting from the sagittal ...
Dutman Annemiek Christien AC a University Medical Center Utrecht, - - 2014
Abstract Cases of unexplained intrauterine fetal death (IUFD) can be reduced by full placental examination, with or without autopsy. Determination of the umbilical coiling index (UCI) is considered to be a part of full placental examination. Umbilical hypercoiling (UCI above 0,30 coils/ cm) is associated with IUFD. In a large ...
Figueras Francesc F Fetal and Perinatal Research Centre, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Maternal-Fetal Medicine Department, Hospital Clínic, University of Barcelona, Spain; University of Barcelona, - - 2014
The objective of this study was to develop an integrated model with the best performing criteria to predict adverse outcome in small-for-gestational age (SGA) pregnancies. Cohort of 509 pregnancies with suspected SGA fetus eligible for trial of labor was recruited prospectively, and data on the perinatal outcome recorded. A predictive ...
Romero Stephanie T ST University of Utah School of Medicine, Department of Obstetrics and Gynecology; Intermountain Medical Center, Division of Maternal Fetal - - 2014
Our objective was to characterize the proportion and type of genetic abnormalities in early pregnancy losses at different developmental stages; we hypothesize that these rates will differ. Women with pregnancy loss < 20 weeks gestation (n = 86) were enrolled at the time of diagnosis. Maternal tissue without a fetal component was found in 13 ...
Hromadnikova Ilona I Department of Molecular Biology and Cell Pathology, Third Faculty of Medicine, Charles University, Ruska 87, 100 00, Prague, Czech Republic, - - 2014
The study describes the stress response in the central cotyledon zone of placental tissue and in maternal whole peripheral blood to pregnancy related complications including gestational hypertension (n = 31), preeclampsia w or w/o fetal growth restriction (n = 95), and fetal growth restriction (n = 39) using real-time RT-PCR and genes encoding Hsp27, Hsp60, Hsp70, ...
Karakus Ruhat R Department of Perinatology, Zekai Tahir Burak Women's Health Care, Training and Research Hospital, Ankara, - - 2014
We aimed to evaluate the association of fetal aortic isthmus (AoI) Doppler flow measurements in intrauterine growth-restricted (IUGR) fetuses with fetal outcome. The data presented in this prospective cohort study were obtained from 74 IUGR and 71 appropriate-for-gestational-age (AGA) fetuses of singleton pregnancies with normal medical and obstetric histories that ...
Ge Qinyu Q Key Laboratory for Child Development and Learning Science, Ministry of Education, Research Center for Learning Science, Southeast University, Nanjing 2100096, P.R. - - 2014
Macrosomia is associated with problems at birth and has life-long health implications for the infant. The aim of this study was to profile the plasma microRNAs (miRNAs or miRs) and evaluate the potential of circulating miRNAs to predict fetal macrosomia. The expression levels of miRNAs in plasma samples obtained from pregnant ...
Trønnes Håvard H Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Department of Pediatrics, Haukeland University Hospital, Bergen, - - 2014
Maternal asthma has been associated with adverse pregnancy outcomes. Little is known about the influence of other atopic diseases on pregnancy outcomes. We assessed how various maternal atopic diseases might affect preterm birth, stillbirth, and neonatal death. By linking Norwegian national registries, we acquired information on maternal health, socio-demographic factors, ...
Yang Zhang Z Department of Obstetrics and Gynecology, Peking University People's - - 2014
Abstract Objective: To investigate the clinical characteristics, management, maternal and fetal outcomes in pregnant patients with myelodysplastic syndrome (MDS). Method: A retrospective analysis was conducted on 25 pregnant women with MDS between June 1998 and January 2013. The clinical data were summarized. These patients were divided into poor outcome group ...
Freud A A Department of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, - - 2014
Abstract Objective: To determine the reproductive outcome following hysteroscopic septum resection in women with a septated uterus and a history of spontaneous miscarriages or premature deliveries. Study Design: A retrospective, cohort study investigating reproductive outcomes following septum resection was conducted. Patients who had no other apparent cause for spontaneous miscarriage ...
Horowitz Kari M KM University of Connecticut Health Center, Department of Maternal-Fetal Medicine, Farmington, - - 2014
Abstract Objective: The purpose of this study was to identify risk factors before or during labor to predict primary cesarean delivery for non-reassuring fetal heart tracing in cases of fetal growth restriction undergoing a trial of labor. Study Design: We reviewed charts of all patients with singleton, non-anomalous fetuses found ...
Nadif Raja R Maternal and Fetal Health Research Centre, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, - - 2014
Mice heterozygous for a signalling-deficient leptin receptor (Leprdb/+(db/+)) are widely used as a model of gestational diabetes that results in poor fetal outcomes. This study investigated the importance of fetal genotype (db/+) relative to abnormal maternal metabolism for placental function and therefore fetal growth and offspring health. Wild type (wt) ...
Nelson David B DB 1Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center at - - 2014
Abstract Objective: To examine fetal malformations in mother-infant pairs with and without pregnancy-related hypertension. Methods: This was an observational, population-based study of women delivering a singleton at our hospital. Specific fetal malformations identified in women with gestational hypertension or preeclampsia were compared to those without pregnancy-related hypertension. Women with chronic ...
Ivey Tesa L TL Department of Obstetrics and Gynecology, University of Arkansas for the Medical Sciences, Little Rock, Arkansas, - - 2014
This study was undertaken to determine whether antenatal care can be achieved in women with at-risk pregnancies residing in rural areas with limited access to antenatal care and maternal fetal medicine (MFM) specialists. Over a period of 15 months, 156 women with high-risk pregnancies (diabetes, hypertensive disorders, suspected fetal anomalies, prior ...
Tong Van T VT Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, - - 2014
Evidence of bias of self-reported smoking cessation during pregnancy is reported in high-income countries but not elsewhere. We sought to evaluate self-reported smoking cessation during pregnancy using biochemical verification and to compare characteristics of women with and without biochemically-confirmed cessation in Argentina and Uruguay. In a cross-sectional study from October ...
Hou Lei - - 2014
BackgroundThe association between fetal gender and pregnancy outcomes has been thoroughly demonstrated in western populations. However, this association has not been thoroughly documented in China. The primary objective of the present study is to determine whether the association of adverse pregnancy and labour outcomes with male fetuses applies to the ...
Guillaume Anne A CMCO Schiltigheim Department of Gynaecology & Obstetrics, Hôpitaux Universitaires de Strasbourg, 67098 Strasbourg Cedex, - - 2014
Abstract Objective: The aim of this study was to assess the benefit of umbilical cord drainage through cord blood collection (CBC) for the prevention of post-partum haemorrhage (PPH). Methods: This is a retrospective cohort study based on data collected prospectively including all vaginal delivery of singletons pregnancies after 37 weeks ...
Su Emily J EJ Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine and/or Division of Reproductive Science in Medicine, Northwestern University Feinberg School of Medicine, Chicago, - - 2014
Context: Fetal growth restriction with abnormal umbilical artery Doppler velocimetry (FGRadv), reflective of elevated fetoplacental vascular resistance, is associated with increased risks of fetal morbidity and mortality even in comparison to growth-restricted fetuses with normal placental blood flow. One major cause of this abnormally elevated fetoplacental vascular resistance is the ...
Dreux Sophie S Biochimie-Hormonologie, CHU Robert Debré, AP-HP, Paris, - - 2014
To analyze the contribution of biochemistry and cytology of fetal ascites fluid to the etiological diagnosis of ascites after ultrasonographic scan, maternal blood sampling and fetal karyotyping. Retrospective study of 100 consecutive cases of non-immune fetal ascites in which ascites fluid was sampled. All women underwent referral ultrasound scan and ...
Cheek Bradley B Laboratory, Children's Hospital of New Orleans, New Orelans, LA, - - 2014
Eosinophilic T-cell chorionic vasculitis (E/TCV) is composed of eosinophils and T-lymphocytes originating within chorionic vessels, radiating toward the intervillous space and away from the amnion in a fashion different from the fetal vascular response seen in amnionitis. Clinical significance and risk factors are not well established. We report four pregnancies ...
Bakacak Murat M Department of Obstetrics and Gynecology, Kahramanmaras Sutcu Imam University, School of Medicine, Kahramanmaraş, - - 2014
Abstract Objective: To investigate the relationship between fetal birth weight and maternal hemoglobin concentrations in different trimesters. Methods: This prospective cross-sectional study comprised 329 women, monitored and delivered between January 2013 and January 2014 in our clinic. Hemoglobin concentrations in all trimesters and all birth weights of the newborns were ...
Bręborowicz Grzegorz H GH Department of Perinatology and Gynecology Poznań University of Medical - - 2014
Abstract Vasa previa is a rare condition in which unsupported by the placenta, umbilical cord blood vessels runs within the placental membranes between internal os of the cervix and presenting part of the fetus. We report an antenatal diagnostic procedure and management of a patient with low-lying placenta and velamentous ...
Edvardsson Kristina - - 2014
Obstetric ultrasound has come to play a significant role in obstetrics since its introduction in clinical care. Today, most pregnant women in the developed world are exposed to obstetric ultrasound examinations, and there is no doubt that the advantages of obstetric ultrasound technique have led to improvements in pregnancy outcomes. ...
Ashley-Martin Jillian - - 2014
Obesity and type-2 diabetes are on the rise and in utero exposure to environmental contaminants is a suspected contributing factor. Our objective was to examine associations between prenatal exposure to potential endocrine disrupting chemicals and markers of fetal metabolic dysfunction. The Maternal-Infant Research on Environmental Chemicals Study (MIREC) recruited 2001 ...
Barry Sinead C SC Department of Obstetrics and Gynecology, Galway University Hospital, National University of Ireland Galway, Newcastle Road, Galway, - - 2014
There are currently limited data describing the natural history and outcome for fetal trisomy 13 diagnosed prenatally. The aim of this study was to evaluate the fetal and neonatal outcome for pregnancies with an established prenatal diagnosis of fetal trisomy 13, and a parental decision for continuation of the pregnancy. ...
Gross Noa N Reproductive Endocrinology and Genetics Unit, Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Jerusalem, Israel; Ultrasound Unit, Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Jerusalem, Israel; The Hebrew University School of Medicine, Jerusalem, - - 2014
The aim of this study was to characterize the fetal phenotype of a cohort of individuals with confirmed diagnoses of Prader-Willi syndrome (PWS), a severe multi-system genetic disorder, diagnosed by a specific methylation test. We interviewed mothers of 106 individuals with PWS to obtain information about the pregnancy of their ...
Zhang Lillian Y LY Clinical and Population Perinatal Health Research, Kolling Institute of Medical Research, University Department of Obstetrics and Gynaecology, Royal North Shore Hospital, St Leonards, New South Wales, - - 2014
American evidence suggests women are not well informed about the optimal duration of pregnancy or the earliest time for safe birth. Similar evidence does not exist in Australia. To explore pregnant women's beliefs about the duration of pregnancy and the earliest time for safe birth, and to compare the results ...
Roberts Sarah C M SC Advancing New Standards in Reproductive Health (ANSIRH) Program, University of California, San Francisco, Oakland, - - 2014
There is little information about pregnancy-related changes in alcohol use and factors contributing to changes among women with unwanted pregnancies. This study describes changes in alcohol use from before pregnancy recognition to during pregnancy and identifies important predictors of alcohol use severity among women with unwanted pregnancies. Data are from ...
Rifouna M S MS Department of Obstetrics and Gynecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC, University Medical Center, Rotterdam, 3000 CA, The - - 2014
Are first trimester trophoblast volume (TV) and placental bed vascular volume (PBVV) different in IVF or IVF/ICSI pregnancies in comparison with spontaneously conceived pregnancies? Any possible abnormal placentation in IVF or IVF/ICSI pregnancies in comparison with spontaneously conceived pregnancies is not detected by a difference in PBVV or TV at ...
Coleman Beverly G BG Division of Abdominal Imaging, Radiology Department, Hospital of the University of Pennsylvania, Philadelphia, Pa., - - 2014
Myelomeningocele (MMC) is one of the most devastating, nonlethal congenital anomalies worldwide. The live birth prevalence of MMC changed dramatically in the 1980s with the introduction of maternal serum screening and the widespread use of prenatal ultrasound imaging. The high-resolution ultrasound affordable today with state-of-the-art equipment allows us to make ...
Dudley Jessica S JS School of Medical Sciences and Bosch Institute, University of Sydney, Sydney, NSW, 2006, - - 2014
Attachment of the blastocyst and formation of the placenta during pregnancy is dependent on structural and cellular changes occurring in the uterine epithelium and in particular to the plasma membrane of these uterine cells. Desmosome expression decreases during pregnancy in eutherians and some squamates, presumably allowing for remodeling of the ...
Fan Xiujun - - 2014
There is strong evidence that overproduction of soluble fms-like tyrosine kinase-1 (sFLT1) in the placenta is a major cause of vascular dysfunction in preeclampsia through sFLT1-dependent antagonism of VEGF. However, the cause of placental sFLT1 upregulation is not known. Here we demonstrated that in women with preeclampsia, sFLT1 is upregulated ...
Adamson S Lee - - 2014
Preeclampsia, a life-threatening complication of human pregnancy, has a spectrum of clinical signs and is likely caused by an array of pathological mechanisms. However, elevated levels of soluble fms-like tyrosine kinase-1 (sFLT1) in the placenta and in the maternal circulation has emerged as a common finding in women with preeclampsia ...
Avcı Muhittin Eftal ME Tepecik Training and Research Hospital, Department of Perinatology, Yenişehir, Izmir, - - 2014
Abstract Objective: Obesity is critically important to maternal and fetal health during the perinatal period. We have detected an increasing prevalence of maternal obesity in recent years and investigated its complications during pregnancy. Methods: A total of 931 pregnant females were investigated between March 2012 and March 2013. The patients ...
Gomez-Lopez Nardhy N Department of Obstetrics and Gynecology, Perinatology Research Branch, Wayne State University, Detroit, MI, - - 2014
Is increased leukocyte chemotactic activity (CA) from gestational tissues necessary for term or preterm labor in guinea pigs? Tissue extracts were prepared from pregnant guinea pig decidua-myometrium, cervix, fetal membranes (amniochorion), and placenta during early third trimester (n = 8), term not in labor (TNL, n = 5), and term spontaneous labor (TL, n = 6), ...
Shang H H Departments of Obstetrics and Division of Experimental Obstetrics, Study Group in Perinatal Programming, Charité Campus Virchow, Berlin, Germany Department of Obstetrics and Gynecology, Hangzhou First People's Hospital, Hangzhou, - - 2014
The effects of endogenous cortisol on binucleate cells (BNCs), which promote fetal growth, may be mediated by glucocorticoid receptors (GRs), and exposure to dexamethasone (DEX) in early pregnancy stages of placental development might modify this response. In this article, we have investigated the expression of GR as a determinant of ...
Goldacre A D AD Nuffield Department of Population Health, University of Oxford, Oxford, - - 2014
Historically, many women with intellectual disability (ID) did not have children. However, a few decades ago it became more common for women with ID to give birth. Our aim was to compare the completed pregnancies of mothers with ID with other completed pregnancies in a large, defined population. We used ...
Zhu Jinliang J Reproductive Medical Center, Department of Obstetrics and Gynecology, Peking University Third Hospital, No. 49 North Huayuan Road, 100191, Haidian District, Beijing, - - 2014
Embryo quality is associated with successful implantation and live births. Our retrospective study was carried out to determine whether or not cleavage stage embryo quality affects the miscarriage rate, pregnancy complications and neonatal outcomes of singletons conceived with assisted reproduction technology. The current study included 11,721 In Vitro Fertilization-Embryo Transfer ...
Zheng Wei W Department of Health Sciences, Interdisciplinary Graduate School of Medicine and Engineering, University of - - 2014
Background: Smoking during pregnancy is related to fetal constraint and accelerated postnatal growth. However, the pathways between these factors have not been clarified. Pathway analyses that link these factors can help us better understand the mechanisms involved in this association. Therefore, this study aimed to examine pathways between maternal smoking ...
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