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Thabah Molly M Department of Medicine, JIPMER, Puducherry, - - 2014
Physiological changes during normal pregnancy are likely to give rise to musculoskeletal symptoms. On the other hand, autoimmune rheumatological diseases disproportionately affect women, often presenting during the childbearing years and sometimes during pregnancy. Contrary to autoimmune rheumatological diseases, the management of non-autoimmune musculoskeletal manifestations is generally conservative and often tends ...
Hamad Nada N Department of Haematology, Royal North Shore Hospital, St Leonards, Sydney, NSW, Australia; Kolling Institute, University of Sydney, St Leonards, Sydney, NSW, Australia; Chronic Lymphocytic Leukaemia Australian Research Consortium (CLLARC), Sydney, NSW, - - 2014
Chronic lymphocytic leukaemia (CLL) occurs rarely with pregnancy and monoclonal B-Lymphocytosis (MBL) has not previously been described in this setting. CLL is predominantly a disease of the elderly and affects men twice as often as women and hence only an estimated 2% of patients are females of childbearing age. We ...
Masselli Gabriele G Department Radiology, Università di Roma Sapienza, Viale del Policlinico 155, Rome, 00161, Italy, - - 2014
Renal colic is the most frequent nonobstetric cause for abdominal pain and subsequent hospitalization during pregnancy. The physio-anatomical changes in the urinary tract and the presence of the fetus may complicate the clinical presentation and management of nephrolithiasis. Ultrasound (US) is the primary radiological investigation of choice. Magnetic resonance urography ...
Murphy Niamh C - - 2014
The management of emergencies in Jehovah's Witnesses presents several challenges to obstetricians and gynaecologists. We present two cases of ectopic pregnancies in Jehovah's Witnesses recently managed in our institution. This is the first case review series of its kind that we could identify. We feel it is of clinical importance ...
Simopoulou Maria M Department of Physiology, University of Athens Medical School, Athens, Greece - - 2014
This review addresses issues regarding the need in the in vitro fertilization (IVF) field for further predictive markers enhancing the standing embryo selection criteria. It aims to serve as a source of defining information for an audience interested in factors related to the wide range of multiple roles played by ...
Welle-Strand G K GK Norwegian Center for Addiction Research (Seraf), University of Oslo, - - 2014
Opioid maintenance treatment (OMT) with methadone or buprenorphine is the treatment of choice for opioid dependent pregnant women. Many women want to lower their OMT-medication dose during pregnancy, thinking this will lead to less neonatal abstinence syndrome (NAS) for their neonates. Many professionals also try to influence women to lower ...
Stockton M C MC University of Nebraska West Central Research and Extension Center, North Platte, Nebraska, 69101 - - 2014
Understanding the biology of heifer maturity and its relationship to calving difficulty and subsequent breeding success is a vital step in building a bio-economic model to identify optimal production and profitability. A limited dependent variable probit model is used to quantify the responses among heifer maturities, measured by a maturity ...
Fakih Souhiela S Centre for Medicine Use and Safety, Monash University, Clayton, - - 2014
With the increase in the overweight and obese population, it is critical that pharmacy staff are able to provide weight management advice to women at different stages of their life. This study utilized case vignettes to identify pharmacists' and pharmacy assistants' current weight management recommendations to women of different ages, ...
Gonzalez-Fiol Antonio A Department of Anesthesiology, Rutgers University School of Medicine, Newark, NJ. Electronic address: - - 2014
Coagulation is an organized and well-orchestrated process that depends on the intrinsic balance between procoagulants, anticoagulants, and fibrinolytic systems. During pregnancy, this balance is affected in various ways and becomes more critical due to the physiologic changes and obligate hemorrhage after delivery. In some instances, this equilibrium will be disrupted. ...
Lassi Zohra S - - 2014
The statistics related to pregnancy and its outcomes are staggering: annually, an estimated 250000-280000 women die during childbirth. Unfortunately, a large number of women receive little or no care during or before pregnancy. At a period of critical vulnerability, interventions can be effectively delivered to improve the health of women ...
Matson Brooke C BC Departments of Cell Biology & Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, - - 2014
The immunology of pregnancy is complex and incompletely understood. Aberrant immune activity in the decidua and in the placenta is believed to play a role in diseases of pregnancy, such as infertility, miscarriage, fetal growth restriction and preeclampsia. Here, we briefly review the endocrine control of uterine natural killer cell ...
Requena Pilar P Barcelona Centre for International Health Research, Hospital Clinic-University of Barcelona, 08036 Barcelona, Spain; - - 2014
Pregnancy triggers immunological changes aimed to tolerate the fetus, but its impact on B lymphocytes is poorly understood. In addition, exposure to the Plasmodium parasite is associated with altered distribution of peripheral memory B cell (MBC) subsets. To study the combined impact of high malaria exposure and pregnancy in B ...
Morisaki Shintaro S Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, - - 2014
This study aimed to investigate the effect of labor on plasma concentrations of cell-free, pregnancy-associated, placenta-specific microRNAs before and after delivery. In the non-labor group (32 women), cesarean section (C/S) was performed before the beginning of labor. In the labor group (32 women), C/S was performed after the beginning of ...
Li Han - - 2014
Given the angiogenic function of vascular endothelial growth factor A (Vegfa), the function of its expression by trophoblast in the avascular placental junctional zone is unknown. In mice, cells from the trophoblast specific protein alpha (Tpbpa) lineage populate this zone and in late gestation some of these cells invade the ...
Unzaga J M JM Laboratorio de Inmunoparasitología, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, 60 y 118 (1900) La Plata, Argentina. Electronic address: - - 2014
The aims of this study were to identify the occurrence of T. gondii and N. caninum abortions in goats from Argentina by serological, macroscopical and microscopical examination and bioassay, and to characterize the obtained isolates by molecular techniques. For this purpose, 25 caprine fetal fluids, 18 caprine fetal brains and ...
Falcón Cristian Roberto CR Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, Ciudad Universitaria, Córdoba, - - 2014
The contribution of Pregnancy-specific glycoproteins (PSG), the major variant of PSG released into the circulation during pregnancy, to the pregnancy-dependent improvement of rheumatoid arthritis (RA) has still not been elucidated. Collagen-induced arthritis (CIA) was used to test the hypothesis that PSG1a when released into circulation has a modulatory role on ...
Ucar Ahmet A Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, - - 2014
Pregnancy induces a rapid and controlled expansion of mammary stem cells. In this issue of Developmental Cell, Desgrosellier et al. (2014) show that β3-integrin is required downstream of hormonal signaling and TGFβ2 to regulate mammary stem cell number and alveolar development specifically during early pregnancy.
Desgrosellier Jay S JS Department of Pathology, Moores UCSD Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: - - 2014
Although integrin αvβ3 is linked to cancer progression, its role in epithelial development is unclear. Here, we show that αvβ3 plays a critical role in adult mammary stem cells (MaSCs) during pregnancy. Whereas αvβ3 is a luminal progenitor marker in the virgin gland, we noted increased αvβ3 expression in MaSCs at midpregnancy. ...
Stilley Julie A W - - 2014
Expression and function of the follicle stimulating hormone receptor (FSHR) in females were long thought to be limited to the ovary. Here though we identify extra-gonadal FSHR in both the human female reproductive tract and the placenta, and test its physiological relevance in mice. We show that in non-pregnant women ...
Ying Wei W Department of Animal Science, TX A&M University, TX, USA, - - 2014
Uteroferrin (UF) is a progesterone-induced acid phosphatase produced by uterine glandular epithelia in mammals during pregnancy and targeted to sites of hematopoiesis throughout pregnancy. The expression pattern of UF is coordinated with early fetal hematopoietic development in the yolk sac and then liver, spleen and bone to prevent anemia in ...
Fonseca B M BM Laboratório de Bioquímica, Departamento Ciências Biológicas, Faculdade de Farmácia da Universidade do Porto - Ciências Biológicas, Rua de Jorge Viterbo Ferreira no. 228, 4050-313, Porto, - - 2014
During rat pregnancy, some of the foetoplacental units undergo complete spontaneous resorption while the adjacent units remain unaffected. In an attempt to clarify the mechanisms implicated in this spontaneous resorption, implantation units from days 14 and 16 of pregnancy were examined. The number of implantation sites and resorption units was ...
Dutta Sudipta - - 2014
Primordial follicle assembly is essential for reproduction in mammalian females. Oocytes develop in germ cell cysts that in late fetal development begin break down into individual oocytes and become surrounded by pregranulosa cells forming primordial follicles. As they separate, many oocytes are lost by apoptosis. Exposure to steroid hormones delays ...
Lima Patricia DA PD Ottawa Hospital Research Institute, The Ottawa Hospital General Campus, Critical Care Wing, Ottawa, ON, - - 2014
Successful pregnancy and long-term, post-natal maternal and offspring cardiac, vascular and metabolic health require key maternal cardiovascular adaptations over gestation. Within the pregnant decidualizing uterus, coordinated vascular, immunological and stromal cell changes occur. Considerable attention has been given to the roles of uterine natural killer (uNK) cells in initiating decidual ...
Braun Thorsten T Division of Experimental Obstetrics, Department of Obstetrics, Study Group Perinatal Programming, Campus Virchow, Berlin, Germany - - 2014
Glucocorticoid treatment given in late pregnancy in sheep resulted in altered placental development and function. An imbalance of placental survival and apoptotic factors resulting in an increased rate of apoptosis may be involved. We have now investigated the effects of dexamethasone (DEX) in early pregnancy on binucleate cells (BNCs), placental ...
Beaman Kenneth D - - 2014
In recent years, our understanding of how the immune system interacts with the developing fetus and placenta has greatly expanded. There are many laboratories that provide tests for diagnosis of pregnancy outcome in women who have recurrent pregnancy loss (RPL) or pre-eclampsia. These tests are based on the premise that ...
Fénichel Patrick P Department of Reproductive Endocrinology, University Hospital of Nice, - - 2014
Context: Persistent secretion of βHCG in the absence of an ongoing or recent pregnancy or no persistent uterine gestational disease, is a rare but challenging situation which demands to locate the extra-uterine secreting tumour and to distinguish between extra-gestational choriocarcinoma and gestational trophoblastic neoplasms. Case Presentation: An unexplained persistent extra-gestational ...
Bazzano Marilena M Department of Veterinary Sciences, University of Messina, Polo Universitario dell'Annunziata, 98168 Messina, - - 2014
The aim of the study was to assess changes in some haematological parameters of periparturient mares from the last three months of pregnancy until the third week after foaling. The study was carried out on 15 healthy pregnant mares (Group A) and 7 healthy non-pregnant non-lactating mares (Group B). Blood ...
Fu Binqing B 1] Institute of Immunology, School of Life Sciences, University of Science and Technology of China, Hefei, China [2] Hefei National Laboratory for Physical Sciences at Microscale, Hefei, - - 2014
T helper 17 (TH17) cells have been identified as a new lineage of helper T cells and have been shown to be important in host defense against extracellular infectious agents, autoimmune disease and chronic inflammatory diseases. Recently, TH17 cells have also been shown to participate in successful pregnancy, as well ...
Rajagopalan Sumati - - 2014
The uterus in early pregnancy is a non-lymphoid organ that is enriched in natural killer (NK) cells. Studies to address the role of these abundant human NK cells at the maternal/fetal interface have focused on their response to the major histocompatibility complex (MHC) molecules on fetal trophoblast cells that they ...
Tarquini F F Department of Obstetrics and Gynaecology, University of Perugia , Perugia , - - 2014
CffDNA, from 344 non-smoking, 38 smoking and 33 ex-smoking pregnant women at 11 (+ 0)-13 (+ 6) gestational weeks, was extracted and quantified by the multicopy DYS14, as the fetal DNA marker and using the quantitative real-time PCR 7300 detection system. The smoking habit was based on maternal self-report, confirmed ...
La Rocca Claudia C Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, via Pansini 5, 80131 Napoli, Italy; Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche (IEOS-CNR), via Pansini 5, 80131 Napoli, - - 2014
Establishment and maintenance of pregnancy represents a challenge for the maternal immune system since it has to defend against pathogens and tolerate paternal alloantigens expressed in fetal tissues. Regulatory T (Treg) cells, a subset of suppressor CD4(+) T cells, play a dominant role in the maintenance of immunological self-tolerance by ...
Badawy Abdulla A-B AA School of Health Sciences, Cardiff Metropolitan University, Wales, - - 2014
The decrease in maternal plasma total (free + albumin-bound) tryptophan (Trp) during the third pregnancy trimester is attributed to induction of indoleamine 2,3-dioxygenase (IDO). When measured, free [Trp] is increased because of albumin depletion and non-esterified fatty acid elevation. The Trp depletion concept in pregnancy is therefore not supported because ...
Kapoor Poonam Malhotra PM Department of Cardiac Anaesthesia, CTC, AIIMS, New Delhi, - - 2014
Peripartum cardiomyopathy is a relatively rare but life threatening disease. The etiology and pathogenesis of peripartum cardiomyopathy is generally centered upon viral and autoimmune mechanism. This case report describes the anesthetic management of a patient with term pregnancy suffering from dilated peripartum cardiomyopathy planned for cesarean section, successfully managed with ...
Payan-Carreira R R Animal and Veterinary Research Centre (CECAV), Universidade de Trás-os-Montes e Alto Douro, UTAD, Vila Real, Portugal. Electronic address: - - 2014
CD10 is a multifunctional transmembrane neutral endopeptidase (NEP) that is considered to be a reliable marker of ectopic human endometrial stroma. Available information on NEP/CD10 protein expression in animal endometria is scarce. This study focused on the immunolocalization of NEP/CD10 in the canine uterus and on its temporal changes during ...
Santos Tatiana C TC Department of Animal Science, State University of Maringá, Maringá, Paraná, Brazil. Electronic address: - - 2014
Vascular endothelial growth factor (VEGF) is known to induce endothelial cell proliferation, to promote cell migration, and to inhibit apoptosis, thus playing a central role in angiogenesis and in the regulation of vasculogenesis. The expression of the VEGF-ligand receptor system was studied in the placenta and uterus of the collared ...
Traver S S CHU Montpellier, Institute for Research in Biotherapy, Hôpital Saint-Eloi, INSERM U1040, Montpellier, - - 2014
Proper folliculogenesis is fundamental to obtain a competent oocyte that, once fertilized, can support the acquisition of embryo developmental competence and pregnancy. MicroRNAs (miRNAs) are crucial regulators of folliculogenesis, which are expressed in the cumulus-oocyte complex and in granulosa cells and some can also be found in the bloodstream. These ...
Schlereth Simona L SL Department of Ophthalmology, University of Cologne, Kerpenerstr. 62, 50924 Cologne, Germany. Electronic address: - - 2014
The adult sclera is free of lymphatic vessels, but contains a net of blood vessels. Whether and when this selectively lymphangiogenic privilege is achieved during embryologic development is not known yet. Therefore, we investigated the developing human sclera for blood- and lymphatic vessels in 34 abortions/stillborns (12-38 weeks of gestation). ...
Miura K K Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. Electronic address: - - 2014
The aim of this study was to investigate the relationship between plasma concentration of cell-free pregnancy-associated placenta-specific microRNAs and clinical variables (placental weight, maternal body mass index, and neonatal birth weight). Circulating levels of cell-free pregnancy-associated placenta-specific microRNAs (miR-515-3p, miR-517a, miR-517c and miR-518b) in maternal plasma were measured by quantitative ...
Orlando Jennie J Rosalind Franklin University, North Chicago, IL, - - 2014
A recent hypothesis has implicated superfertility as a cause of recurrent pregnancy loss. Clinical support for the concept comes from one report that 40% of women experiencing recurrent miscarriages had monthly fecundity rates of 60% or greater and thus were designated as superfertile. To confirm or refute this finding, clinical ...
Spencer Thomas E TE Department of Animal Sciences, Center for Reproductive Biology, Washington State University, Pullman, - - 2014
All mammalian uteri contain glands in the endometrium that synthesize or transport and secrete substances essential for survival and development of the conceptus (embryo/fetus and associated extraembryonic membranes). This review summarizes information related to the biological roles of uterine glands and their secretions in blastocyst/conceptus survival and implantation, uterine receptivity, ...
Tannetta Dionne - - 2014
Extracellular vesicles (EVs) are membrane-bound complexes secreted from cells under both physiological and pathological conditions. They contain proteins, nucleic acids and lipids and act as messengers for cell-cell communication and signalling, particularly between immune cells. EV research is a rapidly evolving and expanding field, and it appears that all biological ...
Bidarimath Mallikarjun M Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ont., - - 2014
MicroRNAs (miRNAs) are a recently discovered class of non-coding RNAs that are expressed in many cell types, where they regulate the expression of complementary RNAs, thus modulating the stability and translation of mRNAs. miRNAs are predicted to regulate the expression of ∼50% of all protein coding genes in mammals. Therefore, ...
Lima Patricia DA PD 1] Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada [2] Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, - - 2014
In humans, specific patterns of killer immunoglobulin-like receptors (KIRs) expressed by uterine natural killer (uNK) cells are linked through HLA-C with pregnancy complications (infertility, recurrent spontaneous abortion, intrauterine growth restriction and preeclampsia). To identify mechanisms underpinning the associations between NK cell activation and pregnancy success, pregnancies were studied in mice ...
Gharwan Helen H National Cancer Institute, Medical Oncology Branch, Bethesda, MD, - - 2014
Background: Myeloablative conditioning regimens given prior to hematopoietic stem cell transplantation (HSCT) frequently cause permanent sterility in men. In patients with sickle cell disease (SCD) we use a non-myeloablative regimen with sirolimus, alemtuzumab, low-dose total body irradiation (300 cGy) with gonadal shielding preceding allogeneic HSCT.Case: A 42 year-old man with ...
Mirabito Katrina M KM From the Department of Physiology (K.M.M., L.M.H., K.M.D.) and Department of Pharmacology (Z.W., R.E.W., A.V.), Monash University, Clayton, Victoria, Australia; and Baker Medical Research Institute, Melbourne, Victoria, Australia - - 2014
During normal pregnancy the renin-angiotensin system is activated, yet pregnant women are resistant to the pressor effects of angiotensin II. Our aim was to determine the role of the angiotensin type 2 receptor (AT2R) in the regulation of arterial pressure, natriuresis, and immune cell infiltration during pregnancy. Mean arterial pressure ...
Nanetti L L Department of Clinic Science, Section of Biochemistry, Biology and - - 2014
Abstract Objective The aim of the present study was to understand the role played by Atosiban, an oxytocin receptor antagonist, on trophoblastic human cells, and the molecular bases of its efficacy and safety in the treatment of preterm labor. NO, peroxinitrite production and NOS expression have been evaluated on placenta ...
Sones Jenny L JL Cornell - - 2014
Preeclampsia is a hypertensive, proteinuric disease that affects 5-10% of all pregnancies and is a leading cause of maternal and perinatal morbidity/mortality (13). The primary treatment for preeclampsia still is delivery of the fetus and placenta. The underlying mechanisms remain elusive. One possibility is inadequate uterine angiogenesis/vascularity (decidualization) at the ...
Chuma Shinichiro S Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan. Electronic address: - - 2014
Fetal oocytes in mammals undergo extensive apoptosis during development. In this issue of Developmental Cell, Malki et al. (2014) provide insight into how and why such massive oocyte loss occurs through the demonstration that the expression level of LINE-1 retrotransposon defines the survival threshold and thus viability of fetal oocytes.
Sotnikova Natalia N Federal State Research Institute of Maternity and Childhood named V.N. Gorodkov, Ivanovo, - - 2014
The immunological paradox of pregnancy, when maternal immune system recognizes but do not reject the semiallogenic fetus, is not yet fully understood. The aim of the present work was to detail the mechanisms of the interaction of decidual CD56+ NK, infiltrating the maternal part of placenta, and trophoblast cells of ...
Hansen Peter J PJ Department of Animal Sciences, D.H. Barron Reproductive and Perinatal Biology Research Program, and Genetics Institute, University of Florida, Gainesville 32611-0910, FL, USA. Electronic address: - - 2014
Events in the preimplantation period can have long-term consequences that affect embryo competence to establish and maintain pregnancy and which can extend into fetal and postnatal life. One of the molecules responsible for maternal modulation of embryonic development during this time is colony stimulating factor 2, also termed granulocyte-macrophage colony ...
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