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Results 301 - 350 of 1333
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Kalkanli S - - 2013
In this study, pre-eclampsia, proteinuria, and edema associated with hypertension in pregnancy were assessed at the Dicle University School of Medicine Department of Obstetrics and Gynecology Clinic. One group included 20 pre-eclamptic pregnant women with gestational age 20-35 weeks of pregnancy and the same in the control group that included; ...
Oliveira Lilian J - - 2013
Despite extensive research in the area of cow fertility, the extent to which the maternal immune system is modulated during pregnancy in cattle remains unclear. Therefore, the objective of the current study was to characterize the presence and response profile of B, T-helper (LTh), T- cytotoxic (LTc), gamma delta-T (γδT) ...
Dorfeshan Parvin P Anatomy Department, Tarbiat Modares University, P.O. Box 14115-111, Tehran, - - 2013
The aim of this study was to determine the influence of ovarian stimulation on endometrial mouse NK cell population. For superovulation, the female adult NMRI mice were injected i.p. with 10 IU of the pregnant mare serum gonadotropin followed 48 h later by an i.p. injection of 10 IU human chorionic gonadotropin hormone. ...
Hung Tai-Ho TH Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Taipei, Taiwan ; Department of Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan, - - 2013
Autophagy has been reported to be essential for pre-implantation development and embryo survival. However, its role in placental development and regulation of autophagy during pregnancy remain unclear. The aims of this study were to (1) study autophagy by characterizing changes in levels of beclin-1, DRAM, and LC3B in human placenta ...
Guzel Ali Irfan AI Dr Zekai Tahir Burak Women's Health Education and Research Hospital, Department of Gynecological Oncology, Ankara, Turkey. - - 2013
Cervical cancer during pregnancy has an incidence of about 1 to 10 in 10.000 individuals and is one of the most common malignancies occurring during pregnancy. In this report, we aimed to evaluate a pregnant women with cervical cancer underwent radical hysterectomy and pelvic and paraaortic lymphadenectomy at our clinic. ...
Thulluru Hari Krishna HK Department of Clinical Chemistry, Vrije Universiteit Medical Center Amsterdam, Netherlands ; Institute for Cardiovascular Research, Vrije Universiteit Medical Center Amsterdam, - - 2013
Nodal, a secreted signaling protein from the transforming growth factor beta (TGF-β)-super family plays a vital role during early embryonic development. Recently, it was found that maternal decidua-specific Nodal knockout mice show intrauterine growth restriction (IUGR) and preterm birth. The chromosomal location of NODAL is in the same linkage area ...
Teles Ana A Experimental Obstetrics and Gynecology, Medical Faculty, Otto-von-Guericke University Magdeburg, Germany ; PDBEB, Center for Neuroscience and Cell Biology, University of Coimbra - - 2013
Pregnancy establishment and maintenance represents a challenge for the maternal immune system because it has to be alert against pathogens while tolerating paternal alloantigens expressed in fetal structures. Regulatory T cells (Tregs) are important for successful implantation and involved in allotolerance towards paternal antigens. The origin and mechanisms leading to ...
BarczyƄski B B Department of Oncological Gynaecology and Gynaecology, Medical University of Lublin, Lublin, Poland. - - 2013
Conservative treatment of metastatic germ-cell tumor of the ovary does not exclude the possibility of pregnancy in the future. Serum beta-human chorionic gonadotropin (beta-hCG) serves as pregnancy test, and has also been proven to be a useful marker for ovarian germ-cell tumors. This paper is a case report of a ...
Ashton Erin E Department of Obstetrics and Gynecology, University of Connecticut Integrated Residency Program, Farmington, CT, - - 2013
•An 18 year old nulliparous woman was diagnosed with clear cell adenocarcinoma of the cervix in pregnancy.•LEEP conization at 33.3 weeks gestation led to premature rupture of membranes. Following cesarean section, a radical hysterectomy was performed.
Hasegawa K K Department of Obstetrics and Gynecology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan. - - 2013
Maternal virilization in pregnancy with or without fetal female pseudohermaphroditism has several etiologies. Of these, pregnancy luteoma is the most common cause of maternal virilization during pregnancy, and approximately 20 cases have been reported in recent years. Moreover, four cases of pregnancy luteomas with female pseudohermaphroditism have been reported. However, ...
Weiss Gerson - - 2013
In primate pregnancy, circulating relaxin, solely a product of the corpus luteum, peaks in the first trimester of pregnancy then declines and levels off for the remainder of pregnancy. Relaxin actions in pregnancy include increasing cervical pro-MMP-1 and pro-MMP-3 and decreasing TIMP-1, changes which soften the cervix. Relaxin, from early ...
Sari Youssef Y Department of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, USA. - - 2013
Experimental designs for investigating the effects of prenatal alcohol exposure during early embryonic stages in fetal brain growth are challenging. This is mostly due to the difficulty of microdissection of fetal brains and their sectioning for determination of apoptotic cells caused by prenatal exposure to alcohol. The experiments described here ...
Kim Young Ju YJ Department of Obstetrics and Gynecology, Ewha Womans University School of Medicine, Seoul, - - 2013
Preeclampsia is one of the leading causes of maternal mortality/morbidity and preterm delivery in the world, affecting 3% to 5% of pregnant women. The pathophysiology of preeclampsia likely involves both maternal and fetal/placental factors. Abnormalities in the development of placental vessels early in pregnancy may result in placental hypoperfusion, hypoxia, ...
Shepard Michelle T MT University of Vermont College of Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Burlington, VT 05405, - - 2013
The regulation of T cell homeostasis during pregnancy has important implications for maternal tolerance and immunity. Evidence suggests that Programmed Death-1 (PD-1) participates in regulation of T cell homeostasis and peripheral tolerance. To examine the contribution of PD-1 signaling on T cell homeostasis during normal mouse pregnancy, we examined T ...
Ji Lei - - 2012
The placenta is a transient organ that forms during pregnancy to support the growth and development of the fetus. During human placental development, trophoblast cells differentiate through two major pathways. In the villous pathway, cytotrophoblast cells fuse to form multinucleated syncytiotrophoblast. In the extravillous pathway, cytotrophoblast cells acquire an invasive ...
Jiang Houli H Department of Pharmacology, New York Medical College, Valhalla, NY, - - 2013
Epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE) are cytochrome P450 metabolites of arachidonic acid posited to act in the circulatory adaptation to pregnancy and the development of preeclampsia. Red blood cells (RBCs) may function as major contributors of cis- and trans-EETs. We performed paired analyses of EETs, dihydroxyeicosatrienoic acids (DHETs), ...
Higgins LE - - 2012
Abstract Background: Maternal obesity is a frequent obstetric risk factor, linked with short- and long-term consequences for mother and child, including fetal overgrowth, growth restriction and stillbirth. The mechanisms underlying these pathologies remain unknown but likely involve the placenta. Aims: To study placental cell turnover in relation to maternal body ...
Sasaki Motoki M Laboratory of Veterinary Anatomy, Department of Basic Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido 080-8555, Japan. - - 2013
There are few reports describing the structure and function of the whale placenta with the advance of pregnancy. In this study, therefore, the placenta and nonpregnant uterus of the Antarctic minke whale were observed morphologically and immunohistochemically. Placentas and nonpregnant uteri were collected from the 15th, 16th and 18th Japanese ...
Galio Laurent - - 2012
The mammary gland undergoes extensive remodelling between the beginning of pregnancy and lactation; this involves cellular processes including cell proliferation, differentiation and apoptosis, all of which are under the control of numerous regulators. To unravel the role played by miRNA, we describe here 47 new ovine miRNA cloned from mammary ...
Hao Kehong - - 2012
The induction and maintenance of immunologic tolerance at the feto-maternal interface is necessary for a successful pregnancy. The most accepted hypothesis for the mechanism underlying this tolerance is that pregnancy-induced foetal antigen-specific maternal T regulatory (T(reg) ) cells mediate maternal tolerance to the foetus. The aryl hydrocarbon receptor (AhR), which ...
Acosta M - - 2012
Pituitary folliculostellate cells (FSC) have several functions. Morphological, immunohistochemical and physiological characteristics of these cells have been reported for many mammalian species. There is little information, however, about the effect of pregnancy on FSC, particularly in wild animals. We conducted an immunohistochemical and morphometric study of the effect of pregnancy ...
Huang Carol C University of Calgary, Health Sciences Centre, 3330 Hospital Drive NW, Room 2281, Calgary, Alberta, Canada T2N 4N1. - - 2013
Abstract  β-Cell mass increases during pregnancy in adaptation to the insulin resistance of pregnancy. This increase is accompanied by an increase in β-cell proliferation, a process that requires intact prolactin receptor (Prlr) signalling. Previously, it was found that during pregnancy, heterozygous prolactin receptor-null (Prlr(+/-)) mice had lower number of β-cells, ...
Ji Yin Fen - - 2012
Previous studies demonstrate significant roles for passive water channels (aquaporins, AQPs) in maintaining water homeostasis in cell membranes of endometrial cells during decidualisation and embryo implantation. However, there is little information regarding the role of AQPs in the human fallopian tube, specifically their role in human tubal ectopic pregnancy. In ...
Amodio Giada G San Raffaele Telethon Institute for Gene Therapy, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, 20132 Milan, - - 2013
Multiple mechanisms underlie the surprising willingness of mothers to tolerate the semi-allogeneic fetal tissues during pregnancy. Chief among these is the expression of the HLA-G molecules that has been largely demonstrated to be responsible for reprogramming the local maternal immune response towards tolerance. We recently identified a subset of tolerogenic ...
Moise K J KJ - - 2012
OBJECTIVE: To determine the sensitivity and specificity of circulating cell-free fetal DNA in determining the fetal RHD status and fetal sex. METHODS: Maternal blood was collected in each trimester of pregnancy from RhD negative nonalloimmunized women. Whole blood was centrifuged, separated into plasma and buffy coat, and frozen at -80°C. ...
Washburn Shannon E SE Department of Veterinary Physiology and Pharmacology and Michael E. DeBakey Institute, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA. - - 2013
Women who drink alcohol during pregnancy are at high risk of giving birth to children with neurodevelopmental disorders. Previous reports from our laboratory have shown that third trimester equivalent binge alcohol exposure at a dose of 1.75 g/kg/day results in significant fetal cerebellar Purkinje cell loss in fetal sheep and that ...
Tsuda Hiroyuki - - 2012
Mucinous cystic neoplasm (MCN) of the pancreas occurs mainly in women aged 40-60 years, so it is extremely rare in pregnant woman. A 28-year-old woman in the ninth week of pregnancy was referred to our hospital due to a tumor of the abdominal cavity. Abdominal ultrasound demonstrated a huge multicystic ...
Luvoni Gc - - 2012
Cryosurvival of feline oocytes preserved as isolated cells (ex situ) or enclosed in ovarian follicles (in situ) has been demonstrated, and significant advances have recently been achieved. However, an ideal protocol for oocyte cryopreservation has not been established to date because of extreme sensitivity of the structural complex to chilling ...
Jewgenow K - - 2012
The corpus luteum (CL) is a transient hormone gland on the ovary that produces progesterone (P4) for the maintenance of pregnancy. It develops from residual follicular granulosa and theca cells after ovulation. Very little is known about the cellular and hormonal processes within CLs obtained from pregnant and pseudopregnant felids. ...
Oliveira F - - 2012
It is known that embryos produced in vitro may have structural alterations that often compromise the normal embryo development, generating a high rate of pregnancy loss. The study of these changes is of great importance because it may elucidate the cause of embryonic loss during the first trimester of pregnancy. ...
Feltrin C - - 2012
Survival to term following embryo transfer is usually low after cloning by somatic cell nuclear transfer (SCNT). The aims of this study were to evaluate the effects of the zona pellucida (presence or absence) and the cell nucleus transfer method (cell fusion or cell injection) on the in vitro survival ...
Escudero Carlos - - 2012
To investigate whether fetal endothelial cell proliferation and migration are modulated by the A(2A) adenosine receptor (A(2A)AR), nitric oxide (NO) and the vascular endothelial growth factor (VEGF) signaling pathway, we isolated human umbilical vein endothelial cells from normal pregnancy (n = 23), preterm delivery (n = 4), and late-onset (LOPE, n = 10) and early-onset preeclampsia ...
Kim Min Jung - - 2012
The aim of this study was to investigate gestation duration and the physiologic characteristics of pregnant dogs bearing cloned fetuses, especially in the prepartum period. A retrospective study was performed to compare gestation duration in females pregnant with cloned (somatic cell nuclear transfer) fetuses (cloned group) with those bearing noncloned fetuses ...
Schoorl Margreet - - 2012
Although a mild degree of anemia is common in the third trimester of pregnancy, it remains a challenge to establish whether a decrease in hemoglobin (Hb) concentration is physiological or pathological. The World Health Organization suggested a Hb concentration of 110 g/L to discriminate anemia. Several European investigators recommended Hb ...
Sen Sarbattama S Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA. - - 2013
Obese pregnancy is associated with significantly higher rates of infection, which can harm both mother and fetus. The objective of this study was to determine the impact of obesity on maternal blood immune function. This was a cross-sectional, case control study of 15 obese (Ob) and 15 lean (Lc) subjects. ...
Tachibana Yurika Y Laboratory of Animal Breeding, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, - - 2013
Despite enormous efforts, biochemical and molecular mechanisms associated with equine reproduction, particularly processes of pregnancy establishment, have not been well characterized. Previously, PCR-selected suppression subtraction hybridization analysis was executed to identify unique molecules functioning in the equine endometrium during periods of pregnancy establishment, and granzyme B (GZMB) cDNA was found ...
Berisha B - - 2012
The aim of this study was to evaluate mRNA expression, protein concentration and localization of the assumedly important lymphangiogenic factors VEGFC and VEGFD and the receptor FLT4 in bovine corpora lutea (CL) during different physiological stages. In experiment 1, CL were collected in a slaughterhouse and stages (days 1-2, 3-4, ...
Alijotas-Reig Jaume - - 2012
OBJECTIVE: To assess current studies on the relationship between cell-derived microparticles (cMP) and recurrent miscarriages (RM) and pre-eclampsia (PE), and review the relationships between cMP and inflammatory and clot pathways, antiphospholipid antibodies (aPL), cytokines, and pregnancy complications. DESIGN: Systematic and comprehensive review of the literature from January 2000 to January 2012. ...
Moise Kenneth J KJ - - 2012
: To evaluate the application of new technologies to the management of the red cell alloimmunized pregnancy. : We searched three computerized databases for studies that described treatment or prevention of alloimmunization in pregnancy (MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials [1990 to July 2012]). The text ...
Siemieniuch Marta J - - 2012
ABSTRACT: BACKGROUND: Until recently, the corpus luteum (CL) was considered to be the main source of progesterone (P4) during pregnancy in the domestic cat (Felis catus). However, other possible sources of P4 have not been ruled out. Although feline placental homogenates were found to be capable of synthesizing P4, expression ...
Zeybek Yosun Görkem - - 2012
AIM: Quantitative changes of cell-free fetal DNA in maternal plasma as an indicator for impending pre-eclampsia was reported in different studies. Cell-free fetal nucleic acids can be detected in maternal circulation during pregnancy. Our aim was to determine the higher rate of fetal DNA levels in maternal blood in pre-eclampsia ...
Xu Xiaoyan - - 2012
OBJECTIVE: To investigate the changes of human decidual natural killer (dNK) cells cocultured with Toxoplasma gondii in vitro and to infer implications on pregnancy. DESIGN: Case-control study. SETTING: College and hospital. PATIENT(S): Decidual tissue was obtained from 85 patients undergoing voluntary abortion during the first trimester of gestation (6-12 weeks). INTERVENTION(S): ...
Cerdeira Ana S - - 2012
This Commentary highlights the article by Hsu et al (in this issue) reporting an enrichment in induced regulatory T cells (iTregs) in normal pregnancy but not in preeclampsia, implicating iTreg defect as central to the pathogenesis of preeclampsia.
Shapiro Bruce S - - 2012
OBJECTIVE: To discern the potential effect of ovarian stimulation on implantation potential by comparing ongoing pregnancy rates from matched blastocysts in fresh and frozen-thawed single-embryo-transfer cycles. DESIGN: Matched cohort study. SETTING: Private fertility center. PATIENT(S): Ninety-three matched pairs of single-blastocyst transfer. INTERVENTION(S): Fresh and frozen-thawed embryo transfers were matched on ...
Christiansen Ole B - - 2012
Much research has been done to investigate why the fetus in most pregnancies, in spite of being semi-allogenic, is not rejected by the immune system. Experiments in transgenic mice have suggested that dysfunctions in both the innate immune system (NK cells) and the adaptive immune system (T-cells and T regulatory ...
Curtis Sophie - - 2012
Abstract Fetal growth restriction (FGR) is a serious pregnancy complication associated with increased perinatal mortality and morbidity. Although the majority of cases with FGR result from placental dysfunction, the pathophysiology is incompletely understood. Autophagy is a physiological form of cell degradation exacerbated by nutrient and oxygen restriction, which are both ...
Hygino Joana - - 2012
Evidences indicate that pregnancy can alter the Ag-specific T-cell responses. This work aims to evaluate the impact of pregnancy on the in vitro HIV-1-specific immune response. As compared with non-pregnant patients, lower T-cell proliferation and higher IL-10 production were observed in T-cell cultures from pregnant patients following addition of either ...
Czamanski-Cohen Johanna - - 2012
This prospective repeated measures study was designed to examine the cell-free DNA (cfDNA) concentrations during ovarian stimulation and the relationship between cfDNA concentration and pregnancy rates in women undergoing IVF-embryo transfer. The study examined 37 women undergoing IVF treatment in an IVF unit in a university medical centre in southern ...
Granot Irit - - 2012
Implantation failure, which is presently the major barrier in human fertility, is attributed, in many cases, to the failure of the uterus to acquire receptivity. The transition into a receptive uterus includes cellular changes in the endometrium and the modulated expression of different cytokines, growth factors, transcription factors and prostaglandins. ...
Rowe Jared H - - 2012
Pregnancy is an intricately orchestrated process where immune effector cells with fetal specificity are selectively silenced. This requires the sustained expansion of immune-suppressive maternal FOXP3(+) regulatory T cells (T(reg) cells), because even transient partial ablation triggers fetal-specific effector T-cell activation and pregnancy loss. In turn, many idiopathic pregnancy complications proposed ...
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