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Lima Patricia DA PD 1] Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada [2] Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, - - 2014
In humans, specific patterns of killer immunoglobulin-like receptors (KIRs) expressed by uterine natural killer (uNK) cells are linked through HLA-C with pregnancy complications (infertility, recurrent spontaneous abortion, intrauterine growth restriction and preeclampsia). To identify mechanisms underpinning the associations between NK cell activation and pregnancy success, pregnancies were studied in mice ...
Gharwan Helen H National Cancer Institute, Medical Oncology Branch, Bethesda, MD, - - 2014
Background: Myeloablative conditioning regimens given prior to hematopoietic stem cell transplantation (HSCT) frequently cause permanent sterility in men. In patients with sickle cell disease (SCD) we use a non-myeloablative regimen with sirolimus, alemtuzumab, low-dose total body irradiation (300 cGy) with gonadal shielding preceding allogeneic HSCT.Case: A 42 year-old man with ...
Mirabito Katrina M KM From the Department of Physiology (K.M.M., L.M.H., K.M.D.) and Department of Pharmacology (Z.W., R.E.W., A.V.), Monash University, Clayton, Victoria, Australia; and Baker Medical Research Institute, Melbourne, Victoria, Australia - - 2014
During normal pregnancy the renin-angiotensin system is activated, yet pregnant women are resistant to the pressor effects of angiotensin II. Our aim was to determine the role of the angiotensin type 2 receptor (AT2R) in the regulation of arterial pressure, natriuresis, and immune cell infiltration during pregnancy. Mean arterial pressure ...
Nanetti L L Department of Clinic Science, Section of Biochemistry, Biology and - - 2014
Abstract Objective The aim of the present study was to understand the role played by Atosiban, an oxytocin receptor antagonist, on trophoblastic human cells, and the molecular bases of its efficacy and safety in the treatment of preterm labor. NO, peroxinitrite production and NOS expression have been evaluated on placenta ...
Sones Jenny L JL Cornell - - 2014
Preeclampsia is a hypertensive, proteinuric disease that affects 5-10% of all pregnancies and is a leading cause of maternal and perinatal morbidity/mortality (13). The primary treatment for preeclampsia still is delivery of the fetus and placenta. The underlying mechanisms remain elusive. One possibility is inadequate uterine angiogenesis/vascularity (decidualization) at the ...
Chuma Shinichiro S Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan. Electronic address: - - 2014
Fetal oocytes in mammals undergo extensive apoptosis during development. In this issue of Developmental Cell, Malki et al. (2014) provide insight into how and why such massive oocyte loss occurs through the demonstration that the expression level of LINE-1 retrotransposon defines the survival threshold and thus viability of fetal oocytes.
Sotnikova Natalia N Federal State Research Institute of Maternity and Childhood named V.N. Gorodkov, Ivanovo, - - 2014
The immunological paradox of pregnancy, when maternal immune system recognizes but do not reject the semiallogenic fetus, is not yet fully understood. The aim of the present work was to detail the mechanisms of the interaction of decidual CD56+ NK, infiltrating the maternal part of placenta, and trophoblast cells of ...
Hansen Peter J PJ Department of Animal Sciences, D.H. Barron Reproductive and Perinatal Biology Research Program, and Genetics Institute, University of Florida, Gainesville 32611-0910, FL, USA. Electronic address: - - 2014
Events in the preimplantation period can have long-term consequences that affect embryo competence to establish and maintain pregnancy and which can extend into fetal and postnatal life. One of the molecules responsible for maternal modulation of embryonic development during this time is colony stimulating factor 2, also termed granulocyte-macrophage colony ...
Köstlin Natascha N Tuebingen University Childrens Hospital, Department of Neonatology, Tuebingen, - - 2014
Immune tolerance towards the semiallogeneic fetus plays a crucial role in the maintenance of pregnancy. Myeloid-derived suppressor cells (MDSCs) are innate immune cells characterized by their ability to modulate T-cell responses. Recently, we showed that MDSCs accumulate in cord blood of healthy newborns, yet their role in materno-fetal tolerance remained ...
Jiang Tony T TT Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229; Medical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH 45229; - - 2014
The immunological alterations required for successful pregnancy in eutherian placental mammals have remained a scientific enigma since the discovery of MHC haplotype diversity and unique immune signatures among individuals. Within the past 10 years, accumulating data suggest that immune-suppressive regulatory T cells (Tregs) confer essential protective benefits in sustaining tolerance ...
Wang Shaojuan S Department of Reproductive Medical Center, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China ; Department of Gynecology, Maternity and Child Healthcare Hospital, Shenzhen, Guangdong 518172, P.R. - - 2014
Pregnancy is associated with complex immunoreactions. In the present study, the effect of SB-273005, an antagonist of αvβ3 integrin, on the alterations of T helper (Th) cells and their derived cytokines that occur during pregnancy was investigated in mice. Five non-pregnant mice were used as a negative control. Mice were ...
Gram A A Institute of Veterinary Anatomy, Vetsuisse Faculty, University of Zurich, Zurich, - - 2014
Oxytocin (OT) plays an important role as an inducer of uterine contractility, acting together with its receptor (OTR) to increase synthesis of prostaglandins. Although OT is commonly used in the treatment for dystocia and uterine inertia in the bitch, little attention has been paid to the role of OT in ...
Cornelius D C DC Department of Pharmacology and Obstetrics and Gynecology University of Mississippi Medical Center Jackson, MS, USA - - - 2014
Pre-eclampsia is a multisystem disorder of pregnancy that affects 5-8% of pregnancies. The pathophysiologic mechanisms that lead to the development of pre-eclampsia are poorly understood. Higher than normal levels of circulating TH17 is observed in preeclamptic women compared to women with normal pregnancy. TH17 cells are a subset of CD4+ ...
Denicol Anna C AC Department of Animal Sciences, D. H. Barron Reproductive and Perinatal Biology Research Program, and Genetics Institute, University of Florida, Gainesville, Florida, - - 2014
Successful embryonic development is dependent on factors secreted by the reproductive tract. Dickkopf-1 (DKK1), an antagonist of the wingless-related mouse mammary tumor virus (WNT) signaling pathway, is one endometrial secretory protein potentially involved in maternal-embryo communication. The purpose of this study was to investigate the roles of DKK1 in embryo ...
Huang Chun C Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), Department of Medical Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin, 300060, People's Republic of - - 2014
To investigate the association between high parity and triple-negative breast cancer (TNBC), and explore the etiologic mechanisms of TNBC in Tientsin Albinao 2 (TA2) mice model. After the TA2 mice model with high parity and TNBC had been established, the cell proliferation and apoptosis were detected by immunohistochemical and TUNEL ...
Yang Hongling - - 2014
Abstract Objective: This study aims to evaluate the value of increasing inflammation in predicting gestational diabetes mellitus (GDM). Materials and methods: Subjects in this cross-sectional study included 302 GDM and 310 normal pregnancies before 20 weeks. Sociodemographic and pregnancy characteristics as well as blood parameters were acquired by maternal health ...
Bolnick Jay M JM Department of Obstetrics and Gynecology, C. S. Mott Center for Human Growth and Development, Wayne State University, Detroit, - - 2014
To use trophoblast cells accumulating in the endocervical canal at the beginning of pregnancy for noninvasive prenatal testing. Prospective, double-blinded test for fetal gender. Academic medical center. Fifty-six women with singleton pregnancies at gestational age 5-20 weeks. Isolation of fetal cells from resident maternal cells in endocervical specimens using anti-human leukocyte ...
Martini Irene - - 2014
Umbilical cord blood (UCB) is an important source of hematopoietic stem cells (HSCs). However, the concentration of cells in cord blood units is limited and this may represent the main restriction to their therapeutic clinical use. The percentage of metabolically active stem cells provides a measure of the viability of ...
Nanjidsuren T T Animal Biotechnology, Graduate School of Bio and Information Technology, Institute of Genetic Engineering, Hankyong National University, Ansung 456-749, Republic of - - 2014
The aims of this study were to determine the specific site of 20α-HSD expression in the reproductive tissues on day 30 of pregnancy and during pre-parturition. 20α-HSD mRNA was demonstrated to have the highest expression in the placenta on day 30 of pregnancy and in the ovary during pre-parturition. Weak ...
Haig David D Department of Organismic and Evolutionary Biology; Harvard University; Cambridge, MA - - 2014
Fetal microchimerism (FMc) is predicted to promote the fitness of the fetus and maternal microchimerism (MMc) to promote the fitness of the mother. Offspring and mothers benefit from each other's health. Therefore, microchimeric cells should usually not be harmful to their host. However, the evolutionary interests of mothers and offspring ...
Tasripoo K K 1 Research and Development Centre for Livestock Production Technology, Faculty of Veterinary Science, Chulalongkorn University, Henri Dunant Road, Bangkok 10330, - - 2014
The world's first cloned swamp buffalo (Bubalus bubalis) derived from adult ear skin fibroblast has been reported. Donor fibroblast cells were produced from biopsies taken from adult male ear skin and in vitro matured oocytes obtained from a slaughterhouse were used as cytoplasts. A total of 39 blastocysts and 19 ...
Stout Molly J MJ Departments of Obstetrics and - - 2014
Abstract Objective: The maternal-fetal interface must modulate immune function to allow tolerance of fetal cells while still reacting to pathogens to suppress infection. Human leukocyte antigen-G (HLA-G) is a class Ib major histocompatibility complex protein involved in maternal-fetal tolerance. We posited that alterations in placental HLA-G expression predispose women to ...
Liu Yang Y Department of Immunology, Binzhou Medical University, Yantai, Shandong, P. R. China, - - 2014
Acute infection with Toxoplasma gondii (T. gondii) during pregnancy is associated with adverse outcomes. The mechanisms that cause this phenomenon are not clear. Regulatory T cells (Tregs) are involved in maternal tolerance, and here we observed a decrease in the absolute numbers of CTLA-4(+) Tregs and PD-1(+) Tregs in spleen ...
Moffett Ashley - - 2014
Pregnancy presents an immunological conundrum because two genetically different individuals coexist. The maternal lymphocytes at the uterine maternal-fetal interface that can recognize mismatched placental cells are T cells and abundant distinctive uterine NK (uNK) cells. Multiple mechanisms exist that avoid damaging T cell responses to the fetus, whereas activation of ...
Yi Hyun Jeong HJ Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine, Seoul, - - 2014
To investigate whether natural killer (NK) cell and autoimmune antibody acts synergistically, by the action of autoantibodies to increase NK cell number and cytotoxicity, to decrease uterine blood flow during early pregnancy in pregnant women with a history of recurrent spontaneous abortion (RSA). Seventy-five pregnant women (between 5 and 7 ...
Ohashi Yasushi Y Department of Nephrology, Faculty of Medicine, Toho University, Tokyo, - - 2014
Juxtaglomerular cell tumor is a rare renal neoplasm. Secondary hypertension with juxtaglomerular cell tumor can be seen in females in their 20s and 30s. We present a case of juxtaglomerular cell tumor during pregnancy. A 32-year-old female was hospitalized for refractory hypertension and nephrotic syndrome in the 23rd gestational week. ...
Unek Gozde G Department of Histology and Embryology, Medical Faculty, Akdeniz University, 07070 Antalya, - - 2014
Placenta is a transitional area making many physiological activities between mother and fetus and therefore, it is a critical organ influencing the outcome of pregnancy. Fetal growth is directly related to placental development. Accurate placental development depends on coordinated action of trophoblasts' proliferation, differentiation and invasion. Information on cell cycle ...
Koga Kaori K Department of Obstetrics and Gynecology, The University of Tokyo, Tokyo, - - 2014
Toll-like receptors (TLRs) form the major family of pattern recognition receptors (PRRs) that are involved in innate immunity. Innate immune responses against microorganisms at the maternal-fetal interface may have a significant impact on the success of pregnancy, as intrauterine infections have been shown to be strongly associated with certain complications ...
Ampomah Paulina P Centre for Medical Parasitology, University of Copenhagen and Copenhagen University Hospital (Rigshospitalet), 2100 Copenhagen Ø, - - 2014
Naturally acquired protective immunity to Plasmodium falciparum malaria takes years to develop. It relies mainly on Abs, particularly IgG specific for Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) proteins on the infected erythrocyte surface. It is only partially understood why acquisition of clinical protection takes years to develop, but it ...
Jeanty Cerine C Eli and Edythe Broad Center of Regeneration Medicine and the Department of Surgery, University of California San Francisco, San Francisco, California, - - 2014
Maternal-fetal cellular trafficking (MFCT) is the bidirectional passage of cells between mother and fetus during pregnancy. This results in the presence of fetal cells in the maternal circulation, known as fetal microchimerism, and maternal cells in the fetal circulation, known as maternal microchimerism. The biologic role of this transplacental cellular ...
Muñoz-Hernandez Rocio R CSIC/Universidad de Sevilla, Unidad Clínico-Experimental de Riesgo - - 2014
Preeclampsia is a pregnancy-related disorder associated with increased cardiovascular risk for the offspring. Endothelial colony-forming cells (ECFCs) are a subset of circulating endothelial progenitor cells that participate in the formation of vasculature during development. However, the effect of preeclampsia on fetal levels of ECFCs is largely unknown. In this study, ...
Emad Ahmed A Division of Genetics, Department of Pediatrics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, - - 2014
Physical separation by density gradient centrifugation (DGC) is usually used as an initial step of multi-step enrichment protocols for purification of fetal cells (FCs) from maternal blood. Many protocols were designed but no single approach was efficient enough to provide non-invasive prenatal diagnosis (NIPD). Procedures and methods were difficult to ...
Dall'aglio Cecilia C Department of Veterinary Medicine, Perugia, Italy. Electronic address: - - 2014
The aim of the present study was to examine the presence and distribution of cells that express immunopositivity for orexin A (OXA) and its type 2 receptor (OX2R) in the dog placenta toward the end of pregnancy using immunohistochemical techniques. In the placental fetal portion, a few OXA and OX2R-positive ...
Kim S H SH Animal Biotechnology, Graduate School of Bio and Information Technology, Institute of Genetic Engineering, Hankyong National University, Ansung 456-749, Republic of - - 2014
The enzyme 20α-hydroxysteroid dehydrogenase (20α-HSD) catalyzes the conversion of progesterone to its inactive form, 20α-hydroxyprogesterone, and this enzyme has an important role in the regulation of luteal function in mammals. It has previously been determined that the 20α-HSD gene is primarily expressed by large luteal cells during the late stage ...
Mahmood Uzma U Anu Research Centre; Department of Obstetrics and Gynaecology; University College Cork; Cork University Maternity Hospital; Cork, - - 2014
Fetal cells persist in mothers for decades after delivery: in a phenomenon called fetal microchimerism. While persistent fetal cells were first implicated in autoimmune disease, parallel studies in animal and human pregnancy now suggest that microchimeric fetal cells play a role in the response to tissue injury. The aim of ...
McDonald-Burrows Zoë - - 2014
Gestational trophoblastic tumours are a rare form of malignancy, which in the majority of cases arise from abnormal trophoblast cells formed in a complete molar pregnancy. These tumours are extremely sensitive to chemotherapy and high cure rates approaching 100% can be expected. The disease is usually limited to the uterus ...
Eskicioglu Fatma - - 2014
There are no well-defined findings about reasons for first trimester abortion in some pregnancy cases. Selectins are cell adhesion proteins which are important for blastocyst implantation in the decidua. The goal of the study was to investigate the role of selectins in first trimester pregnancy loss by immunohistochemistry. Decidual and ...
Nakai Michiko M Genetically Modified Organism Research Center, National Institute of Agrobiological Sciences, Ibaraki 305-0901, - - 2014
In pigs, the embryonic developmental ability after intracytoplasmic sperm injection (ICSI) is inferior to that resulting from in vitro fertilization (IVF). We evaluated the timing of cell division up to blastocyst formation on embryonic development after ICSI using either whole sperm (w-ICSI) or the sperm head alone (h-ICSI) and IVF ...
Balasubramanyam Sathya S Institute of Reproductive Medicine and Women's Health, Madras Medical Mission, Mogappair, Chennai, Tamil Nadu, - - 2014
A 30 year old woman presented 12 days after embryo transfer with lower abdominal pain and orange vaginal discharge. She was diagnosed to have pyometra. A conservative management with drainage of the pyometra was followed by an uneventful pregnancy and term delivery. Conservative management in a case of pregnancy with ...
Navas Paola Beatríz PB CCT MENDOZA CONICET, IMBECU, Capital, Mendoza, Argentina ; - - 2014
Background: Progesterone (P4) is the main steroid secreted by the corpora lutea (CL) and is required for successful implantation and maintenance of pregnancy. Although adequate circulating levels of thyroid hormone (TH) are needed to support formation and maintenance of CL during pregnancy, TH signaling has not been described in this ...
French Clare E CE aPopulation, Policy and Practice, UCL Institute of Child Health bSchool of Health Sciences, City University London, London, - - 2014
During their second pregnancy with diagnosed HIV (n = 1177), two-fifths of women in the United Kingdom/Ireland not on antiretroviral therapy (ART) at conception had an immunological indication for treatment (CD4 <350 cells/μl), of whom nearly half had CD4 at least 350 cells/μl in their previous pregnancy. Those initiating ART during pregnancy had a ...
Schumacher Anne A Department of Experimental Obstetrics & Gynecology, Medical Faculty, Otto-von-Guericke University, Magdeburg, - - 2014
Pregnancy still represents one of the most fascinating paradoxical phenomena in science. Immediately after conception, the maternal immune system is challenged by the presence of foreign paternal antigens in the semen. This triggers mechanisms of recognition and tolerance that all together allow the embryo to implant and later the fetus ...
Xu Peng P State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, - - 2014
Preeclampsia is a major cause of maternal and fetal mortality and morbidity worldwide. The differential expression of several microRNAs (miRNAs) has been found in preeclamptic placentas. However, great conflict exists regarding this aspect, and detailed examinations have largely been lacking of miRNA profiles in different parts of the placenta and ...
Alijotas-Reig Jaume J Systemic Autoimmune Disease Unit, Department of Internal Medicine I, Vall d'Hebron University Hospital, Spain; Department of Medicine, Faculty of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain. Electronic address: - - 2014
Because maternal alloreactive lymphocytes are not depleted during pregnancy, local and/or systemic mechanisms have to play a key role in altering the maternal immune response. Peripheral T regulatory cells (pTregs) at the maternal-foetal interface are necessary in situ to prevent early abortion, but only those pTregs that have been previously ...
Mao Jun J Center for Reproduction and Genetics, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, Jiangsu, - - 2014
Non-invasive prenatal testing (NIPT) by massively parallel sequencing is a useful clinical test for detection of common fetal aneuploidies. While the accuracy of aneuploidy detection can approach 100%, results discordant with the fetus are occasionally reported. In this study we investigated the basis of a discordant T21 positive and T18 ...
Kim Dong Jae DJ Department of Obstetrics and Gynecology, College of Medicine, Konyang University, Seo-gu, Daejeon, - - 2014
Th17 cells and Foxp3(+) regulatory T (Treg) cells have been proposed as new risk factors for recurrent pregnancy loss (RPL). Intravenous immunoglobulin G (IVIG) was reported to modulate various immune cells. In this study, we investigated the effect of IVIG on the levels of Th17 and Treg cells and pregnancy ...
Schminkey Donna L DL University of Virginia, United States. Electronic address: - - 2014
Recent research challenges long-held hypotheses about mechanisms through which pregnancy induces maternal immune suppression or tolerance of the embryo/fetus. It is now understood that normal pregnancy engages the immune system and that the immune milieu changes with advancing gestation. We suggest that pregnancy mimics the innate immune system's response to ...
Wambach Carrie M CM Division of Reproductive Endocrinology and Infertility, Department of OB/GYN, Cedars-Sinai Medical Center, Los Angeles, CA, - - 2014
To determine the interplay between fetal antigenicity and local maternal factors in determining reproductive tract T regulatory (Treg) cell accumulation during pregnancy. Examination of maternal Treg composition in the uterus, cervix, and uteroplacental interface (UPI) of murine syngeneic and allogeneic pregnancies and non-pregnant controls by flow cytometry. The impact of ...
Saddick Salina Y SY Biological Studies Dept., Faculty of Science, King Abdulaziz University, PO Box 42671, Jeddah 21551, Saudi - - 2014
The present study is designed to demonstrate the ovarian surface epithelial cells' (OSE) estrogen receptor α (ERα) and progesterone receptor (PR) during pregnancy and estrous cycle in rat. Moreover, determination of the levels of plasma progesterone, estradiol, FSH and LH was also made. The levels of plasma progesterone, estradiol, FSH ...
Sorrentino Mario M 1Ospedale Civile di Latisana, Latisana (UD), - - 2014
A 27-year-old women requesting assistance for an unspecified abdominal pain localized in the right flank that worsened after a recent delivery was discovered to have a solid mass in the upper pole of her right kidney. Radiological findings showed benign characteristics but without a clear diagnosis. Subsequently, a laparotomic nephron-sparing ...
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