Search Results
Results 201 - 250 of 1110
< 1 2 3 4 5 6 7 8 9 10 >
Tomson Torbjörn - - 2009
Women with epilepsy that plan to become pregnant can in general look forward to uneventful pregnancies and to giving birth to normal children. However, there are certain risks associated with epilepsy and antiepileptic drug (AED) treatment, and it is likely that these risks can be reduced with appropriate prepregnancy counseling. ...
Nguyen Ha T T - - 2009
OBJECTIVE: To review the teratogenic effects associated with the use of Food and Drug Administration-approved agents for bipolar disorder. METHODS: A PubMed search of all English language articles published from January 1966 to December 2008 was conducted. The key search terms included all major bipolar agents, cross-referenced with: teratogenicity, teratogen, ...
Merlob Paul - - 2009
Mycophenolate mofetil (MFM) is an immunosuppressant agent used in organ transplantation, rheumatoid arthritis and lupus nephritis. Experimental data show that doses roughly equivalent to those used clinically in transplant patients may cause fetal resorption and malformations in pregnant rats and rabbits. There are limited data regarding the use of MFM ...
Erić Mirela - - 2009
OBJECTIVE: The course of pregnancy is associated with a number of changes in the female body. Literature data indicate that 1-3% of pregnant women develop some cardiac disorder. The aim of the study was to assess the prevalence of using cardiovascular agents in pregnancy, the rate of congenital malformations in ...
Buhimschi Catalin S - - 2009
This is the second of a two-part series on the use of medication during pregnancy and lactation. Pregnancy risk factors together with an increased incidence of chronic diseases and the rise in mean maternal age predict an increase in medication use during gestation. However, as highlighted in the first installment ...
Seidahmed Mohammed Z - - 2009
Fetal valproate syndrome (FVS) is a well-recognized constellation of dysmorphic features, and neurodevelopmental retardation that results from prenatal exposure to the anticonvulsant valproic acid. In this report, we describe a case with typical features of FVS. A 23-year-old lady with post-traumatic epilepsy controlled by sodium valproate (Depakene) 500 mg twice ...
Mashayekhi Simin O - - 2009
OBJECTIVE: The aim of the study was to examine the awareness of Iranian pregnant women about the effects of drugs in pregnancy. METHODS: Awareness of 400 women in postnatal and prenatal wards was assessed using self-completion questionnaire, which included demographic information, medication use, and the level of information regarding the ...
Crawford Pamela M - - 2009
Epilepsy affects the menstrual cycle, aspects of contraception, fertility, pregnancy and bone health in women. It is common for seizure frequency to vary throughout the menstrual cycle. In ovulatory cycles, two peaks can be seen around the time of ovulation and in the few days before menstruation. In anovulatory cycles, ...
Aksamija Alenka - - 2009
The use of antiepileptic drugs (AEDs) during pregnancy has been associated with an increased risk of major and minor fetal malformations. This paper describes 2 infants with malformations born to epileptic mothers who used AEDs throughout pregnancy. In the first case, the AED used for seizure control was methylphenobarbital, while ...
Palmer Julia - - 2009
The diagnosis of ovarian carcinoma in pregnancy is rare (incidence of 0.018-0.073/1000 pregnancies). Its rarity is reflected by a paucity of cases reported in the literature. The present report concerns a case of advanced serous ovarian carcinoma in a full-term pregnancy. This was an incidental finding discovered during an emergency ...
Nulman Irena - - 2009
BACKGROUND: The delayed-release combination of doxylamine succinate and pyridoxine hydrochloride was the most commonly used antiemetic (Bendectin) approved by FDA for nausea and vomiting of pregnancy (NVP) until its removal of the market in 1983. The drug is widely used today in Canada (Diclectin). The pharmacokinetics of Diclectin has never ...
Einarson Adrienne - - 2009
Psychiatric disorders are relatively common among women of childbearing age, who may be prescribed psychotropic drugs. There remains a high level of anxiety regarding their safety among patients and healthcare providers alike, most likely because of the conflicting studies that have been published in the literature and warnings from government ...
Anderson Gail D - - 2009
In the US, approximately 12% of women have hypertension during their pregnancy. Antihypertensive drugs are often given to lower maternal blood pressure in those with severe hypertension to prevent stroke and hypertensive crises. There is no conclusive evidence that antihypertensive treatment is beneficial to the mother in mild to moderate ...
Sachdeva Punam - - 2009
Pregnancy is a special physiological condition where drug treatment presents a special concern because the physiology of pregnancy affects the pharmacokinetics of medications used and certain medications can reach the fetus and cause harm. Total avoidance of pharmacological treatment in pregnancy is not possible and may be dangerous because some ...
Ververs Tessa - - 2009
The use of antidepressants during pregnancy has increased in recent years. In the Netherlands, almost 2% of all pregnant women are exposed to antidepressants. Although guidelines have been developed on considerations that should be taken into account, prescribing antidepressants during pregnancy is still a subject of debate. Physicians and pharmacists ...
Berthelot Jean-Marie - - 2009
OBJECTIVE: To report on the outcome of 15 cases of pregnancies in women treated with anti-TNF drugs during conception or pregnancy METHODS: French rheumatologists connecting to the web-site of CRI site: http://www.cri-net.com were asked to fill in a structured questionnaire reporting the outcome of pregnancy in women still treated by ...
Simmat-Durand Laurence - - 2009
OBJECTIVE: This study was first conducted to compare the consequences of the use of methadone and high-dose buprenorphine in pregnancy in France and secondly to describe the heterogeneity of women under high-dose buprenorphine. This paper focuses on the second point only. STUDY DESIGN: From October 1998 to September 1999, data ...
Mir Olivier - - 2008
The incidence of cancer during pregnancy is increasing given the trend for women to postpone childbearing. Knowledge of the potential toxicity and teratogenicity of chemotherapy agents is crucial for patient counseling. Platinum derivatives are active against various malignancies that occur more frequently during pregnancy: melanoma, cervical and ovarian cancers, and ...
Uziel Daniela - - 2008
Maternal epilepsy has a potential for fetal injury, either antiepileptic drug (AED)--induced or as a consequence of seizures per se. The intent of this article is to explore this relationship, discussing similar patterns of malformations seen with AEDs or different disease exposure during pregnancy, and the potential role of gap ...
Harden Cynthia L - - 2008
Much new information has now become available regarding outcomes of women with epilepsy (WWE) and pregnancy. Valproate is associated with a risk of major congenital malformations within a range of 6.2-10.7%, though antiepileptic drugs (AEDs) other than valproate when used as monotherapy are associated with major congenital malformation rates ranging ...
Cetinkaya Merih - - 2008
Lamotrigine (LTG) has been used in epilepsia patients for treatment of partial seizures. It can cross the placenta and there are limited data about its use in pregnancy and foetal adverse effects. Extremity and cardiac malformations, dysmorphic facial appearance, coanal atresia and upper respiratory and gastrointestinal anomalies have been reported ...
Pennell Page B PB Department of Nuerology, Emory Epilepsy Program, Emory University School of Medicine, Atlanta, Georgia 30322, USA. - - 2008
Most infants born to women with epilepsy are healthy, but there are increased risks related to in utero antiepileptic drug (AED) exposure and seizures. Emerging data from pregnancy registries and other studies allow us to better balance the anatomic teratogenic and neurodevelopmental effects of AEDs against the need to maintain ...
Garcia-Marcos L - - 2009
BACKGROUND: There seems to be an association between paracetamol consumption during late pregnancy and the prevalence of wheezing in infancy and childhood. The aim of the present study is to determine whether the aforementioned association is modified by the presence of asthma in the mother. METHODS: A total of 1,741 ...
Devereux Graham - - 2008
Evaluation of: Willers SM, Wijga AH, Brunekreef B et al. Maternal food consumption during pregnancy and the longitudinal development of childhood asthma. Am. J. Respir. Crit. Care Med. 178, 124-131 (2008). It has been hypothesized that the recent marked increase in the prevalence of asthma may, in part, be a ...
Minozzi F - - 2008
Pregnancy is a condition characterized by various physiological modifications (placentary and ovarian hormones release) that influence various organic districts, including the oral district. In this review were re-examined the rules about the execution of dental services with the relative indications and contraindications during the different phases of pregnancy, the use ...
Rodríguez-Salgado B - - 2008
The use of risperidone and other antipsychotic drugs during pregnancy is sometimes essential, although it is impossible to design clinical trials to demonstrate the safety of these kinds of drugs. The common method to communicate the absence of drug-related events is through case reports, even though they might be insufficient. ...
Tixier Hervé - - 2008
Selective serotonin reuptake inhibitor (SSRI) antidepressants are preferred to tricyclics, because, for the same efficacy, they are better tolerated. The mechanisms of action are well understood. These drugs may be used during pregnancy. We present here the case of a voluntary intoxication with SSRI in the third trimester of pregnancy.
Westin Andreas Austgulen - - 2009
To study the impact of pregnancy on the serum concentration/dose ratio (C/D-ratio) of topiramate (TPM). Twelve women with epilepsy using TPM during pregnancy, and 15 pregnancies were studied. The main target variable was the C/D-ratio at baseline and during pregnancy. Additional variables were changes in TPM dose, concomitant use of ...
Couderc Jean-Philippe - - 2009
The authors investigated whether computerized parameters quantifying ventricular repolarization delay, heterogeneity, and instability characterize individuals who developed drug-induced Torsades de Pointes. Assessing an individual's propensity to Torsades de Pointes when exposed to a QT-prolonging drug is challenging because baseline QT prolongation has limited predictive value. Five-minute digital 12-lead electrocardiograms were ...
Argyriou Andreas A - - 2008
During the previous decades, women with Multiple Sclerosis (MS) were discouraged from having children, as pregnancy was deemed dangerous for pregnancy outcome and a contributing factor for exacerbation of MS. Current knowledge shows that women with MS are no more likely to have pregnancy or delivery complications compared to healthy ...
Psychoyos Delphine - - 2008
Marijuana is the most commonly abused illicit drug by pregnant women. Its major psychoactive constituent, Delta(9)-THC (Delta(9)-tetrahydrocannabinol), crosses the placenta and accumulates in the foetus, potentially harming its development. In humans, marijuana use in early pregnancy is associated with miscarriage, a fetal alcohol-like syndrome, as well as learning disabilities, memory ...
Fedulov Alexey V - - 2008
Asthma has origins in early life. Epidemiological studies show that maternal, more than paternal, asthma significantly increases a child's risk of developing the disease. Experimental animal models exist which reproduce the increased susceptibility to asthma seen in human studies, and allow analysis of immunotoxic mechanisms that may contribute to neonatal ...
Gentile Salvatore - - 2010
Both first- (FGAs) and second-generation antipsychotics (SGAs) are routinely used in treating severe and persistent psychiatric disorders. However, until now no articles have analyzed systematically the safety of both classes of psychotropics during pregnancy. DATA SOURCES AND SEARCH STRATEGY: Medical literature information published in any language since 1950 was identified ...
Polte T - - 2008
BACKGROUND: Maternal, more than paternal, asthma is a risk factor for the development of asthma in children. Recently, epidemiologic studies have shown that environmental exposures during pregnancy might influence the development of childhood asthma and allergies. OBJECTIVE: The aim of the present study was to investigate whether the induction of ...
Erić Mirela - - 2008
The aim of our study was to study the possible correlation between use of antibacterial drugs in pregnancy and occurrence of congenital malformations. Among 6099 investigated pregnant women, 392 (6.43%) used antibacterial drugs. The most frequently used antibacterials belonged to category B (75.77%), while 14.54% antibiotics belonged to category D ...
Vélez Nydia M - - 2008
BACKGROUND: Tobacco, alcohol and/or illicit drug use during pregnancy are risk factors for neonatal complications. In Puerto Rico, the Department of Health reports that 32% of pregnant women use alcohol and 3% use illicit drugs. Nineteen percent (19.1%) of newborns are born prematurely. The purpose of this study is to ...
Firoozi Faranak - - 2009
Recent studies have found that asthmatic women pregnant with a female fetus reported more symptoms and had slightly lower lung function than women pregnant with a male fetus. In order to further investigate this association, we studied the effect of fetal sex on maternal asthma exacerbations and the use of ...
Meador K J KJ Department of Neurology, Emory University, Atlanta, GA 30322, USA. - - 2008
Most pregnant women with epilepsy require antiepileptic drug (AED) therapy. Present guidelines recommend optimizing treatment prior to conception, choosing the most effective AED for seizure type and syndrome, using monotherapy and lowest effective dose, and supplementing with folate. The Epilepsy Therapy Project established the international Health Outcomes in Pregnancy and ...
Armenti Vincent T - - 2008
The National Transplantation Pregnancy Registry (NTPR) was established in 1991 to study the outcomes of pregnancies in female transplant recipients and pregnancies fathered by male transplant recipients. Data from the NTPR have helped to endorse the reassurances from publications of smaller experiences that successful pregnancies are possible in the transplant ...
Bakhireva Ludmila N - - 2008
BACKGROUND: Concerns regarding potential harmful effect of medications on fetuses often result in inadequate treatment of asthma in pregnancy, whereas risks posed by poorly controlled maternal asthma are often underestimated. OBJECTIVE: To evaluate the effect of maternal asthma on preterm delivery and fetal growth. METHODS: Study participants were individuals enrolled ...
Beckmann Claudia Anderson - - 2008
Asthma is one of the most common medical complications of pregnancy. Asthma control is associated with improved perinatal outcomes. Peak flow measures have been recommended to determine the status of asthma, yet norms for peak flow values in women with asthma are missing from the literature. The purpose of this ...
Vajda F J E - - 2008
BACKGROUND: Antiepileptic drugs (AEDs) in pregnancy are associated with an increased risk of fetal malformations. Concern is expressed about the effects that AEDs may produce on the child's cognition and development. To date, no specific malformations have clearly been proven to be attributable to a specific drug, with the exception ...
Osei-Kumah Annette - - 2008
The mechanisms contributing to worsening of asthma during pregnancy have not been well characterized. Both asthma and pregnancy are conditions associated with a skewing of the immune response from T helper (Th) 1 toward a Th2 response. We hypothesise that worsening of asthma during pregnancy may be due to an ...
Krishnamurthy Kaarkuzhali B - - 2008
In the United States, about 1 million women of childbearing age have epilepsy. Estimates vary as to the percentage of these women who consider pregnancy, but epilepsy is the most common neurologic condition encountered in pregnancy. Women with epilepsy express significant interest in receiving guidance about pregnancy and the effects ...
Olsen Sjurdur F - - 2008
BACKGROUND: Evidence suggests that asthma is rooted in the intrauterine environment and that intake of marine n-3 polyunsaturated fatty acids (n-3 PUFAs) in pregnancy may have immunomodulatory effects on the child. OBJECTIVE: Our aim was to examine whether increasing maternal intake of n-3 PUFAs in pregnancy may affect offspring risk ...
Gerard Elizabeth - - 2008
Multiple surveillance pregnancy registries have been established in order to better understand the effects of antiepileptic drugs (AEDs) on pregnancy. These registries are either hospital based, population based, or pharmaceutical based and are primarily focused on the potential teratogenicity of AEDs. The main outcome variable for most of these registries ...
Bromfield Edward B - - 2008
Maternal valproate (VPA) use is associated with a significant risk for congenital malformations in the exposed fetus. Since VPA is commonly used in epilepsy syndromes with a presumed genetic cause (idiopathic epilepsies), it is possible that maternal genetic background contributes to this outcome. We reviewed responses to telephone questionnaires and ...
Eroğlu Erdal - - 2008
Maternal use of antiepileptic drugs (AEDs) during pregnancy has been associated with an increased risk of congenital abnormalities in the fetus. This is partly attributable to AEDs. We aimed to analyse seizure frequency and the rate and type of any congenital malformation related to pregnancies in women with epilepsy in ...
Bakhireva Ludmila N - - 2008
Asthma is a prevalent chronic disorder that might substantially complicate pregnancy. Some recent reports suggest that the presence of a female fetus might be associated with worse maternal asthma symptoms during pregnancy. We tested this hypothesis using the sample of 719 pregnant women with asthma prospectively enrolled in the OTIS ...
Christensen Carl - - 2008
Although the percentage of pregnant patients who use illicit drugs is relatively low, the effects can be devastating on both mother and fetus-loss of custody, growth restriction, placental abruption, and death. The practicing obstetrician may be unfamiliar with the various presentations of chemical dependency in pregnancy, including intoxication and withdrawal, ...
< 1 2 3 4 5 6 7 8 9 10 >