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Torres-Sánchez Luisa L Center for Population Health Research, National Institute of Public Health, Av. Universidad 655, Col. Sta María Ahuacatitlán, CP 62100, Cuernavaca, Morelos, Mexico, - - 2014
In this study, we evaluated the effects of dietary intake of vitamin B12 and folate during pregnancy and their interactions with maternal polymorphism of MTHFR (677C>T; 1298A>C) on intrauterine development. Anthropometric parameters were obtained from 231 newborns that belong to a prospective birth cohort in Morelos, Mexico. Maternal dietary intake ...
Wilgen Urs U Pathology Queensland, Department of Chemical Pathology, Royal Brisbane and Women's Hospital, Herston Road, Herston 4029, Queensland, Australia; University of Queensland, School of Medicine, Brisbane, St Lucia 4072, Queensland, Australia. Electronic address: - - 2014
Point-of-care testing for β-hCG has been widely advocated to allow rapid diagnosis/exclusion of pregnancy in the emergency department. A quantitative blood β-hCG assay has the additional benefit of being able to monitor the viability of pregnancy, using serial measurements, to determine the appropriate expected increase in β-hCG levels over time ...
So Jane J Stony Brook University Hospital, Stony Brook, - - 2014
Preeclampsia occurs in 6-8% of pregnancies and is the second leading cause of maternal mortality in the United States. Preeclampsia is associated with HELLP (Hemolysis, Elevated Liver enzymes and Low Platelet count) syndrome and it has become a common practice to evaluate for the syndrome with laboratory testing in all ...
Mor Amir A Maimonides Medical Center, Brooklyn, - - 2014
Meconium-stained amniotic fluid occurs in approximately 12% of all pregnancies. Although most pregnancies with meconium-stained amniotic fluid end with no fetal or neonatal complications, there is still a significant number that result in immediate life-threatening complications to the neonate such as meconium aspiration syndrome. Meconium aspiration syndrome still poses a ...
Balssa Frédéric F Laboratoire des Courses Hippiques, 15 rue de Paradis, 91370 Verrières le Buisson, France. Electronic address: - - 2014
5(10)-estrene-3β,17α-diol is an essential reference material for doping analysis in horse-racing laboratories. It is used to detect misuse, for doping purpose, of the pregnancy status in the mare. Its stereoselective synthesis from 17β-estradiol-3-methyl ether (prepared from estrone or 17β-estradiol) was performed in four steps: (1) Mitsunobu inversion of the 17β-alcohol; ...
Panda Akhila Kumar AK Department of Neurology, Institute of Human Behaviour and Allied Sciences, Delhi, - - 2014
Parry-Romberg syndrome (PRS) with hemimasticatory spasm (HMS) is quite an uncommon overlapping phenomenon which very often mimics jaw closing dystonia. A previously healthy 35-year-old female, during her 5(th) month of pregnancy started developing intermittent unilateral painful spasms of jaw while conversation, clinching of teeth, or eating, which led to frequent ...
Bestwick Jonathan P JP Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, - - 2013
Thyroid stimulating hormone (TSH) and free thyroxine (FT4) concentrations vary during pregnancy and conventional units can vary between laboratories. Reference ranges are widely quoted but are arbitrary and do not allow for inter-laboratory differences or gestational age. We therefore explored using multiples of the median (MoM) values to overcome these ...
Ziebe Søren - - 2013
Morphometric and morphokinetic approaches toward embryo quality assessment have for many years been difficult due to technical limitations. Today, with improvements in laboratory techniques and subsequent quality, we have a better understanding of the morphometric and kinetics of embryo development. Fertility clinics are moving from "sensing" embryo quality to measuring ...
Bliddal Sofie - - 2013
Correct interpretation of thyroid status during pregnancy is vital to secure fetal development. Pregnancy-related changes in maternal thyroid status necessitate use of gestational-age-specific reference ranges. We investigated between-laboratory reproducibility of thyroid reference ranges in pregnant women. Comparison of two longitudinal prospective cohort studies including 255 (cohort 1) and 101 (cohort ...
Garla Vishnu V Department of Medicine, Joan C. Edwards School of Medicine, Marshall University, Huntington WV, USA. - - 2013
A 31 year old woman who was 16 weeks pregnant was admitted because of headache, blurred vision, excessive weight gain, and hirsutism. Laboratory tests showed low adrenocorticotropic hormone (ACTH) and elevated serum and urinary cortisol. Magnetic resonance imaging showed a left adrenal mass. Left adrenalectomy was done, and histopathology showed ...
Teng Weiping W Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang, - - 2013
Hypothyroidism is the most common pregnancy-related thyroid disorder, affecting 3-5% of all pregnant women. Subclinical hypothyroidism is more common than is overt hypothyroidism, and is usually defined as a serum thyroid-stimulating hormone (TSH) concentration greater than the pregnancy-specific reference range for each laboratory value, or by serum TSH concentrations greater ...
Gadgil Meghana D - - 2013
Abstract Objective: Bariatric surgery can reduce the risk of obesity-related complications of pregnancy, but may cause essential nutrient deficiencies. To assess adherence to laboratory testing guidelines, we examined frequency of testing for and diagnosis of deficiency during preconception and pregnancy using claims data in women with a delivery and bariatric ...
Mehlhaff Krista M - - 2013
Brodifacoum, a superwarfarin, is a common household agent used for rodenticides. We present a case of maternal brodifacoum ingestion that resulted in neonatal death. A 19-year-old primigravid woman presented at 32 weeks of gestation with spontaneous mucosal bleeding. Her fetus showed evidence of acidosis on external fetal monitoring. Laboratory values ...
Gawron Lori M - - 2013
Context.-Management of second-trimester intrauterine fetal demise via dilation and evacuation results in nonintact specimens for pathologic examination. Surgical pathology examination is often mandated; however, evidence on expected findings and specimen evaluation guidelines are lacking. Objectives.-To assess pathologic findings of nonintact, second-trimester fetal demise specimens, through comparison of anatomic abnormalities identified ...
Tomlinson Mathew - - 2013
Reports on the influence of semen parameters on natural or assisted pregnancy are contradictory, suggesting that the many confounding variables which contribute to outcome have not been taken into account. However, it is possible to derive some consensus for both natural and assisted conception by focussing on studies which use ...
Nelson David B - - 2013
Our aim was to provide a description of clinical and laboratory finding: pregnancy outcomes in women with acute fatty liver of pregnancy (AFLP). We also characterize the duration of recovery of multiorgan system dysfunction that begins after delivery. All women who were admitted to Parkland Hospital with AFLP were identified; ...
De Neubourg D D Department of Obstetrics and Gynaecology, LUFC, University Hospitals Leuven, Leuven, - - 2013
What is the effect of a legal limitation of the number of embryos that can be transferred in an assisted reproductive technology (ART) cycle on the multiple delivery rate? The Belgian national register shows that the introduction of reimbursement of ART laboratory costs in July 2003, and the imposition of ...
Belvini D - - 2013
This article describes prenatal diagnosis (PND) of haemophilia B (HB) within the framework of Italian haemophilia centres and genetics laboratories. The study details the experience from six haemophilia genetic centres (three in the North, one in the Centre and two in the South of Italy) and summarizes the different techniques ...
Africa Charlene Wj - - 2013
Introduction: Bacterial vaginosis (BV) has been associated with pelvic inflammatory disease, adverse pregnancy outcomes, increased susceptibility to sexually transmitted infections and infertility. Diagnosis of BV should be rapid, reliable and safe. This is especially vital in pregnant women where intervention may be necessary for the well-being of both the mother ...
Lovrencić Marijana Vucić - - 2013
An increasing prevalence of gestational diabetes has become a very challenging task in prenatal care worldwide. International Association of Diabetes and Pregnancy Study Groups (IADPSG) has recently issued recommendations on the diagnosis and classification of hyperglycaemia in pregnancy. These recommendations, the first to provide harmonised, evidence-based criteria for the diagnosis ...
Hinrichs Katrin - - 2012
This paper reviews current equine assisted reproduction techniques. Embryo transfer is the most common equine ART, but is still limited by the inability to superovulate mares effectively. Immature oocytes may be recovered by transvaginal ultrasound-guided aspiration of immature follicles, or from ovaries postmortem, and can be effectively matured in vitro. ...
Dias Monike L - - 2012
BACKGROUND: High homology of GH with placental GH (pGH) and hPL frequently resulted in falsely high GH levels in competitive immunoassays during pregnancy. However, in immunometric assays, falsely high or low GH levels can result from GH-like molecules binding to both or only one monoclonal antibody. Since our GH-IFMA assay ...
Basavaraju Anuradha - - 2012
Pregnancy gingivitis is a major oral infection. Periodontium acts as a reservoir of inflammatory mediators and sub gingival biofilms of bacteria. To evaluate the anaerobic oral microbial flora in pregnant women before delivery and after delivery by comparing them with control group. The study group included fifteen cases of pregnant ...
Bubonja-Sonje Marina - - 2012
Abstract Background: Listeria monocytogenes usually causes mild maternal illness, but can be devastating to the fetus. Case: Listeriosis in a pregnant patient successfully treated with empiric antibiotic therapy is described. After induced delivery, despite severe placental infection, a healthy infant was born. Additionally, archived placental specimens with similar pathological manifestation ...
Ema Makoto - - 2012
Historical control data on rabbit prenatal developmental toxicity studies, performed between 1994-2010, were obtained from 20 laboratories, including 11 pharmaceutical and chemical companies and nine contract laboratories, in Japan. In this paper, data were incorporated from a laboratory if the information was based on 10 studies or more. Japanese White ...
Ghartey Jeny P - - 2012
Genital tract secretions exhibit bactericidal activity against Escherichia coli. We hypothesized that this defense may be modulated during pregnancy. Secretions were collected by vaginal swab from 70 pregnant women (35-37 weeks' gestation) and 35 nonpregnant controls. We mixed E coli with swab eluants or control buffer and colonies enumerated to ...
Hawa Nadim - - 2012
The safety of laparoscopic management of adnexal masses in pregnancy has been documented. Herein we report laparoscopic removal during pregnancy of a cystically degenerated leiomyoma of the sigmoid colon, which had been mistaken for an adnexal mass. When smooth muscle gastrointestinal tumors are observed, it is important that they be ...
Draçini Xh - - 2012
Introduction. Acute intestinal obstruction in pregnancy is a rare, but life-threatening complication associated with high fetal and maternal mortality. Case report. A 20-year old gravida presented with a 24 hour history of several episodes of vomiting, complete constipation and severe crampy abdominal pain. The patient was admitted with the diagnosis ...
Giorgakis E E Royal London Hospital , Barts and The London NHS Trust, London, - - 2012
Endometriosis is a common disorder in women of reproductive age. A rare localization is the appendix, which, in most cases, is an incidental finding during appendectomies. The incidence of symptomatic appendiceal endometriosis or endometrial appendicitis might be increased in pregnancy. Moreover, endometrial appendicitis in pregnancy is more likely to present ...
Tam Teresa - - 2012
Abstract Objective: The purpose of the study is to evaluate the incidence of women with prior GBS genital colonization who have recolonization in subsequent pregnancies. Methods: This is a retrospective, cohort study of patients with a prior GBS genital colonization in pregnancy and a subsequent pregnancy with a recorded GBS ...
Chung Judith H - - 2012
: Fetal epignathus, a teratoma arising from the oropharynx that may be lethal, can be diagnosed prenatally. : A 29-year-old woman, gravida 1, was evaluated for an elevated alpha-fetoprotein level. Imaging evaluation revealed a fetal epignathus without intracranial extension. Preterm labor necessitated delivery at 27 5/7 weeks of gestation with ...
Mortimer R H - - 2012
CONTEXT: The thyroid hormone and retinol binding protein transthyretin (TTR) is synthesised by human trophoblasts. Polarised JEG-3 choriocarcinoma cells grown in bicameral chambers secrete TTR predominantly apically but also basally and these cells and human trophoblasts also take up TTR suggesting that there may be a placental TTR shuttle that ...
Bosco Cleofina - - 2012
AIMS: To examine the causes of variability in the effect of maternal drinking on the foetus, with particular reference to the pattern, frequency and duration of the period of drinking, differences in maternal, foetal and placental metabolism of ethanol/acetaldehyde, and genetic factors. METHODS: Narrative review of published studies of the ...
Mitchell R T RT Medical Research Council/University of Edinburgh Centre for Reproductive Health, The Queen's Medical Research Institute, Edinburgh Royal Hospital for Sick Children, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, United Kingdom. - - 2012
Phthalates are ubiquitous environmental chemicals. Fetal exposure to certain phthalates [e.g. di-n-butyl phthalate (DBP)] causes masculinization disorders in rats, raising concern for similar effects in humans. We investigated whether DBP exposure impairs steroidogenesis by the human fetal testis. The aim of the study was to determine effects of DBP exposure ...
Johnstone-Ayliffe Carina - - 2012
Objective. To review the procedure related complication rates following fetal blood sampling and intrauterine red cell transfusion for anaemic fetuses at a single tertiary centre. Design. This is a retrospective study of 114 intrauterine transfusions. Setting. A single tertiary referral fetal medicine centre at Queen Charlotte's and Chelsea Hospital, Imperial ...
Andersen Anne-Marie Nybo - - 2012
Controversies still exist regarding the existence of a 'safe' level of alcohol intake during pregnancy. The aim of this study was to assess the risk of fetal death (spontaneous abortion and stillbirth) according to maternal alcohol consumption in a large Danish pregnancy cohort. A cohort study carried out within the ...
Sudhakaran Nada - - 2012
Fetal intervention encompasses a range of procedures on the fetus with congenital structural anomalies, whilst still on the placental circulation. The concept of fetal surgery was conceived in order to prevent fetal or early postnatal death, or to prevent permanent irreversible organ damage. The benefit of these procedures has to ...
Herrington A'dair - - 2012
A 24-year-old pregnant woman had a bowel obstruction secondary to a gravid uterus. A multispecialty team approach resulted in a restorative proctocolectomy, which led to resolution of acute symptoms and a successful pregnancy.
Ribeiro Nascimento Enzo Fabrício EF Department of General Surgery, São Francisco University Hospital, Bragança Paulista, SP, - - 2012
Colonic obstruction due to sigmoid colon volvulus during pregnancy is a rare but complication with significant maternal and fetal mortality. We describe a case of sigmoid volvulus in a patient with 33 weeks of gestation that developed complete necrosis of the left colon. Case. 27-year-old woman was admitted with 3 ...
Maconi Mariacaterina M Department of Clinical Pathology, ASL Alessandria, Alessandria, Italy. - - 2012
Changes in platelet count (PLT) are very important during pregnancy. Many platelet disorders occur during pregnancy and a reduction in PLT is the most common hemostasis abnormality identified, and this has important implications for mother and foetus. Many of these disorders share clinical and laboratory features, making accurate diagnosis difficult. ...
Geaghan Sharon M - - 2011
BACKGROUND:Emerging antenatal interventions and care delivery to the fetus require diagnostic support, including laboratory technologies, appropriate methodologies, establishment of special algorithms, and interpretative guidelines for clinical decision-making.CONTENT:Fetal diagnostic(1) and therapeutic interventions vary in invasiveness and are associated with a spectrum of risks and benefits. Fetal laboratory assessments are well served ...
Hanson Jessica D - - 2011
Alcohol-exposed pregnancies are especially of concern for American Indians. The Indian Health Service reported that 47% to 56% of pregnant patients admitted to drinking alcohol during their pregnancy. In addition, rates of Fetal Alcohol Syndrome are estimated to be as high as 3.9 to 9.0 per 1,000 live births among ...
Vaisman Sergey - - 2011
Fetal Heart Rate (FHR) monitoring is one of the most important fetal well being tests. Existing FHR monitoring methods are based on Doppler ultrasound technique, which has several disadvantages. Passive fetal monitoring by phonocardiography is an appropriate alternative; however, its implementation is a challenging task due to low energy of ...
Bake Shameena - - 2012
Ethanol (EtOH) consumption during pregnancy can lead to fetal growth retardation, mental retardation, and neurodevelopmental delay. The fetal brain initiates neurogenesis and vasculogenesis during the second trimester, and depends on maternal-fetal circulation for nutrition and growth signals. We used high-resolution in vivo ultrasound imaging to test the hypothesis that EtOH ...
Akinsheye Idowu I Division of Hematology/Oncology, Department of Medicine, Boston University School of Medicine, Boston, MA, USA. - - 2012
Fetal hemoglobin (HbF) is a major modifier of disease severity in sickle cell anemia (SCA). Three major HbF quantitative trait loci (QTL) are known: the Xmn I site upstream of (G)γ- globin gene (HBG2) on chromosome 11p15, BCL11A on chromosome 2p16, and HBS1L-MYB intergenic polymorphism (HMIP) on chromosome 6q23. However, ...
Collier A C AC Dept. Tropical Medicine, Medical Microbiology and Pharmacology, University of Hawaii at Mānoa, Honolulu, HI 96813, United States. - - 2012
Genes from Ugt1a family in placenta and fetal liver are responsible for hormone, nutrient and chemical balance during pregnancy. Assisted reproduction technologies (ART) i.e. intracytoplasmic sperm injection (ICSI) and in vitro fertilization (IVF) alter steroid homeostasis in pregnancy through increased glucuronidation. Here we show that ART (particularly ICSI) upregulates Ugt1a1, 1a2, ...
Wei Zheng - - 2011
Abstract This paper proposes an improved local principal component analysis (LPCA) in pseudo phase space for fetal heart rate estimation from a single lead abdominal ECG signal. The improved LPCA process can extract both the maternal ECG component and the fetal ECG component in an abdominal signal. The instantaneous fetal ...
Kane Andrew D AD Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, - - 2012
In addition to lowering cholesterol, statins increase nitric oxide (NO) bioavailability, improving endothelial function. In the fetus, enhanced NO during acute hypoxia opposes the fetal peripheral vasoconstrictor response, part of the brain-sparing defence. This study tested the hypothesis that treatment with statins depresses the fetal circulatory response to acute hypoxic ...
Schwab Matthias - - 2012
Exposure to glucocorticoid levels inappropriately high for current maturation alters fetal hypothalamo-pituitary-adrenal axis (HPAA) development. In an established fetal sheep model, we determined whether clinical betamethasone doses used to accelerate fetal lung maturation have persistent effects on fetal HPAA hypotensive-stress responses. Pregnant ewes received saline (n = 6) or betamethasone ...
Chockalingam Priya - - 2011
OBJECTIVE: To study the clinical course and outcome of fetal sinus bradycardia (SB) due to maternal antibody-induced sinus node dysfunction. METHODS: We reviewed the maternal, prenatal, and postnatal findings of fetuses with SB associated with elevated maternal anti-SSA/Ro and anti-SSB/La antibodies. RESULTS: Of the 6 cases diagnosed prenatally, 3 had ...
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