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Walker Humphrey G M HG Department of General Surgery, Wansbeck General Hospital, Ashington, UK, NE63 - - 2014
Surgical intervention for acute appendicitis during pregnancy carries significant risk to both mother and foetus. The safety of Laparoscopic Appendicectomy in pregnancy has been a matter of debate among clinicians. We have critically reviewed the available published evidence in regards with this debate. There is no strong current evidence as ...
Thompson Matthew M MM Naval Medical Center, Emergency Department, San Diego, - - 2014
Abdominal pain frequently represents a diagnostic challenge in the acute setting. In pregnant patients, the gravid abdomen and concern for ionizing radiation exposure further limit evaluation. If undiagnosed, appendicitis may cause disastrous consequences for the mother and fetus. We present the case of a pregnant female who was admitted for ...
Chmait Ramen H - - 2014
Objective and importance Homozygous Southeast Asian alpha-thalassemia mutation (--(SEA)/--(SEA)) results in deletion of all alpha-globin genes (alpha(0)-thalassemia). Since all alpha-globin chains are absent, hemoglobin F cannot be synthesized, and hemoglobin Bart's becomes the dominant fetal hemoglobin. Hemoglobin Bart's is a γ tetramer with a very high oxygen affinity, thus oxygen ...
Vidanapathirana Achini K AK Department of Physiology, Brody School of Medicine, East Carolina University, 600, Moye Boulevard, Greenville, NC, 27834, - - 2014
Pregnancy is a unique physiological state, in which C60 fullerene is reported to be distributed in both maternal and fetal tissues. Tissue distribution of C60 differs between pregnant and non-pregnant states, presumably due to functional changes in vasculature during pregnancy. We hypothesized that, polyvinylpyrorrolidone (PVP) formulated C60 (C60/PVP) increases vascular ...
Mele James J University of Texas Health Science Center San - - 2014
The placenta plays a key role in regulation of fetal growth and development and in mediating in utero developmental programming. Obesity, which is associated with chronic inflammation and mitochondrial dysfunction in many tissues, exerts a programming effect in pregnancy. We determined the effect of increasing maternal adiposity and of fetal ...
Grosso Mc M Department of Animal Anatomy, Agronomy and Veterinary Faculty, National University of Río Cuarto , Ruta Nacional 36, Km 601, Río Cuarto (5800) Córdoba , - - 2014
Early pregnancy factor (EPF) is an immunosuppressant that promotes maternal immune system tolerance of the allogenic fetus. Little is known about localization of this factor in different tissues and nothing has been reported about localization in swine reproductive and placental tissues. We determined the concentration of EPF in serum of ...
Schoennagel Bjoern P BP Department of Diagnostic and Interventional Radiology, University Medical Center - - 2014
Purpose: We evaluated the feasibility of prenatal quantification of liver and spleen iron by magnetic resonance imaging (MRI) gradient recalled echo (GRE) measurements of transverse relaxation time (R2*) (MRI-GRE-R2*) in a fetal sheep model and applied the method to a human neonate with suspected neonatal hemochromatosis.Methods: We subjected 13 fetal ...
Kaar Jill L JL Department of Pediatrics, Colorado School of Medicine, University of Colorado Denver, Denver, CO. Electronic address: - - 2014
To determine whether adequate vs excessive gestational weight gain (GWG) attenuated the association between maternal obesity and offspring outcomes. Data from 313 mother-child pairs participating in the Exploring Perinatal Outcomes among Children study were used to test this hypothesis. Maternal prepregnancy body mass index (BMI) and weight measures throughout pregnancy ...
Stupin J H JH Clara Angela Foundation, Witten, Berlin ; Clinic of Obstetrics, Charité-Universitätsmedizin Berlin, - - 2014
Overweight and obesity before conception as well as excessive weight gain during pregnancy are associated with endocrinological changes of mother and fetus. Insulin resistance physiologically increases during pregnancy, additional obesity further increases insulin resistance. In combination with reduced insulin secretion this leads to gestational diabetes which may develop into type-2-diabetes. ...
Trebb Christopher C Northern Ontario School of Medicine, Sudbury - - 2014
Background: Primary hyperparathyroidism is the most common cause of hypercalcemia in the general population. It is a rare complication of pregnancy that is difficult for clinicians to recognize, yet it can have important and devastating effects for both mother and baby. Case: A 27-year-old primigravida at 32+3 weeks' gestation had ...
Baretić Maja M Maja Baretić, Division of Endocrinology, Department of Internal Medicine, University Hospital Centre Zagreb, 10000 Zagreb, - - 2014
A 24-year-old female patient with parathyroid carcinoma, the rarest endocrine malignancy, had two pregnancies. In the first pregnancy, she had severe nausea and fatigue. Hypercalcemia and hyperparathyroidism were diagnosed in the postpartum period. Hyperemesis gravidarum masked a diagnosis of hypercalcemia. Neck ultrasound and Tc-99m sestamibi found an enlarged lower right ...
Hanhan H M HM Department of Obstetrics and Gynecology, Tepecik Education and Research Hospital , Izmir , - - 2014
Primary retroperitoneal mucinous cystadenocarcinoma (PRMC) is an extremely rare tumour. This case report describes the treatment and prognosis of a patient with PRMC during pregnancy. This is the third case of PRMC in a pregnant woman, worldwide. The patient was a 37-year-old woman presenting with a left mid-abdominal and pelvic ...
Watrowski Rafał R Department of Gynecology and Obstetrics, St. Josefskrankenhaus, Teaching Hospital of the University of Freiburg, Sautierstr. 1, 79100, Freiburg, Germany, - - 2014
Laparoscopic salpingotomy has become the gold standard for the treatment of tubal ectopic pregnancy (TEP). Limitations for organ preservation in TEP can result from intra-operative bleeding or potential tubal damage due to application of thermal coagulation. Hemostatic gelatine-thrombin matrix Floseal(®) allows effective local hemostasis when sutures or thermal coagulation are ...
Haghiac Maricela M Center of Reproductive Health, Metrohealth Medical Center, Case Western Reserve University, Cleveland, - - 2014
Context: Adiponectin (adpN) production is down-regulated in several situations associated with insulin resistance. The hypoadiponectinemia which develops in late pregnancy suggests a role of adpN in pregnancy-induced insulin resistance. Hypothesis: In obese pregnancy there is a decrease systemic adpN which result from downregulation of gene expression in adipose tissue. Design: ...
Stanhope Todd J TJ Mayo Clinic, Rochester, - - 2014
HtrA1 is a serine protease with the capacity to degrade a variety of extracellular matrix proteins. Prior study has demonstrated that processes of abnormal placental invasion such as preeclampsia are associated with changes in local tissue regulation. We examined expression of HtrA1 in fallopian tubes containing ectopic pregnancy. Fallopian tubes ...
Nakeer Tabassum T Department of Obstetrics and Gynaecology, Bismillah Taqee Hospital, - - 2014
Presentation of hydatidiform mole as tubal ectopic pregnancy is very rare. These patients usually present with ectopic pregnancy and are later diagnosed with hydatidiform mole on the basis of histological examination following surgery. We present the case of a 32-year-old female who presented with abdominal pain and vaginal bleed since ...
Reif Philipp P Department of Obstetrics and Gynecology, Medical University of Graz, Graz, - - 2014
Cancers in pregnancy affect about 0.1% of all pregnant women and large majority are of maternal origin. While more than 50 cases [1] of maternal cancers with metastases to the placenta and 14 cases [2] of transplacental transmission to the fetus have been reported, primary fetal malignancies with placental involvement ...
Watson Lucy L University of Salford, - - 2014
My first placement in my first year as a nursing student was on a short-stay surgical ward. One of the patients I helped to care for was a 17-year-old girl who was experiencing an incomplete miscarriage, meaning not all of the pregnancy tissue had been miscarried.
Fauza Dario O DO Department of Surgery, Boston Children׳s Hospital, 300 Longwood Ave, Fegan 3, Boston, Massachusetts 02115; Department of Surgery, Harvard Medical School, Boston, Massachusetts. Electronic address: - - 2014
Engineered diaphragmatic repair is emblematic of perinatal regenerative medicine and of the fetal tissue engineering concept. The alternative of a cellularized graft for the repair of a congenital diaphragmatic defect in the neonatal period is both biologically justifiable by the mechanisms behind diaphragmatic hernia recurrence as well as an ideal ...
Vogt M M Department of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum - - 2014
Purpose: Tissue Doppler imaging (TDI) allows the noninvasive quantification of global and regional myocardial function. Since there are changing loading conditions during pregnancy, this study aimed to determine maternal myocardial adaptation in normal pregnancy with TDI and tracking of the heart cycle. Patients and Methods: 106 pregnant women, mean age ...
Widen E M EM 1] New York Obesity Nutrition Research Center, St. Luke's-Roosevelt Hospital, New York, NY, USA [2] Institute of Human Nutrition and Department of Medicine, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA [3] Department of Epidemiology, Mailman School of Public Health, Columbia University Medical Center, New York, NY, - - 2014
Prevalence of overweight and obesity has risen in the United States over the past few decades. Concurrent with this rise in obesity has been an increase in pregravid body mass index and gestational weight gain affecting maternal body composition changes in pregnancy. During pregnancy, many of the assumptions inherent in ...
Johnson Mary Lynn ML M Johnson, Animal Sciences, North Dakota State University, Fargo, 58108, United - - 2014
Scrapie in sheep is spread laterally by placental transmission of an infectious misfolded form (PrPSc) of a normal prion protein (PrPC) used as a template in PrPSc formation. We hypothesized that PrPC would be expressed in uterine and placental tissues and estradiol-17B (E2) would affect uterine PrPC expression. PrPC expression ...
Mathur Nidhee N Department of Obstetrics and Gynecology, University of Chicago Recurrent Pregnancy Loss Program, University of Chicago, Chicago, - - 2014
To assess the utility of comparative genomic hybridization (CGH) and reflex microsatellite analysis (MSA) for chromosome analysis of preserved miscarriage tissue. Observational study. Academic recurrent pregnancy loss program. Patients with recurrent early pregnancy loss, defined as two or more miscarriages at <10 weeks, and at least one preserved miscarriage specimen sent ...
Parsley Laura M LM School of Zoology, University of Tasmania, Sandy Bay Campus, Private Bag 5, 7000 Tasmania, Australia. Electronic address: - - 2014
Aromatase is a key regulator of circulating testosterone (T) and 17-β-oestradiol (E2), two steroids which are critical to the development, maintenance and function of reproductive tissues. The role of aromatase in sexual differentiation in oviparous (egg-laying) reptiles is well understood, yet has never been explored in viviparous (live-bearing) reptiles. As ...
Ebrahimi Mahbod - - 2014
Ovarian pregnancy is a rare form of extra uterine pregnancy. Serous cyst adenoma is a benign variant of epithelial cell tumors of ovary. The coexistence of a cyst adenoma with an ovarian pregnancy in the same ovary is extremely rare. Some studies suggested that infertility or ovulation-inducing drugs can be ...
Huda Shahzya S SS Women and Children's Unit, Forth Valley Royal Hospital, Larbert, United - - 2014
Obesity increases preeclampsia risk, and maternal dyslipidemia may result from exaggerated adipocyte lipolysis. We compared adipocyte function in preeclampsia with healthy pregnancy to establish whether there is increased lipolysis. Subcutaneous and visceral adipose tissue biopsies were collected at caesarean section from healthy (n=31) and preeclampsia (n=13) mothers. Lipolysis in response ...
Kudesia Rashmi - - 2014
Determination of fetal aneuploidy is central to evaluation of recurrent pregnancy loss (RPL). However, obtaining this information at the time of a miscarriage is not always possible or may not have been ordered. Here we report on "rescue karyotyping", wherein DNA extracted from archived paraffin-embedded pregnancy loss tissue from a ...
Idilman Ilkay S IS Department of Radiology, Faculty of Medicine, Hacettepe University, Ankara, - - 2014
Renal angiomyolipoma is a hamartomatous, benign tumor composed of blood vessels, fatty tissue and smooth muscle cells, and is often detected incidentally. It can also be associated with the tuberous-sclerosis complex (TSC). Pregnancy and use of oral contraceptives are known to be associated with an increased risk of tumoral rupture ...
Klibanov Olga M OM Wingate University School of Pharmacy, Wingate, NC, - - 2014
To report a case of infective panniculitis in a morbidly obese, pregnant woman, which was successfully treated with daptomycin. A 34-year-old, 27-week pregnant, morbidly obese woman with a history of skin/soft-tissue infections and diabetes mellitus, presented with panniculitis. Initial treatment with β-lactam antibiotics did not result in clinical improvement. Methicillin-resistant ...
Nafziger Elizabeth E Department of Anatomy and Cell Biology, Indiana University School of Medicine, Fort Wayne, - - 2014
Nuchal translucency (NT) is a hypo-echoic region of subcutaneous fluid accumulation in the posterior neck at the level of the cervical spine between the skin and soft tissues found at 10-14 weeks gestation. This ultrasound finding is important because increased NT measurements place the fetus at increased risk for chromosomal ...
Yao Wang W Department of Mechanical Engineering, Columbia University, New York, NY, - - 2014
The human cervix is an important mechanical barrier in pregnancy which must withstand the compressive and tensile forces generated from the growing fetus. Premature cervical shortening resulting from premature cervical remodeling and alterations of cervical material properties are known to increase a woman׳s risk of preterm birth (PTB). To understand ...
Amusquivar Encarnacíón E Faculties of Pharmacy and Medicine, Universidad San Pablo CEU, Ctra. Boadilla del Monte km 5.3, 28668, Madrid, - - 2014
Dietary trans-fatty acids (t-FA) during pregnancy have adverse effects on growth and development. To determine the effect of dietary t-FA during just the first half of pregnancy, rats were given a diet containing 8 % hydrogenated peanut oil and 2 % olive oil (PO) and compared to rats given a diet containing ...
Stasinopoulou Marianna M Laboratory of Animal Facilities, Centre of Experimental Surgery, Biomedical Research Foundation Academy of Athens, Athens, - - 2014
Researchers sometimes face difficulties in the diagnosis of pregnancy and assessment of embryonic development. Ultrasonography (US) is a non-invasive imaging method with minimal side effects on the subjects or operators. It provides real-time evaluation of the physiology of rapidly moving structures (i.e., heart) and facilitates evaluation of fetal tissue development. ...
Polyzou Electra N EN 3rd Department of Obstetrics and Gynecology, University of Athens, Medical School, Athens, - - 2014
Current knowledge on the participation of angiopoietin-2 (Ang-2) in the inflammatory process and on the importance of bacterial endotoxins (LPS) in the induction of preterm delivery (PTD) led us to investigate the role of Ang-2/LPS interplay in the pathogenesis of PTD. At a first stage, Ang-2 was measured at the ...
Bakkour Sonia S Blood Systems Research Institute; San Francisco, CA - - 2014
Although pregnancy-associated microchimerism is known to exist in humans, the clinical significance remains unclear. Fetal microchimerism has been documented in rhesus monkeys, but the trafficking and persistence of maternal cells in the monkey fetus and infant have not been fully explored. To investigate the frequency of maternal microchimerism in the ...
Ota Hajime H Department of Obstetrics and Gynecology, Hadano Red Cross Hospital, Kanagawa, - - 2014
A 23-year-old woman, gravida 1, para 1, was transferred to our hospital with acute lower abdominal pain and vital signs consistent with shock. Her urine concentration of human chorionic gonadotrophin was 8000 mIU/mL. Transvaginal ultrasound revealed an echo-free space with mosaic echo pattern in the right adnexal area and no ...
Todhunter K H KH School of Agriculture and Food Sciences, The University of Queensland, Gatton, Queensland, - - 2014
Pregnant mares were experimentally exposed to whole caterpillar or exoskeleton of the Processionary caterpillar (Ochrogaster lunifer) via gavage. Tissues were collected from resulting abortions and near or full-term pregnancies consisting of 13 aborted fetuses, 3 fetuses from treated euthanized mares, membranes of 5 foals, and organs from 3 foals. Three ...
Beriot Mathilde - - 2014
This paper describes the isolation and characterization of pregnancy-associated glycoproteins (PAG) from fetal cotyledonary tissue (FCT) and maternal caruncular tissue (MCT) collected from fallow deer (Dama dama) pregnant females. Proteins issued from FCT and MCT were submitted to affinity chromatographies by using Vicia villosa agarose (VVA) or anti-bovine PAG-2 (R#438) ...
Khan Nazoora N Department of Pathology, Jawaharlal Nehru Medical College, Aligarh, Uttar Pradesh, - - 2014
Mature cystic teratomas are benign ovarian neoplasms which account for around 95% of all ovarian germ cell tumours and contain tissues derived from two or three embryonic germ layers. These tumours are frequently diagnosed in women of reproductive age group and can result in fetomaternal distress if concurrent pregnancy occurs. ...
Wester-Rosenlöf Lena L Department of Infection Medicine, Lund University, Lund, - - 2014
Preeclampsia (PE) is a serious pregnancy complication that manifests as hypertension and proteinuria after the 20(th) gestation week. Previously, fetal hemoglobin (HbF) has been identified as a plausible causative factor. Cell-free Hb and its degradation products are known to cause oxidative stress and tissue damage, typical of the PE placenta. ...
Lozoya Teresa T Hospital Universitario La Fe, Valencia, - - 2014
Our objective was to determine the expression of the elements of the Lin28/Let-7 system, and related microRNAs (miRNAs), in early stages of human placentation and ectopic pregnancy, as a means to assess the potential role of this molecular hub in the pathogenesis of ectopic gestation. Seventeen patients suffering from tubal ...
Nikolaou Marinos M 0000-0001-9414-0634 Department of Obstetrics and Gynecology, Medical School, University of Patras, Rio Achaia, 26500 Patras, - - 2014
Necrotizing fasciitis is a rare, life-threatening surgical infection in pregnancy with high rates of morbidity and mortality. A 15-year-old primigravid woman, at 28 weeks of gestation with no significant previous medical history, was admitted to our hospital complaining of severe left lower extremity pain and high fever the last 72 hours. During ...
Chen Ling L Nanjing Maternal and Child Health Hospital of Nanjing Medical University, Nanjing, China; Institute of Pediatrics, Nanjing Medical University, Nanjing, - - 2014
This study assessed the growth trends and reference ranges of the ultrasound parameters, fetal abdominal subcutaneous tissue thickness (ASTT) and subscapular subcutaneous tissue thickness (SSTT), in the last two trimesters of normal pregnancy in a Chinese population. We recruited 744 healthy women with singleton pregnancies. The ASTT and SSTT were ...
Filipescu George Alexandru GA "Carol Davila" University of Medicine and Pharmacy, Elias Emergency Hospital, Bucharest, Romania; - - 2014
Hydatidiform mole represents an abnormal form of conception that occurs in about one in 500-1000 pregnancies. It is a subtype of gestational trophoblastic disease. Hydatidiform moles should be regarded as premalignant lesions because 15-20% of complete hydatidiform moles (CHMs) and 1% of partial hydatidiform moles (PHMs) undergo malignant transformation into ...
Santoso Erna G EG Department of Mechanical Engineering, School of Engineering, The University of Tokyo, Tokyo, - - 2014
Infertility caused by ovarian or tubal problems can be treated using In Vitro Fertilization and Embryo Transfer (IVF-ET); however, this is not possible for women with uterine loss and malformations that require uterine reconstruction for the treatment of their infertility. In this study, we are the first to report the ...
Raman Rajesh R Department of Radiodiagnosis, JSS Medical College, Mysore, Karnataka 570004, - - 2014
A twenty-year-old second gravida presented to the department of radiodiagnosis for routine obstetric ultrasound examination. Ultrasonography revealed a live fetus of 17 weeks with absent falx, fused thalami, monoventricle, proboscis, and cyclopia. Fetal MRI was performed and the findings were confirmed. Even though ultrasonography is diagnostic in the detection of ...
Morelli M M Unit of Obstetrics and Gynaecology, Department of Experimental and Clinical Medicine, 'Magna Graecia' University-Catanzaro, - - 2013
The molecular aspects involved in human implantation include many elements that were first discovered due to their role in cancer cell metastasis. Periostin, a cell adhesion protein that allows the maintenance of cancer stem cells, may influence implantation. The objective of this experimental case-control study was to investigate tissue and ...
Staff A C AC Department of Obstetrics, Oslo University Hospital, Ullevål, Norway; Department of Gynaecology, Oslo University Hospital, Ullevål, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway. Electronic address: - - 2013
The decidua basalis is one of the frontiers between placenta and mother. Its spiral arteries ensure that the placenta and fetus have adequate access to the maternal circulation, without compromising maternal health. Normally this requires a tightly regulated collaboration between tissues of genetically different individuals. But like all frontiers it ...
von Holstein I C C IC BioArCh, Departments of Archaeology and Chemistry, University of York, Heslington, York, YO10 5DD, - - 2013
A variety of metabolic, dietary and climatic influences on isotopic variation have been established in mammalian hair. The relevance of these factors to collagen isotopic composition is unknown, but would be of great interest to zooarchaeological analyses of faunal skeletal tissue. The relationships between carbon (δ(13) C), nitrogen (δ(15) N), ...
Kasher-Meron Michal - - 2013
Abstract Objectives: Chemerin, a novel adipocytokine, has been implicated in major metabolic and inflammatory processes. Study aims were to determine whether circulating maternal chemerin concentration (1) differs between pregnant and non-pregnant women, (2) changes as a function of gestational age, and (3) correlates with maternal insulin resistance. In addition, we ...
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