Search Results
Results 301 - 350 of 1304
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Brent Robert L - - 2007
Over the past 50 years our laboratory has performed and published many studies in the fields of teratology, radiation biology and radiation embryology. The early work took place when I was a research employee at the University of Rochester Manhattan Project in 1944 and where I had my introduction to ...
Garcia-Bournissen Facundo - - 2008
BACKGROUND: Isotretinoin is a known teratogen. Pregnancy prevention programs aimed at minimizing isotretinoin exposure in pregnancy have been implemented in North America with limited success. OBJECTIVE: To compare the management of fetal risk of isotretinoin in three countries, including information given to women, implementation of contraceptive methods, and pregnancy outcomes. ...
Baskin Laurence S - - 2007
Hypospadias is the second most common genital anomaly in children. The etiology of hypospadias remains unknown in the overwhelming majority of patients. Herein, I review the etiology of hypospadias and propose that hypospadias can be explained by a two-hit hypothesis: genetic susceptibility plus environmental exposure to endocrine disruptors. The strategy ...
Rayburn Brittany B - - 2007
OBJECTIVE: To investigate patterns of wine consumption among hazardous drinkers before and after pregnancy recognition. STUDY DESIGN: Using a standard alcohol survey, hazardous drinking was defined as either frequent or binge drinking with related consequences. Patients identified at our clinic during their first prenatal visit as being hazardous drinkers were ...
Li Yujuan - - 2007
In a maternal fetal rat model, we investigated the behavioral and neurotoxic effects of fetal exposure to isoflurane. Pregnant rats at gestational day 21 were anesthetized with 1.3% isoflurane for 6h. Apoptosis was quantified in the hippocampus and cortex at 2 and 18h after exposure in the fetal brain and ...
Delpisheh Ali - - 2008
OBJECTIVE: To determine the association of maternal CYP17 gene polymorphisms and prenatal alcohol consumption with intrauterine growth restriction (IUGR). STUDY DESIGN: A case-control study in singleton livebirths was conducted at the Liverpool Women's Hospital between 2004 and 2005. Cases (n=90) were mothers with an IUGR baby and controls (n=180) those ...
Bretveld R - - 2008
OBJECTIVES: Fertility problems are an increasing public health issue in industrialised countries. Exposure to exogenous agents with endocrine disrupting properties, such as some pesticides, are potential risk factors for subfertility. The aim of this study was to determine whether time-to-pregnancy (TTP) is prolonged in male greenhouse workers exposed to pesticides ...
Abellan Rosario - - 2007
The aim of this study was to assess the effect of intermittent hypoxia exposure on direct and indirect methods used to evaluate recombinant human erythropoietin (rhEPO) misuse. Sixteen male triathletes were randomly assigned to either the intermittent hypoxia exposure group (experimental group) or the control normoxic group (control group). The ...
Zsarnovszky A - - 2007
Environmental and plant oestrogens have been identified as compounds that when ingested, disrupt the physiological pathways of endogenous oestrogen actions and thus, act as agonists or antagonists of oestrogen. Although the risks of exposure to exogenous oestrogens (ExEs) are subject to scientific debate, the question of how ExE exposure affects ...
Ramadoss Jayanth - - 2007
BACKGROUND: Human magnetic resonance imaging (MRI) and autopsy studies reveal abnormal cerebellar development in children who had been exposed to alcohol prenatally, independent of the exposure period. Animal studies conducted utilizing the rat model similarly demonstrate a broad period of vulnerability, albeit the third trimester-equivalent of human brain development is ...
Atkinson Diane E - - 2007
Congenital abnormalities and impaired development in childhood are attributable to fetal exposure to antiepileptic drugs (AEDs). Pregnancy registries set up to obtain information about the potential risks of fetal exposure to AEDs, in particular major congenital malformations (MCMs), suggest that valproate exposure increases the frequency of congenital malformations more than ...
Gao Yu - - 2007
Exposure to hazardous Hg can adversely affect children's neurodevelopment. However, few data are available on either Hg levels in neonates and their mothers or the impact of prenatal exposure to Hg on neonates' neurobehavioral development in the Chinese population. Therefore, this study examined Hg levels in neonates and their mothers ...
Jedrychowski Wieslaw - - 2007
Although the maternal fish consumption is supposed to have beneficial effects on development of infants, it may be harmful for child cognitive development since fish is a common source of methylmercury. Purpose of the study was to describe the usual pattern of fish consumption during pregnancy in Poland and explain ...
Paumen Miriam León - - 2008
During acute exposure, polycyclic aromatic compounds (PACs) act mainly by narcosis, but during chronic exposure the same compounds may exert sublethal life cycle effects. The aim of this study was therefore to evaluate the chronic effects of sediment spiked PACs on the emergence of the midge Chironomus riparius. Three isomer ...
Suh Young-Ju - - 2007
We explored the effects of particulate matter <10 microm (PM(10)) exposure along with CYP1A1 polymorphisms of MspI (T6235C) and NcoI (Ile462Val) on reduced birth weight (BW). A prospective cohort study was done with women who delivered from 2001 to 2004 at Ewha Womans University Hospital, Seoul, Korea. We compared the ...
Browne Marilyn L - - 2007
BACKGROUND: The physiologic effects and common use of caffeine during pregnancy call for examination of maternal caffeine consumption and risk of birth defects. Epidemiologic studies have yielded mixed results, but such studies have grouped etiologically different defects and have not evaluated effect modification. METHODS: The large sample size and precise ...
Burd Larry - - 2007
Review of the prevalence of congenital heart defects (CHD) and fetal alcohol spectrum disorder (FASD). We conducted a search of the Medline and Pubmed databases to identify papers reporting the association. We then searched the reference lists of the papers and reference books for additional sources. We found 29 studies ...
Menegaux Florence - - 2007
We investigated the role of maternal alcohol and coffee drinking during pregnancy and that of parental smoking in the aetiology of childhood leukaemia. A French, population-based, case-control study was conducted, comparing 472 [407 acute lymphoblastic leukaemia (ALL) and 62 acute myeloblastic leukaemia] cases of childhood acute leukaemia (AL) and 567 ...
Humphreys Caitlin - - 2007
An 18-year-old patient of mine, currently under treatment for attention deficit hyperactivity disorder (ADHD) with methylphenidate, just found out that she is pregnant. What are the risks for the baby when the mother uses ADHD medications during pregnancy? Available evidence for amphetamines suggests no increased risk of malformations with use ...
Seip Katharine M - - 2007
Prior studies using a dual-choice conditioned place preference (CPP) procedure revealed that postpartum female rats (dams) strongly prefer chambers associated with pups over those associated with subcutaneously administered cocaine almost exclusively during early but not late postpartum (Mattson et al. 2001). The present study examines whether early postpartum dams retain ...
Vijayavel K - - 2007
Perna viridis is an ideal animal for studying the impairment caused by the effects of heavy metals that are often detected in coastal areas. Preliminary bioassay tests revealed that the lethal (LC(100)), median lethal (LC(50)) and sublethal (LC(0)) concentration of silver and chromium to P. viridis were 6.5, 4.0, 2.0 ...
Pineño Oskar - - 2008
Protection from extinction of conditioned fear has been demonstrated when a conditioned inhibitor of fear is presented during extinction treatment. The present study assessed if similar results could be obtained during the analogous habituation of unconditioned fear. The neophobic response typically elicited by the presentation of a novel flavor was ...
Cooper William O - - 2007
OBJECTIVE: The purpose of this study was to quantify the rate of exposures to antidepressants during pregnancy in a large cohort of women. STUDY DESIGN: This was a retrospective cohort study of 105,335 pregnancies among women enrolled in Tennessee Medicaid from 1999-2003. Pregnancies were classified according to antidepressant exposures during ...
Chapman Kim - - 2007
OBJECTIVE: This investigation examined the influence of parental substance use disorder (SUD) and mother's alcohol consumption during pregnancy on neurobehavior disinhibition (ND) measured in 10- to 12-year-old children. The extent to which ND predicted SUD outcome 7 to 9 years later was also determined. METHODS: SUD was documented in each ...
Ramadoss Jayanth - - 2007
BACKGROUND: The third trimester equivalent has been identified, both in rat and sheep models, as a period of cerebellar vulnerability to alcohol-mediated injury. We wished to determine whether alcohol exposure throughout gestation results in greater injury compared with exposure limited to the third trimester equivalent. While this question has previously ...
Kavanagh Yeo, Catherine R.
Despite the age old warnings against the use of alcohol during pregnancy, and the abundance of scientific research that links Fetal Alcohol Syndrome (FAS) and Fetal Alcohol Effects (FAE) with prenatal maternal alcohol ingestion, FAS/FAE remains one of the leading causes of birth defects and mental retardation. It is critical ...
O'Leary Colleen M - - 2007
It is well accepted that heavy alcohol consumption during pregnancy is a risk factor for fetal alcohol spectrum disorder, but research findings for exposure to low to moderate alcohol levels during pregnancy are equivocal, allowing a range of interpretations. The 2001 guideline from the National Health and Medical Research Council ...
Rayburn William F - - 2007
This short communication represents a systematic review of the literature about beer drinking during gestation. A Medline search was undertaken of articles based on the criterion that beer and pregnancy were in the abstract and central to the article. Manuscripts were to be published in English in peer review medical ...
De Genna Natacha M - - 2007
The goal of this study was to examine the effects of early and adverse experiences with sex and alcohol on adolescent drinking the year before and during pregnancy. Pregnant adolescents, recruited at an outpatient prenatal clinic, were interviewed about their substance use. A subsample was asked about their first sexual ...
Nagata Chisato - - 2007
High levels of estrogen during pregnancy have been hypothesized to increase the risk of breast cancer in offspring. Some studies have reported a positive association of estrogen level during pregnancy with fetal size, which has been linked to the subsequent risk of breast cancer in offspring. We examined whether maternal ...
Iveli María Florencia - - 2007
This study explores the effects of light maternal ethanol consumption during pregnancy on the appearance of minor malformations in neonates as well as on the contractile properties of their umbilical cord arteries (UCAs). Clinical external findings of newborns of women declaring light ethanol consumption during any period of their pregnancies ...
Wijayawardhane Nayana - - 2007
Aniracetam is a nootropic compound and an allosteric modulator of AMPA receptors (AMPARs) which mediate synaptic mechanisms of learning and memory. Here we analyzed impairments in AMPAR-mediated synaptic transmission caused by moderate prenatal ethanol exposure and investigated the effects of postnatal aniracetam treatment on these abnormalities. Pregnant Sprague-Dawley rats were ...
Gross Eric A - - 2007
OBJECTIVES: American Indians (AI's) have the lowest rate of seatbelt use in the nation, putting them at significant risk for motor vehicle crash (MVC) morbidity and mortality. This study compares seatbelt use in victims of level one trauma crashes presenting from on and off AI reservations. Predictors of seatbelt use ...
Magnusson Asa - - 2007
BACKGROUND: We examined alcohol use disorders, psychiatric symptoms and personality traits in women reporting alcohol use during pregnancy. METHODS: In a pilot cohort (n=139), subjects were screened for alcohol use disorders, and assessed for psychopathology, personality traits, and alcohol use during the first trimester. Those reporting consumption exceeding a conservative ...
Lung Shih-Chun Candice - - 2007
Exposure assessment studies for particulates have been conducted in several U.S. and European cities; however, exposure data remain sparse for Asian populations whose cultural practices and living styles are distinct from those in the developed world. This study assessed personal PM(10) exposure in urban residents and evaluated PM(10) indoor/outdoor levels ...
Zeni Olga - - 2007
The aim of this study was to investigate the induction of reactive oxygen species in murine L929 fibrosarcoma cells exposed to radiofrequency (RF) radiation at 900 MHz, with or without co-exposure to 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), a potent environmental carcinogen produced during chlorination of drinking water. Both continuous-wave and GSM mobile phone ...
Colombié Sophie - - 2007
The monitoring of alcoholic fermentation under enological conditions is currently poor due to the lack of sensors for online measurements. Such monitoring is currently limited to the measurement of CO(2) production or changes in density. In this study, we determined the potential value of measuring electrical conductivity. We showed that ...
Stein Aryeh D - - 2007
BACKGROUND: Few studies in humans have related maternal undernutrition to the size of the adult offspring. OBJECTIVE: The objective was to assess whether reductions in food intake by pregnant women during the Dutch famine of 1944-1945 were related to offspring length, weight, and indexes of adiposity in middle age. DESIGN: ...
Colvin Lyn - - 2007
BACKGROUND: High alcohol intake in pregnancy has been linked to abnormal fetal development. There are limited published data in Australia on standard drinks of alcohol consumed on a typical occasion during the periconceptional period or pregnancy. METHODS: During 1995 to 1997, a 10% random sample of all nonindigenous women giving ...
Loughlin Kevin R - - 2007
The pregnant patient presents a unique diagnostic challenge to the urologist because the well-being of both the mother and fetus must be considered. Radiation exposure to the fetus during gestation presents risks such as cell death and teratogenic effects, carcinogenesis, and genetic effects, which must be considered when selecting diagnostic ...
Spohr Hans-Ludwig - - 2007
OBJECTIVE: To test the hypothesis that fetal alcohol syndrome (FAS), with the full phenotype, and fetal alcohol effect (FAE), with some but not all of the features, can be combined under the umbrella term fetal alcohol spectrum disorders (FASD). STUDY DESIGN: We investigated the long-term sequelae of intrauterine alcohol exposure ...
Garcia-Bournissen Facundo - - 2007
Cocaine use during pregnancy is difficult to ascertain, and maternal reports are likely to be inaccurate. Presently, the dose-response characteristics between maternal cocaine use and fetal exposure and adverse effects are unknown. Clinically, some babies are harmed, whereas others are not adversely affected. Taking advantage of the fact that cocaine ...
Lemola S - - 2007
Although drinking and smoking during pregnancy can have hazardous effects to exposed children, a certain number of pregnant women continues to consume alcohol and nicotine. It was investigated whether physicians and midwives in Switzerland ask pregnant women about their drinking and smoking habits. A self-report questionnaire was used to assess ...
Harding Gary W - - 2007
Infrasound (i.e., <20 Hz for humans; <100 Hz for chinchillas) is not audible, but exposure to high-levels of infrasound will produce large movements of cochlear fluids. We speculated that high-level infrasound might bias the basilar membrane and perhaps be able to minimize noise-induced hearing loss. Chinchillas were simultaneously exposed to ...
Torres-Sánchez Luisa - - 2007
Evidence suggests that p,p'-dichlorodiphenyldichloroethene (DDE) affects neurodevelopment in infants, although a critical exposure window has not yet been identified. Our goal was to assess the prenatal DDE exposure window and its effect on the psychomotor development index (PDI) and mental development index (MDI) during the first year of life. We ...
Henderson J - - 2007
OBJECTIVE: The aim of this study was to review systematically the available evidence on studies in humans on the effects of low-moderate levels of prenatal alcohol consumption (up to 10.4 UK units or 83 g/week) compared with consumption of no alcohol on pregnancy outcome. DESIGN: Systematic review. POPULATION: Pregnant women ...
Martínez Susana E - - 2007
Alcohol abuse produces damaging effects on the CNS that leads to several types of disorders. When consumed during pregnancy, alcohol may cause craniofacial malformations, growth retardation and brain damage in offspring. These symptoms are grouped by the term fetal alcohol syndrome (FAS). FAS is the most common cause of non-genetic ...
Niemelä Onni - - 2007
Studies over the past two decades have indicated that protein modifications by acetaldehyde, the first metabolite of ethanol, are generated in the circulation as a result of alcohol abuse and play a major role in the pathogenesis of ethanol-induced diseases. Acetaldehyde can react with nucleophilic groups forming both stable and ...
Ceccanti Mauro - - 2007
In Italy, little is known about the spectrum of adverse fetal effects related to maternal alcohol use during pregnancy. In this paper, we report on the phenotype of Italian children with fetal alcohol spectrum disorders (FASD). These data were gathered as part of a field study assessing the prevalence of ...
Leonardson Gary R - - 2007
BACKGROUND: A substance use screening instrument was used to determine factors predictive of drinking during pregnancy. Alcohol consumption during pregnancy can lead to negative birth outcomes. METHODS: The participants (n = 4,828) for the study were sampled from pregnant women attending prenatal clinics in Montana, South Dakota, and North Dakota. ...
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